EKS-POA-00392
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00392
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR614.85.0E-185593950358
StatusUnreviewed
Ensembl ProteinENSPPYP00000016493
UniProt AccessionH2PDE4;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000014767ENSPPYP00000016493ENSPPYT00000017166
OrganismPongo abelii
Functional Description
Protein Length1089
Protein Sequence
(FASTA)
MGTSHPAFLV LGCLLTGLSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GENEVSWQYP 60
MSEEENSNVE IRNEENNSGL FVTVLEVSSA SAAHTGLYTC YYNHTQTEEN ELEGRHIYIY 120
VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LHNSEGVVPA SYDSRQGFNG 180
TFTVGPYICE ATVKGKKFQT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN 240
EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLTVPEA TVKDSGDYEC AARQATREVK 300
EMKKVTISVH EKGFIEIKPT FSQLEAVNLH EVKHFVVEVR AYPPPRISWL KNNLTLIENL 360
TEITTDVEKI QEIRYRSKLK LIRAKEEDSG HYTIVAQNED AVKSYTFELL TQVPSSILDL 420
VDDHHGSTGG QMVRCTAEGT PLPDIEWMIC KDIKKCNNET SWTILANNVS NIITEVHPRD 480
RSTVEGRVTF AKVEETIAVR CLAKNLLGAE NRELKLVAPT LRSELTVAAA VLVLLVIVII 540
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRVLG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSHHPEK PKKELDIFGL NPADESTRSY 720
VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN 780
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV ENLLPGQYKK 960
SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII 1020
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080
SDLVEDSFL 1089
Nucleotide Sequence
(FASTA)
ATGGGGACTT CCCATCCGGC GTTCCTGGTC TTAGGCTGTC TTCTCACAGG GCTGAGCCTA 60
ATCCTCTGCC AGCTTTCATT ACCCTCTATC CTTCCAAATG AAAATGAAAA GGTTGTGCAG 120
CTGAATTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAATG AAGTGAGCTG GCAGTACCCC 180
ATGTCTGAAG AAGAGAACTC CAATGTGGAA ATCAGAAATG AAGAAAACAA CAGTGGCCTT 240
TTTGTGACGG TCTTGGAAGT GAGCAGTGCC TCGGCGGCCC ACACAGGGTT GTACACTTGC 300
TATTACAACC ACACTCAGAC AGAAGAGAAT GAGCTTGAAG GCAGGCACAT TTACATCTAT 360
GTGCCAGACC CAGATGTAGC CTTTGTACCT CTAGGAATGA CGGATTATTT AGTCATCGTG 420
GAGGATGATG ATTCTGCCAT CATACCTTGT CGCACAACTG ATCCCGAGAC TCCTGTAACC 480
TTACACAACA GTGAGGGAGT GGTACCTGCC TCCTACGACA GCAGACAGGG CTTTAATGGG 540
ACCTTCACTG TAGGGCCCTA TATCTGTGAG GCCACCGTCA AAGGAAAGAA GTTCCAGACC 600
ATCCCATTTA ACGTTTATGC TTTAAAAGCA ACATCAGAGC TGGATCTAGA AATGGAAGCT 660
CTTAAAACCG TGTATAAGTC AGGGGAAACG ATTGTGGTCA CCTGTGCTGT TTTTAACAAT 720
GAGGTGGTTG ACCTTCAATG GACTTACCCT GGAGAAGTGA AAGGCAAAGG CATCACAATG 780
CTGGAAGAAA TCAAAGTCCC ATCCATCAAA TTGGTGTACA CTTTGACGGT CCCCGAGGCC 840
ACGGTGAAAG ACAGTGGAGA TTACGAATGT GCTGCCCGCC AGGCTACCAG GGAGGTCAAA 900
GAAATGAAGA AAGTCACTAT TTCTGTCCAT GAGAAAGGGT TCATTGAAAT CAAACCCACC 960
TTCAGCCAGT TGGAAGCTGT CAACCTGCAT GAAGTCAAAC ATTTTGTTGT AGAGGTGCGG 1020
GCCTACCCAC CTCCCAGGAT ATCCTGGCTG AAAAACAATC TGACTCTGAT TGAAAATCTC 1080
ACTGAGATCA CCACTGATGT GGAAAAGATT CAGGAAATAA GGTATCGAAG CAAATTAAAG 1140
CTGATCCGTG CTAAGGAAGA AGACAGTGGC CATTATACAA TTGTAGCTCA AAATGAAGAT 1200
GCTGTGAAGA GCTATACTTT TGAACTGTTA ACTCAAGTTC CTTCATCAAT TCTGGACTTG 1260
GTCGATGATC ACCATGGCTC AACTGGGGGA CAGATGGTGA GATGCACAGC TGAAGGCACG 1320
CCGCTTCCTG ATATTGAGTG GATGATATGC AAGGATATTA AGAAATGTAA TAATGAAACT 1380
TCCTGGACGA TTTTGGCCAA CAATGTCTCA AACATCATCA CGGAGGTCCA CCCCCGAGAC 1440
AGGAGTACCG TGGAGGGCCG TGTGACTTTC GCCAAAGTGG AGGAGACCAT TGCGGTGCGA 1500
