EKS-POA-00169
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00169
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC434.61.5E-130349603255
StatusUnreviewed
Ensembl ProteinENSPPYP00000015429
UniProt AccessionH2PAH7;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCD
Gene Synonyms/Alias PRKCD;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000013789ENSPPYP00000015429ENSPPYT00000016042
OrganismPongo abelii
Functional Description
Protein Length676
Protein Sequence
(FASTA)
MAPFLRIAFN SYELGSLQAE DEVNQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD 60
AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120
FLEDVDCKQS MRSEDEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKDFVW 180
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVHNYMS 240
PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVTQRASR 300
RSDSASSEPV GIYQGFEKKT GVAGEDTQDN SGTYGKIWEG SSKCNINNFI FHKVLGKGSF 360
GKVLLGELKG RGEYFAIKAL KKDVVLIDDD VECTMVEKRV LTLAAENPFL THLICTFQTK 420
DHLFFVMEFL NGGDLMYHIQ DKGRFELYRA TFYAAEIMCG LQFLHSKGII YRDLKLDNVL 480
LDRDGHIKIA DFGMCKENIF GENRASTFCG TPDYIAPEIL QGLKYTFSVD WWSFGVLLYE 540
MLIGQSPFHG DDEDELFESI RVDTPHYPRW ITKESKDILE KLFEREPTKR LGVTGNIKIH 600
PFFKTINWTL LEKRRLEPPF RPKVKSPRDY SNFDQEFLNE KARLSYSDKN LIDSMDQSAF 660
AGFSFVNPKF EHLLED 676
Nucleotide Sequence
(FASTA)
ATGGCACCAT TCCTGCGCAT CGCCTTCAAC TCCTACGAGC TGGGCTCCCT GCAGGCTGAG 60
GACGAGGTGA ACCAGCCCTT CTGTGCCGTG AAGATGAAGG AGGCACTCAG CACAGAGCGT 120
GGGAAAACAC TGGTGCAGAA GAAGCCGACC ATGTATCCTG AGTGGAAGTC GACATTTGAT 180
GCCCACATCT ACGAGGGGCG CGTCATCCAG ATCGTGCTAA TGCGGGCAGC AGAGGAGCCA 240
GTGTCTGAGG TGACCGTGGG TGTGTCGGTG CTGGCTGAGC GCTGCAAGAA GAACAACGGC 300
AAGGCTGAGT TCTGGCTGGA CCTGCAGCCT CAGGCCAAGG TGTTGATGTC TGTTCAGTAT 360
TTCCTGGAGG ACGTGGATTG CAAACAGTCT ATGCGCAGTG AGGACGAGGC CAAGTTCCCA 420
ACGATGAACC GCCGCGGAGC CATCAAACAG GCCAAAATCC ACTACATCAA GAACCATGAG 480
TTTATTGCCA CCTTCTTTGG GCAACCCACC TTCTGTTCTG TGTGCAAAGA CTTTGTCTGG 540
GGCCTCAACA AGCAAGGCTA CAAATGCAGG CAATGTAACG CTGCCATCCA CAAGAAATGC 600
ATCGACAAGA TCATCGGCAG ATGCACTGGC ACCGCGGCCA ACAGCCGGGA CACTATATTC 660
CAGAAAGAAC GCTTCAACAT CGACATGCCG CACCGCTTCA AGGTTCACAA CTACATGAGC 720
CCCACCTTCT GTGACCACTG CGGCAGCCTG CTCTGGGGAC TGGTGAAGCA GGGATTAAAG 780
TGTGAAGACT GTGGCATGAA TGTGCACCAT AAATGCCGGG AGAAGGTGGC CAACCTCTGC 840
GGCATCAACC AGAAGCTCCT GGCTGAGGCC TTGAACCAAG TCACCCAGAG AGCCTCCCGG 900
AGATCAGACT CGGCCTCCTC AGAGCCTGTT GGGATATATC AGGGTTTCGA GAAGAAGACC 960
GGAGTTGCCG GGGAGGACAC GCAAGACAAC AGTGGGACCT ACGGCAAGAT CTGGGAGGGC 1020
AGCAGCAAGT GCAACATCAA CAACTTCATC TTCCACAAGG TCCTGGGCAA AGGCAGCTTC 1080
GGGAAGGTGC TGCTTGGAGA GCTGAAGGGC AGAGGAGAGT ACTTTGCCAT CAAGGCCCTC 1140
AAGAAGGATG TGGTCCTGAT CGACGACGAT GTGGAATGCA CCATGGTTGA GAAGCGGGTG 1200
CTGACACTCG CCGCGGAGAA TCCCTTTCTC ACCCACCTCA TCTGCACCTT CCAGACCAAG 1260
GACCACCTGT TCTTTGTGAT GGAGTTCCTC AACGGGGGGG ACCTGATGTA CCACATCCAG 1320
GACAAAGGCC GCTTTGAACT CTACCGTGCC ACGTTTTATG CCGCTGAGAT AATGTGTGGA 1380
CTGCAGTTTC TACACAGCAA GGGCATCATT TACAGGGACC TCAAACTGGA CAACGTGCTG 1440
CTGGACCGGG ATGGCCACAT CAAGATTGCC GACTTTGGGA TGTGCAAAGA GAACATATTC 1500
GGGGAGAACC GGGCCAGCAC CTTCTGCGGC ACCCCTGACT ATATCGCCCC TGAGATCCTA 1560
CAGGGCCTGA AGTACACATT CTCTGTGGAC TGGTGGTCTT TCGGGGTCCT TCTATACGAG 1620
ATGCTCATTG GCCAGTCCCC CTTCCATGGT GATGATGAGG ATGAACTCTT CGAGTCCATC 1680
CGTGTGGACA CGCCACATTA TCCCCGCTGG ATCACCAAGG AGTCCAAGGA CATCCTGGAG 1740
AAGCTCTTTG AAAGGGAACC AACCAAGAGG CTGGGAGTGA CTGGAAACAT CAAAATCCAC 1800
CCCTTCTTCA AGACCATAAA CTGGACTCTG CTGGAAAAGC GGAGGTTGGA GCCACCCTTC 1860
AGGCCCAAAG TGAAGTCCCC CAGAGACTAC AGCAACTTCG ACCAGGAGTT CCTGAACGAG 1920
