EKS-POA-00166
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00166
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC471.39.3E-142408668261
StatusUnreviewed
Ensembl ProteinENSPPYP00000013897
UniProt AccessionH2P6C3;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCE
Gene Synonyms/Alias PRKCE;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000012443ENSPPYP00000013897ENSPPYT00000014460
OrganismPongo abelii
Functional Description
Protein Length737
Protein Sequence
(FASTA)
MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT 60
NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE 120
PEGRVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP 180
TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKC AGLKKQETPD QVGSQRFSVN 240
MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA 300
KVLADLGVTP DKITNSGQRR KKLIAGAESP QPASGSSPSE EDRSKSAPTS PCDQEIKELE 360
NNIRKALSFD NRGEEHRAAS SPDGQLMSPG ENGEVRQGQA KRLGLDEFNF IKVLGKGSFG 420
KVMLAELKGK DEVYAVKVLK KDVILQDDDV DCTMTEKRIL ALARKHPYLT QLYCCFQTKD 480
RLFFVMEYVN GGDLMFQIQR SRKFDEPRSR FYAAEVTSAL MFLHQHGVIY RDLKLDNILL 540
DAEGHCKLAD FGMCKEGILN GVTTTTFCGT PDYIAPEILQ ELEYGPSVDW WALGVLMYEM 600
MAGQPPFEAD NEDDLFESIL HDDVLYPVWL SKEAVSILKA FMTKNPHKRL GCVASQNGED 660
AIKQHPFFKE IDWVLLEQKK IKPPFKPRIK TKRDVNNFDQ DFTREEPVLT LVDEAIVKQI 720
NQEEFKGFSY FGEDLMP 737
Nucleotide Sequence
(FASTA)
ATGGTAGTGT TCAATGGCCT TCTTAAGATC AAAATCTGCG AGGCCGTGAG CTTGAAGCCC 60
ACAGCCTGGT CGCTGCGCCA TGCGGTGGGA CCCCGGCCGC AGACTTTCCT TCTCGACCCC 120
TACATTGCCC TCAATGTGGA CGACTCGCGC ATCGGCCAAA CGGCCACCAA GCAGAAGACC 180
AACAGCCCGG CCTGGCACGA CGAGTTCGTC ACCGATGTGT GCAACGGGCG CAAGATCGAG 240
CTGGCTGTCT TTCACGATGC CCCCATAGGC TACGACGACT TCGTGGCCAA CTGCACCATC 300
CAGTTTGAGG AGCTGCTGCA GAACGGGAGC CGCCACTTCG AGGACTGGAT TGATCTGGAG 360
CCAGAAGGAA GAGTGTATGT GATCATCGAT CTCTCAGGGT CGTCGGGTGA AGCCCCTAAA 420
GACAATGAAG AGCGTGTGTT CAGGGAACGC ATGCGGCCGA GGAAGCGGCA GGGGGCCGTC 480
AGGCGCAGGG TCCATCAGGT CAACGGCCAC AAGTTCATGG CCACCTATCT TCGGCAGCCC 540
ACCTACTGCT CCCATTGCAG AGACTTCATC TGGGGTGTCA TAGGAAAGCA GGGATACCAG 600
TGTCAAGTTT GCACCTGTGT GGTCCACAAG CGATGCCACG AGCTCATAAT CACGAAGTGT 660
GCTGGGTTAA AGAAGCAGGA GACCCCTGAC CAGGTGGGCT CCCAGCGGTT CAGCGTCAAC 720
ATGCCCCACA AGTTCGGTAT CCACAACTAC AAGGTCCCCA CCTTCTGCGA TCACTGTGGG 780
TCCCTGCTCT GGGGACTCTT GCGGCAGGGT TTGCAGTGTA AAGTCTGCAA AATGAATGTT 840
CACCGTCGAT GTGAGACCAA CGTGGCTCCC AACTGTGGAG TGGATGCCAG AGGAATCGCC 900
AAAGTCCTGG CCGACCTGGG CGTTACCCCA GACAAAATCA CCAACAGCGG CCAGAGGAGG 960
AAAAAGCTCA TTGCTGGTGC CGAGTCCCCG CAGCCTGCTT CTGGAAGCTC ACCATCTGAG 1020
GAAGATCGAT CCAAGTCAGC ACCCACCTCC CCTTGTGACC AGGAAATAAA AGAACTTGAG 1080
AACAACATTC GGAAAGCCTT GTCATTTGAC AACCGAGGGG AGGAGCACCG GGCAGCATCG 1140
TCTCCTGATG GCCAGCTGAT GAGCCCTGGT GAGAACGGCG AAGTCCGGCA AGGCCAGGCC 1200
AAGCGCCTGG GCCTGGATGA GTTCAACTTC ATCAAGGTGT TAGGCAAAGG CAGCTTTGGC 1260
AAGGTCATGT TGGCAGAACT CAAGGGCAAA GATGAAGTAT ATGCTGTGAA GGTCTTAAAG 1320
AAGGACGTCA TCCTTCAGGA TGATGACGTG GACTGCACAA TGACAGAGAA GAGAATTTTG 1380
GCTCTGGCAC GGAAACACCC GTACCTTACC CAACTCTACT GCTGCTTCCA GACCAAGGAC 1440
CGCCTCTTTT TCGTCATGGA ATATGTAAAT GGTGGAGACC TCATGTTTCA GATTCAGCGC 1500
TCCCGAAAAT TCGACGAGCC TCGTTCACGG TTCTATGCTG CAGAGGTCAC ATCAGCCCTC 1560
ATGTTCCTCC ACCAGCATGG AGTCATCTAC AGGGATTTGA AACTGGACAA CATCCTTCTG 1620
GATGCAGAAG GTCACTGCAA GCTGGCTGAC TTCGGGATGT GCAAGGAAGG GATTCTGAAT 1680
GGTGTGACAA CCACCACGTT CTGTGGGACT CCTGACTACA TAGCTCCTGA GATCCTGCAG 1740
GAGTTGGAGT ACGGCCCCTC CGTGGACTGG TGGGCCCTGG GGGTGCTGAT GTACGAGATG 1800
ATGGCTGGAC AGCCTCCCTT TGAGGCCGAC AATGAGGACG ACCTATTTGA GTCCATCCTC 1860
CATGACGACG TGCTCTACCC AGTCTGGCTC AGCAAGGAGG CTGTCAGCAT CTTGAAAGCT 1920
TTCATGACGA AGAATCCCCA CAAGCGCCTG GGCTGCGTGG CATCACAGAA CGGCGAGGAC 1980
GCCATCAAGC AGCACCCATT CTTCAAAGAG ATTGACTGGG TGCTCCTGGA GCAGAAGAAG 2040
