EKS-POA-00423

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00423

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	328.4	3.6E-98	4	254	251

Status

Unreviewed

Ensembl Protein

ENSPPYP00000014729

UniProt Accession

H2P8L8;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase 36;

Gene Name

STK36

Gene Synonyms/Alias

STK36;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000013181	ENSPPYP00000014729	ENSPPYT00000015326

Organism

Pongo abelii

Functional Description

Protein Length

1315

Protein Sequence
(FASTA)

MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH 60

PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR 120

ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT 180

ADLWSVGCIL YELAVGTPPF YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR 240

QRLSWPDLLY HPFIAGHVTI ITETAGPDLG TPFTSRLPPE LQVLKDKQAH RLSPKGNQSR 300

ILTQAYERMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE SSLLAGILAS 360

ELKSSWAESG TGEAPSAPRE NRTTPDCERA FPEERPEVLG QRSTDAVDLE DEEPDSDNEW 420

QHLLETTEPV PIQLKAPLTL LCNPDFCQRI QSQLHEAGGQ ILKGILEGAS HILPAFRVLS 480

SLLSSCSDSV ALYSFCREAG LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA 540

CTFNLERSQT SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 600

SRAISKAFYS SLLTTKQVVL DGLLHGLTVP QLPVHTPPGA PQVSQPLREQ SEDIPGAISS 660

ALAAICTAPV GLPDCWDGKE QVCWHLANQL TEDSSQLRPS LVSGLQHPIL CLHLLKVLYS 720

CCLVSERLCR LLGQEPLALE SLFMLVQGKV KVVDWEESTE VTLYFLSLLV FRLQNLPCGM 780

EKLGSDVATL FTHSHVVSLV SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL 840

TPPGSCGFYD GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPKEASAQEG 900

ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFAQEPQLC LSCLSQHGSI LMSILKHLLC 960

PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL LIGVLADLRD SEVAAHLLQV 1020

CCYHLPLTQV ELPISLLTRL ALTDPTSLNQ FVNTVAASPR TIISFLSVAL LSDQPLLTSD 1080

LLSLLAHTAR VLSPSHLSFI QELLAGSDES YQSLRSLLGH PENSVRAHTY RLLGHLLQHS 1140

MALRGALQSQ SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL 1200

LGDPQAGIRR NVASALGNLG PEGLGEELLQ CQVPQRLLEM ACGDPQPNVK EAALIALRSL 1260

QQEPGIRQVL VSLGASEKLA LLSLGNQLLP HSSPRPASAK HCRKLIHLLR PAHSM 1315

Nucleotide Sequence
(FASTA)

