EKS-POA-00394
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00394
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR604.66.2E-182383718336
StatusUnreviewed
Ensembl ProteinENSPPYP00000016492
UniProt AccessionH2PDE3;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000014766ENSPPYP00000016492ENSPPYT00000017165
OrganismPongo abelii
Functional Description
Protein Length770
Protein Sequence
(FASTA)
AFKAVPVVSV SKASYLLREG EEFTVTCTIK DVSSSVYSTW KRENSQTKLQ EKYNSWHHGD 60
FNYERQATLT ISSARVNDSG VFMCYANNTF GSANVTTTLE VVDKGFINIF PMINTTVFVN 120
DGENVDLIVE YEAFPRPEHQ HWIYMNRTFT DKWEDYPKSE NESNIRYVSE LHLTRLKGTE 180
GGTYTFLVSN SDVNASIAFN VYVNTKPEIL TYDRLVNGML QCVAAGFPEP TIDWYFCPGT 240
EQRCSASVLP VDVQTLNSSG PPFGKLVVQS SVDSSAFKHN GTVECKAYND VGKTSAYFNF 300
AFKGNNKEQI HPHTLFTPLL IGFVIVAGMM CIIVMILTYK YLQKPMYEVQ WKVVEEINGN 360
NYVYIDPTQL PYDHKWEFPR NRLSFGKTLG AGAFGKVVEA TAYGLIKSDA AMTVAVKMLK 420
PSAHLTEREA LMSELKVLSY LGNHMNIVNL LGACTIGGPT LVITEYCCYG DLLNFLRRKR 480
DSFICSKQED HAEAALYKNL LHSKESSCSD STNEYMDMKP GVSYVVPTKA DKRRSARIGS 540
YIERDVTPAI MEDDELALDL EDLLSFSYQV AKGMAFLASK NCIHRDLAAR NILLTHGRIT 600
KICDFGLARD IKNDSNYVVK GNARLPVKWM APESIFNCVY TFESDVWSYG IFLWELFSLG 660
SSPYPGMPVD SKFYKMIKEG FRMLSPEHAP AEMYDIMKTC WDVDPLKRPT FKQIVQLIEK 720
QISESTNHIY SNLANCSPNR QKPVVDHSVR INSVGSTASS SQPLLVHDDV 770
Nucleotide Sequence
(FASTA)
GCCTTCAAAG CTGTGCCTGT TGTGTCTGTG TCCAAAGCAA GCTATCTTCT TAGGGAAGGG 60
GAAGAATTCA CAGTGACGTG CACAATAAAA GATGTGTCTA GTTCTGTGTA CTCAACGTGG 120
AAAAGAGAAA ACAGTCAGAC TAAACTACAG GAGAAATATA ATAGCTGGCA TCACGGTGAC 180
TTCAATTATG AACGTCAGGC AACGTTGACT ATCAGTTCAG CGAGAGTTAA TGATTCTGGA 240
GTGTTCATGT GTTATGCCAA TAATACTTTT GGATCAGCAA ATGTCACAAC AACCTTGGAA 300
GTAGTAGATA AAGGATTCAT TAATATCTTC CCCATGATAA ACACTACAGT ATTTGTAAAC 360
GATGGAGAAA ATGTAGATTT GATTGTTGAA TATGAGGCAT TCCCCAGACC TGAACACCAG 420
CACTGGATCT ATATGAACAG AACCTTCACT GATAAATGGG AAGATTATCC CAAGTCTGAG 480
AATGAAAGTA ATATCAGATA CGTAAGTGAA CTTCATCTAA CCAGATTAAA AGGCACCGAA 540
GGAGGCACTT ACACATTCCT AGTGTCCAAT TCTGACGTCA ATGCTTCCAT AGCATTTAAT 600
GTTTATGTGA ATACAAAACC AGAAATCCTG ACTTACGACA GGCTCGTGAA TGGCATGCTC 660
CAATGTGTGG CAGCAGGATT CCCAGAGCCC ACAATAGATT GGTATTTTTG TCCAGGAACT 720
GAGCAGAGAT GCTCTGCTTC TGTACTGCCA GTGGATGTGC AGACACTAAA CTCATCTGGG 780
CCACCGTTTG GAAAGCTAGT GGTTCAGAGT TCTGTAGATT CTAGTGCATT CAAGCACAAT 840
GGCACGGTTG AATGTAAGGC TTACAACGAT GTGGGCAAGA CTTCTGCCTA TTTTAACTTT 900
GCATTTAAAG GTAACAACAA AGAGCAAATC CATCCCCACA CCCTGTTCAC TCCTTTGCTG 960
ATTGGTTTCG TAATCGTAGC TGGCATGATG TGCATTATTG TGATGATTCT GACCTACAAA 1020
TATTTACAGA AACCCATGTA TGAAGTACAG TGGAAGGTTG TTGAGGAGAT AAATGGAAAC 1080
AATTATGTTT ACATAGACCC AACACAACTT CCTTATGATC ACAAATGGGA GTTTCCCAGA 1140
AACAGGCTGA GTTTTGGGAA AACCCTGGGT GCTGGTGCTT TCGGGAAAGT TGTTGAGGCA 1200
ACTGCTTATG GCTTAATTAA GTCAGATGCG GCTATGACTG TAGCTGTAAA GATGCTCAAA 1260
CCAAGTGCCC ATTTAACAGA ACGGGAAGCC CTCATGTCTG AACTCAAAGT CTTGAGTTAC 1320
