EKS-POA-00087

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00087

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	457.0	4.2E-137	2285	2611	327

Status

Unreviewed

Ensembl Protein

ENSPPYP00000015853

UniProt Accession

H2PBM9;

Protein Name

Protein Synonyms/Alias

Gene Name

ATR

Gene Synonyms/Alias

ATR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014173	ENSPPYP00000015853	ENSPPYT00000016480

Organism

Pongo abelii

Functional Description

Protein Length

2636

Protein Sequence
(FASTA)

MGEHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV VAVELVKKTD 60

SQPTSVMLLD FIQHIMKSSP LMFVNVNGSH EAKGSCIEFS NWIITRLLRI AATPSCHLLH 120

KKICEVICSL LFLFKSKSPA IFGVLTKELL QLFEDLVYLH RRNVMGHAVE WPVVMSRFLS 180

QLDEHMGYLQ SAPLQLMSMQ NLEFIEVTLL TVLTRIIAIV FFRRQELLLW QIGCVLLEYG 240

SPKIKSLAIS FLTELFQLGG LPAQPASTFF SSFLELLKHL VEMDTDQLKL YEEPLSKLIK 300

TLFPFEAEAY RNIEPVYLNM LLEKLCVMFE DGVLMRLKSD LLKAALCHLL QYFLKFVPAG 360

YESALQVRKV YVRNICKALL DVLGIQVDAE YLLGPLYAAL KMESMEIIEE IQCQTQQENL 420

SSNSDGISPK RRRLSSSLNP SKRAPKQTEE IKHVDMNQKS ILWSALKQKA ESLQISLEYS 480

GLKNPVIEML EGIAVVLQLT ALCAVHCSHP NMNCHTFKDC QHKSKKKPSV VITWMSLDFY 540

TKVLKSCRSL LESVQKPDLE ATIDKVVKIY DALIYMQVNS SFEDHILEDL CGMLSLPWIY 600

SHSDDGCLKL TTFATNLLTL SRRISDSYSP QAQSRCVFLL TLFPRRIFLE WRTAVYNWAL 660

QSSHEVIRAS CVSGFFILLQ QQNSCNRVPK ILIDKVKDDS DIVKKEFASI LGQLVCTLHG 720

MFYLTSSLTE PFSEHGHVDL FCRNLKATSQ HECSSSQLKA SVCKPFLFLL KKKTPSPVKL 780

AFIDNLHHLC KHLDFREDET DVKAVLGTLL NLMEDPDKDV RVAFSGNIKH ILESLDSEDG 840

FIKELFVLRM KEAYTHAQIS RNNELKDTLI LTTGDIGRAA KGDLVPFALL HLLHCLLSKS 900

ASVSGAAYTE IRALVAAKSV KLQNFFSQYK KPICQFLVES LHSSQMTALP STPCRNADMR 960

KQDVAHQREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP DLAAKASPAA SALIRTLGKQ 1020

