EKS-POA-00001
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00001
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph520.55.7E-157562819258
StatusUnreviewed
Ensembl ProteinENSPPYP00000014770
UniProt AccessionH2P8Q7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA4
Gene Synonyms/Alias EPHA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000013217ENSPPYP00000014770ENSPPYT00000015367
OrganismPongo abelii
Functional Description
Protein Length927
Protein Sequence
(FASTA)
MDEKNTPIRT YQVCNVMEPS QNNWLRTDWI TREGAQRVYI EIKFTLRDCN SLPGVMGTCK 60
ETFNLYYYES DNDKERFIRE NQFVKIDTIA ADESFTQVDI GDRIMKLNTE IRDVGPLSKK 120
GFYLAFQDVG ACIALVSVRV FYKKCPLTVR NLAQFPDTIT GADTSSLVEV RGSCVNNSEE 180
KDVPKMYCGA DGEWLVPIGN CLCNAGHEER SGECQACKIG YYKALSTDAT CAKCPPHSYS 240
VWEGATSCTC DRGFFRADND AASMPCTRPP SAPLNLISNV NETSVNLEWS SPQNTGGRQD 300
ISYNVVCKKC GAGDPSKCRP CGSGVHYTPQ QNGLKTTKVS ITDLLAHTNY TFEIWAVNGV 360
SKYNPNPDQS VSVTVTTNQA APSSIALVQA KEVTRYSVAL AWLEPDRPNG VILEYEVKYY 420
EKDQNERSYR IVRTAARNTD IKGLNPLTSY VFHVRARTAA GYGDFSEPLE VTTNTVPSRI 480
IGDGANSTVL LVSVSGSVVL VVILIAAFVI SRRRSKYSKA KQEADEEKHL NQGVRTYVDP 540
FTYEDPNQAV REFAKEIDAS CIKIEKVIGV GEFGEVCSGR LKVPGKREIC VAIKTLKAGY 600
TDKQRRDFLS EASIMGQFDH PNIIHLEGVV TKCKPVMIIT EYMENGSLDA FLRKNDGRFT 660
VIQLVGMLRG IGSGMKYLSD MSYVHRDLAA RNILVNSNLV CKVSDFGMSR VLEDDPEAAY 720
TTRGGKIPIR WTAPEAIAYR KFTSASDVWS YGIVMWEVMS YGERPYWDMS NQDVIKAIEE 780
GYRLPPPMDC PIALHQLMLD CWQKERSDRP KFGQIVNMLD KLIRNPNSLK RTGTESSRPN 840
TALLDPSSPE FSAAVSVGDW LQAIKMDRYK DNFTAAGYTT LEAVVHVNQE DLARIGITAI 900
THQNKILSSV QAMRTQMQQI HGRMVPV 927
Nucleotide Sequence
(FASTA)
ATGGATGAAA AAAATACACC AATCCGAACC TACCAAGTGT GCAATGTGAT GGAACCCAGC 60
CAGAATAACT GGCTACGAAC TGATTGGATC ACCCGAGAAG GGGCTCAGAG GGTGTATATT 120
GAGATTAAAT TCACCTTGAG GGACTGCAAT AGTCTTCCGG GCGTCATGGG GACTTGCAAG 180
GAGACGTTTA ACCTGTACTA CTATGAATCA GACAACGACA AAGAGCGTTT CATCAGAGAG 240
AACCAGTTTG TCAAAATTGA CACCATTGCT GCTGATGAGA GCTTCACCCA AGTGGACATT 300
GGTGACAGAA TCATGAAGCT GAACACCGAG ATCCGGGATG TAGGGCCATT AAGCAAAAAG 360
GGGTTTTACC TGGCTTTTCA GGATGTGGGG GCCTGCATCG CCCTGGTATC AGTCCGTGTG 420
TTCTATAAAA AGTGTCCACT CACAGTCCGC AATCTGGCCC AGTTTCCTGA CACCATCACA 480
GGGGCTGATA CGTCTTCCCT GGTGGAAGTT CGAGGCTCCT GTGTCAACAA CTCAGAAGAG 540
AAGGATGTGC CAAAAATGTA CTGTGGGGCA GATGGTGAAT GGCTGGTACC CATTGGCAAC 600
TGCCTATGCA ACGCTGGGCA TGAGGAGCGG AGCGGAGAAT GCCAAGCTTG CAAAATTGGA 660
TATTACAAGG CTCTCTCCAC AGATGCCACC TGTGCCAAGT GCCCACCCCA CAGCTACTCT 720