CTTGGTAATC ATATGAATAT TGTGAATCTT CTTGGAGCCT GCACCATTGG AGGGCCCACC 1380
TTGGTCATTA CAGAATATTG TTGCTATGGT GATCTTTTGA ATTTTTTGAG AAGAAAACGT 1440
GATTCATTTA TTTGTTCAAA GCAGGAAGAT CATGCAGAAG CTGCACTTTA TAAGAATCTT 1500
CTGCATTCAA AGGAGTCTTC CTGCAGCGAT AGTACCAATG AGTACATGGA CATGAAACCT 1560
GGAGTCTCTT ATGTTGTCCC AACCAAGGCC GACAAAAGGA GATCTGCGAG AATAGGCTCA 1620
TACATAGAAA GAGATGTGAC TCCTGCCATC ATGGAGGATG ATGAGTTGGC CCTAGACTTA 1680
GAAGACTTGC TGAGCTTTTC TTACCAGGTG GCAAAGGGCA TGGCCTTCCT CGCCTCCAAG 1740
AATTGTATTC ACAGAGACTT GGCAGCCAGA AATATCCTCC TTACTCATGG TCGGATCACA 1800
AAGATTTGTG ATTTTGGTCT AGCCAGAGAC ATCAAGAATG ATTCTAATTA TGTGGTTAAA 1860
GGAAACGCTC GACTACCTGT GAAGTGGATG GCACCTGAAA GCATTTTCAA CTGTGTATAC 1920
ACGTTTGAAA GTGACGTCTG GTCCTATGGT ATTTTTCTTT GGGAGCTGTT CTCTTTAGGA 1980
AGCAGCCCCT ATCCTGGAAT GCCGGTCGAT TCTAAGTTCT ACAAGATGAT CAAGGAAGGC 2040
TTCCGGATGC TCAGCCCTGA ACATGCACCT GCTGAAATGT ATGACATAAT GAAGACTTGC 2100
TGGGATGTGG ATCCCCTAAA AAGACCAACA TTCAAGCAAA TTGTTCAGCT AATTGAGAAG 2160
CAGATTTCAG AGAGCACTAA TCACATTTAC TCCAACTTAG CAAACTGCAG CCCCAACCGA 2220
CAGAAGCCCG TGGTGGACCA TTCTGTGCGG ATCAATTCTG TCGGCAGCAC CGCTTCCTCC 2280
TCCCAGCCTC TGCTTGTGCA CGATGACGTC 2310
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 383   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  442
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e++ +k+
Q: 443   NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKN  499
         ******************************************...99999*********9
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++s+s++ey+d+k++vs+v ++kadk++s+++ s++er+v++a++e+d
Q: 500   L-----LHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDD  554
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 555   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  614
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 615   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  674
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++e+y+im++cw+++p krp+fkq+v+l+
Q: 675   KMIKEGFRMLSPEHAPAEMYDIMKTCWDVDPLKRPTFKQIVQLI  718
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDHA EAALYKNLLH 120
SKESSCSDST NEYMDMKPGV SYVVPTKADK RRSARIGSYI ERDVTPAIME DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300
MLSPEHAPAE MYDIMKTCWD VDPLKRPTFK QIVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0035234; P:germ cell programmed cell death
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002320; P:lymphoid progenitor cell differentiation
GO:0008584; P:male gonad development
GO:0002551; P:mast cell chemotaxis
GO:0032762; P:mast cell cytokine production
GO:0043303; P:mast cell degranulation
GO:0002573; P:myeloid leukocyte differentiation
GO:0002318; P:myeloid progenitor cell differentiation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
GO:0007286; P:spermatid development
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013