EKS-POA-00431
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00431
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK465.64.8E-14092354263
StatusUnreviewed
Ensembl ProteinENSPPYP00000014119
UniProt AccessionH2P6Y3;
Protein Name
Protein Synonyms/Alias
Gene NameROCK2
Gene Synonyms/Alias ROCK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000012647ENSPPYP00000014119ENSPPYT00000014691
OrganismPongo abelii
Functional Description
Protein Length1388
Protein Sequence
(FASTA)
MSRPPPTGKM PGAPETAPGD GAGASRQRKL EALIRDPRSP INVESLLDGL NSLVLDLDFP 60
ALRKNKNIDN FLNRYEKIVK KIRGLQMKAE DYDVVKVIGR GAFGEVQLVR HKASQKVYAM 120
KLLSKFEMIK RSDSAFFWEE RDIMAFANSP WVVQLFYAFQ DDRYLYMVME YMPGGDLVNL 180
MSNYDVPEKW AKFYTAEVVL ALDAIHSMGL IHRDVKPDNM LLDKHGHLKL ADFGTCMKMD 240
ETGMVHCDTA VGTPDYISPE VLKSQGGDGY YGRECDWWSV GVFLYEMLVG DTPFYADSLV 300
GTYSKIMDHK NSLCFPEDAE ISKHAKNLIC AFLTDREVRL GRNGVEEIRQ HPFFKNDQWH 360
WDNIRETAAP VVPELSSDID SSNFDDIEDD KGDVETFPIP KAFVGNQLPF IGFTYYRENL 420
LLSDSPSCRE NDSIQSRKNE ESQEIQKKLY TLEEHLSNEI QAKEELEQKC KSVNTRLEKT 480
AKELEEEITL RKSVESALRQ LEREKALLQH KNAEYQRKAD HEADKKRNLE NDVNSLKDQL 540
EDLKKRNQNS QISTEKVNQL QRQLDETNAL LRTESDTAAR LRKTQAESSK QIQQLESNNR 600
DLQDKNCLLE TAKLKLEKEF INLQSALESE RRDRTHGSEI INDLQGRISG LEEDLKNGKI 660
LLAKVELEKR QLQERFTDLE KEKSNMEIDM TYQLKVIQQS LEQEEAEHKA TKARLADKNK 720
IYESIEEAKS EAMKEMEKKL LEERTLKQKV ENLLLEAEKR CSLLDCDLKQ SQQKINELLK 780
QKDVLNEDVR NLTLKIEQET QKRCLTQNDL KMQTQQVNTL KMSEKQLKQE NNHLMEMKMN 840
LEKQNAELRK ERQDADGQMK ELQDQLEAEQ YFSTLYKTQV RELKEECEEK TKLGKELQQK 900
KQELQDERDS LAAQLEITLT KADSEQLARS IAEEQYSDLE KEKIMKELEI KEMMARHKQE 960
LTEKDATIAS LEETNRTLTS DVANLANEKE ELNNKLKDVQ EQLSRLKDEE ISAAAIKAQF 1020
EKQLLTERTL KTQAVNKLAE IMNRKEPVKR GNDTDVRRKE KENRKLHMEL KSEREKLTQQ 1080
MIKYQKELNE MQAQIAEESQ IRIELQMTLD SKDSDIEQLR SQLQALHIGL DSSSIGSGPG 1140
DAEADDGFPE SRLEGWLSLP VRNNTKKFGW VKKYVIVSSK KILFYDSEQD KEQSNPYMVL 1200
DIDKLFHVRP VTQTDVYRAD AKEIPRIFQI LYANEGESKK EQEFPVEPVG EKSNYICHKG 1260
HEFIPTLYHF PTNCEACMKP LWHMFKPPPA LECRRCHIKC HKDHMDKKEE IIAPCKVYYD 1320
ISTAKNLLLL ANSTEEQQKW VSRLVKKIPK KPPAPDPFAR SSPRTSMKIQ QNQSIRRPSR 1380
QLAPNKPS 1388
Nucleotide Sequence
(FASTA)
ATGAGCCGGC CCCCGCCGAC GGGGAAAATG CCCGGCGCCC CCGAGACCGC GCCGGGGGAC 60
GGGGCAGGCG CGAGCCGCCA GAGGAAGCTG GAGGCGCTGA TCCGAGACCC TCGCTCCCCC 120
ATCAACGTGG AGAGCTTGCT GGATGGCTTA AATTCCTTGG TCCTTGATTT AGATTTTCCT 180
GCTTTGAGGA AAAACAAGAA CATAGATAAT TTCTTAAATA GATATGAGAA AATTGTGAAA 240
AAAATCAGAG GTCTACAGAT GAAGGCAGAA GACTATGATG TTGTAAAAGT TATTGGAAGA 300
