EKS-POA-00399

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00399

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	363.4	8.3E-109	210	487	278

Status

Unreviewed

Ensembl Protein

ENSPPYP00000015274

UniProt Accession

H2PA31;

Protein Name

Protein Synonyms/Alias

Interleukin-1 receptor-associated kinase-like 2;

Gene Name

IRAK2

Gene Synonyms/Alias

IRAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000013662	ENSPPYP00000015274	ENSPPYT00000015883

Organism

Pongo abelii

Functional Description

Protein Length

625

Protein Sequence
(FASTA)

MACYIYQLPS WVLDDLCRNM DALSEWDWME FASYVITDLT QLRKIKSMER VQGVSITREL 60

LWWWGMRQAT VQQLVDLLCR LELYRAAQII LNWKPAPEIR CPIPAFPDSV KPEKPLAASV 120

KKAENEQEEG QPVRMATSPG PGSSPARAHQ PAFLQPPEED APHSLRTDLP TSSDSKDFST 180

SIPKQEKLLS LAGDSLFWSE ADVVQATDDF NQNHKISQGT FADVYRGYRH GTPFVFKKLR 240

ETACSSPGSI ERFFQAELQI CLRCCHPNVL PVLGFCAARQ FHSFIYPYMA NGSLQDRLQG 300

QGGSDPLPWP QRVSICSGLL CAVEYLHGLE IIHSNVKSSN VLLDQNLTPK LAHPMAHLCP 360

VNKRSKYTMM KTHLFRTSAA YLPEDFIRVG QLTKRVDIFS CGIVLAEVLT GIPAMDNNRS 420

PVYLKDLLLS EIPSSTASPC SRKTGVENVM AKEICQKYLE KGAGRLPEDC AEALATAACL 480

CLRKRNTSLQ EVRGSVAAVE EWLRGREMLL PWSGLSEGTG SSSNTPEETD DVDNSSLDAS 540

SSVSVAPWAG AATPLLPTEN GEGRLRVIVG READSSSEAC VGPEPPQDVT ETSWQIDINE 600

AKRKLMENIL LYKEEKLDSI ELFGP 625

Nucleotide Sequence
(FASTA)

