EKS-POA-00292

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00292

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	536.1	1.6E-161	1116	1385	270

Status

Unreviewed

Ensembl Protein

ENSPPYP00000013987

UniProt Accession

H2P6K9;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000012522	ENSPPYP00000013987	ENSPPYT00000014554

Organism

Pongo abelii

Functional Description

Protein Length

1620

Protein Sequence
(FASTA)

MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV 60

PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA 120

RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ 180

GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY 240

FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRVPSEEASQ 300

MDLLDGPEAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR 360

YIAQLLPHNE AAREIPLMPT PGKHGWTVLQ GRIGHPDNPF RVALEYVSSG NRSLSAVDFF 420

ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CTQGEDESQM CRKLPVGFYC 480

NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDYQDRALL LSTTDVPTSE SATVTSATFP 540

APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWTVLPL 600

LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKIPQNTAP KSRNLFERNP 660

NKELKPGETS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVASEGPL 720

KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDT LYILVGQQGE 780

DACPRTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII 840

AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA 900

TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS 960

PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS 1020

CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL 1080

SKLRTSTIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN 1140

DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQAL PRFILLELMA 1200

GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP 1260

GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW 1320

EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL 1380

ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KPEEERSPAA 1440

PPPLPTTSSG KAAKKPTAAE VSVRLPRGPA VEGGHVNMAF SQSNPPSELH KVQGSRNKPT 1500

SLWNPTYGSW FTEKPTKKNN PLAKKEPHER GNLGLEGSCT VPPNVATGRL PGASLLLEPS 1560

SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP 1620

Nucleotide Sequence
(FASTA)