LNVNRREILI NNFKYIFSHL VCSCSKDELE RALHYLKNET EIELGSLLRQ DFQGLHNELL 1080

LRIGEHYQQV FNGLSILASF ASSDDPYQGP RDADYLQPKL LGILAFFNMQ LLSSSVGIED 1140

KKMALNSLMS LMKLMGPKHV SSVRVKMMTT LRTGLRFKDD FPELCCRAWD CFVRCLDHAC 1200

LGSLLSHVIV ALLPLIHIQP KETAAIFHYL IIENRDAVQD FLHEIYFLPD HPELKKIKAV 1260

LQEYRKETSE STDLQTTLQL SMKAIQHENV DVRIHALTSL KETLYKNQEK LIKYATDSET 1320

VEPIISQLVT VLLKGCQDAN SQARLLCGEC LGELGAIDPG RLDFSTTETQ GKDFTFVTGV 1380

EDSSFAYGLL MELTRAYLAY ADNSRAQDSA AYAIQELLSI YDCREMETNS PGHQLWRRFP 1440

EHVREILEPH LNTRYKSSQK STDWSGVKKP IYLSKLGSNF AEWSASWAGY LITKVRHDLA 1500

SKIFTCCSIM MKHDFKVTIY LLPHILVYVL LGCNQEDQQE VYAEIMAVLK HDDQHTINTQ 1560

DIASDLCQLS TQTVFSMLDH LTQWARHKFQ ALKAEKCPHS KSNRNKVDSM VSTVDYEDYQ 1620

SVTRFLDLIP QDTLAVASFR SKAYTRAVMH FESFITEKKQ NIQEHLGFLQ KLYAAMHEPD 1680

GVAGVSAIRK AEPSLKEQIL EHESLGLLRD ATACYDRAIQ LEPDQIIHYH GVVKSMLGLG 1740

QLSTVITQVN GVHANRSEWT DELNTYRVEA AWKLSQWDLV ENYLAADGKS TTWSVRLGQL 1800

LLSAKKRDIT AFYDTLKLVR AEQIVPLSAA SFERGSYQRG YEYIVRLHML CELEHSIKPL 1860

FQHSPGDSSQ EDSLNWVARL EMTQNSYRAK EPILALRRAL LSLNKRPDYN EMVGECWLQS 1920

ARVARKAGHH QTAYNALLNA GESRLAELYV ERAKWLWSKG DVHQALIVLQ KGVELCFPEN 1980

ETPPEGKSML IHGRAMLLVG RFMEETANFE SNAIMKKYKD VTACLPEWED GHFYLAKYYD 2040

KLMPMVTDNK MEKQGDLIRY IVLHFGRSLQ YGNQFIYQSM PRMLTLWLDY GTKGYEWKAG 2100

RSDRVQMRND LGKINKVITE HTNYLAPYQF LTAFSQLISR ICHSHDEVFV VLMEIIAKVF 2160

LAYPQQAMWM MTAVSKSSYP MRVNRCKEIL NKAIHMKKSL EKFVGDATRL TDKLLELCNK 2220

PVDGSSSTLS MSTHFKMLKK LVEEATFSEI LIPLQSVMIP TLPSILGTHA NHASHEPFPG 2280

HWAYIAGFDD MVEILASLQK PKKISLKGSD GKFYIMMCKP KDDLRKDCRL MEFNSLINKC 2340

LRKDAESRRR ELHIRTYAVI PLNDECGIIE WVNNTAGLRP ILTKLYKEKG VYMTGKELRQ 2400

CMLPKSAALS EKLKVFREFL LPRHPPIFHE WFLRTFPDPT SWYSSRSAYC RSTAVMSMVG 2460

YILGLGDRHG ENILFDSLTG ECVHVDFNCL FNKGETFEVP EIVPFRLTHN MVNGMGPMGT 2520

EGLFRRACEV TMRLMRDQRE PLMSVLKTFL HDPLVEWSKP VKGHSKAPLN ETGEVVNEKA 2580

KTHVLDIEQR LQGVIKTRNR VTGLPLSIEG HVHYLIQEAT DENLLCQMYL GWTPYM 2636

Nucleotide Sequence
(FASTA)

