EKS-POA-00335
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00335
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ack451.11.1E-135190448259
StatusUnreviewed
Ensembl ProteinENSPPYP00000016143
UniProt AccessionH2PCF4;
Protein Name
Protein Synonyms/Alias
Gene NameTNK2
Gene Synonyms/Alias TNK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000014433ENSPPYP00000016143ENSPPYT00000016789
OrganismPongo abelii
Functional Description
Protein Length1086
Protein Sequence
(FASTA)
MLEARPPRTQ GSDAAGAAAG RGLRALLLSL TAATGLLGSM GERSAYQRLA GSEEGPQRLG 60
GGSMQPEEGT GWLLELLSEV QLQQYFLRLR DDLNITRLSH FEYVKNEDLE KIGMGRPGQR 120
RLWEAVKRRK ALCKRKSWMS KVFSGKRLEA EFPAHHSQST FRKTSPAPGG PAGEGPLQSL 180
TCLIGEKDLR LLEKLGDGSF GVVRRGEWDA PSGKTVSVAV KCLKPDVLSQ PEAMDDFIRE 240
VNAMHSLDHR NLIRLYGVVL TPPMKMVTEL APLGSLLDRL RKHQGHFLLG TLSRYAVQVA 300
EGMGYLESKR FIHRDLAARN LLLATRDLVK IGDFGLMRAL PQNDDHYVMQ EHRKVPFAWC 360
APESLKTRTF SHASDTWMFG VTLWEMFTYG QEPWIGLNGS QILHKIDKEG ERLPRPEDCP 420
QDIYNVMVQC WAHKPEDRPT FVALRDFLLE AQPTDMRALQ DFEEADKLHI QMNDVITVIE 480
GRAENYWWRG QNTRTLCVGP FPRNVVTSVA GLSAQDISQP LQNSFIHTGH GDSDPRHCWG 540
FPDRIDELYL GNPLDPPDLL SVELSTSRPP QHLGGVKREP PPRPPQPAFF TQKPTYDPVS 600
EDQDPLSSDF KRLGLRKPGL PRGLWLAKPS ARVPGTKAGR GSGAEVTLID FGEEPVVPAL 660
RPCAPSLAQL AMDACSLLDE TPPQSPTRAL PRPLHPTPVV DWDARPLPPP PAYDDVAQDE 720
DDFEVCSINS TPVGAGVPAG PSQGQTNYAF VPEQARPPPP LEDNLFLPPQ GGGKPPSSAQ 780
TAEIFQALQQ ECMRQLQVPA GSPAPSPSPG GDDKPQVPPR VPIPPRPTRP HVQLSPASSG 840
EEETGRWPGP ASPPRVPPRE PLTPQGSRTP SPLVPSGSSP LPSRLSSSPG KTMPTTQSFA 900
SDPKYATPQV IQAPGPRAGP CILPIVRDGK KVSSTHYYLL PERPSYLERY QRFLREARSP 960
EEPAPLPVPL LLPPPSTPAP AAPTATVRPM PQAALDPKAN FSTNNSNPGA RPPAPRATAR 1020
PPQRGCPGDG PEAGRPADKI QMVEQLFGLG LRPRGECHKV LEMFDWNLEQ AGCHLLGSWG 1080
PAHHKR 1086
Nucleotide Sequence
(FASTA)
ATGCTCGAGG CCCGGCCTCC CAGGACGCAG GGCAGTGACG CTGCCGGTGC CGCTGCGGGG 60
CGGGGGCTGC GGGCGCTGCT TCTCTCCCTG ACCGCAGCCA CTGGGCTTTT GGGCTCCATG 120
GGGGAGAGAT CTGCTTACCA GCGCCTGGCT GGGAGCGAGG AGGGACCGCA GAGGCTGGGA 180
GGCGGCAGCA TGCAGCCAGA GGAGGGCACA GGCTGGCTGC TGGAGCTGCT GTCCGAGGTG 240
CAGCTGCAAC AGTACTTCCT GCGGCTCCGA GATGACCTCA ATATCACCCG CCTGTCCCAC 300
TTTGAGTACG TCAAGAATGA GGACCTGGAG AAGATCGGCA TGGGCCGGCC TGGCCAGCGG 360
CGGCTGTGGG AGGCTGTGAA GAGGAGGAAG GCCTTGTGCA AACGCAAGTC GTGGATGAGT 420
AAGGTGTTCA GTGGAAAGCG ACTGGAGGCT GAGTTCCCCG CTCATCACTC TCAGAGCACC 480
TTCCGGAAGA CCTCGCCCGC CCCTGGGGGC CCAGCAGGGG AGGGACCCCT GCAGAGCCTT 540
ACCTGCCTCA TTGGGGAGAA GGACCTGCGC CTCCTGGAGA AGCTGGGCGA TGGCTCCTTT 600
GGCGTGGTGC GCAGGGGCGA GTGGGACGCG CCCTCAGGGA AGACGGTGAG TGTGGCTGTG 660
AAGTGCCTGA AGCCCGATGT CCTGAGCCAG CCGGAAGCCA TGGACGACTT CATCCGGGAG 720
GTCAATGCTA TGCACTCGCT CGACCACCGA AACCTCATCC GCCTCTACGG GGTGGTGCTC 780
ACGCCGCCCA TGAAGATGGT GACAGAGCTG GCACCTCTGG GATCGTTGTT GGACCGGCTA 840
CGTAAGCACC AGGGCCACTT CCTCCTGGGG ACTCTGAGCC GCTACGCTGT GCAGGTGGCT 900
