EKS-POA-00113

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00113

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	256.8	2.3E-76	1	186	186

Status

Unreviewed

Ensembl Protein

ENSPPYP00000016219

UniProt Accession

H2PCM5;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014511	ENSPPYP00000016219	ENSPPYT00000016872
ENSPPYG00000014511	ENSPPYP00000016220	ENSPPYT00000016873

Organism

Pongo abelii

Functional Description

Protein Length

1062

Protein Sequence
(FASTA)

GQLVEFLKKM ESRGPLSCDT VLKIFYQTCR AVQHMHRQKP PIIHRDLKVE NLLLSNQGTI 60

KLCDFGSATT ISHYPDYSWS AQRRALVEEE ITRNTTPMYR TPEIIDLYSN FPIGEKQDIW 120

ALGCILYLLC FRQHPFEDGA KLRIVNGKYS IPPHDTQYTV FHSLIRAMLQ VNPEERLSIA 180

EVVHQLQEIA AARNVNPKSP ITELLEQNGG YGNAALSRGP PPPVGPAGSG YSGGLALAEY 240

DQPYGGFLDI LRGGTERLFT NLKDTSSKVI QSVANYAKGD LDISYITSRI AVMSFPAEGV 300

ESALKNSIED VRLFLDSKHP GHYAVYNLSP RTYRPSRFHN RVSECGWAAR RAPHLHTLYN 360

ICRNMHAWLR QDHKNVCVVH CMDGRAASAV AVCSFLCFCR LFSTAEAAVY MFSMKRCPPG 420

IWPSHKRYIE YMCDMVAEEP ITPHSKPILV RAVVMTPVPL FSKQRSGCRP FCEVYVGDER 480

VASTSQEYDK MRDFKIEDGK AVIPLGVTVQ GDVLIVIYHA RSTLGGRLQA KMASMKMFQI 540

QFHTGFVPRN ATTVKFAKYV APACGLVVGA PGGVAGSGRE QQDILSKFGK PELPRQPGST 600

AQYDAGAGSP EAEPTDSDSP PSSSADASRF LHTLDWQEEK EAETGAENAS PKENESALME 660

DRDESEVSDE GGSPISSEGQ EPRADPEPPG LAAGLVQQDL VFEVETPAVL PEPVPQEDGV 720

DLLGLHSEVC AGPAVPPQAC RAPSSNTHLL SCLLGPPEAA SQGPPEDLLG EAPLLLASPA 780

PPLSVQSTPR GGPPAVADPF GPLLPSSGSN SQPCSNPDLF GEFLNSDSVS IPPSFPSAHS 840

APPPSCSADF LHLGNLPGEP SKMTASSSNP DLLGGWAAWT ETAASAVAPT PATEGPLFSP 900

GGQPAPCGSQ ASWTKSQNPD PFADLGDLSS GLQGSPAGFP PGGFVPKTAT TPKGSSSWQT 960

SRPPAQGASW PPQAKPPPKA CTQPRPNYAS NFSVIGAREE RGVRTPSFAQ KPKVSENDFE 1020

DLLSNQGFSS RSDKKGPKTI AEMRKQDLAK DMDPLKLKVG GW 1062

Nucleotide Sequence
(FASTA)