GGTGCTTTTG GTGAAGTGCA GTTGGTTCGT CATAAGGCAT CGCAGAAGGT TTATGCTATG 360
AAGCTTCTTA GTAAGTTTGA GATGATAAAA AGATCAGATT CTGCCTTTTT TTGGGAAGAA 420
AGAGATATTA TGGCCTTTGC CAATAGCCCC TGGGTGGTTC AGCTTTTTTA TGCCTTTCAA 480
GATGATAGGT ATCTGTACAT GGTAATGGAG TACATGCCTG GTGGAGACCT TGTAAACCTT 540
ATGAGTAATT ATGATGTGCC TGAAAAATGG GCCAAATTTT ACACTGCTGA AGTTGTTCTT 600
GCTCTGGATG CAATACACTC CATGGGTTTA ATACACAGAG ATGTGAAGCC TGACAACATG 660
CTCTTGGATA AACATGGACA TCTAAAATTA GCAGATTTTG GCACGTGTAT GAAGATGGAT 720
GAAACAGGCA TGGTACATTG TGATACAGCA GTTGGAACAC CGGATTATAT ATCACCTGAG 780
GTTCTGAAAT CACAAGGGGG TGATGGTTAC TATGGGCGAG AATGTGATTG GTGGTCTGTA 840
GGTGTTTTCC TTTATGAGAT GCTGGTGGGG GATACTCCAT TTTATGCGGA TTCACTTGTA 900
GGAACATATA GCAAAATTAT GGATCATAAG AATTCACTGT GTTTCCCTGA AGATGCAGAA 960
ATTTCCAAAC ATGCAAAGAA TCTCATCTGT GCTTTCTTAA CAGATAGGGA GGTACGACTT 1020
GGGAGAAATG GGGTGGAAGA AATCAGACAG CATCCTTTCT TTAAGAATGA TCAGTGGCAT 1080
TGGGATAACA TAAGAGAAAC GGCAGCTCCT GTAGTACCTG AACTCAGCAG TGACATAGAC 1140
AGCAGCAATT TCGATGACAT TGAAGATGAC AAAGGAGATG TAGAAACCTT CCCAATTCCT 1200
AAAGCTTTTG TTGGAAATCA GCTGCCTTTC ATAGGATTTA CCTACTATAG AGAAAATTTG 1260
CTATTAAGTG ACTCTCCATC TTGTAGAGAA AATGATTCAA TACAATCAAG GAAAAATGAA 1320
GAAAGTCAAG AGATTCAGAA AAAACTGTAT ACATTAGAAG AACATCTTAG CAATGAGATA 1380
CAAGCCAAAG AGGAACTGGA ACAGAAGTGC AAATCTGTTA ATACTCGCCT AGAAAAAACA 1440
GCAAAGGAGC TAGAAGAGGA GATTACCTTA CGGAAAAGTG TGGAATCAGC ATTAAGACAG 1500
TTAGAAAGAG AAAAGGCGCT TCTTCAGCAC AAAAATGCAG AATATCAGAG GAAAGCTGAT 1560
CATGAAGCAG ACAAAAAACG AAATTTGGAA AATGATGTTA ACAGCTTAAA AGATCAACTT 1620
GAAGATTTGA AAAAAAGAAA TCAAAACTCT CAAATATCCA CTGAGAAAGT GAATCAACTC 1680
CAGAGACAAC TGGATGAAAC CAATGCTTTA CTGCGAACAG AATCTGATAC TGCAGCCCGG 1740
TTAAGGAAAA CCCAGGCAGA AAGTTCAAAA CAGATTCAGC AGCTGGAATC TAACAATAGA 1800
GATCTACAAG ATAAAAACTG CCTGCTGGAG ACCGCCAAGT TAAAACTTGA AAAGGAATTT 1860
ATCAATCTTC AGTCAGCTCT AGAATCTGAA AGGAGGGATC GAACCCATGG ATCAGAGATA 1920
ATTAATGATT TACAAGGTAG AATATCTGGC CTAGAAGAAG ATTTAAAGAA CGGCAAAATC 1980
TTATTAGCAA AAGTAGAACT GGAGAAGAGA CAACTACAGG AGAGATTTAC TGATTTGGAA 2040
AAGGAAAAAA GCAACATGGA AATAGATATG ACATACCAAC TAAAAGTTAT ACAGCAGAGC 2100
CTAGAACAAG AAGAAGCTGA ACATAAGGCC ACAAAGGCAC GACTAGCAGA TAAAAATAAG 2160
ATCTATGAGT CCATCGAAGA AGCCAAATCA GAAGCCATGA AAGAAATGGA GAAGAAGCTC 2220
TTGGAGGAAA GAACTTTAAA ACAGAAAGTG GAGAACCTAT TGCTAGAAGC TGAGAAAAGA 2280
TGTTCTCTAT TAGACTGTGA CCTCAAACAG TCACAGCAGA AAATAAATGA GCTCCTTAAA 2340
