EKS-POA-00421

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00421

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Aur	462.1	3.8E-139	134	384	251

Status

Unreviewed

Ensembl Protein

ENSPPYP00000012456

UniProt Accession

H2P2C6;

Protein Name

Protein Synonyms/Alias

Gene Name

AURKA

Gene Synonyms/Alias

AURKA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000011148	ENSPPYP00000012456	ENSPPYT00000012944

Organism

Pongo abelii

Functional Description

Protein Length

404

Protein Sequence
(FASTA)

MDRSKENCIS GPVKVTAPVG GPKRVLVTQQ FPCQNPLPAN SGQAQRVLCP SNSSQRVPLQ 60

AQKLVSSHKP VQNQKQQKQL QATSVPHPVS RPLNNTQKSK QPLPSAPENN PEEELASKQK 120

NEESKKRQWA LEDFEIGRPL GKGKFGNVYL AREKQSKFIL ALKVLFKAQL EKAGVEHQLR 180

REVEIQSHLR HPNILRLYGY FHDATRVYLI LEYAPLGTVY RELQKLSKFD EQRTATYITE 240

LANALSYCHS KRVIHRDIKP ENLLLGSAGE LKIADFGWSV HAPSSRRTTL CGTLDYLPPE 300

MIEGRMHDEK VDLWSLGVLC YEFLVGKPPF EANTYQETYK RISRVEFTFP DFVTEGARDL 360

ISRLLKHNPS QRPMLREVLE HSWITANSSK PSNCQNKEST SKQS 404

Nucleotide Sequence
(FASTA)

ATGGACCGAT CTAAAGAAAA CTGCATTTCA GGGCCTGTTA AGGTTACAGC TCCAGTTGGA 60

GGTCCAAAAC GTGTTCTCGT GACTCAGCAA TTTCCTTGTC AGAATCCATT ACCTGCAAAT 120

AGTGGCCAGG CTCAGCGGGT CCTGTGTCCT TCAAATTCTT CCCAGCGTGT TCCTTTGCAA 180

GCACAAAAGC TTGTCTCCAG TCACAAGCCG GTTCAGAATC AGAAGCAGCA GAAGCAATTG 240

CAGGCAACCA GTGTACCTCA TCCTGTCTCC AGGCCACTGA ATAACACCCA AAAGAGCAAG 300

CAGCCCCTGC CGTCAGCACC TGAAAATAAT CCTGAGGAGG AACTGGCATC AAAACAGAAA 360

AATGAAGAAT CAAAAAAGAG GCAGTGGGCT TTGGAAGACT TTGAAATTGG TCGCCCTCTG 420

GGTAAAGGAA AGTTTGGTAA TGTTTATTTA GCAAGAGAAA AGCAAAGCAA GTTTATTCTG 480

GCTCTTAAAG TGTTATTTAA AGCTCAGCTG GAGAAAGCTG GAGTGGAGCA TCAGCTCAGA 540

AGAGAAGTAG AAATACAGTC CCACCTTCGG CATCCTAATA TTCTCAGACT GTATGGTTAT 600

TTCCATGACG CTACCAGAGT CTACCTAATT CTGGAATATG CACCACTTGG AACAGTCTAT 660

AGAGAACTTC AGAAACTTTC AAAGTTTGAT GAGCAGAGAA CTGCTACTTA TATAACAGAA 720

TTGGCAAATG CCCTGTCTTA CTGTCATTCG AAGAGAGTTA TTCATAGAGA CATTAAGCCA 780

GAGAACTTAC TTCTTGGATC AGCCGGAGAG CTTAAAATTG CAGATTTTGG GTGGTCAGTA 840

CATGCTCCAT CTTCCAGGAG GACCACTCTC TGTGGCACCC TGGACTACCT GCCCCCCGAA 900

ATGATAGAAG GTCGGATGCA TGATGAGAAG GTGGATCTCT GGAGCCTTGG AGTTCTTTGC 960

TATGAATTTT TAGTTGGGAA GCCTCCTTTT GAGGCAAACA CATACCAAGA GACCTACAAA 1020

AGAATATCAC GGGTTGAATT CACATTCCCT GACTTTGTAA CAGAGGGAGC CAGGGACCTC 1080

ATTTCAAGAC TGTTGAAGCA TAATCCCAGC CAGAGGCCAA TGCTCAGAGA AGTACTTGAA 1140

CACTCCTGGA TCACAGCAAA TTCATCAAAA CCATCAAATT GCCAAAACAA AGAATCAACC 1200

AGCAAACAGT CTTAG 1215

Domain Profile

S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60

         feiGr+lGkGkfGnvylarek+skfi+alkvlfk+qlek+gve+qlrre+eiqshl+hpn

Q: 134   FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN  193

         9***********************************************************

S: 61    ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv  120

         ilrlygyfhd++rvylileyap G++y+elqk +k+deqr+a+yi+ela+alsy+h+k+v

Q: 194   ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRV  253

         ************************************************************

S: 121   ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl  180

         ihrdikpenlllgs gelk+adfGwsvhapss+r+tlcGtldylppem+egr++dekvdl

Q: 254   IHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDL  313

         ************************************************************

S: 181   walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl  240

         w+lGvlcye+lvGkppfe+++++etykri++v++++p++v++ga+dlis+llk++p++r

Q: 314   WSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRP  373

         ************************************************************

S: 241   tladvlahpwi  251

         +l++vl+h wi

Q: 374   MLREVLEHSWI  384

         **********8

Domain Sequence
(FASTA)

FEIGRPLGKG KFGNVYLARE KQSKFILALK VLFKAQLEKA GVEHQLRREV EIQSHLRHPN 60

ILRLYGYFHD ATRVYLILEY APLGTVYREL QKLSKFDEQR TATYITELAN ALSYCHSKRV 120

IHRDIKPENL LLGSAGELKI ADFGWSVHAP SSRRTTLCGT LDYLPPEMIE GRMHDEKVDL 180

WSLGVLCYEF LVGKPPFEAN TYQETYKRIS RVEFTFPDFV TEGARDLISR LLKHNPSQRP 240

MLREVLEHSW I 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005876	; C:spindle microtubule
GO:0031616	; C:spindle pole centrosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000278	; P:mitotic cell cycle
GO:0031647	; P:regulation of protein stability

KEGG

pon:100459866

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013