EKS-POA-00251

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00251

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	248.6	6.1E-74	999	1251	253

Status

Unreviewed

Ensembl Protein

ENSPPYP00000014932

UniProt Accession

H2P964;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

PASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000013348	ENSPPYP00000014932	ENSPPYT00000015530

Organism

Pongo abelii

Functional Description

Protein Length

1323

Protein Sequence
(FASTA)

MEDGGLTAFE EDQRCLSQSL PLPVPAEGPA AQTTAEPSRS FSSAHRHLSR RNGLSRLCQS 60

RTALSEDRWS SYCLSSLAAQ SICTSKLHCP AAPEHTDPFG PRGSVSCCSL LRGLSSGWSS 120

PLLPAPVCNP NKAIFTVDAK TTEILVANDK ACRLLGYSSQ DLIGQKLMQF FLRSDSDVVE 180

ALSEEHMEAD GHAAVVFGTV VDIISRSGEK IPVSVWMKRM QQEHRLCCVV VLEPVERVST 240

WVAFQSDGTI TSCDSLFAHL HGYVSGEDVA GQHITDLIPS VQLPPSGQHI PKNLKIQRSV 300

GRARDGTTFP LSLKLKSQPS SEEATTGEAA PVRGYRASVW VFCTISGLIT LLPDGTIHGI 360

NHSFALTLFG YGKTELLGKN ITFLIPGFYS YMDLVYDSSL QLPDLASCLD VGDESGCGER 420

TLDPWQGQDP AEGAQDPGIN VVLAGGHIVP RDETRKLVES QDIFTGTQTE LGAGGQLLSR 480

LSPQPAPGVD SVPEGSLPVH SEQVLPEDQQ VTALGREEPV AIESPGQDLL GESRSEPVDV 540

KPFTSCEDSE APVPAEDGGS DAGMCGLCQK AQLERMGVSG PSGSDLWAGA AVAEPQAKGQ 600

LAGGSLLMHC PCYGSEWGLW WQRQDLAPSP SGMAALSFGT PTLDEPWLGM KNDREELQTC 660

LIKEQLSQLS LVGALDVPHT ELIPTERPAV TAPVSSCDLG GRDLYGGCTG SSSACYALAT 720

DLPGGLKAVE AQEVDVNSFS WNLKELFFSD QKDQTSSDCS CATSELRGTP SSLAVGSDPD 780

VGSLQEEGSC VLDDRELLLL TGTCVDLGQG RRFRDSCLGH DPTEPLEVCL VSSEHYAASD 840

RESPGCIPST LDAGPEDTCP SAEEPRLNVQ VTSTPVIVMP GAAGLQREIQ EGAYSGSCYH 900

RDGLRLSIQF EVRRVELQGP TPLFCCWLVK DLLHSQRDSA ARTRLFLASL PSSTHSTAAE 960

LTGPNLVEVL RARPWFEEPP KAVELEGLAA CEGEYSQKYS TLSPLGSGAF GFVWTAVDKE 1020

KNKEVVVKFI KKEKVLEDCW IEDPKLGKVT LEIAILSRVE HANIIKVLDV FENQGFFQLV 1080

MEKHGSGLDL FAFIDRHPRL DEPLASYIFR QLVSAVGYLR LKDIIHRDIK DENIVIAEDF 1140

TIKLIDFGSA AYLERGKLFY TFCGTIEYCA PEVLLGNPYR GPELEMWSLG VTLYTLVFEE 1200

NPFCELEETV EAAIHPPYLV SKELMSLVSG LLQPVPEKRT TLEKLVTDPW VTQPVNLADY 1260

TWEEVCRVNK PESGVLSTAS LEMGNRSLSE VAQAQELCGG PVPGEAPNGQ GCLHPGDPRL 1320

LTS 1323

Nucleotide Sequence
(FASTA)