CAGAAAGATG TGCTAAATGA GGATGTTAGA AACCTGACAT TAAAAATAGA GCAAGAAACT 2400
CAGAAGCGCT GCCTTACACA AAATGACCTG AAGATGCAAA CACAACAGGT TAACACACTA 2460
AAAATGTCAG AAAAGCAGTT AAAGCAAGAA AATAACCATC TCATGGAAAT GAAAATGAAC 2520
TTGGAAAAAC AAAATGCTGA ACTTCGAAAA GAACGTCAGG ATGCAGATGG GCAAATGAAA 2580
GAGCTCCAGG ATCAGCTCGA AGCAGAACAG TATTTCTCAA CCCTTTATAA AACACAAGTT 2640
AGGGAGCTTA AAGAAGAATG TGAAGAAAAG ACCAAACTTG GTAAAGAATT GCAGCAGAAG 2700
AAACAGGAGT TACAGGATGA ACGGGACTCC TTGGCTGCCC AACTGGAGAT CACCTTGACC 2760
AAAGCAGATT CTGAGCAACT GGCTCGTTCA ATTGCTGAAG AACAATATTC TGATTTGGAA 2820
AAAGAGAAGA TCATGAAAGA GCTGGAGATC AAAGAGATGA TGGCTAGACA CAAACAGGAA 2880
CTTACCGAAA AAGATGCTAC AATTGCTTCT CTTGAAGAAA CTAATAGGAC ACTAACTAGT 2940
GATGTTGCCA ATCTTGCAAA TGAGAAAGAA GAATTAAATA ACAAATTGAA AGATGTTCAA 3000
GAGCAACTGT CAAGATTGAA AGATGAAGAA ATAAGCGCAG CAGCTATTAA AGCACAGTTT 3060
GAGAAACAGC TATTAACAGA AAGAACACTC AAAACTCAAG CTGTGAATAA GTTGGCTGAG 3120
ATCATGAATC GAAAAGAACC TGTCAAGCGT GGTAATGACA CAGATGTGCG GAGAAAAGAG 3180
AAGGAGAATA GGAAGCTACA TATGGAGCTT AAATCTGAAC GTGAGAAATT GACCCAGCAG 3240
ATGATCAAGT ATCAGAAAGA ACTGAATGAA ATGCAGGCAC AAATAGCTGA AGAGAGCCAG 3300
ATTCGAATTG AACTGCAGAT GACATTGGAC AGTAAAGACA GTGACATTGA GCAGCTGCGG 3360
TCACAACTCC AAGCCTTGCA TATTGGTCTG GATAGTTCCA GTATAGGCAG TGGACCAGGG 3420
GATGCTGAGG CAGATGATGG GTTTCCAGAA TCAAGATTAG AAGGATGGCT TTCATTGCCT 3480
GTACGAAACA ACACTAAGAA ATTTGGATGG GTTAAAAAGT ATGTGATTGT AAGCAGTAAG 3540
AAGATTCTTT TCTATGACAG TGAACAAGAT AAAGAACAAT CCAATCCTTA CATGGTTTTA 3600
GATATAGACA AGTTATTTCA TGTCCGACCA GTTACACAGA CAGATGTATA TAGAGCAGAT 3660
GCTAAAGAAA TTCCAAGGAT ATTCCAGATT CTGTATGCCA ATGAAGGAGA AAGTAAGAAG 3720
GAACAAGAAT TTCCAGTGGA GCCAGTTGGA GAAAAATCTA ATTATATTTG CCACAAGGGA 3780
CATGAGTTTA TTCCTACTCT TTATCATTTC CCAACCAACT GTGAGGCTTG TATGAAGCCC 3840
CTGTGGCACA TGTTTAAGCC TCCTCCTGCT TTGGAGTGCC GCCGTTGCCA TATTAAGTGT 3900
CATAAAGATC ACATGGACAA AAAGGAGGAG ATTATAGCAC CTTGCAAAGT ATATTATGAT 3960
ATTTCAACGG CAAAGAATCT ATTATTACTA GCAAATTCTA CAGAAGAGCA GCAGAAGTGG 4020
GTTAGTCGGT TGGTGAAAAA GATACCTAAA AAGCCCCCAG CTCCAGACCC TTTTGCACGA 4080
TCATCTCCTA GAACTTCAAT GAAGATACAG CAAAACCAGT CTATTAGACG GCCAAGTCGA 4140
CAGCTTGCCC CAAACAAACC TAGCTAA 4167
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         ++++kviGrGafgev++vr+ka++kvyamk+l+k+e++kr++saff+eerd++++a+s+w
Q: 92    YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  151
         799*********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g
Q: 152   VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  209
