EKS-POA-00290
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00290
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR480.41.2E-144717965249
StatusUnreviewed
Ensembl ProteinENSPPYP00000014681
UniProt AccessionH2P8H3;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000013138ENSPPYP00000014681ENSPPYT00000015276
OrganismPongo abelii
Functional Description
Protein Length1284
Protein Sequence
(FASTA)
MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 60
GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 120
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST 180
NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 240
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 300
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 360
KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 420
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 480
INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD 540
GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 600
NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHARP LMAAGVIGGL 660
FILVIVGLTF AVYVRRKSIK KKRALRRFLE TELVEPLTPS GTAPNQAQLR ILKETELKRV 720
KVLGSGAFGT VYKGIWVPEG ETVKIPVAIK ILNETTGPKA NVEFMDEALI MASMDHPHLV 780
RLLGVCLSPT IQLVTQLMPH GCLLEYVHEH KDNIGSQLLL NWCVQIAKGM MYLEERRLVH 840
RDLAARNVLV KSPNHVKITD FGLARLLGDK EYHADGGKMP IKWMALECIH YRKFTHQSDV 900
WSYGVTIWEL MTFGGKPYDG IPTREIPDLL EKGERLPQPP ICTIDVYMVM VKCWMIDADS 960
RPKFGDDRMK LPSPNDSKFF QNLLDEEDLE DMMDAEEYLV PQAFNIPPPI YTSRARIDSN 1020
RSEIGHSPPP AYTPMSGNQF VYRDGGFAAE QGVSVPYRAP TSTIPEAPVA QGATAEIFDD 1080
SCCNGTLRKP VAPHVQEDSS TQRYSADPTV FAPERSPRGE LDEEGYMTPM RDKPKQEYLN 1140
PVEENPFVSR RKNGDLQALD NPEYHNASNG PPKAEDEYVN EPLYLNTFAN TLGKAEYLKN 1200
NVLSVPEKAK KAFDNPDYWN HSLPPRSTLQ HPDYLQEYST KYFYKQNGRI RPIVAENPEY 1260
LSEFSLKPGT VLPPPPYRHR NTVV 1284
Nucleotide Sequence
(FASTA)
ATGAAGCCGG CGACAGGACT TTGGGTCTGG GTGAGCCTTC TCGTGGCGGC GGGGACCGTC 60
CAGCCCAGCG ATTCTCAGTC AGTGTGTGCA GGAACGGAGA ATAAACTGAG CTCTCTCTCT 120
GACCTGGAAC AGCAGTACCG AGCCTTGCGC AAGTACTATG AAAACTGTGA GGTTGTCATG 180
GGCAACCTGG AGATAACCAG CATTGAGCAC AACCGGGACC TCTCCTTCCT GCGGTCTGTT 240
CGAGAAGTCA CAGGCTACGT GTTAGTGGCT CTTAATCAGT TTCGTTACCT GCCTCTGGAG 300
AATTTACGCA TTATTCGTGG GACAAAACTT TATGAGGATC GATATGCCTT GGCAATATTT 360
TTAAACTACA GAAAAGATGG AAACTTTGGA CTTCAAGAAC TTGGATTAAA GAACTTGACA 420
GAAATCCTAA ATGGTGGAGT CTATGTAGAC CAGAACAAAT TCCTTTGTTA TGCGGACACC 480
ATTCATTGGC AAGATATTGT TCGGAACCCA TGGCCTTCCA ACTTGACTCT TGTGTCAACA 540
AATGGTAGTT CAGGATGTGG ACGTTGCCAT AAGTCCTGTA CTGGCCGTTG CTGGGGACCC 600
ACAGAAAATC ATTGCCAGAC TTTGACAAGG ACGGTGTGTG CAGAACAATG TGACGGCAGA 660
TGCTACGGAC CTTACGTCAG TGACTGCTGC CATCGAGAAT GTGCTGGAGG CTGCTCAGGA 720