GTCTGGGAAG GAGCCACCTC GTGCACCTGT GACCGAGGCT TTTTCAGAGC TGACAATGAT 780
GCTGCCTCTA TGCCCTGCAC CCGTCCACCA TCTGCTCCCC TGAACTTGAT TTCAAATGTC 840
AACGAGACAT CTGTGAACTT GGAATGGAGT AGCCCTCAGA ATACAGGTGG CCGCCAGGAC 900
ATTTCCTATA ATGTGGTATG CAAGAAATGT GGAGCTGGTG ACCCCAGCAA GTGCCGACCC 960
TGTGGAAGTG GGGTCCACTA CACCCCACAG CAGAATGGCT TGAAGACCAC CAAAGTCTCC 1020
ATCACTGACC TCCTAGCTCA TACCAATTAC ACCTTTGAAA TCTGGGCTGT GAATGGAGTG 1080
TCCAAATATA ACCCTAACCC AGACCAATCA GTTTCTGTCA CTGTGACCAC CAACCAAGCA 1140
GCACCATCAT CCATTGCTTT GGTCCAGGCT AAAGAAGTCA CAAGATACAG TGTGGCACTG 1200
GCTTGGTTGG AACCAGATCG GCCCAATGGG GTAATCCTGG AATATGAAGT CAAGTATTAT 1260
GAGAAGGATC AGAATGAGCG AAGCTATCGT ATAGTTCGGA CAGCTGCCAG GAACACAGAT 1320
ATCAAAGGCC TGAACCCTCT CACTTCGTAT GTTTTCCACG TGCGAGCCAG GACAGCAGCT 1380
GGCTATGGAG ACTTCAGTGA GCCCTTGGAG GTCACAACCA ACACAGTGCC TTCCCGGATC 1440
ATTGGAGATG GGGCCAACTC CACAGTCCTT CTGGTCTCTG TCTCAGGCAG TGTGGTGCTG 1500
GTGGTAATTC TCATTGCAGC TTTTGTCATC AGCCGGAGGC GGAGTAAATA TAGTAAAGCC 1560
AAACAAGAAG CGGATGAAGA GAAACATTTG AATCAAGGTG TAAGAACATA TGTGGACCCC 1620
TTTACGTACG AAGATCCCAA CCAAGCAGTT CGAGAGTTTG CCAAAGAAAT TGATGCATCC 1680
TGCATTAAGA TTGAAAAAGT TATAGGAGTT GGTGAATTTG GTGAGGTATG CAGTGGGCGT 1740
CTCAAAGTGC CTGGCAAGAG AGAGATCTGT GTGGCTATCA AGACTCTGAA AGCTGGTTAT 1800
ACAGACAAAC AGAGGAGAGA CTTCCTGAGT GAGGCCAGCA TCATGGGACA GTTTGACCAT 1860
CCGAACATCA TTCACTTGGA AGGCGTGGTC ACTAAATGTA AACCAGTAAT GATCATAACA 1920
GAGTACATGG AGAATGGCTC CTTGGATGCA TTCCTCAGGA AAAATGATGG CAGATTTACA 1980
GTCATTCAGC TGGTGGGCAT GCTTCGTGGC ATTGGGTCTG GGATGAAGTA TTTATCTGAT 2040
ATGAGCTATG TGCATCGTGA TCTGGCCGCA CGGAACATCC TGGTGAACAG CAACTTGGTC 2100
TGCAAAGTGT CTGATTTTGG CATGTCCCGA GTGCTTGAGG ATGATCCGGA AGCAGCTTAC 2160
ACCACCAGGG GTGGCAAGAT TCCTATCCGG TGGACTGCGC CAGAAGCAAT TGCCTATCGT 2220
AAATTCACAT CAGCAAGTGA TGTATGGAGC TATGGAATCG TTATGTGGGA AGTGATGTCG 2280
TACGGGGAGA GGCCCTATTG GGATATGTCC AATCAAGATG TGATTAAAGC CATTGAGGAA 2340
GGCTATCGGT TACCCCCTCC AATGGACTGC CCCATTGCAC TCCACCAGCT GATGCTAGAC 2400
TGCTGGCAGA AGGAGAGGAG CGACAGGCCT AAATTTGGGC AGATTGTCAA CATGTTGGAC 2460
AAACTCATCC GCAACCCCAA CAGCTTGAAG AGGACAGGGA CGGAGAGCTC CAGACCTAAC 2520
ACTGCCTTGT TGGATCCAAG CTCCCCTGAA TTCTCTGCTG CGGTATCAGT GGGCGATTGG 2580
CTCCAGGCCA TTAAAATGGA CCGGTATAAG GATAACTTCA CAGCTGCTGG TTATACCACA 2640
CTAGAGGCTG TGGTGCACGT GAACCAGGAG GACCTGGCAA GAATTGGTAT CACAGCCATC 2700
ACGCACCAGA ATAAGATTCT GAGCAGTGTC CAGGCAATGC GAACCCAAAT GCAGCAGATA 2760
CACGGCAGGA TGGTTCCCGT CTGA 2784
