EKS-POA-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.0	4.4E-97	1236	1500	265

Status

Unreviewed

Ensembl Protein

ENSPPYP00000017294

UniProt Accession

H2PFL3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000015478	ENSPPYP00000017294	ENSPPYT00000017998

Organism

Pongo abelii

Functional Description

Protein Length

1505

Protein Sequence
(FASTA)

MAAAAGNRAS SSGFPGAGAA SPEAGGGGAL KASSAPAAAT GLLREAGSGG RERADWRRRQ 60

LRKVRSVELD QLPEQPLFLA ASPPSSSTSP SPDPADAARS GTGFQPVAVP PPHGAASRGG 120

AHLAESVAAP DSGASSPAAA EPGEKRAPAA EPSPAAAPAG REMENKETLK GLHKMDDRPE 180

ERMIREKLKA TCMPAWKHEW LERRNRRGPV VVKPIPVKGD GSEMNHLAAE SPGEAQASAA 240

SPASKGRRSP SPGNSPSGRT VKSESPGVRR KRVSPVPFQS GRITPPRRAP SPDGFSPYSP 300

EETNRRVNKV MRARLYLLQQ IGPNSFLIGG DSPDNKYRVF IGPQNCSCAR GTFCIHLLFV 360

MLRVFQLEPS DPMLWRKTLK NFEVESLFQK YHSRRSSRIK APSRNTIQKF VSRMSNSHTL 420

SSSSTSTSSS ENSIKDEEEQ MCPICLLGML DEESLTVCED GCRNKLHHHC MSIWAEECRR 480

NREPLICPLC RSKWRSHDFY SHELSSPVDS PSSVRAAQQQ TVQQQPLAGS QRRNQESNFN 540

LTHYGTQQIP PAYKDLAEPW IQVFGMELVG CLFSRNWNVR EMALRRLSHD VSGALLLANG 600

ESTGNSGGSS GSSPSGGATS GSSQTSISDV VEACCNVLSV CADPVYKVYV AALKTLRAML 660

VYTPCHSLAE RIKLQRLLQP VVDTILVKCA DANSRTSQLS ISTLLELCKG QAGELAVGRE 720

ILKAGSIGIG GVDYVLNCIL GNQTESNNWQ ELLGRLCLID RLLLEFPAEF YPHIVSTDVS 780

QAEPVEIRYK KLLSLLTFAL QSIDNSHSMV GKLSRRIYLS SARMVTTVPH VFSKLLEMLS 840

VSSSTHFTRM RRRLMAIADE VEIAEAIQLG VEDTLDGQQD SFLQASVPSN YPETTENNSL 900

ECTIRLEKTG KGLCATKLSA SSEEISERLA SISVGPSSST TTEQPKPMVQ TKGRPHSQCL 960

NSSPLSHHSQ LMFPALSTPS SSAPSVPAGT ATDVSKQRLQ GFVPCRIPSA SPQTQRKFSL 1020

QFHRNCPENK DSDKLSPVFT QSRPLPSSNI HRPKPSRPTP GNTSKQGDPS KNSMTLDLNS 1080

SSKCDDSFGC SSNSSNAVIP SDETVFTPVE EKCRLDVNTE LNSSIEDLLE ASMPSSDTTV 1140

TFKSEVAVLS PEKAENDDTY KDDVNHNQKC KEKMEAEEEE ALAIAMAMSA SQDALPIVPQ 1200

LQVENGEDII IIQQDTPETL PGHTKAKQPY REDTEWLKGQ QIGLGAFSSC YQAQDVGTGT 1260

LMAVKQVTYV RNTSSEQEEV VEALREEIRM MSHLNHPNII RMLGATCEKS NYNLFIEWMA 1320

GGSVAHLLSK YGAFKESVVI NYTEQLLRGL SYLHENQIIH RDVKGANLLI DSTGQRLRIA 1380

DFGAAARLAS KGTGAGEFQG QLLGTIAFMA PEVLRGQQYG RSCDVWSVGC AIIEMACAKP 1440