ATGGGGGAAC ATGGCCTGGA GCTGGCTTCC ATGATCCCCG CCCTGCGGGA GCTGGGCAGT 60

GCCACACCAG AGGAATATAA TACAGTTGTA CAGAAGCCAA GACAAATTCT GTGTCAATTC 120

ATTGACCGGA TACTTACAGA TGTAAATGTT GTTGCTGTAG AACTTGTAAA GAAAACTGAC 180

TCTCAGCCAA CCTCCGTGAT GTTGCTTGAT TTCATCCAGC ATATCATGAA ATCCTCCCCA 240

CTTATGTTTG TAAATGTGAA TGGAAGCCAT GAGGCCAAAG GCAGTTGTAT TGAATTCAGT 300

AATTGGATCA TAACAAGACT TCTGCGGATT GCAGCAACTC CCTCCTGTCA TTTGTTACAC 360

AAGAAAATCT GTGAAGTCAT CTGTTCATTA TTATTTCTTT TTAAAAGCAA GAGTCCTGCT 420

ATTTTTGGGG TACTCACAAA AGAATTATTA CAACTTTTTG AAGACTTGGT TTACCTCCAT 480

AGAAGAAATG TGATGGGTCA TGCTGTGGAA TGGCCAGTGG TCATGAGCCG ATTTTTAAGT 540

CAATTAGATG AACACATGGG ATATTTACAA TCAGCTCCTT TGCAGTTGAT GAGTATGCAA 600

AATTTAGAAT TTATTGAAGT CACTTTATTA ACGGTTCTTA CTCGTATTAT TGCAATTGTG 660

TTTTTTAGAA GGCAAGAACT CTTACTTTGG CAGATAGGTT GTGTTCTGCT AGAGTATGGT 720

AGTCCAAAAA TTAAATCCCT AGCAATTAGC TTTTTAACAG AACTTTTTCA GCTTGGAGGA 780

CTACCAGCAC AACCAGCTAG CACTTTTTTC AGCTCATTTT TGGAATTACT AAAACACCTT 840

GTAGAAATGG ATACTGACCA ATTAAAACTC TATGAAGAGC CATTATCAAA GCTGATAAAG 900

ACACTATTTC CCTTTGAAGC AGAAGCTTAT AGAAATATTG AACCTGTCTA TTTAAATATG 960

CTGCTGGAAA AACTCTGTGT CATGTTTGAA GACGGTGTGC TCATGCGGCT TAAGTCTGAT 1020

TTGCTAAAAG CAGCTTTGTG CCATTTACTG CAGTATTTCC TTAAATTTGT GCCAGCTGGG 1080

TATGAATCTG CTTTACAAGT CAGGAAGGTC TATGTGAGAA ATATTTGTAA AGCTCTTTTG 1140

GATGTGCTTG GAATTCAGGT AGATGCAGAG TACTTGTTGG GCCCACTTTA TGCAGCTTTG 1200

AAAATGGAAA GTATGGAAAT CATTGAGGAG ATTCAATGCC AAACTCAACA GGAAAACCTC 1260

AGCAGTAATA GTGATGGAAT ATCACCCAAA AGGCGTCGTC TCAGCTCGTC TCTAAACCCT 1320

TCTAAAAGAG CACCAAAACA GACTGAGGAA ATTAAACATG TGGACATGAA TCAAAAGAGC 1380

ATATTATGGA GTGCACTGAA ACAGAAAGCT GAATCCCTTC AGATTTCCCT TGAATACAGT 1440

GGCCTAAAGA ATCCTGTTAT TGAGATGTTA GAAGGAATTG CTGTTGTCTT ACAACTGACT 1500

GCTCTGTGTG CTGTTCATTG TTCTCATCCA AACATGAACT GCCATACTTT CAAGGACTGT 1560

CAACATAAAT CCAAGAAGAA ACCTTCTGTA GTGATAACTT GGATGTCATT GGATTTTTAC 1620

ACAAAAGTGC TTAAGAGCTG TAGAAGTTTG TTAGAATCTG TTCAGAAACC GGACCTGGAG 1680

GCAACCATTG ATAAGGTGGT GAAAATTTAT GATGCTTTGA TTTATATGCA AGTAAACAGT 1740

TCATTTGAAG ATCATATCCT GGAAGATTTA TGTGGAATGC TCTCACTTCC ATGGATTTAT 1800

TCCCATTCTG ATGATGGCTG TTTAAAGTTG ACCACATTTG CCACTAATCT TCTAACATTA 1860

AGCCGTAGGA TTTCAGATAG CTATTCACCA CAGGCACAAT CACGATGTGT GTTTCTTCTG 1920

ACTCTGTTTC CAAGAAGAAT ATTCCTTGAA TGGAGAACAG CAGTTTACAA CTGGGCCCTG 1980

