EKS-POA-00146
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00146
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR192.01.1E-5641350896
StatusUnreviewed
Ensembl ProteinENSPPYP00000016240
UniProt AccessionH2PCP6;
Protein Name
Protein Synonyms/Alias
Gene NameFGFR3
Gene Synonyms/Alias FGFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000014532ENSPPYP00000016240ENSPPYT00000016896
OrganismPongo abelii
Functional Description
Protein Length566
Protein Sequence
(FASTA)
VLGPEPGQQE QLVFGSGDAV ELSCPPPGGG PMGPTVWVKD GTGLVPSERV LVGPQRLQVL 60
NASHEDSGAY SCRQRLTQRV LCHFSVRVTD APSSGDDEDG EDEAEDTGVD TGAPYWTRPE 120
RMDKKLLAVP AANTVRFRCP AAGNPTPSIS WLKNGKEFRG EHRIGGIKLR HQQWSLVMES 180
VVPSDRGNYT CVVENKFGSI RQTYTLDVLE RSPHRPILQA GLPANQTAVL GSDVEFHCKV 240
YSDAQPHIQW LKHVEVNGSK VGPDGTPYVT VLKTAGANTT DKELEVLSLH NVTFEDAGEY 300
TCLAGNSIGF SHHSAWLVVL PAEEELVEAD EAGSVYAGIL SYGVGFFLFI LVVAAVTLCR 360
LRSPPKKGLG SPTVHKISRF PLKRQVSLES NASMSSNTPL VRIARLSSGE GPTGRLPVKW 420
MAPEALFDRV YTHQSDVWSF GVLLWEIFTL GGSPYPGIPV EELFKLLKEG HRMDKPANCT 480
HDLYMIMREC WHAAPSQRPT FKQLVEDLDR VLTVTSTDEY LDLSAPFEQY SPGGQDTPSC 540
SSSGDDSVFA HDLLPPAPPS SGGSRT 566
Nucleotide Sequence
(FASTA)
GTCCTGGGCC CAGAGCCCGG CCAGCAGGAG CAGTTGGTCT TCGGCAGCGG GGATGCTGTG 60
GAGCTGAGCT GTCCCCCGCC CGGGGGTGGT CCCATGGGGC CCACTGTCTG GGTCAAGGAT 120
GGCACAGGGC TGGTGCCCTC GGAGCGTGTC CTGGTGGGGC CCCAGCGGCT GCAGGTGCTG 180
AATGCCTCCC ACGAGGACTC CGGGGCCTAC AGCTGCCGGC AGCGGCTCAC GCAGCGCGTA 240
CTGTGCCACT TCAGTGTGCG GGTGACAGAC GCTCCATCCT CAGGAGATGA CGAAGACGGG 300
GAGGACGAGG CTGAGGACAC AGGTGTGGAC ACAGGGGCCC CTTACTGGAC TCGGCCCGAG 360
CGGATGGACA AGAAGCTGCT GGCCGTGCCG GCCGCCAACA CCGTCCGCTT CCGCTGCCCG 420
GCCGCCGGCA ACCCCACTCC CTCCATCTCC TGGCTGAAGA ATGGCAAGGA GTTCCGCGGC 480
GAGCACCGCA TCGGAGGCAT CAAGCTGCGG CACCAGCAGT GGAGCCTGGT CATGGAAAGC 540
GTGGTGCCCT CAGACCGCGG CAACTACACC TGCGTAGTGG AGAACAAGTT TGGCAGCATC 600
CGGCAGACAT ACACGCTGGA TGTGCTGGAG CGCTCCCCGC ACCGGCCCAT CCTGCAGGCG 660
GGGCTGCCGG CCAACCAGAC GGCGGTGCTG GGCAGCGATG TGGAGTTCCA CTGCAAGGTG 720
TACAGTGACG CACAGCCCCA CATCCAGTGG CTCAAGCACG TGGAGGTGAA CGGCAGCAAG 780
GTGGGCCCGG ACGGCACACC CTACGTTACC GTGCTCAAGA CGGCGGGCGC TAACACCACC 840
GACAAGGAGC TAGAGGTTCT GTCCTTGCAC AACGTCACCT TTGAGGACGC CGGGGAGTAC 900
ACCTGCCTGG CGGGCAATTC TATTGGGTTT TCTCATCACT CTGCGTGGCT GGTGGTGCTG 960
CCAGCTGAGG AGGAGCTGGT GGAGGCTGAC GAGGCGGGCA GTGTGTATGC AGGCATCCTC 1020
AGCTACGGGG TGGGCTTCTT CTTGTTCATC CTGGTGGTGG CGGCTGTGAC GCTCTGCCGC 1080
CTACGCAGCC CCCCCAAGAA AGGCCTGGGC TCCCCCACCG TGCACAAGAT CTCCCGCTTC 1140
CCGCTCAAGC GACAGGTGTC CCTGGAGTCC AACGCGTCCA TGAGCTCCAA CACACCGCTG 1200
GTGCGCATCG CAAGGCTGTC CTCAGGGGAG GGCCCCACGG GCCGGCTGCC CGTGAAGTGG 1260
ATGGCGCCTG AGGCCTTGTT TGACCGAGTC TACACTCACC AGAGTGACGT CTGGTCCTTT 1320
GGGGTCCTGC TCTGGGAGAT CTTCACGCTG GGGGGCTCCC CGTACCCCGG CATCCCTGTG 1380