CCTAAGGATA CAGACTGCTT TGCCTGCATG AATTTCAATG ACAGTGGAGC ATGTGTTACT 780
CAGTGTCCCC AAACCTTTGT CTACAATCCA ACCACTTTTC AACTGGAGCA CAATTTCAAT 840
GCAAAGTACA CATATGGAGC ATTCTGTGTC AAGAAGTGTC CACATAACTT TGTGGTAGAT 900
TCCAGTTCTT GTGTGCGTGC CTGCCCTAGT TCCAAGATGG AAGTAGAAGA AAATGGGATT 960
AAAATGTGTA AACCTTGCAC TGACATTTGC CCAAAAGCTT GTGATGGCAT TGGCACAGGA 1020
TCATTGATGT CAGCTCAGAC TGTGGATTCC AGTAACATTG ACAAATTCAT AAACTGTACC 1080
AAGATCAATG GGAATTTGAT CTTTCTGGTC ACTGGTATTC ATGGGGACCC TTACAATGCA 1140
ATTGAAGCCA TAGACCCAGA GAAACTGAAT GTCTTTCGGA CAGTCAGAGA GATAACAGGT 1200
TTCCTGAACA TACAGTCATG GCCACCAAAC ATGACTGACT TCAGTGTTTT TTCTAACCTG 1260
GTGACAATTG GTGGAAGAGT ACTCTATAGT GGCCTGTCCT TGCTTATCCT CAAGCAACAG 1320
GGCATCACCT CTCTACAGTT CCAGTCCCTG AAGGAAATCA GCGCAGGAAA CATCTATATT 1380
ACTGACAACA GCAACCTGTG TTATTATCAT ACCATTAACT GGACAACACT CTTCAGCACA 1440
ATCAACCAAA GAATAGTAAT CCGGGACAAT AGAAAAGCTG AAAACTGTAC TGCTGAAGGA 1500
ATGGTGTGCA ACCATCTGTG TTCCAGTGAT GGCTGTTGGG GACCTGGGCC AGACCAGTGT 1560
CTGTCGTGTC GCCGCTTCAG TAGAGGAAGG ATCTGCATAG AGTCTTGTAA CCTCTATGAT 1620
GGTGAATTTC GGGAGTTTGA GAATGGCTCC ATCTGTGTGG AGTGTGACCC CCAGTGTGAG 1680
AAGATGGAAG ATGGCCTCCT CACATGCCAT GGACCGGGTC CTGACAACTG TACAAAGTGC 1740
TCTCATTTTA AAGATGGCCC AAACTGTGTG GAAAAATGTC CAGATGGCTT ACAGGGGGCA 1800
AACAGTTTCA TTTTCAAGTA TGCTGATCCG GATCGGGAGT GCCACCCATG CCATCCAAAC 1860
TGCACCCAAG GGTGTAACGG TCCCACTAGT CATGACTGCA TTTACTACCC ATGGACGGGC 1920
CATTCCACTT TACCACAACA TGCTAGACCC CTGATGGCAG CTGGAGTAAT TGGTGGGCTC 1980
TTCATTCTGG TCATTGTGGG TCTGACATTT GCTGTTTATG TTAGAAGGAA GAGCATCAAA 2040
AAGAAAAGAG CCTTGAGAAG ATTCTTGGAA ACAGAGTTGG TGGAACCATT AACTCCCAGT 2100
GGCACAGCAC CCAATCAAGC TCAACTTCGT ATTTTGAAAG AAACTGAGCT GAAGAGGGTA 2160
AAAGTCCTTG GCTCAGGTGC TTTTGGAACG GTTTATAAAG GTATTTGGGT ACCTGAAGGA 2220
GAAACTGTGA AGATTCCTGT GGCTATTAAG ATTCTTAATG AGACAACTGG TCCCAAGGCA 2280
AATGTGGAGT TCATGGATGA AGCTCTGATC ATGGCAAGTA TGGATCATCC ACACCTAGTA 2340
CGGTTGCTGG GTGTGTGTCT GAGCCCAACC ATCCAGCTGG TTACTCAACT TATGCCCCAT 2400
GGCTGCCTGT TGGAGTATGT CCACGAGCAC AAGGATAACA TTGGATCACA ACTGCTGCTT 2460
AACTGGTGTG TCCAGATAGC TAAGGGAATG ATGTACCTGG AAGAAAGACG ACTCGTTCAT 2520
CGGGATTTGG CAGCCCGTAA TGTCTTAGTG AAATCTCCAA ACCATGTGAA AATCACAGAT 2580
TTTGGGCTAG CCAGACTCTT GGGAGATAAA GAGTACCATG CTGATGGAGG AAAGATGCCA 2640
ATTAAATGGA TGGCTCTGGA GTGTATACAT TACAGGAAAT TCACCCATCA GAGTGACGTT 2700
TGGAGCTATG GAGTTACTAT ATGGGAACTG ATGACCTTTG GAGGAAAACC CTATGATGGA 2760
ATTCCAACGC GAGAAATCCC TGATTTATTA GAGAAAGGAG AACGTTTGCC TCAGCCTCCC 2820
ATCTGCACTA TTGACGTTTA CATGGTCATG GTCAAATGTT GGATGATTGA TGCTGACAGT 2880
AGACCTAAAT TTGGTGATGA TCGTATGAAG CTTCCCAGTC CAAATGACAG CAAGTTCTTT 2940
CAGAATCTCT TGGATGAAGA GGATTTGGAA GATATGATGG ATGCTGAGGA GTACTTGGTC 3000