ATGGAAAAGT ACCACGTGTT GGAGATGATT GGAGAAGGCT CTTTTGGGAG GGTGTACAAG 60

GGTCGAAGAA AATACAGTGC TCAGGTTGTG GCCCTGAAGT TCATCCCAAA ATTGGGGCGC 120

TCAGAGAAGG AGCTGAGGAA TTTGCAACGA GAGATTGAAA TAATGCGGGG TCTGCGGCAT 180

CCCAACATTG TGCATATGCT TGACAGCTTT GAAACTGACA AAGAGGTGGT GGTGGTGACA 240

GACTATGCTG AGGGAGAGCT CTTTCAGATC CTAGAAGATG ACGGAAAACT TCCTGAAGAC 300

CAGGTTCAGG CCATTGCTGC CCAGTTGGTG TCAGCCCTGT ACTATCTGCA TTCCCACCGC 360

ATCCTACACC GAGACATGAA GCCTCAGAAC ATCCTCCTCG CCAAGGGTGG TGGCATCAAG 420

CTCTGTGACT TTGGATTTGC CCGGGCTATG AGCACCAATA CAATGGTGCT GACGTCCATC 480

AAAGGCACAC CACTCTATAT GTCTCCAGAG CTGGTGGAGG AGCGACCATA CGACCACACA 540

GCGGACCTCT GGTCTGTTGG CTGCATACTG TATGAACTGG CAGTAGGCAC CCCTCCCTTC 600

TATGCTACAA GCATCTTTCA GCTGGTCAGC CTCATTCTCA AGGACCCTGT GCGCTGGCCC 660

TCAACCATCA GTCCCTGCTT TAAGAACTTC CTGCAGGGAC TGCTCACCAA AGACCCACGG 720

CAGCGACTGT CCTGGCCAGA CCTCTTATAT CACCCCTTTA TTGCTGGTCA TGTCACCATA 780

ATAACTGAGA CAGCAGGCCC AGATTTGGGG ACTCCATTCA CCAGCCGCCT ACCCCCAGAA 840

CTTCAGGTCC TAAAGGACAA ACAGGCCCAT CGATTGTCCC CCAAGGGTAA TCAGTCTCGC 900

ATCTTGACTC AAGCCTATGA ACGCATGGCT GAGGAGGCCA TGCAAAAGAA ACATCAGAAC 960

ACAGGACCTG CCCTTGAGCA AGAGGACAAG ACCAGCAAGG TGGCTCCTGG CACAGCCCCT 1020

CTGCCCAGAC TCGGGGCCAC TCCTCAGGAA TCAAGCCTCC TGGCTGGGAT CTTAGCCTCA 1080

GAATTGAAGA GCAGCTGGGC TGAGTCAGGG ACTGGAGAGG CGCCGTCTGC ACCTCGGGAA 1140

AACCGGACCA CCCCAGATTG TGAACGAGCA TTCCCAGAGG AGAGGCCAGA GGTGCTGGGC 1200

CAGCGGAGCA CTGATGCAGT GGACCTGGAA GATGAGGAGC CAGACAGTGA CAATGAGTGG 1260

CAACACCTGC TAGAGACCAC TGAGCCTGTG CCTATTCAAC TGAAGGCTCC TCTCACCTTG 1320

CTGTGCAATC CTGACTTCTG CCAGCGCATC CAGAGTCAGC TGCATGAAGC TGGAGGGCAG 1380

ATCCTGAAAG GCATCTTGGA GGGTGCTTCC CACATCCTGC CTGCATTCCG GGTCCTGAGC 1440

AGTCTTCTCT CCAGCTGCAG TGACTCTGTT GCCTTGTATT CCTTCTGCCG GGAGGCAGGG 1500

CTTCCTGGGC TGCTGCTGAG TCTACTCAGG CACAGTCAGG AGAGCAACAG CCTCCAGCAG 1560

CAATCTTGGT ATGGGACCTT CTTACAGGAC CTGATGGCTG TGATTCAGGC CTACTTTGCC 1620

TGTACCTTCA ATCTGGAGAG GAGCCAGACA AGTGACAGCC TGCAGGTGTT TCAGGAGGCT 1680

GCCAATCTTT TTCTGGACCT GTTGGGGAAA CTGCTGGCCC AACCAGATGA CTCTGAGCAG 1740

ACTTTGCGGA GGGACAGCCT CATGTGCTTT ACTGTCCTGT GCGAAGCCAT GGATGGGAAC 1800

AGCCGGGCCA TCTCCAAAGC CTTTTACTCC AGCTTGCTGA CGACAAAGCA GGTTGTCTTG 1860

GATGGGCTCC TTCATGGCTT GACAGTTCCA CAGCTCCCTG TCCACACTCC CCCAGGAGCC 1920

CCACAAGTGA GCCAGCCACT GCGAGAGCAG AGTGAGGATA TACCTGGAGC CATTTCCTCT 1980

GCCCTGGCAG CCATATGCAC TGCTCCTGTG GGACTACCCG ACTGCTGGGA CGGCAAGGAG 2040

CAGGTCTGTT GGCATTTGGC AAATCAGCTA ACTGAAGACA GCAGCCAGCT CAGGCCATCC 2100

CTCGTCTCTG GCCTGCAGCA TCCCATCCTG TGCCTGCACC TTCTCAAGGT TCTATACTCC 2160

TGCTGCCTTG TCAGTGAGCG CCTGTGCCGT CTTCTAGGGC AGGAGCCCCT GGCCTTGGAA 2220

TCCCTGTTTA TGTTGGTTCA GGGCAAGGTA AAAGTAGTAG ATTGGGAAGA GTCTACTGAA 2280

GTGACACTCT ACTTCCTCTC CCTTCTTGTC TTTCGGCTCC AAAACCTGCC TTGTGGAATG 2340

GAGAAGCTAG GCAGTGACGT TGCTACTCTC TTTACCCATT CGCATGTCGT CTCTCTTGTG 2400

AGTGCAGCAG CCTGTCTATT GGGACAGCTT GGTCAGCAAG GGGTGACCTT TGACCTCCAG 2460

CCCATGGAAT GGATGGCTGC AGCCACACAT GCCTTGTCTG CCCCTGCAGA GGTTCGGTTG 2520

ACTCCACCGG GTAGTTGTGG ATTCTATGAT GGCCTCCTTA TCCTTCTGTT GCAGCTCCTC 2580

ACTGAGCAGG GGAAGGCTAG CCTAATCAGG GATATGTCCA GTTCAGAAAT GTGGACCGTT 2640

TTGTGGCACC GCTTCTCCAT GGTCCTGAGG CTCCCCAAGG AGGCATCTGC ACAGGAAGGG 2700

GAGCTTTCGC TATCCAGTCC ACCAAGCCCT GAGCCGGACT GGACACTGAT TTCTCCGCAG 2760

GGCATGGCAG CCCTGCTGAG CCTGGCCATG GCCACCTTTG CCCAGGAGCC CCAGTTATGC 2820

