EKS-POA-00101
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00101
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec486.41.6E-146271521251
StatusUnreviewed
Ensembl ProteinENSPPYP00000016438
UniProt AccessionH2PD90;
Protein Name
Protein Synonyms/Alias
Gene NameTXK
Gene Synonyms/Alias TXK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000014715ENSPPYP00000016438ENSPPYT00000017107
OrganismPongo abelii
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MILSSYNTIQ SVFCCCCCCS VQKRQVRTQI SLSTDEELPE KYTQRRRPWL SQLSNKKQSS 60
TGRVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN LALRRAEEYL ILEKYNPHWW 120
KARDRLGNEG LIPSNYVTEN KITNLEIYEW YHRNITRNQA EHLLRQESKE GAFIVRDSRH 180
LGSYTISVFM GARRSTEAAI KHYQIKKNDS GQWYVAERHV FQSIPELIWY HQHNAAGLMT 240
RLRYPVGLMG SCLPATAGFS YEKWEIDPSE LAFIKEIGSG QFGVVHLGEW RSHIQVAIKA 300
INEGSMSEED FIEEAKVMMK LSHSKLVQLY GVCIQRKPLY IVTEFMENGC LLNYLRENKG 360
KLRKEMLLSV CQDICEGMEY LERNGYIHRD LAARNCLVSS TCIVKISDFG MTRYVLDDEY 420
VSSFGAKFPI KWSPPEVFLF NKYSSKSDVW SFGVLMWEVF TEGKMPFENK SNLQVVEAIS 480
KGFRLYRPHL APMSIYEVMY SCWHEKPEGR PTFAELLRAL TEIAETW 527
Nucleotide Sequence
(FASTA)
ATGATCCTTT CCTCCTATAA CACCATCCAG TCGGTTTTCT GTTGCTGCTG TTGCTGTTCA 60
GTGCAGAAGC GACAAGTGAG AACACAGATA AGCCTGAGCA CAGATGAAGA GCTTCCAGAA 120
AAATACACCC AGCGCCGCAG GCCGTGGCTC AGCCAATTGT CAAATAAGAA GCAATCCAGC 180
ACGGGCCGTG TGCAGCCGTC AAAACGAAAG CCACTGCCTC CCCTCCCACC CTCTGAGGTT 240
GCTGAAGAGA AGATCCAAGT CAAGGCACTT TATGATTTTC TGCCCAGAGA ACCCTGTAAT 300
TTAGCCTTAA GGAGAGCAGA AGAATACCTG ATACTGGAGA AATATAATCC TCACTGGTGG 360
AAGGCAAGAG ACCGTTTGGG GAATGAAGGC TTAATCCCAA GCAACTATGT GACTGAAAAC 420
AAAATAACTA ATTTGGAAAT ATATGAGTGG TACCATAGAA ACATTACCAG AAATCAGGCA 480
GAACATCTAT TGAGACAAGA GTCTAAAGAA GGTGCATTTA TTGTCAGAGA TTCAAGACAT 540
TTAGGATCCT ACACAATTTC CGTATTTATG GGAGCTAGAA GAAGTACGGA GGCTGCCATA 600
AAACATTATC AGATAAAAAA GAATGACTCA GGACAGTGGT ATGTGGCTGA AAGACACGTC 660
TTTCAATCAA TCCCTGAGTT AATCTGGTAT CACCAGCACA ATGCAGCCGG TCTCATGACT 720
CGTCTCCGAT ATCCAGTAGG GCTGATGGGC AGTTGTTTAC CAGCCACAGC TGGGTTTAGC 780
TACGAAAAGT GGGAGATAGA TCCATCTGAG TTGGCTTTTA TAAAGGAGAT TGGAAGCGGT 840
CAGTTTGGAG TGGTCCATTT AGGTGAATGG CGATCACATA TCCAGGTAGC TATCAAGGCC 900
ATCAATGAAG GCTCCATGTC TGAAGAGGAT TTCATTGAAG AGGCCAAAGT GATGATGAAA 960
TTATCTCATT CAAAGCTAGT GCAACTTTAT GGGGTCTGTA TACAGCGGAA GCCCCTTTAC 1020
ATTGTGACAG AGTTCATGGA AAATGGCTGC CTGCTTAACT ATCTCAGGGA GAATAAAGGA 1080
AAGCTCAGGA AGGAAATGCT ACTGAGTGTA TGCCAGGATA TATGTGAAGG AATGGAATAT 1140
CTGGAGAGGA ATGGCTATAT TCATAGGGAT TTGGCGGCAA GGAATTGTTT GGTCAGTTCA 1200
ACATGCATAG TAAAAATTTC GGACTTTGGA ATGACAAGGT ACGTTTTGGA TGATGAGTAT 1260
GTCAGTTCTT TTGGAGCCAA GTTCCCAATC AAGTGGTCCC CTCCTGAAGT TTTTCTTTTC 1320
AATAAGTACA GCAGTAAATC TGATGTCTGG TCATTTGGAG TTTTAATGTG GGAAGTTTTT 1380
ACAGAAGGAA AAATGCCTTT TGAAAATAAG TCAAATTTGC AAGTCGTGGA AGCTATTTCT 1440
AAAGGCTTCA GGCTATATCG CCCTCACCTG GCACCAATGT CCATATATGA AGTCATGTAC 1500
AGCTGCTGGC ATGAGAAACC TGAAGGCCGC CCTACGTTTG CCGAGCTGCT GCGGGCTCTC 1560
ACAGAGATTG CGGAAACCTG GTGA 1584
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         l+++ke+gsgqfgvv+lg+wr++i+vaikai+eg+mseedfieeakvmmklsh+klvqly
Q: 271   LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLY  330
         68**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+++kp+yivte++engcllnylre+k+kl+ke+ll++c+d+cegmeyler+ +ihrd
Q: 331   GVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRD  390
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++++vk+sdfg++ryvldd+yvss gakfp+kwsppev+ ++kyssksdvw
Q: 391   LAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVW  450
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+p+e+ksn +vve++s+g+rlyrp+la++++yevm+scw+ekpe+r
Q: 451   SFGVLMWEVFTEGKMPFENKSNLQVVEAISKGFRLYRPHLAPMSIYEVMYSCWHEKPEGR  510
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ell+al+
Q: 511   PTFAELLRALT  521
         ********986
Domain Sequence
(FASTA)
LAFIKEIGSG QFGVVHLGEW RSHIQVAIKA INEGSMSEED FIEEAKVMMK LSHSKLVQLY 60
GVCIQRKPLY IVTEFMENGC LLNYLRENKG KLRKEMLLSV CQDICEGMEY LERNGYIHRD 120
LAARNCLVSS TCIVKISDFG MTRYVLDDEY VSSFGAKFPI KWSPPEVFLF NKYSSKSDVW 180
SFGVLMWEVF TEGKMPFENK SNLQVVEAIS KGFRLYRPHL APMSIYEVMY SCWHEKPEGR 240
PTFAELLRAL T 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00100
EKS-BOT-00109
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-EQC-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GAG-00089
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MAM-00104
EKS-MEG-00084
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MUP-00112
EKS-MYL-00122
EKS-NOL-00101
EKS-ORC-00100
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-RAN-00106
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0001865; P:NK T cell differentiation
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
pon:100455862;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013