GAGGAGCTCT TCAAGCTGCT GAAGGAGGGA CACCGCATGG ACAAGCCCGC CAACTGCACA 1440
CACGACCTGT ACATGATCAT GCGGGAGTGC TGGCATGCTG CACCCTCCCA GAGGCCCACC 1500
TTCAAGCAGC TGGTGGAGGA CCTGGACCGT GTCCTTACCG TGACATCCAC CGATGAGTAC 1560
CTGGACCTGT CGGCGCCTTT CGAGCAGTAC TCTCCTGGTG GCCAGGACAC CCCCAGCTGC 1620
AGCTCCTCAG GGGATGACTC CGTGTTTGCC CACGACCTGC TGCCCCCGGC CCCACCCAGC 1680
AGTGGGGGCT CGCGGACGTG A 1701
Domain Profile
S: 182   nGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGhr  241
          Grlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGhr
Q: 413   TGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR  472
         69**********************************************************
S: 242   mekpakctkelyvlmrecwhakaserptfkqlvedl  277
         m+kpa+ct++ly++mrecwha++s+rptfkqlvedl
Q: 473   MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL  508
         **********************************97
Domain Sequence
(FASTA)
TGRLPVKWMA PEALFDRVYT HQSDVWSFGV LLWEIFTLGG SPYPGIPVEE LFKLLKEGHR 60
MDKPANCTHD LYMIMRECWH AAPSQRPTFK QLVEDL 96
KeywordComplete proteome; Disulfide bond; Immunoglobulin domain; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0009898; C:internal side of plasma membrane
GO:0005764; C:lysosome
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0061144; P:alveolar secondary septum development
GO:0060385; P:axonogenesis involved in innervation
GO:0060349; P:bone morphogenesis
GO:0051216; P:cartilage development
GO:0022010; P:central nervous system myelination
GO:0090102; P:cochlea development
GO:0048546; P:digestive tract morphogenesis
GO:0072148; P:epithelial cell fate commitment
GO:0060113; P:inner ear receptor cell differentiation
GO:0070307; P:lens fiber cell development
GO:0002089; P:lens morphogenesis in camera-type eye
GO:0000165; P:MAPK cascade
GO:0002009; P:morphogenesis of an epithelium
GO:0043066; P:negative regulation of apoptotic process
GO:0048712; P:negative regulation of astrocyte differentiation
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0045879; P:negative regulation of smoothened signaling pathway
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597; P:positive regulation of cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518; P:positive regulation of phospholipase activity
GO:0031398; P:positive regulation of protein ubiquitination
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777; P:protein autophosphorylation
GO:0048678; P:response to axon injury
GO:0035019; P:somatic stem cell maintenance
GO:0021762; P:substantia nigra development
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF07679; I-set; 2.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
Prosites
PS50835; IG_LIKE; 3.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013