EKS-POA-00034
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00034
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RAD53316.41.4E-94278463186
StatusUnreviewed
Ensembl ProteinENSPPYP00000013022
UniProt AccessionH2P3X6;
Protein Name
Protein Synonyms/Alias
Gene NameCHEK2
Gene Synonyms/Alias CHEK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000011675ENSPPYP00000013022ENSPPYT00000013553
OrganismPongo abelii
Functional Description
Protein Length520
Protein Sequence
(FASTA)
MSRESDVEAQ QSHGSSACSQ PHGSITQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL 60
SSLKTVSTQE LYSIPEDQEP EDQEPEEPTP PWARLWALDG FANLECVNDN YWFGRDKSCE 120
YCFDEPLLKR TDKYRTYSKK HFRIFREVGP KNSYIAYIED HSGNGTFVNT ELVGKGKRRP 180
LNNNSEIALS LSRNKVFVFF DLTVDDQSVY PKALRDEYIM SKTLGSGACG EVKLAFERKT 240
CKKVAIKIIS KRKFAIGSAR ETDPALNVET EIEILKKLNH MEGGELFDKV VGNKRLKEAT 300
CKLYFYQMLL AVQYLHENGI IHRDLKPENV LLSSQEEDCL IKITDFGHSK ILGETSLMRT 360
LCGTPTYLAP EVLVSVGTAG YNRAVDCWSL GVILFICLSG YPPFSEHRTQ VSLKDQITSG 420
KYNFIPEVWA EVSEKALDLV KKLLVVDPKA RFTTEEALRH PWLQDEDMKR KFQDLLSEEN 480
ESTALPQVLA QPSTSRKRPR EGEAEGAETT KRPAVCAAVL 520
Nucleotide Sequence
(FASTA)
ATGTCTCGGG AGTCGGATGT TGAGGCTCAG CAGTCCCATG GCAGCAGTGC CTGTTCACAG 60
CCCCATGGCA GCATTACCCA GTCCCAAGGC TCCTCCTCAC AGTCCCAGGG CATATCCAGC 120
TCCTCTACCA GCACGATGCC AAACTCCAGC CAGTCCTCTC ACTCCAGCTC TGGGACACTG 180
AGCTCCTTAA AGACAGTGTC CACTCAGGAA CTCTATTCTA TTCCTGAGGA CCAAGAACCT 240
GAGGACCAAG AACCTGAGGA GCCTACCCCT CCCTGGGCTC GATTATGGGC CCTTGATGGA 300
TTTGCCAATC TTGAATGTGT GAATGACAAC TACTGGTTTG GGAGGGACAA AAGCTGTGAA 360
TATTGCTTTG ATGAACCACT GCTGAAAAGA ACAGATAAAT ACCGGACATA TAGCAAGAAA 420
CACTTTCGGA TTTTCAGGGA AGTGGGTCCT AAAAACTCTT ACATTGCATA CATAGAAGAT 480
CACAGTGGCA ATGGAACCTT TGTAAATACA GAGCTTGTAG GGAAAGGAAA ACGCCGTCCT 540
TTGAATAACA ATTCTGAAAT TGCACTGTCA CTAAGCAGAA ATAAAGTTTT TGTCTTTTTT 600
GATCTGACTG TAGATGATCA GTCAGTTTAT CCTAAGGCAT TAAGAGATGA ATACATCATG 660
TCAAAAACTC TTGGAAGTGG TGCCTGTGGA GAGGTAAAGC TGGCTTTCGA GAGGAAAACA 720
TGTAAGAAAG TAGCCATAAA GATCATCAGC AAAAGGAAGT TTGCTATTGG TTCAGCAAGA 780
GAGACAGACC CAGCTCTCAA TGTTGAAACA GAAATAGAAA TTTTGAAAAA GCTAAATCAT 840
ATGGAAGGGG GAGAGCTGTT TGACAAAGTG GTGGGGAATA AACGCCTGAA AGAAGCTACC 900
TGCAAGCTCT ATTTTTACCA GATGCTCTTG GCTGTGCAGT ACCTTCATGA AAACGGTATT 960
ATACACCGTG ACTTAAAGCC AGAGAATGTT TTACTGTCAT CTCAAGAAGA GGACTGTCTT 1020
ATAAAGATTA CTGATTTTGG GCACTCCAAG ATTTTGGGAG AGACCTCTCT CATGAGAACC 1080
TTATGTGGAA CCCCCACCTA CTTGGCTCCT GAAGTTCTTG TTTCTGTTGG GACTGCTGGG 1140
TATAACCGTG CTGTGGACTG CTGGAGTTTA GGAGTTATTC TTTTTATCTG CCTTAGTGGG 1200
TATCCACCTT TCTCTGAGCA TAGGACTCAA GTGTCACTGA AGGATCAGAT CACCAGTGGA 1260
AAATACAACT TCATTCCTGA AGTCTGGGCC GAAGTCTCAG AGAAAGCTCT GGACCTTGTC 1320
AAGAAGTTGT TGGTAGTGGA TCCAAAGGCA CGTTTTACGA CAGAAGAAGC CTTAAGACAC 1380
CCATGGCTTC AGGATGAAGA TATGAAGAGA AAGTTTCAAG ATCTTCTGTC TGAGGAAAAT 1440