ATGGCCTGCT ACATCTACCA GCTGCCCTCT TGGGTGCTGG ACGACCTGTG CCGCAACATG 60

GACGCGCTCA GCGAGTGGGA CTGGATGGAG TTCGCCTCCT ACGTGATCAC AGACCTGACC 120

CAGCTGCGGA AGATCAAGTC CATGGAGCGG GTGCAGGGCG TGAGCATCAC ACGGGAGCTG 180

CTGTGGTGGT GGGGCATGCG GCAGGCCACT GTCCAGCAAC TTGTGGACCT CCTGTGCCGC 240

CTGGAGCTCT ACCGGGCTGC CCAGATCATC CTGAACTGGA AACCGGCTCC TGAAATCAGG 300

TGTCCCATTC CAGCCTTCCC TGACTCTGTG AAGCCAGAAA AACCTTTGGC AGCTTCTGTA 360

AAAAAGGCTG AGAATGAACA GGAAGAGGGG CAGCCTGTGA GGATGGCCAC CTCTCCAGGC 420

CCAGGGTCCT CTCCAGCCAG AGCCCACCAG CCGGCCTTTC TCCAGCCTCC TGAAGAAGAT 480

GCCCCTCATT CCTTGAGAAC CGACCTCCCC ACTTCGTCTG ATTCAAAGGA CTTCAGCACC 540

TCCATTCCTA AGCAGGAAAA ACTTTTGAGC TTGGCTGGAG ACAGCCTTTT CTGGAGTGAG 600

GCAGACGTGG TCCAGGCAAC CGATGACTTC AATCAAAACC ACAAAATCAG CCAGGGGACC 660

TTTGCTGACG TCTACAGAGG GTACAGGCAC GGGACGCCAT TCGTCTTCAA GAAGCTCAGA 720

GAGACAGCCT GTTCAAGTCC AGGATCAATC GAAAGATTCT TCCAGGCAGA GCTGCAGATT 780

TGTCTTAGAT GCTGCCACCC CAATGTCTTA CCTGTGCTGG GCTTCTGTGC TGCAAGACAG 840

TTTCACAGCT TCATCTACCC CTACATGGCA AATGGTTCCC TACAGGACAG ACTGCAGGGT 900

CAGGGTGGCT CCGACCCCCT CCCCTGGCCC CAGCGTGTCA GCATCTGCTC AGGGCTGCTC 960

TGTGCCGTCG AGTACCTGCA TGGTCTGGAG ATCATCCACA GCAATGTCAA GAGCTCTAAT 1020

GTCTTGCTGG ACCAAAATCT CACCCCCAAA CTTGCTCACC CAATGGCTCA CCTGTGTCCT 1080

GTCAACAAAA GGTCAAAATA CACCATGATG AAGACTCACT TATTCCGGAC GTCAGCCGCG 1140

TATCTGCCAG AGGATTTCAT CCGGGTGGGG CAGCTGACAA AGCGCGTGGA CATCTTCAGC 1200

TGTGGAATAG TGTTGGCCGA GGTCCTCACA GGCATCCCTG CAATGGATAA TAACCGAAGC 1260

CCGGTTTACC TGAAGGACTT ACTCCTCAGT GAAATTCCAA GCAGCACCGC CTCGCCCTGC 1320

TCCAGGAAGA CGGGCGTGGA GAACGTGATG GCAAAGGAGA TCTGCCAGAA GTACCTGGAG 1380

AAGGGCGCAG GGAGGCTTCC GGAGGACTGC GCCGAGGCCC TGGCCACGGC TGCCTGCCTG 1440

TGCCTGCGGA AGCGTAACAC CAGCCTGCAG GAGGTGCGTG GCTCTGTGGC TGCTGTGGAA 1500

GAGTGGCTCC GAGGTCGGGA GATGTTGCTC CCTTGGAGTG GGCTTTCTGA GGGTACAGGC 1560

TCTTCTTCCA ACACCCCAGA GGAAACAGAC GACGTTGACA ATTCCAGCCT TGATGCCTCC 1620

TCCTCCGTGA GTGTGGCACC CTGGGCGGGG GCTGCCACCC CACTTCTCCC CACAGAGAAT 1680

GGGGAAGGAA GACTGCGGGT CATCGTGGGA AGGGAGGCCG ACTCCTCCTC TGAGGCCTGT 1740

GTTGGCCCGG AGCCTCCCCA GGATGTTACA GAGACTTCAT GGCAAATTGA CATCAATGAG 1800

GCCAAAAGGA AACTGATGGA GAATATTCTG CTCTACAAAG AGGAGAAACT GGACAGCATT 1860

GAGCTCTTTG GCCCCTGA 1878

Domain Profile

S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60

         f+++++i++G+f++vyrg +++t +++kkl+e+a++s+ +++++f++El++++r++H+n+

Q: 210   FNQNHKISQGTFADVYRGYRHGTPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNV  269

         899*********************************************************

S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120

         l++lg++a++++++++Y+ym+nGsL+drLq q+gs+pL+WpqR+si++G+++a+e+LH

Q: 270   LPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGL  329

         ************************************************************

S: 121   spslihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeef  180

           ++ih+++ks+N+LLD++ltpKl+ +++a+++p ++++++t+++t+ +r+++aYlpe+f

Q: 330   --EIIHSNVKSSNVLLDQNLTPKLA-HPMAHLCPVNKRSKYTMMKTHLFRTSAAYLPEDF  386

         ..***********************.**********************************

S: 181   irvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekv.........  231

         irvgqlt++vD++S+GiVl+EvltG++a+d++r+++yLkdll +ei+++++

Q: 387   IRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSEIPSSTAspcsrktgv  446

         ************************************************************

S: 232   ......eilekfldkkagkleeellealielalaclaekak  266

               ei++k+l+k ag+l+e+++eal+++a+ cl +++

Q: 447   envmakEICQKYLEKGAGRLPEDCAEALATAACLCLRKRNT  487

         ************************************96653

Domain Sequence
(FASTA)

FNQNHKISQG TFADVYRGYR HGTPFVFKKL RETACSSPGS IERFFQAELQ ICLRCCHPNV 60

LPVLGFCAAR QFHSFIYPYM ANGSLQDRLQ GQGGSDPLPW PQRVSICSGL LCAVEYLHGL 120

EIIHSNVKSS NVLLDQNLTP KLAHPMAHLC PVNKRSKYTM MKTHLFRTSA AYLPEDFIRV 180

GQLTKRVDIF SCGIVLAEVL TGIPAMDNNR SPVYLKDLLL SEIPSSTASP CSRKTGVENV 240

MAKEICQKYL EKGAGRLPED CAEALATAAC LCLRKRNT 278

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0070498	; P:interleukin-1-mediated signaling pathway
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0032088	; P:negative regulation of NF-kappaB transcription factor activity
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0001959	; P:regulation of cytokine-mediated signaling pathway

KEGG

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013