GAGGGCATGG GCTACCTGGA GTCCAAGCGC TTTATTCACC GTGACCTGGC TGCCCGCAAT 960
CTGCTGTTGG CTACCCGCGA CCTGGTCAAG ATCGGGGACT TTGGGCTGAT GCGAGCACTA 1020
CCTCAGAATG ACGACCATTA CGTCATGCAG GAACATCGCA AGGTGCCCTT CGCCTGGTGT 1080
GCCCCTGAGA GCCTGAAGAC ACGCACCTTC TCCCATGCCA GCGACACCTG GATGTTCGGG 1140
GTGACACTGT GGGAAATGTT CACCTACGGC CAGGAGCCCT GGATCGGCCT CAACGGCAGT 1200
CAGATCCTGC ATAAGATCGA CAAAGAGGGG GAGCGGCTGC CTCGGCCCGA GGACTGTCCC 1260
CAGGACATCT ACAATGTCAT GGTCCAGTGC TGGGCTCACA AGCCAGAGGA CAGACCCACG 1320
TTTGTGGCCC TGCGGGACTT CCTGCTGGAG GCCCAGCCCA CGGACATGCG GGCCCTTCAG 1380
GACTTTGAGG AAGCGGACAA GCTGCACATC CAGATGAATG ATGTCATCAC CGTTATCGAG 1440
GGAAGGGCCG AGAACTACTG GTGGCGTGGC CAGAACACGC GGACGCTGTG TGTGGGGCCC 1500
TTCCCTCGCA ACGTGGTGAC CTCCGTGGCC GGCCTGTCGG CCCAGGACAT CAGCCAGCCC 1560
TTGCAGAACA GCTTCATCCA CACGGGGCAT GGCGACAGTG ACCCCCGCCA CTGCTGGGGC 1620
TTCCCGGACA GGATTGACGA ACTGTATCTG GGAAACCCCC TGGACCCCCC CGACCTGCTG 1680
AGCGTGGAAC TGAGCACCTC CCGGCCCCCC CAGCATCTAG GAGGGGTGAA AAGGGAGCCT 1740
CCACCTCGCC CACCTCAGCC TGCCTTCTTC ACTCAGAAAC CAACCTATGA CCCTGTGAGC 1800
GAAGACCAAG ACCCCCTGTC CAGCGACTTC AAGAGGCTGG GCCTGCGGAA GCCAGGCCTG 1860
CCCCGAGGGC TGTGGCTGGC GAAGCCCTCG GCGCGCGTGC CGGGCACCAA GGCCGGCCGA 1920
GGCAGCGGGG CTGAGGTCAC GCTCATCGAC TTTGGTGAGG AGCCCGTGGT CCCGGCCCTA 1980
CGGCCCTGTG CGCCCTCCCT GGCGCAGCTG GCCATGGACG CCTGCTCCCT GCTGGACGAG 2040
ACCCCGCCTC AGAGCCCCAC GCGGGCACTG CCCCGGCCCC TGCACCCCAC GCCTGTGGTG 2100
GACTGGGACG CACGCCCGCT GCCTCCCCCG CCCGCTTATG ACGATGTGGC CCAGGATGAG 2160
GATGACTTTG AGGTCTGCTC CATCAACAGC ACCCCGGTGG GCGCGGGGGT CCCTGCCGGG 2220
CCCAGCCAGG GCCAGACCAA CTACGCATTT GTGCCTGAGC AGGCGCGGCC GCCCCCTCCC 2280
CTAGAGGACA ACCTGTTCCT CCCGCCCCAG GGTGGGGGCA AGCCGCCCAG CTCCGCACAG 2340
ACGGCAGAGA TCTTCCAGGC TCTACAGCAG GAGTGCATGA GGCAACTGCA GGTTCCAGCC 2400
GGCTCCCCGG CCCCCTCTCC CAGCCCGGGG GGTGACGACA AGCCCCAGGT GCCCCCTCGG 2460
GTACCCATCC CCCCTCGGCC GACGCGCCCA CACGTCCAGC TGTCTCCAGC CTCCTCGGGC 2520
GAGGAGGAGA CCGGTCGGTG GCCTGGACCT GCCTCCCCTC CCCGGGTGCC TCCACGGGAG 2580
CCCCTGACCC CTCAAGGCTC GAGGACACCC AGCCCCCTGG TACCATCTGG CAGCTCCCCG 2640
CTGCCATCCC GGCTCTCAAG CTCACCTGGG AAGACCATGC CCACCACCCA GAGCTTCGCC 2700
TCAGACCCCA AGTACGCCAC CCCCCAGGTG ATCCAGGCGC CTGGCCCGCG GGCCGGTCCC 2760
TGCATCCTGC CCATCGTCCG GGATGGCAAG AAGGTCAGCA GCACCCACTA TTACTTGCTG 2820
CCCGAGCGAC CGTCCTACCT GGAGCGCTAC CAGCGCTTCC TGCGTGAGGC CCGGAGCCCC 2880
GAGGAGCCAG CCCCGCTGCC TGTGCCTCTG CTGCTGCCCC CCCCCAGCAC CCCAGCCCCC 2940
GCCGCCCCCA CGGCCACCGT GCGGCCGATG CCCCAGGCCG CCTTGGACCC CAAGGCCAAC 3000
TTCTCCACCA ACAACAGCAA CCCAGGGGCC CGGCCACCAG CCCCGAGGGC CACTGCTCGG 3060
CCACCACAGA GGGGCTGCCC TGGCGATGGG CCAGAGGCGG GCCGACCAGC AGACAAGATC 3120
CAGATGGTGG AGCAGCTCTT TGGGCTGGGT CTACGGCCCA GAGGGGAGTG CCACAAAGTG 3180
CTGGAAATGT TCGACTGGAA CCTGGAGCAG GCCGGCTGCC ACCTTCTGGG CTCCTGGGGC 3240
CCTGCCCACC ACAAGCGCTG A 3261
Domain Profile