CCTCAGGCTT TCAACATCCC ACCTCCCATC TATACTTCCA GAGCAAGAAT TGACTCAAAT 3060
AGGAGTGAAA TTGGACACAG CCCTCCTCCT GCCTACACCC CCATGTCAGG AAACCAGTTT 3120
GTATACCGAG ATGGAGGTTT TGCTGCAGAA CAAGGAGTGT CTGTGCCCTA CAGAGCCCCA 3180
ACTAGCACAA TTCCAGAAGC TCCTGTGGCA CAGGGTGCTA CTGCTGAGAT TTTTGATGAC 3240
TCCTGCTGTA ATGGCACCCT ACGCAAGCCA GTGGCACCCC ATGTCCAAGA GGACAGTAGC 3300
ACCCAGAGGT ACAGCGCTGA CCCCACCGTG TTTGCCCCAG AACGGAGCCC ACGAGGCGAG 3360
CTGGATGAGG AGGGTTACAT GACTCCTATG CGAGACAAAC CCAAACAAGA ATACCTGAAT 3420
CCAGTGGAGG AGAACCCTTT TGTTTCTCGG AGAAAAAATG GAGACCTTCA AGCATTGGAT 3480
AATCCCGAAT ATCACAATGC ATCCAATGGT CCACCCAAGG CCGAGGATGA GTATGTGAAT 3540
GAGCCACTGT ACCTCAACAC CTTTGCCAAC ACCTTGGGAA AAGCTGAGTA CCTGAAGAAC 3600
AACGTACTGT CAGTGCCAGA GAAGGCCAAG AAAGCGTTTG ACAACCCTGA CTACTGGAAC 3660
CACAGCCTGC CACCTCGGAG CACCCTTCAG CACCCAGACT ACCTGCAGGA GTACAGCACA 3720
AAATATTTTT ATAAACAGAA TGGGCGGATC CGGCCTATTG TGGCAGAGAA TCCTGAATAC 3780
CTCTCTGAGT TCTCCCTGAA GCCAGGCACT GTGCTGCCGC CTCCACCTTA CAGACACCGG 3840
AATACTGTGG TGTAA 3855
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 717   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  776
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gcll+yv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 777   PHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  836
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll   +ke++a+ggk+pikw+ale+i++rk+
Q: 837   RLVHRDLAARNVLVKSPNHVKITDFGLARLLG--DKEYHADGGKMPIKWMALECIHYRKF  894
         *******************************6..799***********************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 895   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  954
         ************************************************************
S: 241   midaesrpkfk  251
         mida+srpkf 
Q: 955   MIDADSRPKFG  965
         *********95
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LGDKEYHADG GKMPIKWMAL ECIHYRKFTH 180
QSDVWSYGVT IWELMTFGGK PYDGIPTREI PDLLEKGERL PQPPICTIDV YMVMVKCWMI 240
DADSRPKFG 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MAM-00300
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0061026; P:cardiac muscle tissue regeneration
GO:0045165; P:cell fate commitment
GO:0021551; P:central nervous system morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0007507; P:heart development
GO:0007595; P:lactation
GO:0060749; P:mammary gland alveolus development
GO:0060644; P:mammary gland epithelial cell differentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0001755; P:neural crest cell migration
GO:0021889; P:olfactory bulb interneuron differentiation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013