CAGAGCTCCC ATGAAGTAAT CCGGGCTAGT TGTGTTAGTG GATTTTTTAT CTTATTGCAG 2040

CAGCAGAATT CTTGTAACAG AGTTCCCAAG ATTCTTATAG ATAAAGTCAA AGATGATTCT 2100

GACATTGTCA AGAAAGAATT TGCTTCTATA CTTGGTCAAC TTGTCTGCAC TCTTCACGGC 2160

ATGTTTTATC TGACAAGTTC TTTAACAGAA CCTTTCTCTG AACATGGACA TGTGGACCTC 2220

TTCTGTAGGA ACTTGAAAGC TACTTCTCAA CATGAATGTT CATCTTCTCA ACTAAAAGCT 2280

TCTGTCTGCA AGCCGTTCCT TTTCCTATTG AAAAAAAAAA CACCTAGTCC AGTAAAACTT 2340

GCTTTCATAG ATAATCTACA TCATCTTTGT AAGCATCTTG ATTTTAGAGA AGATGAAACA 2400

GATGTAAAAG CAGTTCTTGG AACTTTATTA AATTTAATGG AAGATCCAGA CAAAGATGTT 2460

AGAGTGGCTT TTAGTGGAAA TATCAAGCAT ATATTGGAAT CCTTGGACTC TGAAGATGGA 2520

TTTATAAAGG AGCTTTTTGT CTTAAGAATG AAGGAAGCAT ATACACATGC CCAAATATCA 2580

AGAAATAATG AGCTGAAGGA TACCTTGATT CTTACAACAG GGGATATTGG AAGAGCCGCA 2640

AAAGGAGATT TGGTACCTTT TGCACTCTTA CACTTATTGC ATTGTTTGTT ATCCAAGTCA 2700

GCATCTGTCT CTGGAGCAGC ATACACAGAA ATTAGAGCTC TGGTTGCAGC TAAAAGTGTT 2760

AAACTGCAAA ATTTTTTCAG CCAGTATAAG AAACCCATCT GTCAGTTTTT GGTAGAATCC 2820

CTTCACTCTA GTCAGATGAC GGCACTTCCG AGTACTCCAT GCCGGAATGC TGACATGCGA 2880

AAACAAGATG TGGCTCACCA GAGAGAAATG GCTTTAAATA CCTTGTCTGA AATTGCCAAC 2940

GTTTTCGACT TTCCTGATCT TAATCGTTTT CTTACTAGGA CATTACAAGT TCTACTACCT 3000

GATCTTGCTG CCAAAGCAAG CCCTGCAGCT TCTGCTCTCA TTCGAACTTT AGGAAAACAA 3060

TTAAATGTCA ATCGTAGAGA GATTTTAATA AACAACTTCA AATATATTTT TTCTCATTTG 3120

GTCTGTTCTT GTTCCAAAGA TGAATTAGAA CGTGCCCTTC ATTATCTGAA GAATGAAACA 3180

GAAATTGAAC TGGGGAGCCT GTTGAGACAA GATTTCCAAG GATTGCATAA TGAATTATTG 3240

CTGCGTATTG GAGAACACTA TCAACAGGTT TTCAATGGTT TGTCAATACT TGCCTCATTT 3300

GCATCCAGTG ATGATCCATA TCAGGGCCCA AGAGATGCTG ACTATTTACA ACCCAAATTG 3360

TTGGGCATTT TGGCTTTTTT TAACATGCAG TTACTGAGCT CTAGTGTTGG CATTGAAGAT 3420

AAGAAAATGG CCTTGAACAG TTTGATGTCT TTGATGAAGT TAATGGGACC CAAACATGTC 3480

AGTTCTGTGA GGGTGAAGAT GATGACCACA CTGAGAACTG GCCTTCGATT CAAGGATGAT 3540

TTTCCTGAAT TGTGTTGCAG AGCTTGGGAC TGCTTTGTTC GCTGCCTGGA TCATGCTTGT 3600

CTGGGCTCCC TTCTCAGTCA TGTAATAGTA GCTTTGTTAC CTCTTATACA CATCCAGCCT 3660

AAAGAAACTG CAGCTATCTT TCACTACCTC ATAATTGAAA ACAGGGATGC TGTGCAAGAT 3720

TTTCTTCATG AAATATATTT TTTACCTGAT CATCCAGAAT TAAAAAAGAT AAAAGCCGTT 3780

CTCCAGGAAT ACAGAAAGGA GACCTCTGAG AGCACTGATC TTCAGACAAC TCTTCAGCTC 3840

TCTATGAAGG CCATTCAACA TGAAAATGTC GATGTTCGTA TTCATGCTCT TACAAGCTTG 3900

AAGGAAACCT TGTATAAAAA TCAGGAAAAA CTGATAAAGT ATGCAACAGA CAGTGAAACA 3960

