EKS-POA-00275

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00275

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	396.0	1.0E-118	269	562	294

Status

Unreviewed

Ensembl Protein

ENSPPYP00000015718

UniProt Accession

H2PBA1;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014049	ENSPPYP00000015718	ENSPPYT00000016339

Organism

Pongo abelii

Functional Description

Protein Length

592

Protein Sequence
(FASTA)

MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SDVEMEAQKD EIICPSCNRT AHPLRHINND 60

MMVTDNNGAV KFPQLCKFCD VRFSTCDNQK SCMSNCSITS ICEKPQEVCV AVWRKNDENI 120

TLETVCHDPK LPYHDFILED AASPKCIMKE KKKPGETFFM CSCSSDECND NIIFSEEYNT 180

SNPDLLLVIF QVTGISLLPP LGVAISVIII FYCYRVNRQQ KLSSSWETGK TRKLMEFSEH 240

CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA 300

VKIFPYEEYA SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE 360

YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL 420

CDFGLSLRLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW 480

EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDNVLRDR GRPEIPSFWL NHQGIQMVCE 540

TLTECWDHDP EARLTAQCVA ERFSELEHLD RLSGRSCSEE KIPEDGSLNT TK 592

Nucleotide Sequence
(FASTA)

ATGGGTCGGG GGCTGCTCAG GGGCCTGTGG CCGCTGCACA TCGTCCTGTG GACGCGTATC 60

GCCAGCACGA TCCCACCGCA CGTTCAGAAG TCGGATGTGG AAATGGAGGC CCAGAAAGAT 120

GAAATCATCT GCCCCAGCTG TAATAGGACT GCCCATCCAC TGAGACATAT TAATAATGAC 180

ATGATGGTCA CTGACAACAA TGGTGCAGTC AAGTTTCCAC AACTGTGTAA ATTTTGTGAT 240

GTGAGATTTT CCACCTGTGA CAACCAGAAA TCCTGCATGA GCAACTGCAG CATCACCTCC 300

ATCTGTGAGA AGCCACAGGA AGTCTGTGTG GCTGTATGGA GAAAGAATGA TGAGAACATA 360

ACACTAGAGA CAGTTTGCCA TGACCCCAAG CTGCCCTACC ATGACTTTAT TCTGGAAGAT 420

GCTGCTTCTC CAAAGTGCAT TATGAAGGAA AAAAAAAAGC CTGGTGAGAC TTTCTTCATG 480

TGTTCCTGTA GCTCTGATGA GTGCAATGAC AACATCATCT TCTCAGAAGA ATATAACACC 540

AGCAATCCTG ACTTGTTGCT AGTCATATTT CAAGTGACAG GCATCAGCCT CCTGCCACCA 600

CTGGGAGTTG CCATATCTGT CATCATCATC TTCTACTGCT ACCGCGTTAA CCGGCAGCAG 660

AAGCTGAGTT CATCCTGGGA AACCGGCAAG ACGCGGAAGC TCATGGAGTT CAGTGAGCAC 720

TGTGCCATCA TCCTGGAAGA CGACCGCTCT GACATCAGCT CCACGTGCGC CAACAACATC 780

AACCACAACA CAGAGCTGCT GCCCATTGAG CTGGACACGC TGGTGGGGAA AGGTCGCTTT 840

GCTGAGGTCT ATAAGGCCAA GCTGAAGCAG AACACTTCAG AGCAGTTTGA GACAGTGGCA 900

GTCAAGATCT TTCCCTATGA GGAGTATGCC TCTTGGAAGA CAGAGAAGGA CATCTTCTCA 960

GACATCAACC TGAAGCATGA GAACATACTC CAGTTCCTGA CGGCTGAGGA GCGGAAGACG 1020

GAGTTGGGGA AACAGTACTG GCTGATCACC GCTTTCCACG CCAAGGGCAA CCTACAGGAG 1080

TACCTGACAC GGCATGTCAT CAGCTGGGAG GACCTGCGCA AGCTGGGCAG CTCCCTCGCC 1140

CGGGGGATTG CTCACCTCCA CAGTGATCAC ACTCCATGTG GGAGGCCCAA GATGCCCATC 1200

GTGCACAGGG ACCTCAAGAG CTCCAATATC CTCGTGAAGA ACGACCTAAC CTGCTGCCTG 1260

TGTGACTTTG GGCTTTCCCT GCGTCTGGAC CCTACTCTGT CTGTGGATGA CCTGGCTAAC 1320

AGTGGGCAGG TGGGAACTGC AAGATACATG GCTCCAGAAG TCCTAGAATC CAGGATGAAT 1380

TTGGAGAATG TTGAGTCCTT CAAGCAGACC GATGTCTACT CCATGGCTCT GGTGCTCTGG 1440

GAAATGACAT CTCGTTGTAA TGCAGTGGGA GAAGTAAAAG ATTATGAGCC TCCATTTGGT 1500

TCCAAGGTGC GGGAGCACCC CTGTGTGGAA AGCATGAAGG ACAACGTGTT GAGAGATCGA 1560

GGGCGACCAG AAATTCCCAG CTTCTGGCTC AACCACCAGG GCATCCAGAT GGTGTGTGAG 1620

ACGTTGACTG AGTGCTGGGA CCACGACCCA GAGGCCCGTC TCACAGCCCA GTGTGTGGCA 1680

GAACGCTTCA GTGAGCTGGA GCATCTGGAC AGGCTCTCGG GGAGGAGCTG CTCGGAGGAG 1740

AAGATTCCTG AAGACGGCTC CCTAAACACT ACCAAGTAG 1779

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 269   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  328

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 329   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  388

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 389   D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  447

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 448   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  506

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip+ w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 507   PCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  562

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120

DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSF WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0007420	; P:brain development
GO:0060434	; P:bronchus morphogenesis
GO:0051216	; P:cartilage development
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0035162	; P:embryonic hemopoiesis
GO:0007369	; P:gastrulation
GO:0007507	; P:heart development
GO:0001701	; P:in utero embryonic development
GO:0002088	; P:lens development in camera-type eye
GO:0060463	; P:lung lobe morphogenesis
GO:0060443	; P:mammary gland morphogenesis
GO:0043011	; P:myeloid dendritic cell differentiation
GO:0060021	; P:palate development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0060440	; P:trachea formation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001570	; P:vasculogenesis

KEGG

pon:100459236

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013