EKS-POA-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	421.1	2.3E-126	204	481	278

Status

Unreviewed

Ensembl Protein

ENSPPYP00000016680

UniProt Accession

H2PDX5;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014938	ENSPPYP00000016680	ENSPPYT00000017359

Organism

Pongo abelii

Functional Description

Protein Length

492

Protein Sequence
(FASTA)

MLLRSAGKLN VGTKKEDGES TATTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60

DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120

GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQETRPRYS IGLEQDETYI PPGESLRDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG SWTQLYLITD YHENGSLYDY LKSTTLDTKS MLKLAYSSVS 300

GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD TNEVDIPPNT 360

RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV EEYQLPYHDL 420

VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS RLTALRVKKT 480

LAKMSESQDI KL 492

Nucleotide Sequence
(FASTA)

ATGCTTTTGC GAAGTGCAGG AAAATTAAAC GTGGGCACCA AGAAAGAGGA TGGTGAGAGT 60

ACAGCCACCA CCCCCCGTCC AAAGGTCTTG CGTTGTAAAT GCCACCACCA TTGCCCAGAA 120

GACTCAGTCA ACAATATTTG CAGCACAGAC GGATATTGTT TCACGATGAT AGAAGAGGAT 180

GACTCTGGGA TGCCTGTGGT CACTTCTGGA TGCCTAGGAC TAGAAGGCTC AGATTTTCAG 240

TGTCGGGACA CTCCCATTCC TCATCAAAGA AGATCAATTG AATGCTGCAC AGAAAGGAAC 300

GAATGTAATA AAGACCTACA CCCTACACTG CCTCCATTGA AAAACAGAGA TTTTGTTGAT 360

GGACCTATAC ACCACAAGGC TTTACTTATA TCTGTGACTG TCTGTAGTTT GCTCTTGGTC 420

CTTATCATTT TATTTTGTTA CTTCCGGTAT AAAAGACAAG AAACCAGACC TCGATACAGC 480

ATTGGGTTAG AACAGGATGA AACTTACATT CCTCCTGGAG AATCCCTGAG AGACTTAATT 540

GAGCAGTCTC AGAGCTCAGG AAGTGGATCA GGCCTCCCTC TGCTGGTCCA GAGGACTATA 600

GCTAAGCAGA TTCAGATGGT GAAACAGATT GGAAAAGGTC GCTATGGGGA AGTTTGGATG 660

GGAAAGTGGC GTGGCGAAAA GGTAGCTGTG AAAGTGTTCT TCACCACAGA GGAAGCCAGC 720

TGGTTCAGAG AGACAGAAAT ATATCAGACA GTGTTGATGA GGCATGAAAA CATTTTGGGG 780

TCCTGGACCC AGTTGTACCT AATCACAGAC TATCATGAAA ATGGTTCCCT TTATGATTAT 840

CTGAAGTCCA CCACCCTAGA CACTAAATCA ATGCTGAAGT TAGCCTACTC TTCTGTCAGT 900

GGCTTATGTC ATTTACACAC AGAAATCTTT AGTACTCAAG GCAAACCAGC AATTGCCCAT 960

CGAGATCTGA AAAGTAAAAA CATTCTGGTG AAGAAAAATG GAACTTGCTG TATTGCTGAC 1020

CTGGGCCTGG CTGTTAAATT TATTAGTGAT ACAAATGAAG TTGACATACC ACCTAACACT 1080

CGAGTTGGCA CCAAACGCTA TATGCCTCCA GAAGTGTTGG ACGAGAGCTT GAACAGAAAT 1140

CACTTCCAGT CTTACATCAT GGCTGACATG TATAGTTTTG GCCTCATCCT TTGGGAGGTT 1200

GCTAGGAGAT GTGTATCAGG AGGTATAGTG GAAGAATACC AGCTTCCTTA TCATGACCTA 1260

GTGCCCAGTG ACCCCTCTTA CGAGGACATG AGGGAGATTG TGTGCATCAA GAAGTTACGC 1320

CCCTCATTCC CAAACCGGTG GAGCAGTGAT GAGTGTCTAA GGCAGATGGG GAAACTCATG 1380

ACAGAATGCT GGGCTCACAA TCCTGCATCA AGGCTGACAG CCCTGCGGGT TAAGAAAACA 1440

CTTGCCAAAA TGTCAGAGTC CCAGGACATT AAACTCTGA 1479

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILG---  260

         799****************************************************95...

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

                s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 261   -------SWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  313

         .......8****************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 314   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  371

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 372   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  430

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 431   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  481

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGSWT 60

QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ GKPAIAHRDL 120

KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL DESLNRNHFQ 180

SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI VCIKKLRPSF 240

PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 278

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0001502	; P:cartilage condensation
GO:0009953	; P:dorsal/ventral pattern formation
GO:0006954	; P:inflammatory response
GO:0035108	; P:limb morphogenesis
GO:0001550	; P:ovarian cumulus expansion
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0060041	; P:retina development in camera-type eye
GO:0031290	; P:retinal ganglion cell axon guidance
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013