ATGGGAGCCA TCGGGCTCCT GTGGCTGCTG CCGCTGCTGC TTTCCACGGC AGCTGTGGGC 60

TCCGGGATGG GGACCGGCCA GCGCGCGGGC TCCCCAGCTG CGGGGCCGCC GCTGCAGCCC 120

CGGGAGCCGC TCAGCTACTC GCGCCTGCAG AGGAAGAGTC TGGCAGTGGA CTTCGTGGTG 180

CCCTCGCTCT TCCGTGTCTA CGCCCGGGAC CTACTGCTGC CACCATCCTC CTCGGAGCTG 240

AAGGCTGGCA GGCCCGAGGC GCGCGGCTCG CTCGCTCTGG ACTGCGCCCC GCTGCTCAGG 300

TTGCTGGGGC CGGCGCCGGG GGTCTCCTGG ACCGCCGGCT CACCCGCCCC GGCAGAGGCC 360

CGGACGCTGT CCAGGGTGCT GAAGGGCGGC TCCGTGCGCA AGCTCCGGCG TGCCAAGCAG 420

TTGGTGCTGG AGCTGGGCGA GGAGGCGATC TTGGAGGGTT GCGTTGGGCC CCCCGGGGAG 480

GCGGCTGTGG GGCTGCTGCA GTTCAATCTC AGCGAGCTGT TCAGTTGGTG GATTCGCCAG 540

GGCGAAGGGC GACTGAGGAT CCGCCTGATG CCCGAGAAGA AGGCGTCGGA AGTGGGCAGA 600

GAGGGAAGGC TGTCCGCGGC AATTCGCGCC TCCCAGCCCC GCCTTCTCTT CCAGATCTTC 660

GGGACTGGTC ATAGCTCCTT GGAATCACCA ACAAACATGC CTTCTCCTTC TCCTGATTAT 720

TTTACATGGA ATCTCACCTG GATAATGAAA GACTCCTTCC CTTTCCTGTC TCATCGCAGC 780

CGATATGGTC TGGAGTGCAG CTTTGACTTC CCCTGTGAGC TGGAATATTC CCCTCCACTG 840

CACGATCTCA GGAACCAGAG TTGGTCCTGG CGCCGCGTCC CCTCCGAGGA GGCCTCCCAG 900

ATGGACTTGC TGGATGGGCC TGAGGCAGAG CGTTCTAAGG AGATGCCCAG AGGCTCCTTT 960

CTCCTCCTCA ACACCTCAGC TGACTCCAAG CACACCATCC TGAGTCCGTG GATGAGGAGC 1020

AGCAGTGAGC ACTGCACACT GGCCGTCTCG GTGCACAGGC ACCTGCAGCC CTCTGGAAGG 1080

TACATCGCCC AGCTGCTGCC CCACAACGAA GCTGCAAGAG AGATCCCCCT GATGCCCACT 1140

CCAGGGAAGC ATGGTTGGAC AGTGCTCCAG GGAAGAATCG GGCACCCAGA CAACCCATTT 1200

CGAGTGGCCC TGGAATACGT CTCCAGTGGA AACCGCAGCT TGTCTGCAGT GGACTTCTTT 1260

GCCCTGAAGA ACTGCAGTGA AGGAACATCC CCAGGCTCCA AGATGGCCCT GCAGAGCTCC 1320

TTCACTTGTT GGAATGGGAC AGTCCTCCAG CTTGGGCAGG CCTGTGACTT CCACCAGGAC 1380

TGCACCCAGG GAGAAGATGA GAGCCAGATG TGCCGGAAAC TGCCTGTGGG TTTTTACTGC 1440

AACTTTGAAG ATGGCTTCTG TGGCTGGACC CAAGGTACAC TCTCACCCCA CACTCCTCAG 1500

TGGCAGGTCA GGACCCTAAA GGATGCCCGG TTCCAGGACT ACCAAGACCG TGCTCTATTG 1560

CTCAGTACCA CTGATGTCCC CACTTCTGAA AGTGCTACAG TGACCAGTGC TACGTTTCCT 1620

GCACCGATCA AGAGCTCTCC ATGTGAGCTC CGAATGTCCT GGCTCATTCG TGGAGTCTTG 1680

AGGGGAAACG TGTCCTTGGT GCTAGTGGAG AACAAAACCG GGAAGGAGCA AGGCAGGATG 1740

GTCTGGCATG TCGCCGCCTA CGAAGGCTTG AGCCTGTGGC AGTGGACGGT GTTGCCTCTC 1800

CTCGATGTGT CTGACAGGTT CTGGCTGCAG ATGGTCGCAT GGTGGGGACA AGGATCCAGA 1860

GCCATCGTGG CTTTTGACAA TATCTCCATC AGCCTGGACT GCTACCTCAC CATTAGTGGA 1920

GAAGACAAGA TCCCACAGAA TACAGCACCC AAATCAAGAA ACCTGTTTGA GAGAAACCCA 1980

AACAAGGAGC TGAAACCCGG GGAAACTTCA CCAAGACAGA CCCCCATCTT CGACCCTACA 2040

GTTCATTGGC TGTTCACCAC ATGTGGGGCC AGCGGGCCCC ATGGTCCCAC CCAGGCGCAG 2100

TGCAACAACG CCTACCAGAA CTCCAACTTG AGCGTGGAGG TGGCGAGCGA GGGCCCCCTG 2160

AAGGGCATCC AGATCTGGAA GGTGCCAGCT ACCGACACCT ACAGCATCTC GGGCTACGGA 2220

GCTGCTGGCG GGAAAGGCGG GAAGAACACC ATGATGCGGT CCCATGGCGT GTCTGTGCTG 2280

GGCATCTTCA ACCTGGAGAA GGATGACACA CTGTACATCC TGGTTGGGCA GCAGGGAGAG 2340

GACGCCTGCC CCCGTACAAA CCAGTTAATC CAGAAAGTCT GCATTGGAGA GAACAATGTG 2400

ATAGAAGAAG AAATCCGTGT GAACAGAAGC GTGCATGAGT GGGCAGGAGG AGGAGGAGGA 2460

GGGGGTGGAG CCACCTACGT ATTTAAGATG AAGGATGGAG TGCCGGTGCC CCTGATCATT 2520

GCAGCCGGAG GTGGCGGCAG GGCCTACGGG GCCAAGACAG ACACGTTCCA CCCAGAGAGA 2580

CTGGAGAATA ACTCCTCGGT TCTAGGGCTA AACGGCAATT CCGGAGCCGC AGGTGGTGGA 2640

GGTGGCTGGA ATGATAACAC TTCCTTGCTC TGGGCCGGAA AATCTTTGCA GGAGGGTGCC 2700

ACCGGAGGAC ATTCCTGCCC CCAGGCCATG AAGAAGTGGG GGTGGGAGAC AAGAGGGGGT 2760

TTCGGAGGGG GTGGAGGGGG GTGCTCCTCA GGTGGAGGAG GCGGAGGATA TATAGGCGGC 2820

AATGCAGCCT CAAACAATGA CCCCGAAATG GATGGGGAAG ATGGGGTTTC CTTCATCAGT 2880