         **********************************..9***********************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180
         ++hrd+kpdn+lldk+Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+
Q: 210   LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GD  268
         ********************************************************9.**
S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240
         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski++hk+sl+fped+++s++ak+l
Q: 269   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNL  328
         ************************************************************
S: 241   ikklltsreerlgregiedlkkhpff  266
         i+++lt+re rlgr+g+e++++hpff
Q: 329   ICAFLTDREVRLGRNGVEEIRQHPFF  354
         *************************9
Domain Sequence
(FASTA)
YDVVKVIGRG AFGEVQLVRH KASQKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60
VVQLFYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120
HRDVKPDNML LDKHGHLKLA DFGTCMKMDE TGMVHCDTAV GTPDYISPEV LKSQGGDGYY 180
GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMDHKN SLCFPEDAEI SKHAKNLICA 240
FLTDREVRLG RNGVEEIRQH PFF 263
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00414
EKS-ANC-00429
EKS-BOT-00443
EKS-CAJ-00447
EKS-CAF-00442
EKS-CAP-00477
EKS-CII-00252
EKS-CIS-00203
EKS-DAR-00838
EKS-DRM-00209
EKS-EQC-00434
EKS-FEC-00423
EKS-GAG-00374
EKS-GAA-00538
EKS-LAC-00457
EKS-LOA-00452
EKS-MAM-00442
EKS-MEG-00367
EKS-MOD-00431
EKS-MUM-00475
EKS-MUP-00434
EKS-MYL-00435
EKS-NOL-00404
EKS-ORN-00562
EKS-ORA-00388
EKS-ORC-00415
EKS-OTG-00448
EKS-PAT-00418
EKS-PES-00393
EKS-PEM-00242
EKS-RAN-00456
EKS-SAH-00409
EKS-SUS-00392
EKS-TAG-00509
EKS-TAR-00553
EKS-TEN-00556
EKS-VIP-00080
EKS-XET-00594
EKS-XIM-00554
Gene Ontology
GO:0031616; C:spindle pole centrosome
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0051298; P:centrosome duplication
GO:0000910; P:cytokinesis
GO:0035556; P:intracellular signal transduction
GO:0016525; P:negative regulation of angiogenesis
GO:0001843; P:neural tube closure
GO:0010825; P:positive regulation of centrosome duplication
GO:0045616; P:regulation of keratinocyte differentiation
KEGG
pon:100461801;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR020684; Rho-assoc_coiled-coil_kin.
IPR015008; Rho-bd.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
PF08912; Rho_Binding; 1.
SMARTs
SM00109; C1; 1.
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
Created Date20-Feb-2013