GGGCAGCTGG TGGAATTTTT GAAGAAAATG GAATCTCGAG GTCCCCTGTC GTGTGACACG 60

GTTCTGAAGA TCTTCTACCA GACATGCCGT GCCGTGCAGC ACATGCACCG GCAGAAGCCG 120

CCCATCATCC ACAGGGACCT CAAGGTTGAG AACTTGTTGC TTAGTAACCA AGGGACCATT 180

AAGCTGTGTG ACTTTGGCAG TGCCACGACC ATCTCGCACT ACCCTGACTA CAGCTGGAGT 240

GCCCAGAGGC GAGCCCTGGT GGAGGAAGAG ATCACGAGGA ACACAACACC AATGTATAGA 300

ACGCCAGAAA TCATAGACTT GTATTCCAAC TTCCCGATCG GCGAGAAGCA GGATATCTGG 360

GCCCTGGGCT GCATCTTGTA CCTGCTGTGC TTCCGGCAGC ACCCTTTTGA GGATGGAGCG 420

AAACTTCGAA TAGTCAATGG GAAGTACTCA ATCCCCCCGC ACGACACGCA GTACACGGTC 480

TTCCACAGCC TCATCCGCGC CATGCTGCAG GTGAACCCGG AGGAGCGGCT GTCCATCGCC 540

GAGGTGGTGC ACCAGCTGCA GGAGATAGCG GCTGCCCGCA ACGTGAACCC CAAGTCTCCC 600

ATCACAGAGC TCCTGGAGCA GAATGGAGGC TACGGGAACG CCGCGCTGTC CCGAGGGCCA 660

CCCCCTCCCG TGGGTCCCGC TGGCAGTGGC TACAGTGGAG GCCTGGCCCT GGCGGAGTAC 720

GACCAGCCCT ACGGCGGCTT CCTGGACATT CTGCGGGGTG GGACAGAGCG GCTCTTCACC 780

AACCTCAAGG ACACCTCCTC CAAGGTCATA CAGTCCGTCG CTAATTATGC AAAGGGTGAC 840

CTGGACATAT CTTACATCAC ATCCAGAATT GCAGTGATGT CGTTCCCAGC AGAAGGTGTG 900

GAGTCAGCGC TTAAAAACAG CATCGAAGAT GTGCGGTTGT TCCTGGATTC CAAGCACCCA 960

GGGCACTATG CCGTCTACAA CCTGTCCCCG AGGACCTACC GGCCCTCCAG GTTCCACAAC 1020

CGGGTCTCCG AGTGTGGCTG GGCAGCACGG CGGGCCCCGC ACCTGCACAC CCTGTACAAC 1080

ATCTGCAGGA ACATGCACGC CTGGCTGCGG CAGGACCACA AGAACGTCTG CGTCGTGCAC 1140

TGCATGGACG GGAGAGCTGC ATCTGCTGTG GCCGTCTGCT CCTTCCTGTG CTTCTGCCGT 1200

CTCTTCAGCA CTGCGGAGGC TGCCGTGTAC ATGTTCAGCA TGAAGCGCTG CCCACCAGGC 1260

ATCTGGCCGT CCCACAAAAG GTACATCGAG TACATGTGTG ACATGGTGGC AGAGGAGCCC 1320

ATCACACCCC ACAGCAAGCC CATCCTGGTG AGGGCCGTGG TCATGACGCC CGTGCCGCTG 1380

TTCAGCAAGC AGAGGAGCGG CTGCAGGCCC TTCTGCGAGG TCTACGTGGG GGACGAGCGT 1440

GTGGCCAGCA CCTCCCAGGA GTACGACAAG ATGCGGGATT TTAAGATTGA GGATGGCAAA 1500

GCGGTGATTC CCCTGGGCGT CACGGTGCAA GGAGACGTGC TTATTGTCAT CTATCACGCC 1560

CGGTCCACTC TGGGCGGCCG GCTGCAGGCC AAGATGGCAT CCATGAAGAT GTTCCAGATT 1620

CAATTCCACA CGGGATTTGT GCCTCGGAAC GCCACCACTG TGAAATTTGC CAAGTATGTT 1680

GCACCTGCAT GTGGGCTGGT TGTGGGAGCC CCAGGGGGAG TGGCGGGCTC CGGGAGAGAG 1740

CAGCAAGACA TTCTGTCTAA GTTTGGGAAG CCGGAGCTTC CCCGGCAGCC CGGCTCCACG 1800

GCTCAGTATG ATGCTGGGGC AGGGTCCCCG GAAGCCGAAC CCACGGACTC TGACTCACCG 1860

CCAAGCAGCA GCGCGGACGC CAGTCGCTTC CTGCACACGC TGGACTGGCA GGAAGAGAAG 1920

GAGGCAGAGA CTGGTGCAGA AAATGCCTCT CCCAAGGAGA ACGAGTCTGC CCTGATGGAG 1980

GACAGAGACG AGAGCGAGGT GTCCGACGAA GGGGGGTCCC CGATCTCCAG CGAGGGCCAG 2040

GAGCCCAGGG CCGACCCGGA GCCCCCTGGC CTGGCAGCAG GGCTGGTGCA GCAGGACTTG 2100

GTTTTTGAGG TGGAGACGCC GGCTGTGCTG CCGGAGCCTG TGCCACAGGA AGACGGGGTC 2160