CTGAGCTGCC TGTCCCAGCA TGGAAGTATC CTCATGTCCA TCCTGAAGCA TCTGCTTTGC 2880

CCCAGCTTCC TGAATCAACT GCGCCAGGCG CCTCATGGGT CTGAGTTTCT CCCTGTCGTG 2940

GTGCTCTCTG TCTGCCAGCT CCTTTGCTTC CCCTTTGCGC TGGACATGGA TGCTGACCTC 3000

CTTATAGGTG TCTTGGCCGA CCTCAGGGAC TCAGAAGTTG CAGCCCATCT GCTGCAGGTC 3060

TGCTGCTACC ATCTTCCGTT GACGCAAGTG GAGCTGCCCA TCAGCCTCCT CACGCGCCTG 3120

GCCCTCACAG ATCCCACCTC TCTCAACCAG TTTGTGAACA CAGTGGCCGC CTCCCCTAGA 3180

ACCATCATCT CGTTTCTCTC AGTTGCCCTC CTGAGTGACC AGCCACTGCT GACCTCCGAC 3240

CTTCTCTCTC TGCTGGCCCA TACCGCCAGG GTCCTGTCTC CCAGCCACTT GTCCTTTATC 3300

CAAGAGCTTC TGGCTGGCTC TGATGAATCC TATCAGTCCC TGCGCAGCCT CCTGGGCCAC 3360

CCAGAGAATT CTGTGCGGGC ACACACTTAT AGGCTCCTGG GACACTTGCT CCAACACAGC 3420

ATGGCCCTGC GTGGGGCACT GCAGAGCCAG TCTGGACTGC TCAGCCTTCT GCTGCTTGGG 3480

CTTGGAGACA AGGATCCTGT TGTGCGGTGC AGTGCCAGCT TTGCTGTGGG CAATGCAGCC 3540

TACCAGGCTG GTCCTCTGGG ACCTGCCCTG GCAGCTGCAG TGCCCAGTAT GACCCAGCTG 3600

CTTGGAGATC CTCAGGCTGG TATCCGGCGC AATGTTGCAT CGGCTCTGGG CAACTTGGGA 3660

CCTGAAGGTT TGGGAGAGGA GCTGTTACAG TGCCAGGTAC CCCAGCGGCT CCTAGAAATG 3720

GCATGTGGAG ACCCCCAGCC AAATGTGAAG GAGGCCGCCC TCATTGCCCT CCGGAGCCTG 3780

CAACAGGAGC CTGGCATCCG TCAGGTACTG GTGTCCCTGG GTGCCAGTGA GAAACTAGCC 3840

TTGCTCTCTC TGGGGAATCA ATTACTGCCA CACAGCAGTC CTAGGCCTGC CTCTGCCAAA 3900

CACTGCAGGA AACTCATTCA CCTCCTGAGG CCAGCCCATA GCATGTGA 3948

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen  59

         y++ e+iG+Gsf+ vykgr rk ++qvvA+k++ k ++ +k+l+nl++ei+i++ l+h+n

Q: 4     YHVLEMIGEGSFGRVYKGR-RKYSAQVVALKFIPKLGRsEKELRNLQREIEIMRGLRHPN  62

         8999***************.******************9*********************

S: 60    ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki  119

         iv++ld++et+kev++v++y++ g+L ++l+++++L+ed+v+++++ql+sal++Lhs++i

Q: 63    IVHMLDSFETDKEVVVVTDYAE-GELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRI  121

         **********************.*************************************

S: 120   vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesma.atlkGsplYmaPEvvk  178

         +hrD+kPqniLl+        k +++kl+dFg+ar++++++m  +++kG+plYm+PE+v+

Q: 122   LHRDMKPQNILLA--------KGGGIKLCDFGFARAMSTNTMVlTSIKGTPLYMSPELVE  173

         *************........89********************9****************

S: 179   eqqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdl  238

         e+ yd++aDlWS+G+ilyel+vG+pPf+a+si++Lv+ i k++v   ++p++is+++k++

Q: 174   ERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPV---RWPSTISPCFKNF  230

         ********************************************...*************

S: 239   lqsLLqrdpkkRisfeelfahpfl  262

         lq+LL++dp++R+s+ +l+ hpf+

Q: 231   LQGLLTKDPRQRLSWPDLLYHPFI  254

         **********************96

Domain Sequence
(FASTA)

YHVLEMIGEG SFGRVYKGRR KYSAQVVALK FIPKLGRSEK ELRNLQREIE IMRGLRHPNI 60

VHMLDSFETD KEVVVVTDYA EGELFQILED DGKLPEDQVQ AIAAQLVSAL YYLHSHRILH 120

RDMKPQNILL AKGGGIKLCD FGFARAMSTN TMVLTSIKGT PLYMSPELVE ERPYDHTADL 180

WSVGCILYEL AVGTPPFYAT SIFQLVSLIL KDPVRWPSTI SPCFKNFLQG LLTKDPRQRL 240

SWPDLLYHPF I 251

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0042384	; P:cilium assembly
GO:0007228	; P:positive regulation of hh target transcription factor activity
GO:0045880	; P:positive regulation of smoothened signaling pathway
GO:0009791	; P:post-embryonic development

KEGG

pon:100436724

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013