EKS-POA-00454
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00454
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK367.54.4E-11027295269
StatusUnreviewed
Ensembl ProteinENSPPYP00000013363
UniProt AccessionH2P4V8;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK12
Gene Synonyms/Alias MAPK12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000011980ENSPPYP00000013363ENSPPYT00000013909
OrganismPongo abelii
Functional Description
Protein Length351
Protein Sequence
(FASTA)
MSSPPPARSG FYRQEVTKTA WEVRAVYRDL QPVGSGAYGA VCSAVDSRTG AKVAIKKLYR 60
PFQSDLFAKR AYRELRLLKH MRHENVIGLL DVFTPDETLD DFTDFYLVMP FMGTDLGKLM 120
KHEKLGEDRI QFLVYQMLKG LRYIHAAGII HRILDFGLAR QADSEMTGYV VTRWYRAPEV 180
ILNWMRYTQT VDIWSVGCIM AEMITGKTLF KGSDHLDQLK EIMKVTGTPP AEFVQRLQSD 240
EAKNYMKGLP ELEKKDFASI LTNASPLAVN LLEKMLVLDA EQRVTAAEAL AHPYFESLHD 300
TEDEPQVQKY DDSFDDVDRT LDEWKRVTYK EVLSFKPPQQ LGARVSKETA L 351
Nucleotide Sequence
(FASTA)
ATGAGCTCTC CGCCGCCCGC CCGCAGTGGC TTTTACCGCC AGGAGGTGAC CAAGACGGCC 60
TGGGAGGTGC GCGCCGTGTA CCGGGACCTG CAGCCCGTGG GCTCGGGCGC CTATGGCGCG 120
GTGTGCTCGG CCGTGGACAG CCGCACCGGC GCTAAGGTAG CCATCAAGAA GCTGTATCGG 180
CCCTTCCAGT CCGACCTGTT CGCCAAGCGC GCCTACCGCG AGCTGCGCCT GCTCAAGCAC 240
ATGCGCCACG AGAACGTGAT CGGGCTGCTG GACGTATTCA CTCCTGATGA GACCCTGGAT 300
GACTTCACGG ACTTTTACCT GGTGATGCCG TTCATGGGCA CCGACCTGGG CAAGCTCATG 360
AAACATGAGA AGCTAGGCGA GGACCGGATC CAGTTTCTCG TGTACCAGAT GCTGAAGGGG 420
CTGAGGTATA TCCACGCTGC TGGCATCATC CACAGAATCC TGGACTTCGG CCTGGCCAGG 480
CAGGCAGACA GTGAGATGAC TGGGTACGTG GTGACCCGGT GGTACCGGGC TCCCGAGGTC 540
ATCTTGAATT GGATGCGCTA CACGCAGACG GTGGACATCT GGTCTGTGGG CTGCATCATG 600
GCAGAGATGA TCACAGGCAA GACGCTGTTC AAGGGCAGCG ACCACCTGGA CCAGCTGAAG 660
GAGATCATGA AGGTGACGGG GACGCCTCCG GCTGAGTTTG TGCAGCGGCT GCAGAGCGAT 720
GAGGCCAAGA ACTACATGAA GGGCCTCCCC GAATTGGAGA AGAAGGATTT TGCCTCCATC 780
CTCACCAATG CAAGCCCTCT GGCTGTGAAC CTCCTGGAGA AGATGCTGGT GCTGGATGCG 840
GAGCAGCGGG TGACAGCGGC CGAGGCGCTG GCCCATCCCT ACTTTGAGTC CCTGCACGAC 900
ACGGAAGATG AGCCCCAGGT CCAGAAGTAT GATGACTCCT TTGACGACGT GGACCGCACA 960
CTGGATGAAT GGAAGCGTGT TACTTACAAA GAGGTGCTCA GCTTCAAGCC TCCCCAGCAG 1020
CTGGGGGCCA GGGTCTCCAA GGAGACGGCT CTGTGA 1056
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++l+p+g+Gayg v+savd+rt+ +vaikkl rpfq+   akr++REl+llk+++heN+
Q: 27    YRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYRPFQSDLFAKRAYRELRLLKHMRHENV  86
         7899********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i lldvftp+e+l++++d+Ylv+ +m+tdL k++k++kl +++i++l+yq+l+gl+y+H+
Q: 87    IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA  146
         ************************************************************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHr                ildFGlar+ad+e    +t+yv+trwYraPe++l++++
Q: 147   AGIIHR----------------ILDFGLARQADSE----MTGYVVTRWYRAPEVILNWMR  186
         *****8................99**********9....*********************
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         yt++vDiWsvGCI+aE++tgk+lf+g+d++dql++i++v+gtp +ef+++++s+ea+ny+
Q: 187   YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM  246
         ************************************************************
S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         k lp+ +kkdf++++++as+ a++Llek+Lvld+++R++++eaL+hpY+
Q: 247   KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAAEALAHPYF  295
         ************************************************6
Domain Sequence
(FASTA)
YRDLQPVGSG AYGAVCSAVD SRTGAKVAIK KLYRPFQSDL FAKRAYRELR LLKHMRHENV 60
IGLLDVFTPD ETLDDFTDFY LVMPFMGTDL GKLMKHEKLG EDRIQFLVYQ MLKGLRYIHA 120
AGIIHRILDF GLARQADSEM TGYVVTRWYR APEVILNWMR YTQTVDIWSV GCIMAEMITG 180
KTLFKGSDHL DQLKEIMKVT GTPPAEFVQR LQSDEAKNYM KGLPELEKKD FASILTNASP 240
LAVNLLEKML VLDAEQRVTA AEALAHPYF 269
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00430
EKS-ANC-00447
EKS-BOT-00461
EKS-CAJ-00471
EKS-CAF-00462
EKS-CAP-00495
EKS-DAR-00870
EKS-EQC-00455
EKS-GAM-00269
EKS-GAA-00569
EKS-HOS-00471
EKS-LOA-00477
EKS-MAM-00460
EKS-MEG-00381
EKS-MUM-00492
EKS-MUP-00461
EKS-MYL-00458
EKS-NOL-00419
EKS-ORN-00583
EKS-ORC-00436
EKS-ORL-00532
EKS-OTG-00468
EKS-PAT-00441
EKS-PES-00404
EKS-RAN-00474
EKS-SAH-00439
EKS-TAG-00528
EKS-TAR-00575
EKS-TUT-00169
EKS-XET-00611
EKS-XIM-00575
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
GO:0045445; P:myoblast differentiation
GO:0018105; P:peptidyl-serine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR008352; MAPK_p38.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00069; Pkinase; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR01773; P38MAPKINASE.
Created Date20-Feb-2013