EKS-POA-00255

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00255

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	388.6	1.4E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSPPYP00000016820

UniProt Accession

H2PEA6;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase PLK4;

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000015057	ENSPPYP00000016820	ENSPPYT00000017501

Organism

Pongo abelii

Functional Description

Protein Length

970

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRVKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSMEAKD 240

LIHQLLRRNP ADRLSLSSVL DHPFMSQNSS TKSKDLGTVE DSIDSGHATL STAITASSST 300

SISGSLFDKR RLLIGQPLPN KMTVFPKNKS SSDFSSSGDG NSFYTQWGNQ ETSNSGRGRV 360

IQDAEERPHS RYLRRAYSSD RSGTFNSPSQ AKTYTMERCH SAEMLSMSKR SGGGENEERY 420

SPTDNNANIF NFFKEKTSSS SGSFERPDNN QTLSNHLCPG KTPFPFADPT PQTETVQQWF 480

GNLQINAHLR KTTEYDSISP TRDFQGHPDL QKDTSKNAWT DTKVKKNSDA SDNAHSVKQP 540

NTMKYMTALH SKPEIIQQEC VFGSDPLSEQ SKTRGMEPPL GYQNRTLRSI TSPLVAHRLK 600

PIRQKTKKAV VSILDSEEVC VELLKEYASQ EYVKEVLQIS SDGNMITIYY PNGGRGFPLA 660

DRPPSPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS PKITYFTRYA KCILMENSPG 720

ADFEVWFYDG VKIHKTEDFI QVIEKTGKSY TLKSESEVNS LKEEIKMYMD HANEGHRICL 780

ALESIISEEE RKTRSAPFFP IIIGRKPGST SSPKALSPPP SVDSNYPTRD RASFNRMVMH 840

SAASPTQAPI LNPSMVTNEG LGLTTTASGT DISSNSLKDC LPKSAQLLKS VFVKNVGWAT 900

QLTSGAVWVQ FNDGSQLVVQ AGVSSISYTS PNGQTTRYGE NEKLPEYIKQ KLQCLSSILL 960

MFSNPTPNFH 970

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGAAATCT GCTTGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CTGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCAGGAATGG TACAGAGAGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAATT GAAACATCCT TCTATCTTGG AGCTTTATAA CTATTTTGAA 240