GACCTCCTGG GCCTGCACTC CGAGGTGTGC GCAGGGCCAG CTGTACCCCC GCAGGCCTGT 2220

AGGGCCCCCT CCAGCAACAC TCACCTGCTC AGCTGCCTCC TTGGGCCCCC CGAGGCCGCC 2280

TCCCAGGGGC CCCCGGAGGA TCTGCTCGGC GAGGCCCCCC TGCTCCTGGC AAGCCCGGCC 2340

CCTCCCCTGA GCGTGCAGAG CACCCCAAGA GGAGGGCCCC CTGCCGTTGC TGACCCCTTC 2400

GGCCCGCTCC TGCCATCTTC AGGCAGCAAC TCCCAGCCCT GCTCCAATCC TGATCTCTTC 2460

GGTGAATTTC TCAATTCGGA CTCTGTGAGC ATCCCACCGT CCTTCCCGTC TGCCCACAGT 2520

GCCCCGCCCC CGTCCTGCAG CGCCGACTTC CTGCACCTGG GGAATCTGCC AGGAGAGCCC 2580

AGCAAGATGA CAGCCTCATC CAGCAACCCA GACCTGCTGG GAGGATGGGC TGCCTGGACC 2640

GAGACTGCGG CGTCGGCAGT GGCCCCCACA CCAGCCACGG AAGGCCCCCT CTTCTCTCCT 2700

GGAGGTCAGC CGGCCCCTTG TGGCTCTCAG GCCAGCTGGA CCAAGTCTCA GAACCCGGAC 2760

CCATTTGCTG ACCTTGGCGA CCTCAGCTCC GGCCTCCAAG GCTCACCAGC TGGATTCCCT 2820

CCTGGGGGCT TCGTTCCCAA AACGGCCACC ACGCCCAAAG GCAGTAGCTC CTGGCAGACA 2880

AGTCGGCCGC CAGCCCAGGG CGCCTCATGG CCCCCTCAGG CCAAGCCGCC CCCCAAAGCC 2940

TGCACACAGC CAAGGCCTAA CTATGCCTCG AACTTCAGTG TGATCGGGGC GCGAGAGGAG 3000

CGGGGGGTCC GCACACCCAG CTTTGCTCAA AAGCCAAAAG TCTCTGAGAA CGACTTTGAA 3060

GATCTGTTGT CCAATCAAGG CTTCTCCTCC AGGTCTGACA AGAAAGGGCC AAAGACCATT 3120

GCAGAGATGA GGAAGCAGGA CCTGGCTAAA GACATGGACC CGCTCAAGCT GAAGGTGGGT 3180

GGGTGG 3186

Domain Profile

S: 88    gslvdllnkrlekgelseaeilkilldvtravaalHalsvpliHRDlkveNillsdegel  147

         g+lv++l+k++++g ls++++lki+++++rav+++H++++p+iHRDlkveN+lls++g++

Q: 1     GQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTI  60

         79**********************************************************

S: 148   vlcDlGSattaileve...skqelsalqeeieknttlsyrsPElidlysnlvideksDiW  204

         +lcD+GSatt+++ ++   s+q+++ ++eei++ntt++yr+PE+idlysn++i+ek+DiW

Q: 61    KLCDFGSATTISHYPDyswSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIW  120

         ***************999999***************************************

S: 205   aLGcllYklcffesPfeesvklailngkysiPensryseklkslikkmlevdpeeRptia  264

         aLGc+lY lcf+++Pfe+++kl+i+ngkysiP+++++++ ++sli++ml+v+peeR++ia

Q: 121   ALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIA  180

         ************************************************************

S: 265   qvlell  270

         +v+++l

Q: 181   EVVHQL  186

         **9986

Domain Sequence
(FASTA)

GQLVEFLKKM ESRGPLSCDT VLKIFYQTCR AVQHMHRQKP PIIHRDLKVE NLLLSNQGTI 60

KLCDFGSATT ISHYPDYSWS AQRRALVEEE ITRNTTPMYR TPEIIDLYSN FPIGEKQDIW 120

ALGCILYLLC FRQHPFEDGA KLRIVNGKYS IPPHDTQYTV FHSLIRAMLQ VNPEERLSIA 180

EVVHQL 186

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013