EKS-POA-00474

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00474

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	431.4	9.3E-130	18	273	256

Status

Unreviewed

Ensembl Protein

ENSPPYP00000016730

UniProt Accession

H2PE21;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000014980	ENSPPYP00000016730	ENSPPYT00000017409

Organism

Pongo abelii

Functional Description

Protein Length

848

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTIIH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSS STVLCIAFEV LQGLQYMNKH GIVHRALSPH 120

NILLDRKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKTT DHIPSKKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLD CVDDTLLVLA EEHGCLDIIK 240

ELPETVIDLL KKCLTFHPSK RPTPDELMKD KVFSEVSPLY TPFTKPASLF SSSLRCADLT 300

LPEDISQFCK DINNDYLAER SIEEVYYLWL AGGDLEKELV NKEIIRSKPP ICTLPNFLFE 360

DGESFGQGRD RSSLLDDTTV TLSLCQLRNR LKDVGGEAFY PLLEDAYPYK KNQIWKEARV 420

DIPPLMRGLT WAALLGVEGA IHAKYDAIDK DTPIPTDRQI EVDIPRCHQY DELLSSPEGH 480

AKFRRVLKAW VVSHPDLVYW QGLDSLCAPF LYLNFNNEAL AYACMSAFIP KYLYNFFLKD 540

NSHVIQEYLT VFSQMIAFHD PELSNHLNEI GFIPDLYAIP WFLTMFTHVF PLHKIFHLWD 600

TLLLGNSSFP FCIGVAILQQ LRDRLLANGF NECILLFSDL PEIDIERCVR ESINLFCWTP 660

KSATYRQHAQ PPKPTSDSSG VRSSAPYFSA ECPDPPKTDL SRESIPLNDL KSEVSPRISA 720

EDLIDLCELT VTGHFKTPTK KTKSSKPKLL VVDIRNSEDF IRGHISGSIN IPFSAAFTAE 780

GELTQGPYTA MLQNFKGKVI VIVGHVAKHT AEFAAHLVKM KYPRICILDG GINKIKPTGL 840

LTIPSPQI 848

Nucleotide Sequence
(FASTA)

