EPS-POA-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-POA-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	229.3	7.0E-68	93	349	257

Status

Unreviewed

Ensembl Protein

ENSPPYP00000015943

UniProt Accession

H2PBW5;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1L

Gene Synonyms/Alias

PPM1L;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014261	ENSPPYP00000015943	ENSPPYT00000016579

Organism

Pongo abelii

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK SSRDAVKMVK 60

GKVAEIMQND RLGGLDVLEA EFSKTWEFKN HNVAVYSIQG RRDHMEDRFE VLTDLANKTH 120

PSIFGIFDGH GGETAAEYVK SRLPEALKQH LQDYEKDKEN SVLSYQTILE QQILSIDREM 180

LEKLTVSYDE AGTTCLIALL SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK 240

RIKRAGGFIS FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA 300

SDGLWDAFSN EEAVRFIKER LDEPHFGAKS IVLQSFYRGC PDNITVMVVK FRNSSKTEEQ 360

Nucleotide Sequence
(FASTA)

ATGATAGAGG ATACAATGAC TTTGCTATCT CTGCTGGGTC GCATCATGCG CTACTTCTTG 60

CTGAGACCCG AGACGCTTTT CCTGCTGTGC ATCAGCTTGG CTCTATGGAG TTACTTCTTC 120

CACACCGACG AGGTGAAGAC CATCGTGAAG TCCAGCCGGG ACGCCGTGAA GATGGTGAAG 180

GGCAAGGTAG CCGAGATCAT GCAGAATGAT CGACTCGGGG GGCTTGATGT GCTCGAGGCC 240

GAGTTTTCCA AGACCTGGGA GTTCAAGAAC CACAACGTGG CGGTGTACTC CATCCAGGGG 300

CGGAGAGACC ACATGGAGGA CCGCTTCGAA GTTCTCACGG ATCTGGCCAA CAAGACGCAC 360

CCGTCCATCT TCGGGATCTT CGACGGGCAC GGGGGAGAGA CTGCAGCTGA ATATGTAAAA 420

TCTCGACTCC CAGAGGCCCT TAAACAGCAT CTTCAGGACT ACGAGAAAGA CAAAGAAAAT 480

AGTGTATTGT CTTACCAGAC CATCCTTGAA CAGCAGATTT TGTCAATTGA CCGAGAAATG 540

CTAGAAAAAT TGACTGTATC CTATGATGAA GCAGGCACAA CGTGTTTGAT TGCTCTGTTA 600

TCAGATAAAG ACCTCACTGT GGCCAATGTG GGTGACTCGC GCGGGGTCCT GTGTGACAAA 660

GATGGGAACG CTATTCCTTT GTCTCATGAT CACAAGCCTT ACCAGTTGAA GGAAAGAAAG 720

AGGATAAAGA GAGCAGGTGG TTTCATCAGT TTCAATGGCT CTTGGAGGGT CCAGGGAATC 780

CTGGCCATGT CTCGGTCCCT GGGGGATTAT CCGCTGAAAA ATCTCAACGT GGTCATCCCA 840

GATCCAGACA TCCTGACCTT TGACCTGGAC AAGCTTCAGC CCGAGTTCAT GATCTTGGCA 900

TCAGATGGCC TCTGGGATGC CTTCAGCAAT GAAGAAGCAG TTCGATTCAT CAAGGAGCGC 960

TTGGATGAAC CTCACTTTGG GGCCAAGAGC ATAGTTTTAC AGTCATTTTA CAGAGGCTGC 1020

CCTGACAATA TAACAGTCAT GGTGGTGAAG TTCAGAAATA GCAGCAAAAC AGAAGAGCAG 1080

TGA 1083

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         v v+s++grr++med++++ +++++++      ++fg++DGhgg+++a++++++l e+l+

Q: 93    VAVYSIQGRRDHMEDRFEVLTDLANKTHP----SIFGIFDGHGGETAAEYVKSRLPEALK  148

         6789***************9999998665....69*************************

S: 63    eele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskly  118

         + l+    ++e++    +++l++  ls+d+e+  le+ + + d+ G+t+++al++d++l+

Q: 149   QHLQdyekDKENSVLSYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLT  206

         ****654333333344459*************..999999********************

S: 119   vanvGdSravLcr.ngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsR  176

         vanvGdSr vLc+ +g+a++ls dHkp + +E++Ri++agg +  + g  Rv+G La+sR

Q: 207   VANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSwRVQGILAMSR  265

         *************566************************999977.667**********

S: 177   alGdlylk..pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekke  233

         +lGd+ lk   +v+p+P++  ++l++ +  f+iLasDGlwd +sneeav++++++l+

Q: 266   SLGDYPLKnlNVVIPDPDILTFDLDKLQPeFMILASDGLWDAFSNEEAVRFIKERLD---  322

         ********8889************765544***************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

         ++   ak++v ++  rg+ dn++++vv

Q: 323   EPHFGAKSIVLQSFYRGCPDNITVMVV  349

         999********************9997

Domain Sequence
(FASTA)

VAVYSIQGRR DHMEDRFEVL TDLANKTHPS IFGIFDGHGG ETAAEYVKSR LPEALKQHLQ 60

DYEKDKENSV LSYQTILEQQ ILSIDREMLE KLTVSYDEAG TTCLIALLSD KDLTVANVGD 120

SRGVLCDKDG NAIPLSHDHK PYQLKERKRI KRAGGFISFN GSWRVQGILA MSRSLGDYPL 180

KNLNVVIPDP DILTFDLDKL QPEFMILASD GLWDAFSNEE AVRFIKERLD EPHFGAKSIV 240

LQSFYRGCPD NITVMVV 257

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000165	; P:MAPK cascade
GO:0006470	; P:protein dephosphorylation
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013