EKS-POA-00283

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00283

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	387.2	3.4E-116	785	1050	266

Status

Unreviewed

Ensembl Protein

ENSPPYP00000013551

UniProt Accession

H2P5E0;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000012153	ENSPPYP00000013551	ENSPPYT00000014104

Organism

Pongo abelii

Functional Description

Protein Length

1082

Protein Sequence
(FASTA)

MDTPENVLQM LEAHMHSYKG NDPLGEWERY IQWVEENFPE NKEYLITLLE HLMKEFLDKK 60

KYHNDPRFIN YCLKFAEYNS DLHQFFEFLY NHGIGTLSSP LYIAWAGHLE AQGELQHASA 120

VLQRGIQNQA EPRDFLQQQY RLFQIRLTET HLPAQARTSE PLHNVQVLNQ MITSKSNPGN 180

NMACISKNQG SELSGVISSA CDKESNMEQR VIMISKSEYS VHSSLASKVD VEQVVMYCKE 240

KLIRGESEFS FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL 300

HQVVETSHED LPASQERSEV NPACMGPSVG SQQELRAPCL PVTYQQTPVN MEKNPREAPP 360

VVPPLANAIS AALVSPATSQ SIAPPVPLKA QTVTDSMFAV ASKDAGCVNK STHEFKPQSG 420

AEIKEGCETH KVANTSSFHT TPNTSLGMVQ ATPSKVQPSP TVHTKEALGF IMNMFQAPTL 480

PDISDDKDEW QSLDQNEDAF EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL 540

PQPKNKPTGA RTFGERSVSR LPSKPKEEVP HAEEFLDDST VWGIRCNKTL APSPKSPGDF 600

TSAAQLASTP FHKLPAESVH ILEDKENVVA KQCTQVTCEE NMVVPSRDGK FSPIQEKSPE 660

QAFSSHMYSA SLLRLSQPAA GGVLTCEAEL GVEACRLTDT DAAIAEDPPD AIAGLQAEWM 720

QMSSLGNVDA PNFIVGNPWD DKLIFKLLSG LSKPVSSYPN IFEWQCKLPA IKPKTEFQLG 780

SKLVYVHHLL GEGAFAQVYE ATQGDLNDAK NKQKFVLKVQ KPANPWEFYI GTQLMERLKP 840

SMQHMFMKFY SAHLFQNGSV LVGELYSYGT LLNAINLYKN TPEKVMPQGL VISFAMRMLY 900

MIEQVHDCEI IHGDIKPDNF ILGNGFLEQD DEDDLSAGLA LIDLGQSIDM KLFPKGTVFT 960

AKCETSGFQC VEMLSNKPWN YQIDYFGVAA TVYCMLFGTY MKVKNEGGEC KPEGLFRRLP 1020

HLDMWNEFFH VMLNIPDCHH LPSLDLLRQK LKKVFQQHYT NKIRALRNRL IVLLLECKRS 1080

RK 1082

Nucleotide Sequence
(FASTA)

