EKS-POA-00276
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00276
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR388.91.4E-116203501299
StatusUnreviewed
Ensembl ProteinENSPPYP00000014623
UniProt AccessionH2P8B8;
Protein Name
Protein Synonyms/Alias
Gene NameBMPR2
Gene Synonyms/Alias BMPR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000013085ENSPPYP00000014623ENSPPYT00000015214
OrganismPongo abelii
Functional Description
Protein Length1038
Protein Sequence
(FASTA)
MTSSLQRPWR VPWLPWTILL VSTAAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 60
SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST 120
DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALYF GYRMLTGDRK 180
QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 240
INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 300
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG 360
NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC 420
TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 480
EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI 540
GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS 600
PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETNL HTTNVAQSIG PTPVCLQLTE 660
EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEATGQ 720
QDFTQAANGQ ACLIPDVLPT QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGSKHKSN 780
LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRNHSVNSHA ATTQYANGTV LSGQTTNIVT 840
HRAQEMLQNQ FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT 900
NSNNNNSNPC SEQDVLTQGV PSTAADPGPS KPRRAQRPNS LDLSATNVLD GSIIQIGEST 960
QDGKSGSGEK IKKRVKTPYS LKRWRPSTWV ISTESLDCEV NNNGSNRAVH SKSSTAVYLA 1020
EGGTATTMVS KDIGMNCL 1038
Nucleotide Sequence
(FASTA)
ATGACTTCGT CGCTGCAGCG GCCCTGGCGG GTGCCCTGGC TACCATGGAC CATCCTGCTG 60
GTCAGCACTG CGGCTGCTTC GCAGAATCAA GAACGGCTAT GTGCATTTAA AGATCCATAT 120
CAGCAAGACC TTGGGATAGG TGAGAGTAGA ATCTCTCATG AAAATGGGAC AATATTATGC 180
TCAAAAGGTA GCACCTGCTA TGGCCTTTGG GAGAAATCAA AAGGGGACAT AAATCTTGTA 240
AAACAAGGAT GTTGGTCTCA CATTGGAGAT CCCCAAGAGT GTCACTATGA AGAATGTGTA 300
GTAACTACCA CTCCTCCCTC AATTCAGAAT GGAACATACC GTTTCTGCTG TTGTAGCACA 360
GATTTATGTA ATGTCAACTT TACTGAGAAT TTTCCACCTC CTGACACAAC ACCACTCAGT 420
CCACCTCATT CATTTAACCG AGATGAGACA ATAATCATTG CTTTGGCATC AGTCTCTGTA 480
TTAGCTGTTT TGATAGTTGC CTTATACTTT GGATACAGAA TGTTGACAGG AGACCGTAAA 540
CAAGGTCTTC ACAGTATGAA CATGATGGAG GCAGCAGCAT CCGAACCCTC TCTTGACCTA 600
GATAATCTGA AACTGTTGGA GCTGATTGGC CGAGGTCGAT ATGGAGCAGT ATATAAAGGC 660
TCCTTGGATG AGCGTCCAGT TGCTGTAAAA GTGTTTTCCT TTGCAAACCG TCAGAATTTT 720
ATCAACGAAA AGAACATTTA CAGAGTGCCT TTGATGGAAC ATGACAACAT TGCCCGCTTT 780
ATAGTTGGAG ATGAGAGAGT CACTGCAGAT GGACGCATGG AATATTTGCT TGTGATGGAG 840
TATTATCCCA ATGGATCTTT ATGCAAGTAT TTAAGTCTCC ACACAAGTGA CTGGGTAAGC 900
TCTTGCCGTC TTGCTCATTC TGTTACTAGA GGACTGGCTT ATCTCCACAC AGAATTACCA 960
CGAGGAGATC ATTATAAACC TGCAATTTCC CATCGAGATT TAAACAGCAG AAATGTCCTA 1020
GTGAAAAATG ATGGAACCTG TGTTATTAGT GACTTTGGAC TGTCCATGAG GCTGACTGGA 1080
AATAGACTGG TGCGCCCAGG GGAGGAAGAT AATGCAGCCA TAAGCGAGGT TGGCACTATC 1140
AGATATATGG CACCAGAAGT GCTAGAAGGA GCTGTGAACT TGAGGGACTG TGAATCAGCT 1200
TTGAAACAAG TAGACATGTA TGCTCTTGGA CTAATCTATT GGGAGATATT TATGAGATGT 1260
ACAGACCTCT TCCCAGGGGA ATCCGTACCA GAGTACCAGA TGGCTTTTCA GACAGAGGTT 1320
GGAAACCATC CCACTTTTGA GGATATGCAG GTTCTTGTGT CTAGGGAAAA ACAGAGACCC 1380
AAGTTCCCAG AAGCCTGGAA AGAAAATAGC CTGGCAGTGA GGTCACTCAA GGAGACAATC 1440
GAAGACTGTT GGGACCAGGA TGCAGAGGCT CGGCTTACTG CACAGTGTGC TGAGGAAAGG 1500
ATGGCTGAAC TTATGATGAT TTGGGAAAGA AACAAATCTG TGAGCCCAAC AGTCAATCCA 1560
ATGTCTACTG CTATGCAGAA TGAACGCAAC CTGTCACATA ATAGGCGTGT GCCAAAAATT 1620
GGTCCTTATC CAGATTATTC TTCCTCCTCA TACATTGAAG ACTCTATCCA TCATACTGAC 1680
AGCATCGTGA AGAATATTTC CTCTGAGCAT TCTATGTCCA GCACACCTTT GACTATAGGG 1740
GAAAAAAACC GAAATTCAAT TAACTATGAA CGACAGCAAG CACAAGCTCG AATCCCCAGC 1800
CCTGAAACAA GTGTCACCAG CCTCTCCACC AACACAACAA CCACAAACAC CACAGGCCTC 1860
ACGCCAAGTA CTGGCATGAC TACTATATCT GAGATGCCAT ACCCAGATGA AACAAATCTG 1920
CATACCACAA ATGTTGCACA GTCAATTGGG CCAACCCCTG TCTGCTTACA GCTGACAGAA 1980
GAAGACTTGG AGACCAACAA GCTAGACCCA AAAGAAGTTG ATAAGAACCT CAAGGAGAGC 2040
TCTGATGAGA ATCTCATGGA GCACTCTCTT AAACAGTTCA GTGGCCCAGA CCCACTGAGC 2100
AGTACTAGTT CTAGCTTGCT TTACCCACTC ATAAAACTTG CAGTAGAGGC AACTGGACAG 2160
CAGGACTTCA CACAGGCTGC AAATGGCCAA GCATGTTTGA TTCCTGATGT TCTGCCTACT 2220