ATGGAGGACG GGGGCTTAAC AGCCTTTGAA GAGGACCAGA GATGCCTTTC CCAGAGCCTC 60

CCCTTGCCAG TGCCAGCAGA GGGCCCAGCT GCACAGACCA CTGCTGAGCC CAGCAGGTCG 120

TTTTCCTCAG CCCACAGACA TTTGAGCAGA AGGAATGGGC TTTCCAGACT CTGCCAGAGC 180

AGGACAGCGC TCTCCGAAGA CAGATGGAGC TCCTACTGTC TATCATCACT GGCTGCCCAG 240

AGTATTTGTA CAAGTAAACT GCACTGCCCT GCTGCCCCCG AGCACACGGA CCCGTTCGGG 300

CCCCGAGGCA GTGTGTCCTG CTGCTCCCTG CTGCGGGGAC TGTCCTCAGG GTGGTCCTCA 360

CCTCTGCTTC CAGCCCCTGT GTGCAACCCT AACAAGGCCA TCTTCACGGT GGATGCCAAG 420

ACCACAGAGA TCCTGGTTGC TAACGACAAA GCTTGCAGGC TCCTGGGGTA CAGCAGCCAG 480

GACCTGATTG GCCAGAAGCT CATGCAGTTC TTTCTGAGAT CAGATTCCGA CGTGGTGGAG 540

GCCCTCAGCG AGGAGCACAT GGAGGCTGAC GGCCACGCTG CGGTGGTGTT CGGCACGGTG 600

GTGGACATCA TCAGCCGTAG TGGGGAGAAG ATTCCAGTGT CTGTGTGGAT GAAGAGGATG 660

CAGCAGGAGC ACCGCCTATG CTGCGTGGTG GTCCTGGAGC CTGTGGAGAG GGTCTCGACC 720

TGGGTCGCTT TCCAGAGCGA TGGCACCATC ACGTCATGCG ACAGTCTCTT TGCTCATCTT 780

CACGGGTACG TGTCTGGGGA GGACGTGGCT GGGCAGCACA TCACAGACCT GATCCCTTCT 840

GTGCAGCTCC CTCCTTCTGG CCAGCACATC CCAAAGAATC TCAAGATTCA GAGGTCTGTT 900

GGAAGAGCCA GGGATGGTAC CACCTTCCCT CTGAGCTTAA AGCTGAAATC CCAACCCAGC 960

AGTGAGGAGG CGACCACCGG TGAGGCGGCC CCTGTGAGGG GCTACCGGGC ATCCGTCTGG 1020

GTGTTCTGCA CCATCAGCGG CCTCATCACC CTCCTGCCGG ATGGGACCAT CCACGGCATC 1080

AACCACAGCT TCGCGCTGAC GCTGTTTGGT TACGGAAAGA CCGAGCTCCT GGGCAAGAAT 1140

ATCACTTTCC TGATTCCTGG TTTCTACAGC TACATGGACC TTGTGTATGA CAGCTCATTA 1200

CAGCTCCCAG ACCTGGCCAG CTGCCTGGAC GTCGGCGATG AGAGTGGGTG TGGGGAGAGA 1260

ACCTTGGACC CTTGGCAGGG CCAGGACCCA GCTGAGGGGG CCCAGGATCC AGGGATTAAT 1320

GTCGTGCTTG CTGGTGGCCA CATTGTGCCC CGAGATGAGA CCCGGAAGCT GGTGGAAAGC 1380

CAAGACATCT TCACCGGGAC TCAGACTGAA CTGGGAGCTG GAGGCCAGCT CCTTTCCCGC 1440

CTCTCACCTC AGCCTGCTCC AGGGGTGGAC AGTGTCCCAG AAGGAAGCCT GCCAGTGCAC 1500

AGTGAACAGG TGCTGCCCGA GGACCAGCAA GTCACTGCCT TGGGGAGAGA GGAACCTGTG 1560

GCAATAGAGA GCCCTGGACA GGATCTTCTG GGAGAAAGCA GGTCTGAACC AGTGGATGTG 1620

AAGCCATTTA CTTCCTGCGA AGATTCTGAA GCTCCAGTCC CAGCTGAGGA TGGGGGCAGT 1680

GACGCTGGCA TGTGTGGCCT GTGTCAGAAG GCCCAGCTAG AGCGGATGGG AGTCAGTGGT 1740

CCCAGCGGTT CAGACCTTTG GGCTGGGGCT GCCGTGGCTG AGCCCCAGGC CAAGGGTCAG 1800

CTGGCGGGGG GCAGCCTCCT GATGCACTGC CCTTGCTATG GGAGTGAATG GGGCTTGTGG 1860

TGGCAAAGGC AGGACTTGGC CCCCAGCCCC TCTGGGATGG CAGCCCTCTC GTTTGGGACA 1920