ATGTTTCCCC TGAAGGACGC TGAAATGGGA GCCTTTACCT TCTTTGCCTC GGCTCTGCCA 60

CATGATGTTT GTGGAAGCAA TGGACTTCCT CTCACACCAA ATTCCATCAA AATTTTAGGG 120

CGCTTTCAAA TCCTTAAAAC CATCATCCAT CCCAGACTCT GCCAGTATGT GGATATTTCT 180

AGGGGAAAGC ATGAACGACT AGTGGTCGTG GCTGAACATT GTGAACGTAG TCTGGAAGAC 240

TTGCTTCGAG AAAGGAAACC TGTAAGCTCT TCAACGGTTC TGTGTATAGC ATTTGAGGTT 300

CTTCAGGGCT TGCAGTATAT GAACAAACAT GGTATAGTAC ACAGGGCATT GTCTCCTCAT 360

AATATCCTGT TGGACCGAAA GGGACATATT AAATTGGCTA AATTTGGACT TTATCACATG 420

ACAGCTCATG GTGATGATGT TGATTTCCCA ATAGGGTATC CCTCATACTT GGCCCCTGAG 480

GTAATTGCAC AGGGAATTTT CAAAACCACT GATCACATAC CAAGTAAAAA ACCATTGCCT 540

TCTGGCCCCA AATCAGATGT ATGGTCTCTT GGAATCATTT TATTTGAGCT TTGTGTGGGA 600

AGAAAATTAT TTCAGAGCTT GGATATTTCT GAAAGACTAA AATTTCTGCT TACTTTGGAC 660

TGTGTAGATG ACACTTTACT AGTTCTGGCT GAAGAGCATG GTTGTTTGGA CATTATAAAG 720

GAGCTTCCTG AAACTGTGAT AGATCTTTTG AAGAAGTGCC TTACCTTCCA TCCTTCTAAG 780

AGGCCAACCC CAGATGAATT AATGAAGGAC AAAGTGTTCA GTGAGGTATC ACCTTTATAT 840

ACCCCCTTTA CCAAACCTGC CAGTCTGTTT TCATCTTCTC TGAGATGTGC TGATTTAACT 900

CTGCCTGAGG ATATCAGTCA GTTTTGTAAA GATATAAATA ATGATTACCT GGCAGAAAGA 960

TCTATTGAAG AAGTTTATTA CCTTTGGTTG GCTGGAGGTG ACTTGGAGAA AGAGCTTGTC 1020

AACAAGGAAA TCATTCGATC CAAACCACCT ATCTGCACAC TACCCAATTT TCTCTTTGAG 1080

GATGGTGAAA GCTTTGGACA AGGTCGAGAT AGAAGCTCGC TTTTAGATGA TACCACTGTG 1140

ACATTGTCGT TATGCCAGCT AAGAAATAGA TTGAAAGATG TTGGTGGAGA AGCATTTTAC 1200

CCATTACTTG AAGATGCTTA TCCATATAAA AAAAACCAAA TTTGGAAAGA AGCAAGAGTT 1260

GACATTCCTC CTCTTATGAG AGGTTTAACC TGGGCTGCTC TTCTGGGAGT TGAGGGAGCT 1320

ATTCATGCCA AGTACGATGC AATTGATAAA GACACTCCAA TTCCTACAGA TAGACAAATT 1380

GAAGTGGATA TTCCTCGCTG TCATCAGTAC GATGAACTGT TATCATCACC AGAAGGTCAT 1440

GCAAAATTTA GGCGTGTATT AAAAGCCTGG GTAGTGTCTC ATCCTGATCT TGTGTATTGG 1500

CAAGGTCTTG ACTCACTCTG TGCTCCATTC CTATATCTAA ACTTCAATAA TGAAGCCTTG 1560

GCTTATGCAT GTATGTCTGC TTTTATTCCC AAATACCTGT ATAACTTCTT CTTAAAAGAC 1620

AACTCACATG TAATACAAGA GTATCTGACT GTCTTCTCTC AGATGATTGC ATTTCATGAT 1680

CCAGAGCTGA GTAATCATCT CAATGAGATT GGCTTCATTC CAGATCTCTA TGCCATCCCT 1740

TGGTTTCTTA CCATGTTTAC TCATGTATTT CCACTACACA AAATTTTCCA CCTCTGGGAT 1800

ACCTTACTAC TTGGGAATTC CTCTTTCCCA TTCTGTATTG GAGTAGCAAT TCTTCAGCAG 1860

CTGCGGGACC GGCTTTTGGC TAATGGCTTT AATGAGTGCA TTCTTCTCTT CTCCGATTTA 1920

CCAGAAATTG ACATTGAACG CTGTGTGAGA GAATCTATCA ACCTGTTTTG TTGGACTCCT 1980

AAAAGTGCTA CTTACAGACA GCATGCTCAA CCTCCAAAGC CAACTTCTGA CAGCAGTGGA 2040

GTCAGAAGTT CGGCACCTTA TTTCTCTGCT GAGTGTCCGG ATCCTCCAAA GACAGATCTG 2100

TCAAGAGAAT CCATCCCATT AAATGACCTA AAGTCAGAAG TATCACCACG GATTTCAGCA 2160

GAGGACCTGA TTGACTTGTG TGAGCTCACA GTGACAGGCC ACTTCAAAAC ACCCACCAAG 2220

AAAACGAAGT CCAGTAAACC AAAGCTCCTG GTGGTTGACA TCCGGAATAG TGAAGACTTT 2280

ATTCGTGGTC ACATTTCAGG AAGCATCAAC ATTCCATTCA GTGCTGCCTT CACTGCAGAA 2340

GGGGAGCTTA CCCAGGGCCC TTACACTGCT ATGCTCCAGA ACTTCAAAGG GAAGGTCATT 2400

GTCATCGTGG GGCATGTGGC AAAGCACACA GCTGAGTTTG CAGCTCACCT TGTGAAGATG 2460

AAATATCCAA GAATCTGTAT TCTAGATGGT GGCATTAATA AAATAAAGCC AACAGGCCTC 2520

CTCACCATCC CATCTCCTCA AATATGA 2547

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk++ h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTIIHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s+vl+ia+evl+gl+y+nkh+ivhral+p++illdrkg+ +kLak+G

Q: 78    LEDLLRERKPVSSSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH-IKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGifkttdhipSKKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+tl +laee++cldiik+l+e++++llkkCLt+

Q: 197   LCVGRKLFQSLDISERLKFLLTLDCVDDTLLVLAEEHGCLDIIKELPETVIDLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+pdel+k+kvf

Q: 257   HPSKRPTPDELMKDKVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT IIHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSSSTVLCIA FEVLQGLQYM NKHGIVHRAL SPHNILLDRK GHIKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIF KTTDHIPSKK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DISERLKFLL TLDCVDDTLL VLAEEHGCLD IIKELPETVI DLLKKCLTFH 240

PSKRPTPDEL MKDKVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013