PWNAEKHSNH LALIFKIASA TTAPSIPSHL SPGLRDVALR CLELQPQDRP PSRELLKHPV 1500

FRTMW 1505

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGGGAA TCGCGCCTCG TCGTCGGGAT TCCCGGGCGC CGGGGCTGCG 60

AGCCCTGAGG CGGGCGGTGG CGGAGCCCTC AAGGCGAGCA GCGCGCCCGC GGCGGCCACG 120

GGACTGCTGC GGGAGGCGGG CAGCGGGGGC CGCGAGCGGG CGGACTGGCG GCGGCGGCAG 180

CTGCGCAAAG TGCGGAGTGT GGAGCTGGAC CAGCTGCCTG AGCAGCCGCT CTTCCTTGCC 240

GCCTCACCGC CGTCCTCCTC GACTTCCCCG TCGCCGGATC CCGCGGACGC AGCGCGGAGT 300

GGGACCGGCT TCCAGCCTGT GGCGGTGCCG CCGCCCCACG GAGCCGCGAG CCGCGGCGGC 360

GCCCACCTTG CCGAGTCGGT AGCGGCGCCG GACAGCGGCG CCTCGAGTCC CGCAGCGGCC 420

GAGCCCGGGG AGAAGCGGGC GCCCGCCGCC GAGCCGTCTC CTGCAGCGGC CCCCGCCGGT 480

CGTGAAATGG AGAATAAAGA AACTCTCAAA GGGTTGCACA AGATGGACGA TCGTCCAGAG 540

GAACGAATGA TCAGGGAGAA ACTGAAGGCA ACCTGTATGC CAGCCTGGAA GCACGAATGG 600

TTGGAAAGGA GAAATAGGCG AGGGCCTGTG GTGGTAAAAC CAATCCCAGT TAAAGGAGAT 660

GGATCTGAAA TGAATCACTT AGCAGCTGAG TCTCCAGGAG AGGCCCAGGC AAGTGCGGCT 720

TCACCAGCTT CCAAAGGCCG ACGCAGTCCT TCTCCTGGCA ACTCCCCATC AGGTCGCACA 780

GTGAAATCAG AATCTCCAGG AGTAAGGAGA AAAAGAGTTT CCCCAGTGCC TTTTCAGAGT 840

GGCAGAATCA CACCACCCCG AAGAGCCCCT TCACCAGATG GCTTCTCACC ATATAGCCCT 900

GAGGAAACAA ACCGCCGTGT TAACAAAGTG ATGCGGGCCA GACTGTACTT ACTGCAGCAG 960

ATAGGGCCCA ACTCTTTCCT GATTGGAGGA GACAGCCCAG ACAATAAATA CCGGGTGTTT 1020

ATTGGGCCTC AGAACTGCAG CTGTGCACGT GGAACATTCT GTATTCATCT GCTATTTGTG 1080

ATGCTCCGGG TGTTTCAACT AGAACCTTCA GACCCAATGT TATGGAGAAA AACTTTAAAG 1140

AATTTTGAGG TTGAGAGTTT GTTCCAGAAA TATCACAGTA GGCGTAGCTC AAGGATCAAA 1200

GCTCCATCTC GTAACACCAT CCAGAAGTTT GTTTCACGCA TGTCAAATTC TCATACATTG 1260

TCATCATCTA GTACTTCTAC GTCTAGTTCA GAAAACAGCA TAAAGGATGA AGAGGAACAG 1320

ATGTGTCCTA TTTGCTTATT GGGCATGCTT GATGAAGAAA GTCTTACAGT GTGTGAAGAC 1380

GGCTGCAGGA ACAAGCTGCA CCACCACTGC ATGTCAATTT GGGCAGAAGA GTGTAGAAGA 1440

AATAGAGAAC CTTTAATATG TCCCCTTTGT AGATCTAAGT GGAGATCTCA TGATTTCTAC 1500

AGCCACGAGT TGTCAAGTCC TGTGGATTCC CCTTCTTCCG TCAGAGCTGC ACAGCAGCAA 1560

ACTGTACAGC AGCAGCCTTT GGCTGGATCA CAAAGAAGGA ATCAAGAGAG CAATTTTAAC 1620