CCTACTCTAG ATGAGCCATG GCTGGGAATG AAAAACGACC GAGAAGAGCT GCAGACCTGC 1980

TTGATTAAGG AGCAGCTATC CCAGTTGAGC CTTGTGGGAG CCCTGGATGT CCCCCACACC 2040

GAACTCATTC CGACAGAGCG CCCAGCTGTC ACCGCTCCTG TGTCGTCCTG CGATCTGGGA 2100

GGCAGAGACC TGTATGGTGG CTGCACGGGC AGCTCCTCAG CCTGCTATGC CTTGGCCACG 2160

GACCTCCCCG GGGGCCTGAA AGCAGTGGAG GCCCAGGAGG TTGATGTGAA TTCGTTTTCC 2220

TGGAACCTCA AGGAACTCTT TTTCAGTGAC CAGAAAGACC AAACATCATC AGATTGTTCC 2280

TGTGCTACGT CTGAACTCAG AGGGACACCC TCTTCCTTGG CAGTGGGCTC CGATCCAGAT 2340

GTAGGCAGTC TCCAGGAAGA GGGGTCATGT GTCCTGGATG ACAGGGAGCT GTTACTACTG 2400

ACCGGCACCT GTGTTGACCT TGGCCAAGGC CGACGGTTCC GGGATAGCTG TCTGGGACAT 2460

GATCCAACAG AACCGCTTGA GGTTTGTTTG GTGTCCTCTG AGCATTATGC AGCAAGCGAC 2520

AGAGAAAGCC CAGGATGCAT TCCTTCCACG TTGGATGCTG GCCCTGAGGA CACGTGCCCA 2580

TCAGCAGAGG AGCCAAGGCT GAACGTCCAG GTCACCTCCA CACCCGTGAT CGTGATGCCC 2640

GGGGCTGCTG GCCTGCAGCG GGAGATCCAG GAGGGTGCCT ACTCCGGGAG CTGCTACCAT 2700

CGAGACGGCT TACGGCTGAG TATACAGTTT GAGGTGAGGC GGGTGGAGCT CCAGGGCCCC 2760

ACACCTCTGT TCTGCTGCTG GCTGGTGAAA GACCTCCTCC ACAGCCAACG CGACTCAGCC 2820

GCCAGGACCC GCCTGTTCCT TGCCAGCCTG CCCAGCTCCA CCCACTCCAC CGCTGCTGAG 2880

CTCACCGGAC CCAACCTGGT GGAAGTGCTC AGAGCGAGAC CTTGGTTTGA GGAGCCCCCC 2940

AAGGCTGTGG AACTGGAGGG GTTGGCGGCT TGTGAGGGCG AGTACTCCCA AAAGTACAGT 3000

ACCCTGAGCC CGCTGGGCAG TGGGGCCTTC GGCTTCGTGT GGACTGCTGT GGACAAGGAA 3060

AAAAACAAGG AGGTGGTAGT GAAGTTTATT AAGAAGGAGA AGGTCTTGGA GGATTGTTGG 3120

ATTGAGGATC CCAAACTTGG GAAAGTTACT TTAGAGATTG CAATTCTCTC CAGGGTGGAG 3180

CACGCCAATA TCATAAAGGT GTTGGATGTA TTTGAAAACC AAGGGTTCTT CCAGCTCGTG 3240

ATGGAGAAGC ACGGCTCCGG CCTAGACCTT TTTGCTTTCA TCGACCGCCA CCCCAGGTTG 3300

GATGAGCCCC TGGCGAGCTA CATCTTCCGA CAACTAGTGT CAGCAGTGGG ATACCTGCGC 3360

TTGAAGGACA TCATCCACCG TGACATCAAG GATGAGAACA TCGTGATCGC CGAGGACTTC 3420

ACAATCAAGC TGATAGACTT TGGCTCGGCC GCCTACTTGG AAAGGGGAAA ATTATTTTAT 3480

ACTTTCTGTG GAACCATCGA GTACTGTGCA CCGGAAGTTC TCCTGGGGAA TCCCTACAGA 3540

GGGCCGGAGC TGGAGATGTG GTCTCTGGGA GTCACTCTGT ACACACTGGT CTTTGAGGAG 3600

AACCCCTTCT GTGAGCTGGA GGAGACTGTG GAGGCTGCCA TCCACCCGCC ATACCTGGTG 3660

TCCAAAGAAC TCATGAGCCT TGTGTCCGGG CTGCTGCAGC CAGTCCCTGA GAAGCGCACC 3720

ACCTTGGAGA AGCTGGTGAC GGACCCGTGG GTAACACAGC CTGTGAATCT TGCTGACTAC 3780

ACATGGGAAG AGGTGTGTCG AGTAAACAAG CCAGAAAGCG GAGTTCTGTC CACTGCGAGC 3840