GTAGAACCTA TTATCTCACA GTTGGTGACA GTGCTTTTGA AAGGTTGCCA AGATGCAAAC 4020

TCTCAAGCTC GGTTGCTCTG TGGGGAATGT TTAGGGGAAT TGGGGGCGAT AGATCCAGGT 4080

CGATTAGATT TCTCAACAAC TGAAACTCAA GGAAAAGATT TTACATTTGT GACTGGAGTA 4140

GAAGATTCAA GCTTTGCCTA TGGATTATTG ATGGAGCTAA CAAGAGCTTA CCTTGCATAT 4200

GCTGATAATA GCCGAGCTCA AGATTCAGCT GCCTATGCCA TTCAGGAGTT GCTTTCTATT 4260

TATGACTGTA GAGAGATGGA GACCAACAGC CCAGGTCACC AATTGTGGAG GAGGTTTCCT 4320

GAGCATGTTC GGGAAATACT AGAACCTCAT CTAAATACCA GATACAAGAG TTCTCAGAAG 4380

TCAACCGATT GGTCTGGAGT AAAGAAGCCA ATTTACTTAA GTAAATTGGG TAGTAACTTT 4440

GCAGAATGGT CAGCATCTTG GGCAGGTTAT CTTATTACAA AGGTTCGGCA TGATCTTGCC 4500

AGTAAAATTT TCACCTGCTG TAGCATTATG ATGAAGCATG ATTTCAAAGT GACCATCTAT 4560

CTTCTTCCAC ATATTCTGGT GTATGTCTTA CTGGGTTGTA ATCAAGAAGA TCAGCAGGAG 4620

GTTTATGCAG AAATTATGGC AGTTCTAAAG CATGACGATC AGCATACCAT AAATACCCAA 4680

GACATTGCAT CTGATCTGTG TCAACTCAGT ACACAAACTG TGTTCTCCAT GCTTGACCAT 4740

CTCACACAGT GGGCAAGGCA CAAATTTCAG GCACTGAAAG CTGAGAAATG TCCACACAGC 4800

AAATCAAACA GAAATAAGGT AGACTCAATG GTATCTACTG TGGATTATGA AGACTATCAG 4860

AGTGTAACCC GTTTTCTAGA CCTCATACCC CAGGATACTC TGGCAGTAGC TTCCTTTCGC 4920

TCCAAAGCAT ACACACGAGC TGTAATGCAC TTTGAATCAT TTATTACAGA AAAGAAGCAA 4980

AATATTCAGG AACATCTTGG ATTTTTACAG AAATTGTATG CTGCTATGCA TGAACCTGAT 5040

GGAGTGGCCG GAGTCAGCGC AATTAGAAAG GCAGAACCAT CTCTAAAAGA ACAGATCCTT 5100

GAACATGAAA GCCTTGGCTT GCTGAGGGAT GCCACTGCTT GTTATGACAG GGCTATTCAG 5160

CTAGAACCAG ACCAGATCAT TCATTATCAT GGTGTAGTAA AGTCCATGTT AGGTCTTGGT 5220

CAGCTGTCTA CTGTTATCAC TCAGGTGAAT GGAGTGCATG CTAACAGGTC CGAGTGGACA 5280

GATGAATTAA ACACGTACAG AGTGGAAGCA GCTTGGAAAT TGTCACAGTG GGATTTGGTG 5340

GAAAACTATT TGGCAGCAGA TGGAAAATCT ACAACATGGA GTGTCAGACT GGGACAGCTA 5400

TTATTATCAG CCAAAAAAAG AGATATCACA GCTTTTTATG ACACACTGAA ACTAGTGAGA 5460

GCAGAACAAA TTGTACCTCT TTCAGCTGCA AGCTTTGAAA GAGGCTCCTA CCAACGAGGA 5520

TATGAATATA TTGTGAGATT GCACATGTTG TGTGAGTTGG AGCATAGCAT CAAACCACTT 5580

TTCCAGCATT CTCCAGGTGA CAGTTCTCAA GAAGATTCTC TAAACTGGGT AGCTCGACTA 5640

GAAATGACCC AGAATTCCTA CAGAGCCAAG GAGCCTATCC TGGCTCTCCG GAGGGCTTTA 5700

CTAAGCCTCA ACAAAAGACC AGATTACAAT GAAATGGTTG GAGAATGCTG GCTGCAGAGT 5760

GCCAGAGTAG CTAGAAAGGC TGGTCACCAC CAGACAGCCT ACAATGCTCT CCTTAATGCA 5820

GGAGAATCAC GACTCGCTGA ACTGTATGTG GAAAGGGCAA AGTGGCTCTG GTCCAAGGGT 5880

GATGTTCACC AGGCACTAAT TGTTCTTCAA AAAGGTGTTG AATTATGTTT TCCTGAAAAT 5940

