EKS-POA-00356
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00356
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.37.1E-135287536250
StatusUnreviewed
Ensembl ProteinENSPPYP00000012270
UniProt AccessionH2P1V4;
Protein Name
Protein Synonyms/Alias
Gene NameSRC
Gene Synonyms/Alias SRC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000010985ENSPPYP00000012270ENSPPYT00000012751
OrganismPongo abelii
Functional Description
Protein Length553
Protein Sequence
(FASTA)
MGSNKSKPKD ASQRRRSLEP TENVHGAGGG AFPASQTPSK PASADGHRGP SAAFAPAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTRKV 120
DVSQTWFTFR WLQREGDWWL AHSLSTGQTG YIPSNYVAPS DSIQAEEWYF GKITRRESER 180
LLLNAENPRG TFLVRESETT KGAYCLSVSD FDNAKGLNVK HYKIRKLDSG GFYITSRTQF 240
NSLQQLVAYY SKHADGLCHR LTTVCPTSKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE 300
VWMGTWNGTT RVAIKTLKPG TMSPEAFLQE AQVMKKLRHE KLVQLYAVVS EEPIYIVTEY 360
MSKGSLLDFL KGETGKYLRL PQLVDMAAQI ASGMAYVERM NYVHRDLRAA NILVGENLVC 420
KVADFGLARL IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LLTELTTKGR 480
VPYPGMVNRE VLDQVERGYR MPCPPECPES LHDLMCQCWR KEPEERPTFE YLQAFLEDYF 540
TSTEPQYQPG ENL 553
Nucleotide Sequence
(FASTA)
ATGGGCAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAGC GGCGCCGCAG CCTGGAGCCC 60
ACCGAGAACG TGCACGGCGC TGGCGGGGGC GCTTTCCCCG CCTCGCAGAC CCCCAGCAAG 120
CCAGCCTCGG CCGACGGCCA CCGCGGCCCA AGTGCGGCCT TCGCCCCCGC GGCCGCCGAG 180
CCCAAGCTGT TCGGAGGCTT CAACTCCTCG GACACCGTCA CCTCCCCGCA GAGGGCGGGC 240
CCGCTGGCCG GGGGAGTGAC CACCTTTGTG GCCCTCTATG ACTATGAGTC TAGGACGGAG 300
ACAGACCTGT CCTTCAAGAA AGGCGAGCGG CTCCAGATTG TCAACAACAC GAGGAAGGTG 360
GATGTCAGCC AGACCTGGTT CACATTCAGA TGGCTGCAAA GAGAGGGAGA CTGGTGGCTG 420
GCCCACTCGC TCAGCACAGG ACAGACAGGC TACATCCCCA GCAACTACGT GGCGCCCTCC 480
GACTCCATCC AGGCCGAGGA GTGGTATTTT GGCAAGATCA CCAGACGGGA GTCAGAGCGG 540
TTACTGCTCA ACGCGGAGAA CCCGAGAGGG ACCTTCCTCG TGCGAGAAAG TGAGACCACG 600
AAAGGTGCCT ACTGCCTCTC AGTGTCTGAC TTCGACAACG CCAAGGGCCT CAACGTGAAG 660
CACTACAAGA TCCGCAAGCT GGACAGCGGC GGCTTCTACA TCACCTCCCG CACCCAGTTC 720
AACAGCCTGC AGCAGCTGGT GGCCTACTAC TCCAAACACG CCGACGGCCT GTGCCACCGC 780
CTCACCACCG TGTGCCCCAC GTCCAAGCCA CAGACTCAGG GCCTGGCCAA GGATGCCTGG 840
GAGATCCCTC GGGAGTCGCT GCGGCTGGAG GTCAAGCTGG GCCAGGGCTG CTTTGGCGAG 900
GTGTGGATGG GGACCTGGAA CGGTACCACC AGGGTGGCCA TCAAAACCCT GAAGCCCGGC 960
ACGATGTCTC CAGAGGCCTT CCTACAGGAG GCCCAGGTCA TGAAGAAGCT GAGGCATGAG 1020
AAGCTGGTGC AGTTGTATGC TGTGGTTTCG GAGGAGCCTA TTTACATCGT CACGGAGTAC 1080
ATGAGCAAGG GGAGTTTGCT GGACTTTCTC AAGGGGGAGA CAGGCAAGTA CCTGCGGCTG 1140
CCTCAGCTGG TGGACATGGC TGCTCAGATC GCCTCAGGCA TGGCATACGT GGAGCGGATG 1200
AACTACGTCC ACCGGGACCT TCGTGCAGCC AACATCCTGG TGGGAGAGAA CCTGGTGTGC 1260
AAAGTGGCCG ACTTCGGGCT GGCTCGGCTC ATCGAAGACA ATGAGTACAC GGCGCGGCAA 1320
GGTGCCAAAT TCCCCATCAA GTGGACGGCT CCGGAAGCTG CCCTCTATGG CCGCTTCACC 1380
ATCAAGTCGG ACGTATGGTC CTTCGGGATC CTGCTGACTG AGCTCACCAC AAAGGGACGG 1440
GTGCCCTACC CTGGGATGGT GAACCGCGAG GTGCTGGACC AGGTGGAGCG GGGCTACCGG 1500
ATGCCCTGCC CGCCGGAGTG TCCCGAGTCC CTGCACGACC TCATGTGCCA GTGCTGGCGG 1560
AAGGAGCCTG AGGAGCGGCC CACCTTCGAG TACCTGCAGG CCTTCCTGGA GGACTACTTC 1620
ACGTCCACCG AGCCCCAGTA CCAGCCCGGG GAGAACCTCT AG 1662
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 287   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  346
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 347   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  405
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 406   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  465
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee
Q: 466   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  525
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 526   RPTFEYLQAFL  536
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-CII-00206
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAM-00220
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00475
EKS-ORC-00344
EKS-ORL-00435
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
pon:100436498;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013