GAATCCACAG CTCTACCCCA GGTTCTAGCC CAGCCTTCTA CTAGTCGAAA GCGGCCCCGT 1500
GAAGGGGAAG CCGAGGGTGC TGAGACCACA AAGCGCCCAG CTGTGTGTGC TGCTGTGTTG 1560
TGA 1563
Domain Profile
S: 82    lelvegGelldkvvakkllkedlskllfkqlltavkylhekgiihrDlkPeniLlsekee  141
         l+ +egGel+dkvv +k+lke+++kl+f+q+l av+ylhe+giihrDlkPen+Lls++ee
Q: 278   LNHMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE  337
         578*********************************************************
S: 142   dvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvkkgraeytskvDiWslGvvlfvi  201
         d+l+kitDfG++k+lge+slm+tlCGtp+y+aPevlv+ g+a+y+++vD+WslGv+lf++
Q: 338   DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC  397
         ************************************************************
S: 202   lsGypPfseeltqvslkeqilkgkyafieekwkkiseeakdlikklLvvdPeerlsieea  261
         lsGypPfse++tqvslk+qi++gky+fi+e+w+++se+a+dl+kklLvvdP++r+++eea
Q: 398   LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA  457
         ************************************************************
S: 262   lnhpWl  267
         l+hpWl
Q: 458   LRHPWL  463
         *****8
Domain Sequence
(FASTA)
LNHMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE 60
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC 120
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA 180
LRHPWL 186
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00032
EKS-BOT-00037
EKS-CAE-00032
EKS-CAJ-00036
EKS-CAF-00037
EKS-CAP-00037
EKS-CII-00014
EKS-CIS-00038
EKS-DAR-00048
EKS-DRM-00013
EKS-EQC-00034
EKS-FEC-00034
EKS-GAG-00030
EKS-GOG-00035
EKS-HOS-00037
EKS-ICT-00032
EKS-LAC-00038
EKS-LOA-00036
EKS-MAM-00036
EKS-MEG-00032
EKS-MOD-00036
EKS-MUM-00038
EKS-MUP-00038
EKS-MYL-00038
EKS-NOL-00035
EKS-ORN-00053
EKS-ORA-00032
EKS-ORC-00035
EKS-ORL-00049
EKS-OTG-00038
EKS-PAT-00034
EKS-PES-00033
EKS-RAN-00038
EKS-SAH-00035
EKS-TAG-00034
EKS-TAR-00053
EKS-TEN-00057
EKS-XET-00037
EKS-XIM-00051
EKS-SCP-00036
Gene Ontology
GO:0000781; C:chromosome, telomeric region
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0044257; P:cellular protein catabolic process
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0006302; P:double-strand break repair
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0046777; P:protein autophosphorylation
GO:0042176; P:regulation of protein catabolic process
GO:0010332; P:response to gamma radiation
GO:0072428; P:signal transduction involved in intra-S DNA damage checkpoint
GO:0090307; P:spindle assembly involved in mitosis
KEGG
InterPros
IPR000253; FHA_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR008984; SMAD_FHA_domain.
Pfam
PF00498; FHA; 1.
PF00069; Pkinase; 1.
SMARTs
SM00240; FHA; 1.
SM00220; S_TKc; 1.
Prosites
PS50006; FHA_DOMAIN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013