EKS-POA-00167

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00167

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	442.9	4.2E-133	348	616	269

Status

Unreviewed

Ensembl Protein

ENSPPYP00000015972

UniProt Accession

H2PBZ2;

Protein Name

Protein Synonyms/Alias

Protein kinase C iota type;

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014289	ENSPPYP00000015972	ENSPPYT00000016611

Organism

Pongo abelii

Functional Description

Protein Length

690

Protein Sequence
(FASTA)

MWAFGASEVG GTDAGGVLGP GGCRGGGAYG QWEEPRGSGC SGEATLGSAL RARGAGRWAD 60

GRGSPTGAGG GVPHGVRSAP PHPRPPALRR GSEEMPTQRD SSTMSHTVAG GGSGDHSHQV 120

RVKAYYRGDI MITHFEPSIS FEGLCNEVRD MCSFDNEQLF TMKWIYDEGD PCTVSSQLEL 180

EEAFRLYELN KDSELLIHVF PCVPERPGMP CPGEDKSIYR RGARRWRKLY CANGHTFQAK 240

RFNRRAHCAI CTDRIWGLGR QGYKCINCKL LVHKKCHKLV TIECGRHSLP PEPMMPMDQS 300

SMHSDHAQTV IPYNPSSHES LDQVGEEKEA MNTRESGKAS SSLGLQDFDL LRVIGRGSYA 360

KVLLVRLKKT DRIYAMKVVK KELVNDDEDI DWVQTEKHVF EQASNHPFLV GLHSCFQTES 420

RLFFVIEYVN GGDLMFHMQR QRKLPEEHAR FYSAEISLAL NYLHERGIIY RDLKLDNVLL 480

DSEGHIKLTD YGMCKEGLRP GDTTSTFCGT PNYIAPEILR GEDYGFSVDW WALGVLMFEM 540

MAGRSPFDIV GSSDNPDQNT EDYLFQVILE KQIRIPRSLS VKAASVLKSF LNKDPKERLG 600

CHPQTGFADI QGHPFFRNVD WDMMEQKQVV PPFKPNISGE FGLDNFDSQF TNEPVQLTPD 660

DDDIVRKIDQ SEFEGFEYIN PLLMSAEECV 690

Nucleotide Sequence
(FASTA)