ATCAAGCCAC CCTTCAAACC ACGCATTAAA ACCAAAAGAG ACGTCAATAA TTTTGACCAA 2100
GACTTTACAC GGGAAGAGCC GGTACTCACC CTTGTGGACG AAGCAATTGT AAAGCAGATC 2160
AACCAGGAGG AATTCAAAGG TTTCTCCTAC TTTGGTGAAG ACCTGATGCC CTGA 2214
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+++kvlGkGsfgkv+laelk++de+ya+kvlkkdv+lqdddv++t++ekr+lala+k+p
Q: 408   FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP  467
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g
Q: 468   YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHG  527
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         +iyrdlkldn+lldaeGh+kladfG+cke+il+g tt+tfcGtPdyiaPeil+e eyg s
Q: 528   VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPS  587
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+ilk+++tk+p+
Q: 588   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPH  647
         ************************************************************
S: 241   krlGv..keegeedikehaff  259
         krlG+  +++ge++ik+h+ff
Q: 648   KRLGCvaSQNGEDAIKQHPFF  668
         *****6559***********9
Domain Sequence
(FASTA)
FNFIKVLGKG SFGKVMLAEL KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP 60
YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG 120
VIYRDLKLDN ILLDAEGHCK LADFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS 180
VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPH 240
KRLGCVASQN GEDAIKQHPF F 261
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00162
EKS-ANC-00164
EKS-BOT-00170
EKS-CAE-00130
EKS-CAJ-00174
EKS-CAF-00177
EKS-CAP-00170
EKS-DAR-00463
EKS-DRM-00083
EKS-EQC-00168
EKS-FEC-00160
EKS-GAG-00146
EKS-GAA-00205
EKS-GOG-00168
EKS-HOS-00176
EKS-ICT-00165
EKS-LAC-00185
EKS-LOA-00169
EKS-MAM-00168
EKS-MEG-00135
EKS-MIM-00077
EKS-MOD-00169
EKS-MUM-00175
EKS-MUP-00174
EKS-MYL-00179
EKS-NOL-00163
EKS-ORN-00215
EKS-ORC-00157
EKS-ORL-00201
EKS-OTG-00176
EKS-PAT-00161
EKS-PES-00150
EKS-PTV-00149
EKS-RAN-00165
EKS-SAH-00168
EKS-SUS-00146
EKS-TAG-00198
EKS-TAR-00222
EKS-TAS-00059
EKS-TEN-00214
EKS-TUT-00153
EKS-XET-00158
EKS-XIM-00208
EKS-SAC-00081
EKS-SCP-00081
Gene Ontology
GO:0005829; C:cytosol
GO:0005783; C:endoplasmic reticulum
GO:0005794; C:Golgi apparatus
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004699; F:calcium-independent protein kinase C activity
GO:0008047; F:enzyme activator activity
GO:0035276; F:ethanol binding
GO:0046872; F:metal ion binding
GO:0030546; F:receptor activator activity
GO:0071361; P:cellular response to ethanol
GO:0071456; P:cellular response to hypoxia
GO:0035556; P:intracellular signal transduction
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0035641; P:locomotory exploration behavior
GO:0002281; P:macrophage activation involved in immune response
GO:0030838; P:positive regulation of actin filament polymerization
GO:0071777; P:positive regulation of cell cycle cytokinesis
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:2001031; P:positive regulation of cellular glucuronidation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0010763; P:positive regulation of fibroblast migration
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032024; P:positive regulation of insulin secretion
GO:0050996; P:positive regulation of lipid catabolic process
GO:0043410; P:positive regulation of MAPK cascade
GO:0070257; P:positive regulation of mucus secretion
GO:0032230; P:positive regulation of synaptic transmission, GABAergic
GO:0090303; P:positive regulation of wound healing
GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0051209; P:release of sequestered calcium ion into cytosol
GO:0043278; P:response to morphine
GO:0035669; P:TRAM-dependent toll-like receptor 4 signaling pathway
KEGG
pon:100440778;
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013