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kiekviG GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfdhp
Q: 562   IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP  621
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ftviqlvgmlrGi+sgmkylsdm
Q: 622   NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM  681
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiayrk
Q: 682   SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  741
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlmldc
Q: 742   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDC  801
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqk+r++rpkf qiv++l
Q: 802   WQKERSDRPKFGQIVNML  819
         ***************985
Domain Sequence
(FASTA)
IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP 60
NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV IQLVGMLRGI GSGMKYLSDM 120
SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC 240
WQKERSDRPK FGQIVNML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00001
EKS-ANC-00001
EKS-BOT-00001
EKS-CAJ-00001
EKS-CAF-00001
EKS-CAP-00001
EKS-CII-00001
EKS-CIS-00002
EKS-DAR-00001
EKS-EQC-00001
EKS-FEC-00001
EKS-GAG-00001
EKS-GAA-00001
EKS-GOG-00001
EKS-HOS-00002
EKS-ICT-00001
EKS-LAC-00002
EKS-LOA-00001
EKS-MAM-00001
EKS-MEG-00001
EKS-MOD-00001
EKS-MUM-00001
EKS-MUP-00001
EKS-MYL-00001
EKS-NOL-00001
EKS-ORN-00001
EKS-ORA-00001
EKS-ORC-00001
EKS-ORL-00001
EKS-OTG-00005
EKS-PAT-00001
EKS-PES-00001
EKS-PEM-00004
EKS-PRC-00001
EKS-PTV-00001
EKS-RAN-00001
EKS-SAH-00001
EKS-SUS-00001
EKS-TAG-00001
EKS-TAR-00001
EKS-TAS-00001
EKS-TEN-00006
EKS-XET-00002
EKS-XIM-00001
Gene Ontology
GO:0030424; C:axon
GO:0030425; C:dendrite
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0007628; P:adult walking behavior
GO:0021957; P:corticospinal tract morphogenesis
GO:0097156; P:fasciculation of motor neuron axon
GO:0097155; P:fasciculation of sensory neuron axon
GO:0008045; P:motor neuron axon guidance
GO:0048681; P:negative regulation of axon regeneration
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043507; P:positive regulation of JUN kinase activity
GO:2001108; P:positive regulation of Rho guanyl-nucleotide exchange factor activity
GO:0046777; P:protein autophosphorylation
GO:0048710; P:regulation of astrocyte differentiation
GO:0061001; P:regulation of dendritic spine morphogenesis
GO:0032314; P:regulation of Rac GTPase activity
GO:0032317; P:regulation of Rap GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013