ATGGACACCC CGGAAAATGT CCTTCAGATG CTTGAAGCCC ACATGCATAG CTACAAGGGC 60

AATGACCCTC TTGGTGAATG GGAAAGATAC ATACAGTGGG TAGAAGAGAA TTTTCCTGAG 120

AATAAAGAAT ACTTGATAAC TTTACTAGAA CATTTAATGA AGGAATTTTT AGATAAGAAG 180

AAATACCACA ATGACCCAAG ATTCATCAAT TATTGTTTAA AATTTGCTGA GTACAACAGT 240

GACCTCCATC AATTTTTTGA GTTTCTATAC AACCATGGGA TTGGAACCCT GTCATCCCCT 300

CTGTACATTG CCTGGGCGGG GCATCTGGAA GCCCAAGGAG AGCTGCAGCA TGCCAGTGCT 360

GTCCTTCAGA GAGGAATTCA AAACCAGGCT GAACCCAGAG ACTTCCTGCA ACAACAATAC 420

AGGTTATTTC AGATACGCCT CACTGAAACC CATTTGCCAG CTCAAGCTAG AACCTCAGAA 480

CCTCTGCATA ATGTTCAGGT TTTAAATCAA ATGATAACAT CAAAATCAAA TCCAGGAAAT 540

AACATGGCCT GCATTTCTAA GAATCAGGGT TCAGAGCTTT CTGGAGTGAT ATCTTCAGCT 600

TGTGATAAAG AGTCAAATAT GGAACAAAGA GTGATCATGA TTTCTAAATC AGAATATTCT 660

GTGCACTCAT CTTTGGCATC CAAAGTTGAT GTTGAGCAGG TTGTTATGTA TTGCAAGGAG 720

AAGCTTATTC GTGGGGAATC AGAATTTTCC TTTGAAGAAC TGAGAGCCCA GAAATACAAT 780

CAACGGAGAA AGCATGAGCA ATGGGTAAAT GAAGACAGAC ATTATATGAA AAGGAAAGAA 840

GCAAATGCTT TTGAAGAACA GCTATTAAAA CAGAAAATGG ATGAACTTCA TAAGAAGTTG 900

CATCAGGTGG TGGAGACATC CCATGAGGAT CTGCCCGCTT CCCAGGAAAG GTCTGAGGTT 960

AATCCAGCAT GTATGGGGCC AAGTGTAGGC TCCCAGCAGG AACTGAGAGC TCCATGTCTT 1020

CCAGTCACCT ATCAGCAGAC ACCAGTGAAC ATGGAAAAGA ACCCAAGAGA GGCACCTCCT 1080

GTTGTTCCTC CTTTGGCAAA TGCTATTTCT GCAGCTTTGG TGTCCCCAGC CACCAGCCAG 1140

AGCATTGCTC CTCCTGTTCC TTTGAAAGCC CAGACAGTAA CAGACTCCAT GTTTGCAGTG 1200

GCCAGCAAAG ATGCTGGATG TGTGAATAAG AGTACTCATG AATTCAAGCC ACAGAGTGGA 1260

GCAGAGATCA AAGAAGGGTG TGAAACACAT AAGGTTGCCA ACACAAGTTC TTTTCACACA 1320

ACTCCAAACA CATCACTGGG AATGGTTCAG GCAACGCCAT CCAAAGTGCA GCCATCACCC 1380

ACCGTGCACA CAAAAGAAGC ATTAGGTTTC ATCATGAATA TGTTTCAGGC TCCTACACTT 1440

CCTGATATTT CTGATGACAA AGATGAATGG CAATCTCTAG ATCAAAATGA AGATGCATTT 1500

GAAGCCCAGT TTCAAAAAAA TGTAAGGTCA TCTGGGGCTT GGGGAGTCAA TAAAATCATC 1560

TCTTCTTTGT CATCTGCTTT TCATGTGTTT GAAGATGGAA ACAAAGAAAA TTATGGATTA 1620

CCACAGCCTA AAAATAAACC CACAGGAGCC AGGACCTTTG GAGAACGCTC TGTCAGCAGA 1680

CTTCCTTCAA AACCAAAGGA GGAAGTGCCT CATGCTGAAG AGTTTTTGGA TGATTCAACC 1740

GTATGGGGTA TTCGCTGCAA CAAAACCCTG GCACCCAGTC CTAAGAGCCC AGGAGACTTC 1800

ACATCTGCTG CACAACTTGC ATCTACACCA TTCCACAAGC TTCCAGCGGA GTCAGTGCAC 1860

ATTTTAGAAG ATAAAGAAAA TGTGGTAGCA AAACAGTGTA CCCAGGTGAC TTGTGAAGAA 1920

AACATGGTGG TGCCTTCAAG GGATGGAAAA TTCAGTCCAA TTCAAGAGAA AAGCCCAGAA 1980

CAGGCCTTCT CGTCTCACAT GTATTCAGCA TCCTTACTTC GTCTGAGCCA GCCTGCTGCA 2040

GGTGGGGTAC TTACCTGTGA GGCAGAGTTG GGCGTTGAGG CTTGCAGACT CACAGACACT 2100

GATGCTGCCA TTGCAGAAGA TCCACCAGAT GCTATTGCTG GGCTCCAAGC AGAATGGATG 2160

CAGATGAGTT CACTTGGGAA TGTTGATGCT CCAAACTTCA TTGTTGGGAA CCCATGGGAT 2220

GATAAGCTGA TCTTCAAACT TTTATCTGGG CTTTCTAAAC CCGTGAGTTC CTATCCAAAT 2280

ATTTTTGAAT GGCAATGTAA ACTTCCAGCC ATCAAGCCCA AGACTGAATT TCAATTGGGT 2340