TGCCTGGCTA AGAATCTCCT TGGAGCTGAG AACCGAGAGC TGAAGCTGGT GGCTCCCACC 1560
CTGCGTTCTG AACTCACGGT GGCTGCTGCA GTCCTGGTGC TGTTGGTGAT TGTGATCATC 1620
TCACTCATTG TCCTGGTTGT CATTTGGAAA CAGAAACCGA GGTATGAAAT TCGCTGGAGG 1680
GTCATTGAAT CAATCAGCCC GGATGGACAT GAATATATTT ATGTGGACCC GATGCAGCTG 1740
CCTTATGACT CAAGATGGGA GTTTCCAAGA GATGGACTAG TGCTTGGTCG GGTCTTGGGG 1800
TCTGGAGCAT TTGGGAAGGT GGTTGAAGGA ACAGCCTATG GATTAAGTCG GTCCCAACCT 1860
GTCATGAAAG TTGCAGTGAA GATGCTAAAA CCCACGGCCA GATCCAGTGA AAAACAAGCT 1920
CTCATGTCTG AACTGAAGAT AATGACTCAC CTGGGGCCAC ATTTGAACAT TGTAAACTTG 1980
CTGGGAGCCT GCACCAAGTC AGGCCCCATT TACATCATCA CGGAGTACTG CTTCTATGGA 2040
GATTTGGTCA ACTATTTGCA TAAGAATAGG GATAGCTTCC TGAGCCACCA CCCAGAGAAG 2100
CCAAAGAAAG AGCTGGATAT CTTTGGATTG AACCCTGCTG ATGAAAGCAC ACGGAGCTAT 2160
GTTATTTTAT CTTTTGAAAA CAATGGTGAC TACATGGACA TGAAGCAGGC TGATACTACA 2220
CAGTATGTCC CCATGCTAGA AAGAAAAGAG GTTTCTAAAT ATTCCGACAT CCAGAGATCA 2280
CTCTATGATC GTCCAGCCTC ATATAAGAAG AAATCTATGT TAGACTCAGA AGTCAAAAAC 2340
CTCCTTTCAG ATGATAACTC AGAAGGCCTT ACTTTATTGG ATTTGTTGAG CTTCACCTAT 2400
CAAGTTGCCC GAGGAATGGA GTTTTTGGCT TCAAAAAATT GTGTCCACCG TGATCTGGCT 2460
GCTCGCAACG TCCTCCTGGC ACAAGGAAAA ATCGTGAAGA TCTGTGACTT TGGCCTGGCC 2520
AGAGACATCA TGCATGATTC AAACTATGTG TCAAAAGGCA GTACCTTTCT GCCCGTGAAG 2580
TGGATGGCTC CTGAGAGCAT CTTTGACAAC CTCTACACCA CACTGAGTGA TGTCTGGTCT 2640
TACGGCATTC TGCTCTGGGA GATCTTTTCC CTTGGTGGCA CCCCTTACCC CGGCATGATG 2700
GTGGATTCTA CTTTCTACAA TAAGATCAAG AGTGGGTACC GGATGGCTAA GCCTGACCAT 2760
GCTACCAGTG AAGTCTACGA GATCATGGTG AAATGCTGGA ACAGTGAGCC GGAGAAGAGA 2820
CCCTCCTTTT ACCACCTGAG TGAGATTGTG GAGAATCTGC TGCCTGGACA ATATAAAAAG 2880
AGTTATGAAA AAATTCACCT GGACTTCCTG AAGAGTGACC ATCCTGCTGT GGCACGCATG 2940
CGTGTGGACT CAGACAATGC GTACATTGGT GTCACCTACA AAAACGAGGA AGACAAGCTG 3000
AAGGACTGGG AGGGTGGTCT GGATGAGCAG AGACTGAGCG CTGACAGTGG CTACATCATT 3060
CCTCTGCCTG ACATTGACCC TGTCCCTGAG GAGGAGGACC TGGGCAAGAG GAACAGACAC 3120
AGCTCGCAGA CCTCTGAAGA GAGTGCCATT GAGACGGGTT CCAGCAGTTC CACCTTCATC 3180
AAGAGAGAGG ACGAGACCAT TGAAGACATC GACATGATGG ACGACATCGG CATAGACTCT 3240
TCAGACCTGG TAGAAGACAG CTTCCTGTAA 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG+vlGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---PKKELDIFG  709
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 710   LnPADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkevskYSDIQRSLYDRPASYK  769
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRVLGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSHHPEKPK KELDIFGLNP 120
ADESTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
MLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0055003; P:cardiac myofibril assembly
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0048701; P:embryonic cranial skeleton morphogenesis
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0060325; P:face morphogenesis
GO:0001701; P:in utero embryonic development
GO:0033327; P:Leydig cell differentiation
GO:0030324; P:lung development
GO:0001553; P:luteinization
GO:0030539; P:male genitalia development
GO:0072277; P:metanephric glomerular capillary formation
GO:0010544; P:negative regulation of platelet activation
GO:0042475; P:odontogenesis of dentin-containing tooth
GO:0060021; P:palate development
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0070527; P:platelet aggregation
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013