CTGGAGATGG GGAACAGGAG CCTGAGTGAA GTGGCCCAGG CTCAGGAGCT TTGTGGGGGC 3900

CCCGTTCCAG GCGAGGCTCC TAATGGCCAA GGCTGTTTGC ATCCTGGGGA TCCCCGTCTG 3960

CTGACCAGCT AA 3972

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkk  54

         y++l+ lG+g+fg V +a++ke++++v+vK+ikk+k+      ++ +l k++ Ei+il++

Q: 999   YSTLSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVledcwiEDPKLGKVTLEIAILSR  1058

         88999*******************************99999998899*************

S: 55    lkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkqlvsavkY  113

         ++h niik+l+v+e++ +++lv+e + sg +Lf  i ++ rl+e  a+ +f+qlvsav Y

Q: 1059  VEHANIIKVLDVFENQGFFQLVMEkHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGY  1118

         ************************888899******************************

S: 114   lhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkk  173

         l+ k+i+HrD+K eN+++ ++ +ik++DFG a+++++gkl+ tfcG+++Y+aPe+l g++

Q: 1119  LRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLLGNP  1178

         ************************************************************

S: 174   YegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklL  233

         Y+gp++++WslGv+Ly+lv+++ Pf e       e++ +  ++ p+ +skel+sL++ lL

Q: 1179  YRGPELEMWSLGVTLYTLVFEENPFCEL------EETVEAAIHPPYLVSKELMSLVSGLL  1232

         *************************998......788899999*****************

S: 234   vvdpekRatieeilkhewl  252

         +  pekR+t+e++++++w+

Q: 1233  QPVPEKRTTLEKLVTDPWV  1251

         ******************7

Domain Sequence
(FASTA)

YSTLSPLGSG AFGFVWTAVD KEKNKEVVVK FIKKEKVLED CWIEDPKLGK VTLEIAILSR 60

VEHANIIKVL DVFENQGFFQ LVMEKHGSGL DLFAFIDRHP RLDEPLASYI FRQLVSAVGY 120

LRLKDIIHRD IKDENIVIAE DFTIKLIDFG SAAYLERGKL FYTFCGTIEY CAPEVLLGNP 180

YRGPELEMWS LGVTLYTLVF EENPFCELEE TVEAAIHPPY LVSKELMSLV SGLLQPVPEK 240

RTTLEKLVTD PWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0045719	; P:negative regulation of glycogen biosynthetic process
GO:0046777	; P:protein autophosphorylation
GO:2000505	; P:regulation of energy homeostasis
GO:0070092	; P:regulation of glucagon secretion
GO:0043576	; P:regulation of respiratory gaseous exchange

KEGG

pon:100454642

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091	; PAS; 3.
SM00220	; S_TKc; 1.

Prosites

PS50112	; PAS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013