CTTACTCATT ATGGAACTCA GCAAATCCCT CCTGCTTACA AAGATTTAGC TGAGCCATGG 1680

ATTCAGGTGT TTGGAATGGA ACTCGTTGGC TGCTTATTTT CTAGAAACTG GAATGTGAGA 1740

GAGATGGCCC TCAGGCGTCT TTCCCATGAT GTCAGTGGGG CCCTGCTGTT GGCAAATGGG 1800

GAGAGCACTG GAAATTCTGG GGGCAGCAGT GGAAGCAGCC CGAGTGGGGG AGCCACCAGT 1860

GGGTCTTCCC AGACCAGTAT CTCAGATGTG GTGGAGGCGT GCTGCAACGT TCTGTCAGTC 1920

TGTGCTGACC CTGTCTACAA AGTGTACGTT GCTGCTTTAA AAACATTGAG AGCCATGCTG 1980

GTATATACTC CTTGCCACAG TTTAGCAGAA AGAATCAAAC TTCAGAGACT TCTCCAGCCA 2040

GTTGTAGACA CCATCCTAGT CAAATGTGCA GATGCCAATA GCCGCACAAG TCAGCTGTCC 2100

ATATCAACAC TGTTGGAGCT GTGCAAAGGC CAAGCAGGAG AGTTGGCAGT TGGCAGAGAA 2160

ATACTAAAAG CTGGATCCAT TGGTATTGGT GGTGTTGATT ATGTCTTAAA TTGTATTCTT 2220

GGAAACCAAA CTGAATCAAA CAATTGGCAA GAACTTCTTG GCCGCCTTTG TCTTATAGAT 2280

AGACTGTTGT TGGAATTTCC TGCTGAATTT TATCCTCATA TTGTCAGTAC TGATGTTTCA 2340

CAAGCTGAGC CTGTTGAAAT CAGGTATAAG AAGCTGCTGT CCCTCTTAAC CTTTGCTTTG 2400

CAGTCCATTG ATAATTCCCA CTCAATGGTT GGCAAACTTT CCAGAAGGAT CTACTTGAGT 2460

TCTGCAAGAA TGGTTACTAC AGTACCCCAT GTGTTCTCAA AACTGTTAGA AATGCTGAGT 2520

GTTTCCAGTT CCACTCACTT CACCAGGATG CGTCGCCGTT TGATGGCTAT TGCAGATGAG 2580

GTGGAGATTG CCGAAGCCAT CCAGTTGGGT GTAGAAGACA CTTTGGATGG TCAACAGGAC 2640

AGCTTCTTGC AGGCATCTGT TCCCAGCAAC TATCCGGAAA CCACAGAGAA CAATTCCCTT 2700

GAGTGCACAA TCCGTTTAGA GAAAACTGGA AAAGGATTAT GTGCTACAAA ATTGAGTGCC 2760

AGTTCAGAGG AAATTTCTGA GAGACTGGCC AGCATTTCAG TAGGACCTTC TAGTTCAACA 2820

ACAACAGAGC AACCAAAGCC AATGGTTCAA ACAAAAGGCA GACCCCACAG TCAGTGTTTG 2880

AACTCCTCTC CTTTATCTCA TCATTCCCAA TTAATGTTTC CAGCCTTGTC AACCCCTTCT 2940

TCTTCGGCCC CATCTGTACC AGCTGGCACT GCAACAGATG TCTCTAAGCA GAGACTTCAG 3000

GGATTCGTTC CCTGCAGAAT ACCTTCTGCA TCTCCTCAAA CACAGCGCAA GTTTTCTCTA 3060

CAATTCCACA GAAACTGTCC TGAAAACAAA GACTCAGATA AACTTTCCCC AGTCTTTACT 3120

CAGTCAAGAC CCTTGCCCTC CAGTAACATA CACAGGCCAA AGCCATCTCG ACCTACCCCA 3180

GGTAATACAA GTAAACAGGG AGATCCCTCA AAAAATAGCA TGACACTTGA TCTGAACAGT 3240

AGTTCCAAAT GTGATGACAG CTTTGGCTGT AGCAGCAATA GTAGTAATGC TGTTATACCC 3300