CAGATCTATC CTCTCCCCAA GCAGCAGAAC CTTCCCAAGA GACCTACTAG TTTGCCTTTG 2280
AACACCAAAA ATTCAACAAA AGAGCCCCGG CTAAAATTTG GCAGCAAGCA CAAATCAAAC 2340
TTGAAACAAG TCGAAACTGG AGTTGCCAAG ATGAATACAA TCAATGCAGC AGAACCTCAT 2400
GTGGTGACAG TCACCATGAA TGGTGTGGCA GGTAGAAACC ACAGTGTTAA CTCCCATGCT 2460
GCCACAACCC AATATGCCAA TGGGACAGTA CTATCTGGCC AAACAACCAA CATAGTGACA 2520
CATAGGGCCC AAGAAATGTT GCAGAATCAG TTTATCGGTG AGGACACCCG GCTGAATATT 2580
AATTCCAGTC CTGATGAGCA TGAGCCTTTA CTGAGACGAG AGCAACAAGC TGGCCATGAT 2640
GAAGGTGTTC TGGATCGTCT TGTGGACAGG AGGGAACGGC CACTAGAAGG TGGCCGAACT 2700
AATTCCAATA ACAACAACAG CAATCCATGT TCAGAACAAG ATGTTCTTAC ACAAGGTGTT 2760
CCAAGCACAG CGGCAGATCC TGGGCCATCA AAGCCCAGAA GAGCACAGAG GCCTAATTCT 2820
CTGGATCTTT CAGCCACAAA TGTCCTGGAT GGCAGCATTA TACAGATAGG TGAGTCAACA 2880
CAAGATGGCA AATCAGGATC AGGTGAAAAG ATCAAGAAAC GTGTGAAAAC TCCCTATTCT 2940
CTTAAGCGGT GGCGCCCCTC CACCTGGGTC ATCTCCACTG AATCGCTGGA CTGTGAAGTC 3000
AACAATAATG GCAGTAACAG GGCAGTTCAT TCCAAATCCA GCACTGCTGT TTACCTTGCA 3060
GAAGGAGGCA CTGCCACAAC CATGGTGTCT AAAGATATAG GAATGAACTG TCTGTGA 3117
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+
Q: 203   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  262
         6899********************************************************
S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119
          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++  
Q: 263   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  322
         **9999**************************************************9766
S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175
          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R
Q: 323   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  381
         .46***********************************999877787999**********
S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232
         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg
Q: 382   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  441
         *****************99*****************************************
S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291
         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+
Q: 442   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  501
         ***************************9999*************************9987
Domain Sequence
(FASTA)
LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60
GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120
DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180
MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240
HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00267
EKS-ANC-00273
EKS-BOT-00285
EKS-CAJ-00291
EKS-CAF-00291
EKS-CAP-00320
EKS-DAR-00625
EKS-DRM-00145
EKS-EQC-00277
EKS-FEC-00271
EKS-GAG-00238
EKS-GAA-00349
EKS-GOG-00284
EKS-HOS-00291
EKS-ICT-00269
EKS-LAC-00296
EKS-LOA-00295
EKS-MAM-00287
EKS-MEG-00225
EKS-MOD-00280
EKS-MUM-00316
EKS-MUP-00281
EKS-MYL-00287
EKS-NOL-00263
EKS-ORN-00368
EKS-ORA-00247
EKS-ORC-00267
EKS-OTG-00290
EKS-PAT-00269
EKS-PES-00254
EKS-PEM-00153
EKS-PRC-00027
EKS-PTV-00041
EKS-RAN-00301
EKS-SAH-00267
EKS-SUS-00250
EKS-TAG-00297
EKS-TAR-00369
EKS-TAS-00021
EKS-TEN-00366
EKS-VIP-00019
EKS-XET-00358
EKS-XIM-00360
Gene Ontology
GO:0005901; C:caveola
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0009952; P:anterior/posterior pattern specification
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0009267; P:cellular response to starvation
GO:0048286; P:lung alveolus development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0001707; P:mesoderm formation
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0003085; P:negative regulation of systemic arterial blood pressure
GO:0045906; P:negative regulation of vasoconstriction
GO:0030513; P:positive regulation of BMP signaling pathway
GO:0030501; P:positive regulation of bone mineralization
GO:0010595; P:positive regulation of endothelial cell migration
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916; P:regulation of lung blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0006366; P:transcription from RNA polymerase II promoter
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0060841; P:venous blood vessel development
KEGG
pon:100441517;
InterPros
IPR000472; Activin_rcpt.
IPR015770; BMPRII.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013