GATAGCAATT ATGTGTATCT GGTATTAGAA ATGTGCCATA ATGGAGAAAT GAACAGGTAT 300

CTGAAGAATA GAGTGAAACC CTTCTCAGAA AATGAAGCTC GACACTTCAT GCACCAGATC 360

ATCACAGGGA TGTTGTATCT TCATTCTCAT GGTATACTAC ACCGGGACCT CACACTTTCT 420

AACCTCCTAC TGACTCGTAA TATGAACATC AAGATTGCTG ATTTTGGGCT GGCAACTCAA 480

CTGAAAATGC CACATGAAAA GCACTATACA TTATGTGGAA CTCCTAACTA CATTTCACCA 540

GAAATTGCCA CTCGAAGTGC ACATGGCCTT GAATCTGATG TTTGGTCCCT GGGCTGTATG 600

TTTTATACAT TACTTATCGG GAGACCACCC TTTGACACTG ACACAGTCAA GAACACATTA 660

AATAAAGTAG TATTGGCAGA TTATGAAATG CCAACTTTTT TGTCAATGGA GGCCAAGGAC 720

CTTATTCACC AGTTACTTCG TAGAAATCCA GCAGATCGTT TAAGTCTGTC TTCAGTATTG 780

GACCATCCTT TTATGTCCCA AAATTCTTCA ACAAAAAGTA AAGATTTAGG AACTGTGGAA 840

GACTCAATTG ATAGTGGGCA TGCCACACTT TCTACTGCGA TTACAGCTTC TTCCAGTACC 900

AGTATAAGTG GTAGTTTATT TGACAAAAGA AGACTTTTGA TTGGTCAGCC ACTCCCAAAT 960

AAAATGACTG TATTTCCAAA GAATAAAAGT TCAAGTGATT TTTCTTCTTC AGGAGATGGA 1020

AACAGTTTTT ATACTCAGTG GGGAAATCAA GAAACCAGTA ATAGTGGAAG GGGAAGAGTA 1080

ATTCAAGATG CAGAAGAAAG GCCACATTCT CGATACCTTC GTAGAGCTTA TTCCTCTGAT 1140

AGATCTGGCA CTTTTAATAG TCCATCTCAA GCAAAAACAT ATACAATGGA ACGATGTCAC 1200

TCAGCAGAAA TGCTTTCAAT GTCCAAAAGA TCAGGAGGAG GTGAAAATGA AGAGAGGTAC 1260

TCACCCACAG ACAACAATGC CAACATTTTT AACTTCTTTA AAGAAAAGAC ATCCAGTAGT 1320

TCTGGATCTT TTGAAAGACC TGATAACAAT CAAACACTCT CCAATCATCT TTGTCCAGGA 1380

AAAACTCCTT TTCCATTTGC AGACCCGACA CCTCAGACTG AAACGGTACA ACAGTGGTTT 1440

GGGAATCTGC AAATAAATGC TCATTTAAGA AAAACTACTG AATATGACAG CATCAGCCCA 1500

ACTCGGGATT TCCAGGGCCA TCCAGATTTG CAGAAGGACA CATCAAAAAA TGCCTGGACT 1560

GATACAAAAG TCAAAAAGAA CTCTGATGCT TCTGATAATG CACATTCTGT AAAACAGCCA 1620

AATACCATGA AATATATGAC TGCACTTCAC AGTAAACCTG AGATAATCCA ACAAGAATGT 1680

GTTTTTGGCT CAGATCCTCT TTCTGAACAG AGCAAGACTA GGGGTATGGA GCCACCATTG 1740

GGTTATCAGA ATCGTACATT AAGAAGCATT ACGTCTCCGT TGGTTGCTCA CAGGTTGAAA 1800

CCAATCAGAC AGAAAACCAA AAAGGCTGTG GTGAGCATAC TTGATTCAGA GGAGGTGTGT 1860

GTGGAGCTTC TAAAGGAGTA TGCATCTCAA GAATATGTGA AAGAAGTTCT TCAGATATCT 1920

AGTGATGGAA ATATGATCAC TATTTATTAT CCAAATGGTG GAAGAGGTTT TCCTCTTGCT 1980

GATAGACCAC CCTCACCTAC TGACAACATC AGTAGGTACA GCTTTGACAA TTTACCAGAA 2040

AAATACTGGC GAAAATATCA ATATGCTTCC AGGTTTGTAC AGCTTGTAAG ATCTAAATCT 2100

CCCAAAATCA CTTATTTTAC AAGATATGCT AAATGCATTT TGATGGAGAA TTCTCCTGGT 2160

GCTGATTTTG AGGTTTGGTT TTATGATGGG GTAAAAATAC ACAAAACAGA AGATTTCATT 2220

CAGGTGATTG AAAAGACAGG GAAGTCTTAC ACTTTAAAAA GTGAAAGTGA AGTTAATAGC 2280

TTGAAAGAGG AGATAAAAAT GTATATGGAC CATGCTAATG AGGGTCATCG TATTTGTTTA 2340

GCACTGGAAT CCATAATTTC AGAAGAGGAA AGGAAAACTA GGAGTGCTCC CTTTTTCCCA 2400

ATAATCATAG GAAGAAAACC TGGTAGTACT AGTTCACCTA AGGCCTTATC ACCTCCTCCT 2460

TCTGTGGATT CAAATTACCC AACAAGAGAC AGAGCATCTT TCAATAGAAT GGTCATGCAT 2520

AGTGCTGCTT CTCCAACACA GGCACCAATC CTTAATCCCT CTATGGTTAC AAATGAAGGA 2580

CTTGGTCTTA CAACTACAGC TTCTGGAACA GACATCTCTT CTAATAGTCT AAAAGATTGT 2640

CTTCCTAAAT CAGCACAACT TTTGAAATCT GTTTTTGTGA AAAATGTTGG TTGGGCTACA 2700

CAGTTAACTA GTGGAGCTGT GTGGGTTCAG TTTAATGATG GGTCCCAGTT GGTTGTGCAG 2760

GCAGGAGTGT CTTCTATCAG TTATACCTCA CCAAATGGTC AAACAACTAG GTATGGAGAA 2820

AATGAAAAAT TACCAGAATA CATCAAACAG AAATTACAGT GTCTGTCTTC CATCCTTTTG 2880

ATGTTTTCTA ATCCGACTCC TAATTTTCAC TGA 2913

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRvKPFSENEARHFMHQIITGMLYLHSHG  131

         *********************************9**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSMEAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED SNYVYLVLEM CHNGEMNRYL KNRVKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLSMEAKDL IHQLLRRNPA 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication
GO:0060707	; P:trophoblast giant cell differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013