GAAACCCCAC CTGAGGGTAA GAGCATGTTA ATCCACGGTC GAGCTATGCT ACTAGTGGGC 6000

CGATTTATGG AAGAAACAGC TAACTTTGAA AGCAATGCAA TTATGAAAAA ATATAAGGAT 6060

GTGACTGCAT GCCTGCCAGA ATGGGAGGAT GGGCATTTTT ACCTTGCCAA GTACTATGAC 6120

AAATTGATGC CCATGGTCAC AGACAACAAA ATGGAAAAGC AAGGTGATCT CATCCGGTAT 6180

ATAGTTCTTC ATTTTGGCAG ATCTCTACAA TATGGAAATC AGTTCATATA TCAGTCCATG 6240

CCACGAATGT TAACTCTATG GCTTGATTAT GGTACAAAGG GCTATGAATG GAAAGCTGGC 6300

CGCTCCGATC GTGTACAAAT GAGGAATGAT TTGGGTAAAA TAAACAAGGT TATCACAGAG 6360

CATACAAACT ATTTAGCTCC ATATCAGTTT TTGACTGCTT TTTCACAATT GATCTCTCGA 6420

ATTTGTCATT CCCATGATGA AGTTTTTGTT GTCTTGATGG AAATAATAGC CAAAGTATTT 6480

CTAGCCTATC CTCAACAAGC AATGTGGATG ATGACAGCTG TGTCAAAGTC ATCTTATCCC 6540

ATGCGTGTGA ACAGATGCAA GGAAATCCTC AATAAAGCCA TTCATATGAA AAAATCCTTA 6600

GAGAAGTTTG TTGGAGATGC AACTCGCCTA ACAGATAAGC TTCTAGAATT GTGCAATAAA 6660

CCGGTTGATG GAAGTAGTTC CACATTAAGC ATGAGCACTC ATTTTAAAAT GCTTAAAAAG 6720

CTGGTAGAAG AAGCAACATT TAGTGAAATC CTCATTCCTC TACAATCAGT CATGATACCT 6780

ACACTTCCAT CAATTCTGGG TACCCATGCT AACCATGCTA GCCATGAGCC ATTTCCTGGA 6840

CATTGGGCCT ATATTGCAGG GTTTGATGAT ATGGTGGAAA TTCTTGCTTC TCTTCAGAAA 6900

CCAAAGAAGA TTTCTTTAAA AGGGTCAGAT GGAAAGTTCT ACATCATGAT GTGTAAGCCA 6960

AAAGATGACC TGAGAAAGGA TTGTAGACTA ATGGAATTCA ATTCCTTGAT TAATAAGTGC 7020

TTAAGAAAAG ATGCAGAGTC TCGTAGAAGA GAACTTCATA TTCGAACATA TGCAGTTATT 7080

CCACTAAATG ATGAATGTGG GATTATTGAA TGGGTGAACA ACACTGCTGG TTTGAGACCG 7140

ATTCTGACCA AACTATATAA AGAAAAGGGA GTGTATATGA CAGGAAAAGA ACTTCGCCAG 7200

TGTATGCTAC CAAAGTCAGC AGCTTTATCT GAAAAACTCA AAGTATTCCG AGAATTTCTC 7260

CTGCCCAGGC ATCCTCCTAT TTTTCATGAG TGGTTTCTGA GAACATTCCC TGATCCTACA 7320

TCATGGTACA GTAGTAGATC AGCATACTGC CGTTCCACTG CAGTAATGTC AATGGTTGGT 7380

TATATTCTGG GGCTTGGAGA CCGTCATGGT GAAAATATTC TCTTTGATTC TTTGACTGGT 7440

GAATGCGTAC ATGTAGATTT CAACTGTCTT TTCAATAAGG GAGAAACCTT TGAAGTTCCA 7500

GAAATTGTAC CATTTCGCCT GACTCATAAT ATGGTTAATG GAATGGGTCC TATGGGAACA 7560

GAGGGTCTTT TTCGAAGAGC ATGTGAAGTT ACAATGAGGC TGATGCGTGA TCAGCGAGAG 7620

CCTTTAATGA GTGTCTTAAA GACTTTTCTA CATGATCCTC TTGTGGAATG GAGTAAACCA 7680

GTGAAAGGGC ATTCCAAAGC GCCACTGAAT GAAACTGGAG AAGTTGTCAA TGAAAAGGCC 7740

AAGACCCATG TTCTTGACAT TGAGCAGCGA CTACAAGGTG TAATCAAGAC TCGAAATAGA 7800

GTGACAGGAC TGCCATTATC TATTGAAGGA CATGTGCATT ACCTTATACA AGAAGCTACT 7860

GATGAAAACT TACTATGCCA GATGTATCTT GGTTGGACCC CATATATGTG A 7911