CCACTGGGCA TCCTGTACAC CCCAGCTTTA AAAGTGATGG AAGGCCACGG GGAAGTGAAT 2940

ATTAAGCACT ATCTAAACTG CAGTCACTGT GAGGTAGACG AATGTCACAT GGACCCTGAA 3000

AGCCACAAGG TCATCTGCTT TTGTGACCAC GGGACGGTGC TGGCTGAGGA TGGCGTCTCC 3060

TGCATTGTGT CACCCACCCC GGAGCCACAC CTGCCACTGT CGCTGATCCT TTCTGTGGTG 3120

ACCTCTGCCC TCGTGGCTGC CCTGGTCCTG GCTTTCTCCG GCATCATGAT TGTGTACCGC 3180

CGGAAGCACC AGGAGCTGCA AGCCATGCAG ATGGAGCTGC AGAGCCCTGA GTACAAGCTG 3240

AGCAAGCTCC GCACCTCGAC CATCATGACC GACTACAACC CCAACTACTG CTTTGCTGGC 3300

AAGACCTCCT CCATCAGTGA CCTGAAGGAG GTGCCGCGGA AAAACATCAC CCTCATTCGG 3360

GGTCTGGGCC ATGGCGCCTT TGGGGAGGTG TATGAAGGCC AGGTGTCCGG AATGCCCAAT 3420

GACCCAAGCC CCCTGCAAGT GGCTGTGAAG ACGCTGCCTG AAGTGTGCTC AGAACAGGAC 3480

GAACTGGATT TCCTCATGGA AGCCCTGATC ATCAGCAAAT TCAACCACCA GAACATCGTT 3540

CGCTGCATCG GAGTGAGCCT GCAAGCCCTG CCCCGGTTCA TCCTGCTGGA GCTCATGGCA 3600

GGGGGAGACC TCAAGTCCTT CCTCCGAGAG ACCCGCCCTC GCCCGAGCCA GCCCTCCTCC 3660

CTGGCCATGC TGGACCTTCT GCACGTGGCT CGGGACATTG CCTGTGGCTG TCAGTATTTG 3720

GAGGAAAACC ACTTCATCCA CCGAGACATT GCTGCCAGAA ACTGCCTCTT GACCTGTCCA 3780

GGCCCTGGAA GAGTGGCCAA GATTGGAGAC TTTGGGATGG CCCGAGACAT CTACAGGGCG 3840

AGCTACTATA GAAAGGGAGG CTGTGCCATG CTGCCAGTTA AGTGGATGCC CCCAGAGGCC 3900

TTCATGGAAG GAATATTCAC TTCTAAAACA GACACATGGT CCTTTGGAGT GCTGCTGTGG 3960

GAAATCTTTT CTCTCGGATA TATGCCATAC CCCAGCAAAA GCAACCAGGA AGTTCTGGAG 4020

TTCGTCACCA GTGGAGGCCG GATGGACCCA CCCAAGAACT GCCCTGGGCC TGTATACCGG 4080

ATAATGACTC AGTGCTGGCA ACATCAGCCT GAAGACAGGC CCAACTTTGC CATCATTTTG 4140

GAGAGGATTG AATACTGCAC CCAGGACCCG GATGTAATCA ACACCGCTTT GCCGATAGAA 4200

TATGGTCCAC TTGTGGAAGA GGAAGAGAAA GTGCCCGTGA GGCCCAAGGA CCCTGAGGGG 4260

GTTCCTCCTC TCCTGGTCTC TCAACAGGCG AAACCGGAGG AGGAGCGCAG CCCAGCTGCC 4320

CCACCACCTC TGCCTACCAC CTCCTCTGGC AAGGCTGCAA AGAAACCCAC AGCTGCAGAG 4380

GTCTCTGTTC GACTCCCTAG AGGGCCGGCT GTGGAAGGGG GACACGTGAA TATGGCATTC 4440

TCTCAGTCCA ACCCCCCTTC GGAGTTGCAC AAGGTCCAGG GATCCAGAAA CAAGCCCACC 4500

AGTTTGTGGA ACCCAACGTA CGGCTCCTGG TTTACAGAGA AACCCACCAA AAAGAATAAT 4560

CCTCTAGCAA AGAAGGAGCC ACACGAGAGG GGTAACCTGG GGCTGGAGGG AAGCTGTACT 4620

GTCCCACCTA ACGTTGCAAC TGGGAGACTT CCGGGGGCCT CACTGCTCCT AGAGCCCTCT 4680

TCGCTGACTG CCAATATGAA GGAGGTACCT CTGTTCAGGC TACGTCACTT CCCTTGTGGG 4740

AATGTCAATT ACGGCTACCA GCAACAGGGC TTGCCCTTAG AAGCCGCTAC TGCCCCTGGA 4800

GCTGGTCATT ACGAGGACAC CATTCTGAAA AGCAAGAATA GCATGAACCA GCCTGGGCCC 4860

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfn

Q: 1116  ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  1175

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+sslam dll+va+d+a+

Q: 1176  HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIAC  1235

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 1236  GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW  1295

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 1296  MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP  1355

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pedrp+f++iler+++

Q: 1356  GPVYRIMTQCWQHQPEDRPNFAIILERIEY  1385

         ***************************986

Domain Sequence
(FASTA)

ITLIRGLGHG AFGEVYEGQV SGMPNDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP SQPSSLAMLD LLHVARDIAC 120

GCQYLEENHF IHRDIAARNC LLTCPGPGRV AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP 240

GPVYRIMTQC WQHQPEDRPN FAIILERIEY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013