S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllkleh  60
         +lleklG+Gsfgvv+rgeW+apsgk+v+vavk+lk+d+l+++e+ ddf+rev+++++l+h
Q: 190   RLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDH  249
         789****************************************99***************
S: 61    enlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayle  120
         +nl+rlyGvvlt p+k+vtela+lgslldrlrk++   ++l+ +l++yavq+aeg+ yle
Q: 250   RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG--HFLLGTLSRYAVQVAEGMGYLE  307
         ***********************************9..9*********************
S: 121   skrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrt  180
         skr++hrdlaarnllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+t
Q: 308   SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT  367
         ************************************************************
S: 181   rkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysll  240
         r+fs+asd+W+fGvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+diy+++
Q: 368   RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVM  427
         ************************************************************
S: 241   lkcWakkpadrpkfsalkekl  261
         ++cWa+kp+drp+f+al+++l
Q: 428   VQCWAHKPEDRPTFVALRDFL  448
         ******************986
Domain Sequence
(FASTA)
RLLEKLGDGS FGVVRRGEWD APSGKTVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH 60
RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK 120
RFIHRDLAAR NLLLATRDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT 180
FSHASDTWMF GVTLWEMFTY GQEPWIGLNG SQILHKIDKE GERLPRPEDC PQDIYNVMVQ 240
CWAHKPEDRP TFVALRDFL 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00323
EKS-ANC-00334
EKS-BOT-00345
EKS-CAE-00280
EKS-CAJ-00351
EKS-CAF-00350
EKS-CAP-00379
EKS-CII-00192
EKS-CIS-00099
EKS-DAR-00712
EKS-DRM-00169
EKS-EQC-00337
EKS-FEC-00333
EKS-GAA-00426
EKS-GOG-00342
EKS-HOS-00352
EKS-ICT-00326
EKS-LAC-00357
EKS-LOA-00354
EKS-MAM-00346
EKS-MEG-00282
EKS-MOD-00338
EKS-MUM-00377
EKS-MUP-00340
EKS-MYL-00346
EKS-NOL-00315
EKS-OCP-00064
EKS-ORN-00449
EKS-ORC-00324
EKS-ORL-00414
EKS-OTG-00350
EKS-PES-00305
EKS-PTV-00086
EKS-RAN-00360
EKS-SUS-00305
EKS-TAG-00421
EKS-TAR-00449
EKS-TEN-00446
EKS-XET-00440
EKS-XIM-00439
Gene Ontology
GO:0030424; C:axon
GO:0030136; C:clathrin-coated vesicle
GO:0005905; C:coated pit
GO:0030425; C:dendrite
GO:0070436; C:Grb2-EGFR complex
GO:0030426; C:growth cone
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:2000369; P:regulation of clathrin-mediated endocytosis
KEGG
InterPros
IPR015116; GTPase_binding.
IPR021619; Inhibitor_Mig-6.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF09027; GTPase_binding; 1.
PF11555; Inhibitor_Mig-6; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50002; SH3; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013