EKS-POA-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	417.0	3.6E-125	26	321	296

Status

Unreviewed

Ensembl Protein

ENSPPYP00000016644

UniProt Accession

H2PDT9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014907	ENSPPYP00000016644	ENSPPYT00000017323

Organism

Pongo abelii

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MSKSKVDNQF YSVEVGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAVLDR NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMVR HKILFPGRDY IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRNYV ENRPKYAGLT FPKLFPDSLF PADSEHNKLK ASQARDLLSK 300

MLVIDPAKRI SVDDALQHPY INVWYDPAEV EAPPPQIYDK QLDEREHTID EWKELIYKEV 360

MNSEEKTKNG VVKGQPSPSA QVQQ 384

Nucleotide Sequence
(FASTA)

ATGAGCAAAA GCAAAGTTGA CAACCAGTTC TACAGTGTGG AAGTGGGAGA CTCAACCTTC 60

ACAGTTCTCA AGCGCTACCA GAATCTAAAG CCTATTGGCT CTGGGGCTCA GGGCATAGTT 120

TGTGCCGCGT ATGATGCTGT CCTTGACAGA AATGTGGCCA TTAAGAAGCT CAGCAGACCC 180

TTTCAGAACC AAACACATGC CAAGAGAGCG TACCGGGAGC TGGTCCTCAT GAAGTGTGTG 240

AACCATAAAA ACATTATTAG TTTATTAAAT GTCTTCACAC CCCAGAAAAC GCTGGAGGAG 300

TTCCAAGATG TTTACTTAGT AATGGAACTG ATGGATGCCA ACTTATGTCA AGTGATTCAG 360

ATGGAATTAG ACCACGAGCG AATGTCTTAC CTGCTGTACC AAATGTTGTG TGGCATTAAG 420

CACCTCCATT CTGCTGGAAT TATTCACAGG GATTTAAAAC CAAGTAACAT TGTAGTCAAG 480

TCTGATTGCA CATTGAAAAT CCTGGACTTT GGACTGGCCA GGACAGCAGG CACAAGCTTC 540

ATGATGACTC CATATGTGGT GACACGTTAT TACAGAGCCC CTGAGGTCAT CCTGGGGATG 600

GGCTACAAGG AGAACGTGGA TATATGGTCT GTGGGATGCA TTATGGGAGA AATGGTTCGC 660

CACAAAATCC TCTTTCCAGG AAGGGACTAT ATTGACCAGT GGAATAAGGT AATTGAACAA 720

CTAGGAACAC CATGTCCAGA ATTCATGAAG AAATTGCAAC CCACAGTAAG AAACTATGTG 780

GAGAATCGGC CCAAGTATGC AGGACTCACC TTCCCCAAGC TCTTCCCAGA TTCCCTCTTC 840

CCAGCGGACT CCGAGCACAA TAAACTCAAA GCCAGCCAAG CCAGGGACTT GTTGTCAAAG 900

ATGCTAGTGA TTGACCCAGC AAAAAGAATA TCAGTGGACG ATGCCTTACA GCATCCCTAC 960

ATCAACGTCT GGTATGACCC AGCCGAAGTG GAGGCGCCTC CACCTCAGAT ATATGACAAG 1020

CAGTTGGATG AAAGAGAACA CACAATCGAT GAATGGAAAG AACTTATCTA CAAGGAAGTA 1080

ATGAACTCAG AAGAAAAGAC TAAAAATGGC GTAGTAAAAG GACAGCCTTC TCCTTCAGCA 1140

CAGGTGCAGC AGTGA 1155

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 202   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 261   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013