AGTGACGAGA CAGTGTTCAC CCCAGTAGAG GAGAAATGCA GATTAGATGT CAATACAGAG 3360

CTCAACTCCA GTATTGAGGA CCTTCTTGAA GCATCTATGC CTTCAAGTGA TACAACAGTA 3420

ACTTTTAAGT CAGAAGTTGC TGTCCTGTCT CCTGAAAAGG CTGAAAACGA TGATACCTAC 3480

AAAGATGATG TGAATCATAA TCAAAAGTGC AAAGAAAAGA TGGAAGCTGA AGAAGAAGAA 3540

GCTTTAGCAA TTGCCATGGC AATGTCAGCG TCTCAGGATG CCCTCCCCAT AGTTCCTCAG 3600

CTGCAGGTTG AAAATGGAGA AGATATCATC ATTATTCAAC AGGATACACC AGAGACTCTC 3660

CCAGGACATA CCAAAGCAAA ACAACCGTAT AGAGAAGACA CTGAATGGCT GAAAGGTCAA 3720

CAGATAGGCC TTGGAGCATT TTCTTCTTGT TATCAGGCTC AAGATGTGGG AACTGGGACT 3780

TTAATGGCTG TTAAACAGGT GACTTATGTC AGAAACACAT CTTCTGAGCA AGAAGAAGTA 3840

GTAGAAGCAT TAAGAGAAGA GATAAGAATG ATGAGCCATC TGAATCATCC AAACATCATT 3900

AGGATGTTGG GAGCCACGTG TGAGAAGAGC AATTACAATC TCTTCATTGA ATGGATGGCA 3960

GGGGGATCGG TGGCTCATTT GCTGAGTAAA TATGGAGCCT TCAAAGAATC AGTAGTTATT 4020

AACTACACTG AACAGTTACT TCGTGGCCTT TCATATCTCC ATGAAAACCA AATCATTCAC 4080

AGAGATGTCA AAGGTGCCAA TTTGCTAATT GACAGCACTG GTCAGAGACT AAGAATTGCA 4140

GATTTTGGAG CTGCAGCCAG GTTGGCATCT AAAGGAACTG GTGCAGGGGA GTTTCAGGGA 4200

CAATTACTGG GGACAATTGC ATTTATGGCA CCTGAGGTAC TAAGAGGTCA ACAGTATGGA 4260

AGGAGCTGTG ATGTATGGAG TGTTGGCTGT GCTATTATAG AAATGGCTTG CGCAAAACCA 4320

CCATGGAATG CAGAAAAACA CTCCAATCAT CTTGCTTTGA TATTTAAGAT TGCTAGCGCA 4380

ACTACTGCTC CATCGATCCC TTCACATTTG TCTCCTGGTT TACGAGATGT GGCTCTTCGT 4440

TGTTTAGAAC TTCAACCTCA GGACAGACCT CCATCAAGAG AGCTACTGAA GCATCCAGTC 4500

TTTCGTACTA TGTGGTAG 4518

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1236  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1295

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1296  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1355

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1356  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1415

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1416  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1473

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1474  LRDVALRCLELQPQDRPPSRELLKHPV  1500

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013