EKS-POA-00226

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00226

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	428.0	1.3E-128	44	304	261

Status

Unreviewed

Ensembl Protein

ENSPPYP00000015481

UniProt Accession

H2PAM8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK3

Gene Synonyms/Alias

MAPKAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000013835	ENSPPYP00000015481	ENSPPYT00000016096

Organism

Pongo abelii

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MDGETAEEQG GPVPPPVAPG GPGLGGAPGG RREPKKYAVT DDYQLSKQVL GLGVNGKVLE 60

CFHRRTGQKC ALKLLYDSPK ARQEVDHHWQ ASGGPHIVRI LDVYENMHHG KRCLLIIMEC 120

MEGGELFSRI QERGDQAFTE REAAEIMRDI GTAIQFLHSH NIAHRDVKPE NLLYTSKEKD 180

AVLKLTDFGF AKETTQNALQ TPCYTPYYVA PEVLGPEKYD KSCDMWSLGV IMYILLCGFP 240

PFYSNTGQAI SPGMKRRIRL GQYGFPNPEW SEVSEDAKQL IRLLLKTDPT ERLTITQFMN 300

HPWINQSMVV PQTPLHTARV LQEDKDHWDE VKEEMTSALA TMRVDYDQVK IKDLKTSNNR 360

LLNKRRKKQA GSSSASQGCN NQ 382

Nucleotide Sequence
(FASTA)

ATGGATGGTG AAACAGCAGA GGAGCAGGGA GGCCCTGTGC CTCCGCCAGT TGCACCCGGC 60

GGACCCGGCT TGGGCGGTGC TCCGGGGGGG CGGCGGGAGC CCAAGAAGTA CGCAGTGACC 120

GACGACTACC AGTTGTCCAA GCAGGTGCTG GGCCTGGGTG TGAACGGCAA AGTGCTGGAG 180

TGCTTCCATC GGCGCACTGG GCAGAAGTGT GCCCTGAAGC TCCTGTATGA CAGCCCCAAG 240

GCCCGGCAGG AGGTAGACCA TCACTGGCAG GCTTCTGGCG GCCCCCATAT TGTCCGCATC 300

CTGGATGTGT ATGAGAACAT GCACCATGGC AAGCGCTGTC TCCTCATCAT CATGGAATGC 360

ATGGAAGGTG GTGAGTTGTT CAGCAGGATT CAGGAGCGTG GCGACCAGGC TTTCACTGAG 420

AGAGAAGCTG CAGAGATAAT GAGGGATATC GGCACTGCCA TCCAGTTTCT GCACAGCCAT 480

AACATCGCCC ACCGAGATGT CAAGCCTGAA AACCTGCTCT ACACATCTAA GGAGAAAGAC 540

GCAGTGCTTA AGCTCACCGA TTTTGGCTTT GCTAAGGAGA CCACCCAAAA TGCCCTGCAG 600

ACACCCTGCT ATACTCCCTA TTATGTGGCC CCTGAGGTCC TGGGTCCAGA GAAGTATGAC 660

AAGTCATGCG ACATGTGGTC CCTGGGTGTC ATCATGTACA TCCTCCTTTG TGGCTTCCCA 720

CCCTTCTACT CCAACACCGG CCAGGCCATC TCCCCAGGGA TGAAGAGGAG GATCCGCCTG 780

GGCCAGTACG GCTTCCCCAA TCCTGAGTGG TCAGAAGTCT CTGAGGATGC CAAGCAGCTG 840

ATCCGCCTCC TGTTGAAGAC AGACCCCACA GAGAGGCTGA CCATCACTCA GTTCATGAAC 900

CATCCCTGGA TCAATCAATC GATGGTGGTG CCACAGACCC CACTCCACAC GGCCCGAGTG 960

CTGCAGGAGG ACAAAGACCA CTGGGATGAA GTCAAGGAGG AGATGACCAG TGCCTTGGCC 1020

ACTATGCGGG TAGACTACGA CCAGGTGAAG ATCAAGGACC TGAAGACCTC TAACAACCGG 1080

CTCCTCAACA AGAGGAGAAA AAAGCAGGCA GGCAGCTCCT CTGCCTCACA GGGCTGCAAC 1140

AACCAATAG 1149

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         +l+++vlG G++gkvlec++++tg+k+alk+l+d++k+r+ev++h+qasg ++iv+++dv

Q: 44    QLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRILDV  103

         5789********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en+++++++ll+++e++eGGel+sriqer  +afte+ea+e+++di++a++flhs+nia

Q: 104   YENMHHGKRCLLIIMECMEGGELFSRIQERgdQAFTEREAAEIMRDIGTAIQFLHSHNIA  163

         *******************************9****************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy+skek+a++kl+Dfg+ake +++++l+tpc+t++yvaPevl++ek

Q: 164   HRDVKPENLLYTSKEKDAVLKLTDFGFAKE-TTQNALQTPCYTPYYVAPEVLGPEK----  218

         *****************************7.7899*********************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCD+WslGvi+yillcG+pPfys++g+ais+++k+ri+ g+y fP++eWsevse+a

Q: 219   -YDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDA  277

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         k+lir lLk+dp+erlti++++nhpw+

Q: 278   KQLIRLLLKTDPTERLTITQFMNHPWI  304

         **************************8

Domain Sequence
(FASTA)

QLSKQVLGLG VNGKVLECFH RRTGQKCALK LLYDSPKARQ EVDHHWQASG GPHIVRILDV 60

YENMHHGKRC LLIIMECMEG GELFSRIQER GDQAFTEREA AEIMRDIGTA IQFLHSHNIA 120

HRDVKPENLL YTSKEKDAVL KLTDFGFAKE TTQNALQTPC YTPYYVAPEV LGPEKYDKSC 180

DMWSLGVIMY ILLCGFPPFY SNTGQAISPG MKRRIRLGQY GFPNPEWSEV SEDAKQLIRL 240

LLKTDPTERL TITQFMNHPW I 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0044351	; P:macropinocytosis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032496	; P:response to lipopolysaccharide
GO:0006950	; P:response to stress
GO:0002224	; P:toll-like receptor signaling pathway

KEGG

pon:100449366

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013