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         iagfd++veilas+qkpkk++l+Gsdgk+y++++k+k+Dlr+d+r+++++sl+N++L+kd

Q: 2285  IAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKD  2344

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e++rr+L+irty+V+pl++++g+iewv+nt++L+ +l+kl+++k+v++        + +

Q: 2345  AESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYM--------TGK  2396

         *************************************************........599

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         + +q++ pk+++l+++l+vf+e+l +++p+ ++++++l++fp+p++w+++r+ay+rs+Av

Q: 2397  ELRQCMLPKSAALSEKLKVFREFLLPRHPP-IFHEWFLRTFPDPTSWYSSRSAYCRSTAV  2455

         *****************************8.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

         +s+vgyiLgLgdrh en+l+d+ tge+vh+df++ f+k++t ++vpe+vPFRLT+n+vn+

Q: 2456  MSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGET-FEVPEIVPFRLTHNMVNG  2514

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk.....kkktsketee  295

         +g++g+eG+fr++ce ++r++r+++e l+++L++fl+dplv+w+k     +k++ +et+e

Q: 2515  MGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKpvkghSKAPLNETGE  2574

         *************************************************99*********

S: 296   elaekakaealkikkllskvekaenavatrdllllee  332

         +++ekak++ l+i+++l++v k++n+v+ ++l+++++

Q: 2575  VVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGH  2611

         ********************************99987

Domain Sequence
(FASTA)

IAGFDDMVEI LASLQKPKKI SLKGSDGKFY IMMCKPKDDL RKDCRLMEFN SLINKCLRKD 60

AESRRRELHI RTYAVIPLND ECGIIEWVNN TAGLRPILTK LYKEKGVYMT GKELRQCMLP 120

KSAALSEKLK VFREFLLPRH PPIFHEWFLR TFPDPTSWYS SRSAYCRSTA VMSMVGYILG 180

LGDRHGENIL FDSLTGECVH VDFNCLFNKG ETFEVPEIVP FRLTHNMVNG MGPMGTEGLF 240

RRACEVTMRL MRDQREPLMS VLKTFLHDPL VEWSKPVKGH SKAPLNETGE VVNEKAKTHV 300

LDIEQRLQGV IKTRNRVTGL PLSIEGH 327

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0001741	; C:XY body
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071480	; P:cellular response to gamma radiation
GO:0034644	; P:cellular response to UV
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0008156	; P:negative regulation of DNA replication
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	; P:protein autophosphorylation
GO:0043393	; P:regulation of protein binding
GO:0090399	; P:replicative senescence

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013