TCTAAGCTGG TCTATGTCCA TCACCTTCTT GGAGAAGGAG CCTTTGCCCA GGTGTACGAA 2400

GCTACCCAGG GAGATCTGAA TGATGCTAAA AATAAACAGA AATTTGTTTT AAAGGTCCAG 2460

AAGCCTGCCA ACCCCTGGGA ATTCTACATT GGGACCCAGT TGATGGAAAG ACTAAAGCCA 2520

TCTATGCAGC ACATGTTTAT GAAGTTCTAT TCTGCCCACT TATTCCAGAA TGGCAGTGTA 2580

TTAGTAGGAG AGCTCTACAG CTATGGAACA TTATTAAATG CCATTAACCT CTATAAAAAT 2640

ACCCCTGAAA AAGTGATGCC TCAAGGTCTC GTCATCTCTT TTGCTATGAG AATGCTTTAC 2700

ATGATTGAGC AAGTGCATGA CTGTGAAATC ATTCATGGAG ACATTAAGCC AGACAATTTC 2760

ATACTTGGAA ACGGATTTTT GGAACAGGAT GATGAAGATG ATTTATCTGC TGGCTTGGCA 2820

CTGATTGACC TGGGTCAGAG TATAGATATG AAACTTTTTC CAAAAGGAAC TGTATTCACA 2880

GCAAAGTGTG AAACATCTGG TTTTCAGTGT GTTGAGATGC TCAGCAACAA ACCATGGAAC 2940

TACCAGATCG ATTACTTTGG GGTTGCTGCA ACAGTATATT GCATGCTCTT TGGCACTTAC 3000

ATGAAAGTGA AAAATGAAGG AGGAGAGTGT AAGCCTGAAG GTCTTTTTAG AAGGCTTCCT 3060

CATTTGGATA TGTGGAATGA ATTTTTTCAC GTTATGTTGA ATATTCCAGA TTGTCATCAT 3120

CTTCCATCTT TGGATTTGTT AAGGCAAAAG CTGAAGAAAG TATTTCAACA ACACTATACT 3180

AACAAGATTA GGGCCCTACG TAATAGGCTA ATTGTACTGC TCTTAGAATG TAAGCGTTCA 3240

CGAAAATAA 3249

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++++geGa+a+vy+a++    d+k++++++lKv+kpan+WefYI +ql+eRlk ++++

Q: 785   YVHHLLGEGAFAQVYEATQgdlnDAKNKQKFVLKVQKPANPWEFYIGTQLMERLK-PSMQ  843

         79******************9999*******************************.77**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++++++sa+lfq++s+lv e++sygtll++in++k++ +kvm++ lv+++++++l+++e

Q: 844   HMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIE  903

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllpdgtkfkgka  177

         ++H++eIiHgD+kPdnf+lgn + ++ d+d+ ++gl+liD+g+siDmkl+p+gt f++k+

Q: 904   QVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTVFTAKC  963

         ************************************************************

S: 178   ktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkke  237

         +t++f+c+eml++k+w+Yq+D+fg+aa+++++lfg+y++v++egg++k++  ++rl++ +

Q: 964   ETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLD  1023

         ************************************************************

S: 238   lwekiferlLNisdastlpsleelveek  265

         +w+++f+++LNi+d+++lpsl+ l++ k

Q: 1024  MWNEFFHVMLNIPDCHHLPSLDLLRQ-K  1050

         ************************95.4

Domain Sequence
(FASTA)

YVHHLLGEGA FAQVYEATQG DLNDAKNKQK FVLKVQKPAN PWEFYIGTQL MERLKPSMQH 60

MFMKFYSAHL FQNGSVLVGE LYSYGTLLNA INLYKNTPEK VMPQGLVISF AMRMLYMIEQ 120

VHDCEIIHGD IKPDNFILGN GFLEQDDEDD LSAGLALIDL GQSIDMKLFP KGTVFTAKCE 180

TSGFQCVEML SNKPWNYQID YFGVAATVYC MLFGTYMKVK NEGGECKPEG LFRRLPHLDM 240

WNEFFHVMLN IPDCHHLPSL DLLRQK 266

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

pon:100439295

;

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013