ATGTGGGCCT TTGGAGCGAG CGAAGTGGGA GGGACCGACG CAGGAGGTGT CTTGGGCCCG 60

GGCGGCTGTA GAGGCGGCGG AGCCTACGGG CAGTGGGAGG AGCCGCGCGG TTCCGGCTGC 120

TCGGGCGAGG CGACCCTTGG GTCCGCGCTG CGGGCGAGGG GGGCAGGTAG GTGGGCGGAC 180

GGCCGCGGTT CTCCGACAGG CGCGGGCGGC GGAGTCCCCC ACGGAGTCCG TAGCGCCCCT 240

CCGCACCCCC GGCCTCCAGC GTTGAGGCGG GGGAGTGAGG AGATGCCGAC CCAGAGGGAC 300

AGCAGCACCA TGTCCCACAC GGTCGCAGGC GGCGGCAGCG GGGACCATTC CCACCAGGTC 360

CGGGTGAAAG CCTACTACCG CGGGGATATC ATGATAACTC ATTTTGAACC TTCCATCTCC 420

TTTGAGGGCC TTTGCAATGA GGTTCGAGAC ATGTGTTCTT TTGACAACGA ACAGCTCTTC 480

ACCATGAAAT GGATATATGA TGAAGGAGAC CCGTGTACAG TATCATCTCA GTTGGAGTTA 540

GAAGAAGCCT TTAGACTTTA TGAGCTAAAC AAGGATTCTG AACTCTTGAT TCATGTGTTC 600

CCTTGTGTAC CAGAACGTCC TGGGATGCCT TGTCCAGGAG AAGATAAATC CATCTACCGT 660

AGAGGTGCAC GCCGCTGGAG AAAGCTTTAT TGTGCCAATG GCCACACTTT CCAAGCCAAG 720

CGTTTCAACA GGCGTGCTCA CTGTGCCATC TGCACAGACC GAATATGGGG ACTTGGACGC 780

CAAGGATATA AGTGCATCAA CTGCAAACTC TTGGTTCATA AGAAGTGCCA TAAACTCGTC 840

ACAATTGAAT GTGGGCGGCA TTCTTTGCCA CCGGAACCAA TGATGCCCAT GGATCAGTCA 900

TCCATGCATT CTGACCATGC ACAGACAGTA ATTCCATATA ATCCTTCAAG TCATGAGAGT 960

TTGGATCAAG TTGGTGAAGA AAAAGAGGCA ATGAACACCA GGGAAAGTGG CAAAGCTTCA 1020

TCCAGTCTAG GTCTTCAGGA TTTTGATTTG CTCCGGGTAA TAGGAAGAGG AAGTTATGCC 1080

AAAGTACTGT TGGTTCGATT AAAAAAAACA GATCGTATTT ATGCAATGAA AGTTGTGAAA 1140

AAAGAGCTTG TTAATGATGA TGAGGATATT GATTGGGTGC AGACAGAGAA GCATGTGTTT 1200

GAGCAGGCAT CTAATCATCC TTTCCTTGTT GGGCTGCATT CTTGCTTTCA GACAGAAAGC 1260

AGATTGTTCT TTGTCATAGA GTATGTAAAT GGAGGAGACC TAATGTTTCA TATGCAGCGA 1320

CAAAGAAAAC TTCCTGAAGA ACATGCCAGA TTTTACTCTG CAGAAATCAG TCTAGCATTA 1380

AATTATCTTC ATGAGCGAGG GATAATTTAT AGAGATTTGA AACTGGACAA TGTATTACTG 1440

GACTCTGAAG GCCACATTAA ACTCACTGAC TATGGCATGT GTAAGGAAGG ATTACGGCCA 1500

GGAGATACAA CCAGCACTTT CTGTGGTACT CCTAATTACA TTGCTCCTGA AATTTTAAGA 1560

GGAGAAGATT ATGGTTTCAG TGTTGACTGG TGGGCTCTTG GAGTGCTAAT GTTTGAGATG 1620

ATGGCAGGAA GGTCTCCATT TGATATTGTT GGGAGCTCCG ATAACCCTGA CCAAAACACA 1680

GAGGATTATC TCTTCCAAGT TATTTTGGAA AAACAAATTC GCATACCACG TTCTCTGTCT 1740

GTAAAAGCTG CAAGTGTTCT GAAGAGTTTT CTTAACAAGG ACCCTAAGGA ACGATTGGGT 1800

TGTCATCCTC AAACAGGATT TGCTGATATT CAGGGACACC CGTTCTTCCG AAATGTTGAT 1860

TGGGATATGA TGGAGCAAAA ACAGGTGGTA CCTCCCTTTA AACCAAATAT TTCTGGGGAA 1920

TTTGGTTTGG ACAACTTTGA TTCTCAGTTT ACTAATGAAC CTGTCCAGCT CACTCCGGAT 1980

GACGATGACA TTGTGAGGAA GATTGATCAG TCTGAATTTG AAGGTTTTGA GTATATCAAT 2040

CCTCTTTTGA TGTCTGCAGA AGAATGTGTC TGA 2073

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+ll+v+G+Gs++kvll++lkktd++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 348   FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  407

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 408   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  467

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 468   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  527

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++l

Q: 528   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASVL  587

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         k++l+kdp++rlG++ ++g +di+ h+ff

Q: 588   KSFLNKDPKERLGCHpQTGFADIQGHPFF  616

         **************989***********9

Domain Sequence
(FASTA)

FDLLRVIGRG SYAKVLLVRL KKTDRIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAASVL 240

KSFLNKDPKE RLGCHPQTGF ADIQGHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0043220	; C:Schmidt-Lanterman incisure
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0007015	; P:actin filament organization
GO:0045216	; P:cell-cell junction organization
GO:0035089	; P:establishment of apical/basal cell polarity
GO:0042462	; P:eye photoreceptor cell development
GO:0035556	; P:intracellular signal transduction
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:2000353	; P:positive regulation of endothelial cell apoptotic process
GO:0090004	; P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252	; P:positive regulation of glial cell proliferation
GO:0046326	; P:positive regulation of glucose import
GO:0010976	; P:positive regulation of neuron projection development
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013