EPS-POA-00035

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-POA-00035

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	172.5	1.4E-50	94	330	237

Status

Unreviewed

Ensembl Protein

ENSPPYP00000016662

UniProt Accession

H2PDV7;

Protein Name

Protein Synonyms/Alias

Protein phosphatase 1K, mitochondrial;

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014923	ENSPPYP00000016662	ENSPPYT00000017341

Organism

Pongo abelii

Functional Description

Protein Length

358

Protein Sequence
(FASTA)

MSTAALITLV RSGGNQVRRR VLLSSRLLQD DRRATPTCHS STSEPRCSRF DPDGSGSPAT 60

WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASQ IGKRKENEDR FDFAQLTDEV 120

LYFAVYDGHG GPAAADFCHT HMEKCIMDLL PKEKNLETLL TLAFLEIDKA FSSHARLSAD 180

ATLLTSGTTA TVALLRDGIE LVVASVVIGR AILCRKGKPM KLIKKCGGFV AWNSLGQPHV 240

NGRLAMTRSI GDLDLKTSGV IAEPETKRIK LHHADDSFLV LTTDGINFMV NSQEICDFVN 300

QCRDPNEAAH AVTEQAIQYG TEDNSTAVVV PFGAWGKYKN SEINFSFSRS FASSGRWA 358

Nucleotide Sequence
(FASTA)

ATGTCAACAG CTGCCTTAAT TACTTTGGTC AGAAGTGGTG GGAACCAGGT GAGAAGGAGA 60

GTGCTGCTAA GCTCCCGCCT GCTGCAGGAC GACAGGCGGG CAACACCCAC GTGCCACAGC 120

TCCACTTCAG AGCCTAGGTG TTCTCGGTTT GACCCAGACG GTAGTGGGAG TCCAGCTACC 180

TGGGACAATT TTGGTATCTG GGATAACCGC ATTGATGAGC CAATTCTGCT GCCACCCAGC 240

ATTAAGTATG GCAAGCCAAT TCCCAAAATC AGCTTGGAAA ATGTGGGGTG CGCCTCACAG 300

ATTGGCAAAC GGAAAGAGAA TGAAGACCGG TTTGACTTCG CTCAGCTGAC AGATGAGGTC 360

CTGTACTTTG CAGTGTATGA TGGACACGGT GGACCTGCAG CAGCTGATTT CTGTCATACC 420

CACATGGAGA AATGTATTAT GGATTTGCTT CCTAAGGAGA AGAACTTGGA AACTCTGTTG 480

ACCTTGGCTT TTCTAGAAAT AGATAAAGCC TTTTCGAGTC ATGCCCGCCT GTCTGCTGAT 540

GCAACTCTTC TGACCTCTGG GACTACTGCA ACAGTAGCCC TATTGCGAGA TGGTATTGAA 600

CTGGTTGTAG CCAGTGTTGT TATTGGCCGG GCTATTTTGT GTAGAAAAGG AAAACCCATG 660

AAGCTGATCA AGAAATGTGG TGGTTTTGTA GCTTGGAATA GTTTGGGGCA GCCTCACGTA 720

AATGGCAGGC TTGCAATGAC AAGAAGTATT GGAGATTTGG ACCTTAAGAC CAGTGGTGTC 780

ATAGCAGAAC CTGAAACTAA GAGGATTAAG TTACACCATG CTGATGACAG CTTCCTGGTC 840

CTCACCACAG ATGGAATTAA CTTTATGGTG AATAGTCAAG AGATTTGTGA CTTTGTCAAT 900

CAGTGCCGTG ATCCCAACGA AGCAGCCCAT GCAGTGACTG AACAGGCAAT ACAGTATGGT 960

ACTGAGGATA ACAGTACTGC AGTAGTAGTG CCTTTTGGTG CCTGGGGAAA ATATAAGAAC 1020

TCTGAAATCA ACTTCTCATT CAGCAGAAGC TTTGCCTCCA GTGGACGATG GGCCTGA 1077

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s+ g+r+e ed++    +f++ +++   + +f+vyDGhgg  +a+fc++++++++

Q: 94    NVGCASQIGKRKENEDRF----DFAQLTDE---VLYFAVYDGHGGPAAADFCHTHMEKCI  146

         5899**************....57887666...78*************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.k  116

            l     +e+++++ l+ aFl++d+++   ++++l+ d+    sG+ta+val++d  +

Q: 147   MDLLP----KEKNLETLLTLAFLEIDKAF--SSHARLSADAtlltSGTTATVALLRDGiE  200

         ***87....********************..44444444445799*************9*

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLav  174

         l+va v   ra+Lcr+gk+++l              i++ gg v+ ++ g+ +v+G La+

Q: 201   LVVASVVIGRAILCRKGKPMKL--------------IKKCGGFVAWNSlGQpHVNGRLAM  246

         ******************9776..............********98889999********

S: 175   sRalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekk  232

         +R++Gdl+lk + v++ePe+  ++l++ d+ fl+L +DG+  +v+++e++++v+++ +

Q: 247   TRSIGDLDLKtSGVIAEPETKRIKLHHADDsFLVLTTDGINFMVNSQEICDFVNQCRD--  304

         **********566************999999***************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           ++eaa+ ++++a+++g++dn +a+vv

Q: 305   --PNEAAHAVTEQAIQYGTEDNSTAVVV  330

         ..***********************997

Domain Sequence
(FASTA)

NVGCASQIGK RKENEDRFDF AQLTDEVLYF AVYDGHGGPA AADFCHTHME KCIMDLLPKE 60

KNLETLLTLA FLEIDKAFSS HARLSADATL LTSGTTATVA LLRDGIELVV ASVVIGRAIL 120

CRKGKPMKLI KKCGGFVAWN SLGQPHVNGR LAMTRSIGDL DLKTSGVIAE PETKRIKLHH 180

ADDSFLVLTT DGINFMVNSQ EICDFVNQCR DPNEAAHAVT EQAIQYGTED NSTAVVV 237

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013