AAGGCGCGCC TCTCCTACAG CGACAAGAAC CTCATCGACT CCATGGACCA GTCTGCATTC 1980
GCCGGCTTCT CCTTTGTGAA CCCCAAATTC GAGCACCTCC TGGAAGATTG A 2031
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f ++kvlGkGsfgkvll elk++ e++aik lkkdvvl dddve+t+vekrvl+la+++p
Q: 349   FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENP  408
         889*********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl++l+++fqt+d+lffv+e++nGGdlm+hiq++++++  ra+fyaaei+++l+flh+kg
Q: 409   FLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKG  468
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvlld++Ghik+adfG+cke+i+ ++++stfcGtPdyiaPeil++ +y++s
Q: 469   IIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGENRASTFCGTPDYIAPEILQGLKYTFS  528
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP++++ke+++il++l++++p+
Q: 529   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPT  588
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlGv  +g  +ik h+ff
Q: 589   KRLGV--TG--NIKIHPFF  603
         *****..56..79999998
Domain Sequence
(FASTA)
FIFHKVLGKG SFGKVLLGEL KGRGEYFAIK ALKKDVVLID DDVECTMVEK RVLTLAAENP 60
FLTHLICTFQ TKDHLFFVME FLNGGDLMYH IQDKGRFELY RATFYAAEIM CGLQFLHSKG 120
IIYRDLKLDN VLLDRDGHIK IADFGMCKEN IFGENRASTF CGTPDYIAPE ILQGLKYTFS 180
VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRVDTPHYP RWITKESKDI LEKLFEREPT 240
KRLGVTGNIK IHPFF 255
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00166
EKS-ANC-00168
EKS-BOT-00176
EKS-CAE-00133
EKS-CAJ-00179
EKS-CAF-00183
EKS-CAP-00173
EKS-CIS-00207
EKS-DAR-00469
EKS-DRM-00086
EKS-EQC-00174
EKS-FEC-00164
EKS-GAM-00094
EKS-GAG-00150
EKS-GAA-00213
EKS-GOG-00175
EKS-HOS-00182
EKS-ICT-00169
EKS-LAC-00183
EKS-LOA-00173
EKS-MAM-00172
EKS-MEG-00108
EKS-MOD-00172
EKS-MUM-00180
EKS-MYL-00181
EKS-NOL-00169
EKS-OCP-00109
EKS-ORN-00221
EKS-ORC-00160
EKS-ORL-00208
EKS-OTG-00181
EKS-PAT-00166
EKS-PES-00154
EKS-RAN-00172
EKS-SAH-00166
EKS-SUS-00150
EKS-TAG-00204
EKS-TAR-00227
EKS-TEN-00221
EKS-XET-00163
EKS-XIM-00214
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005829; C:cytosol
GO:0005783; C:endoplasmic reticulum
GO:0016363; C:nuclear matrix
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0008047; F:enzyme activator activity
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0006915; P:apoptotic process
GO:0042100; P:B cell proliferation
GO:0090398; P:cellular senescence
GO:0016064; P:immunoglobulin mediated immune response
GO:0032613; P:interleukin-10 production
GO:0032615; P:interleukin-12 production
GO:0035556; P:intracellular signal transduction
GO:0030837; P:negative regulation of actin filament polymerization
GO:0051490; P:negative regulation of filopodium assembly
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0043407; P:negative regulation of MAP kinase activity
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0090331; P:negative regulation of platelet aggregation
GO:0042119; P:neutrophil activation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:2000304; P:positive regulation of ceramide biosynthetic process
GO:2000753; P:positive regulation of glucosylceramide catabolic process
GO:1900163; P:positive regulation of phospholipid scramblase activity
GO:0035307; P:positive regulation of protein dephosphorylation
GO:2001022; P:positive regulation of response to DNA damage stimulus
GO:2000755; P:positive regulation of sphingomyelin catabolic process
GO:0032930; P:positive regulation of superoxide anion generation
GO:0023021; P:termination of signal transduction
KEGG
pon:100452668;
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013