EKS-POA-00099

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00099

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	492.5	2.2E-148	254	504	251

Status

Unreviewed

Ensembl Protein

ENSPPYP00000016439

UniProt Accession

H2PD91;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014716	ENSPPYP00000016439	ENSPPYT00000017108

Organism

Pongo abelii

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

MIKYHPKFWT DGSYQCCRQT EKLAPGCEKY NLFESSIRKA LPPAPETKKR RPPPPIPLEE 60

EDNSEEIVVA MYDFQATEGH DLRLERGQEY LILEKNDVHW WRARDKYGNE GYIPSNYVTG 120

KKSNNLDQYE WYCRNMNRSK AEQLLRSEDK EGGFMVRDSS QPGLYTVSLY TKFGGEGSSG 180

FRHYHIKETT TSPKKYYLAE KHAFGSIPEI IEYHKHNAAG LVTRLRYPVS VKGKNAPTTA 240

GFSYEKWEIN PSELTFMREL GSGLFGVVRL GKWRAQYKVA IKAIREGAMC EEDFIEEAKV 300

MMKLTHPKLV QLYGVCTQQK PIYIVTEFME RGCLLNFLRQ RQGHFSRDVL LSMCQDVCEG 360

MEYLERNSFI HRDLAARNCL VSEAGVVKVS DFGMARYVLD DQYTSSSGAK FPVKWCPPEV 420

FNYSRFSSKS DVWSFGVLMW EVFTEGRMPF EKYTNYEVVT MVTRGHRLYQ PKLASNYVYE 480

VMLRCWQEKP EGRPSFEDLL RTIDELVECE ETFGR 515

Nucleotide Sequence
(FASTA)

ATGATTAAAT ATCATCCTAA ATTCTGGACA GATGGAAGTT ATCAGTGTTG TAGACAAACT 60

GAAAAATTAG CACCCGGATG TGAAAAATAC AATCTTTTTG AGAGTAGTAT AAGGAAAGCA 120

CTACCTCCAG CACCAGAAAC AAAGAAGCGA AGGCCTCCCC CACCAATTCC ACTAGAAGAA 180

GAAGATAACA GTGAAGAAAT CGTTGTAGCC ATGTATGATT TCCAAGCGAC AGAAGGACAT 240

GATCTCAGAT TAGAGAGAGG CCAAGAGTAT CTCATTTTAG AAAAGAATGA TGTTCATTGG 300

TGGAGAGCAA GAGATAAATA TGGGAATGAA GGATATATCC CAAGTAATTA TGTAACGGGA 360

AAGAAATCAA ACAACTTAGA TCAATATGAA TGGTATTGCA GAAATATGAA TAGAAGTAAG 420

GCAGAGCAAC TCCTCCGCAG TGAAGATAAA GAAGGTGGTT TTATGGTAAG GGATTCCAGT 480

CAACCAGGCT TGTACACAGT CTCCCTTTAT ACCAAGTTTG GAGGAGAAGG TTCATCGGGT 540

TTCAGGCATT ATCATATAAA GGAAACAACA ACATCTCCAA AGAAGTATTA CCTAGCTGAA 600

AAACATGCTT TTGGCTCCAT TCCTGAGATT ATTGAATATC ATAAGCACAA TGCAGCAGGA 660

CTTGTCACCC GGCTTCGGTA CCCAGTTAGT GTGAAAGGGA AGAATGCACC CACCACTGCA 720

GGATTCAGCT ATGAGAAATG GGAGATTAAC CCTTCAGAGC TGACCTTTAT GAGGGAATTG 780

GGAAGTGGAC TGTTTGGAGT GGTGAGGCTT GGCAAATGGC GAGCCCAGTA CAAAGTCGCA 840

ATCAAAGCTA TTCGGGAAGG TGCAATGTGC GAGGAGGACT TTATAGAAGA AGCTAAAGTG 900

ATGATGAAAC TGACACACCC GAAGTTAGTG CAGCTTTATG GTGTATGCAC CCAGCAGAAA 960

CCAATATACA TTGTTACCGA GTTCATGGAA AGGGGCTGCC TTCTGAATTT CCTCCGACAG 1020

AGACAAGGTC ATTTCAGTAG AGACGTGCTG CTGAGCATGT GTCAGGATGT GTGTGAAGGG 1080

ATGGAGTATC TGGAGAGAAA CAGCTTCATC CACAGAGATC TGGCTGCCAG AAATTGTCTA 1140

GTAAGTGAGG CGGGAGTTGT AAAAGTATCT GATTTTGGAA TGGCCAGGTA TGTTCTGGAT 1200

GATCAGTACA CAAGTTCTTC TGGTGCTAAG TTTCCCGTGA AGTGGTGTCC ACCAGAAGTG 1260

TTTAATTACA GCCGCTTCAG CAGCAAATCA GATGTCTGGT CATTTGGTGT TTTAATGTGG 1320

GAAGTATTCA CGGAAGGCAG AATGCCTTTT GAAAAATACA CCAATTATGA AGTGGTAACC 1380

ATGGTCACTC GAGGCCACCG ACTCTACCAG CCGAAGTTGG CGTCCAACTA TGTATATGAG 1440

GTGATGCTGA GATGTTGGCA GGAGAAACCA GAGGGAAGGC CTTCTTTTGA AGATCTGCTG 1500

CGCACAATAG ATGAACTAGT TGAATGTGAA GAAACTTTTG GAAGATAA 1548

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikai+egam+eedfieeakvmmkl+hpklvqly

Q: 254   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY  313

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++qkpiyivte++e+gclln+lr++++++++++ll+mc+dvcegmeyler+sfihrd

Q: 314   GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD  373

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e+ vvkvsdfg+aryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 374   LAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  433

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevf+eg++p+ek++n+evv++v+rg+rly+pklas++vyevm +cw+ekpe+r

Q: 434   SFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGR  493

         ************************************************************

S: 241   ptfkellsale  251

         p+f++ll+++

Q: 494   PSFEDLLRTID  504

         ********995

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMCEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQKPIY IVTEFMERGC LLNFLRQRQG HFSRDVLLSM CQDVCEGMEY LERNSFIHRD 120

LAARNCLVSE AGVVKVSDFG MARYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEVF TEGRMPFEKY TNYEVVTMVT RGHRLYQPKL ASNYVYEVML RCWQEKPEGR 240

PSFEDLLRTI D 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0050853	; P:B cell receptor signaling pathway
GO:0007229	; P:integrin-mediated signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0010543	; P:regulation of platelet activation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013