EKS-POA-00396
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00396
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR499.94.6E-150539831293
StatusUnreviewed
Ensembl ProteinENSPPYP00000017838
UniProt AccessionH2PH24;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000015942ENSPPYP00000017838ENSPPYT00000018553
OrganismPongo abelii
Functional Description
Protein Length898
Protein Sequence
(FASTA)
MGPGVLLLLL VATAWHGQGI PVIEPSGPEL VVKPGAMVTL RCVGNGSVEW DGPVSPHWTL 60
HSDGSSSVLT NNNATFQNTG TYRCTEPNPL GGSAAIHLYV KDPARPWNVL AQEVVVFEDQ 120
DALLPCLLTD PVLEAGVSLV RVRGRPLMRH TNYSFSPWHG FTIHRAKFIQ SQDYQCSALM 180
GGRKVMSISI RLKVQKVIPG PPALTLAPAE LVRIRGEAAQ IVCSASNVDV NFDVFLQHND 240
TKLTIPQQSD FHNNRYQKVL TFNLDQVDFQ HAGNYSCVAN NVQGKHSTSM FFRVVETAYL 300
NLSSEQNLIQ EVTVGEGLNL KVMVEAYPGL QGFNWTYLGP FSDHQPEPKL ANATTKDTYR 360
HTFPLSLPRL KPSEAGRYSF LARNPGGWRA LTFELTLRYP PEVSVIWTFI NGSGTLVCAA 420
SGYPQPNVTW LQCSGHTDRC DEAQVLQVWD DPYPEVLSQE PFHKVTVQSL LTVETLEHNQ 480
TYECRAHNSV GSGSWAFIPI SAGARTHPPD EFLFTPVVVA CMSIMALLLL LLLLLLYKYK 540
QTAHADEKEA LMSELKIMSH LGQHENIVNL LGACTHGGPV LVITEYCCYG DLLNFLRRKA 600
EAMLGPSLSP GQDPKGGVDY KNIHLEKKYV HRDSGFSSQG VDTYVEMRPV STSSNDSFSE 660
QDLDKEDGRP LELWDLLHFS SQVAQGMAFL ASKNCIHRDV AARNVLLTNG HVAKIGDFGL 720
ARDIMNDSNY IVKGNARLPV KWMAPESIFD CIYTVQSDVW SYGILLWEIF SLGLNPYPGI 780
LVNSKFYKLV KDGYQMAQPA FAPKNIYSIM QACWALEPTH RPTFQQICSF LQEQAQEDRR 840
QQDYTNLPSS SRSGGSGSGS GSGSSSELEE ESASEHLTCC EQGDIAQPLL QPNNYQFC 898
Nucleotide Sequence
(FASTA)
ATGGGCCCAG GAGTTCTGCT GCTCCTGCTG GTGGCCACAG CTTGGCATGG TCAGGGAATC 60
CCAGTGATAG AGCCCAGTGG CCCTGAGCTG GTCGTGAAGC CAGGAGCAAT GGTGACCCTG 120
CGATGTGTGG GCAATGGCAG CGTGGAATGG GATGGCCCCG TATCACCTCA CTGGACCCTG 180
CACTCTGATG GCTCCAGCAG CGTCCTCACC AACAACAACG CTACCTTCCA AAACACGGGG 240
ACCTATCGCT GCACTGAGCC TAACCCCCTG GGAGGCAGTG CTGCCATCCA CCTCTATGTC 300
AAAGACCCTG CCCGGCCCTG GAACGTGCTA GCACAGGAGG TGGTCGTGTT CGAGGACCAG 360
GACGCACTGC TGCCCTGTCT GCTCACAGAC CCGGTGCTGG AAGCAGGCGT CTCGCTGGTG 420
CGTGTGCGTG GCCGGCCCCT CATGCGCCAC ACCAACTACT CCTTCTCGCC TTGGCATGGC 480
TTCACCATCC ACAGGGCCAA GTTCATTCAG AGCCAGGACT ATCAATGCAG TGCCCTGATG 540
GGTGGCAGGA AGGTGATGTC CATCAGCATC CGGCTGAAAG TGCAGAAAGT CATCCCAGGG 600
CCCCCAGCCT TGACACTGGC GCCTGCAGAG CTGGTGCGGA TTCGAGGGGA GGCTGCCCAG 660
ATCGTGTGCT CAGCCAGCAA CGTTGATGTT AACTTTGATG TCTTCCTCCA ACACAACGAC 720
ACTAAGCTCA CAATCCCTCA ACAATCTGAC TTTCATAATA ACCGTTACCA AAAAGTCCTG 780
ACCTTCAACC TCGATCAAGT AGATTTCCAA CATGCCGGCA ACTACTCCTG CGTGGCCAAC 840
AATGTGCAGG GCAAGCACTC CACCTCCATG TTCTTCCGGG TGGTAGAGAC TGCCTACTTG 900
AACTTGAGCT CTGAGCAGAA CCTCATCCAG GAGGTGACCG TGGGGGAGGG GCTCAACCTC 960
AAAGTCATGG TGGAGGCCTA CCCAGGCCTG CAAGGTTTTA ACTGGACCTA CCTGGGACCC 1020
TTTTCTGACC ACCAGCCTGA GCCCAAGCTT GCTAATGCTA CCACCAAGGA CACATACAGG 1080
CACACCTTCC CCCTCTCTCT GCCCCGCCTG AAGCCCTCTG AGGCTGGCCG CTACTCCTTC 1140
CTAGCCAGAA ACCCAGGAGG CTGGAGAGCT CTGACATTTG AGCTCACCCT TCGATACCCC 1200
CCAGAGGTAA GTGTCATATG GACCTTCATC AATGGCTCTG GCACCCTTGT GTGTGCTGCC 1260
TCCGGGTACC CCCAGCCCAA CGTGACATGG CTGCAGTGCA GTGGCCACAC TGATAGGTGT 1320
GATGAGGCCC AAGTGCTGCA GGTCTGGGAT GACCCATACC CTGAGGTCCT GAGCCAGGAG 1380
CCCTTCCACA AGGTGACCGT GCAAAGCCTG CTGACTGTTG AGACCTTAGA GCACAACCAA 1440
ACCTACGAGT GCAGGGCCCA CAACAGCGTG GGGAGTGGCT CCTGGGCCTT CATACCCATC 1500
TCTGCAGGAG CCCGCACGCA TCCCCCAGAT GAGTTCCTCT TCACACCAGT GGTGGTCGCC 1560
TGCATGTCCA TCATGGCCTT ACTGCTGCTG CTGCTCCTGC TGCTATTGTA CAAGTATAAG 1620
CAGACGGCCC ATGCTGATGA GAAGGAGGCC CTCATGTCCG AGCTGAAGAT CATGAGCCAC 1680
CTGGGCCAGC ACGAGAACAT CGTCAACCTT CTGGGAGCCT GCACCCATGG AGGCCCTGTA 1740
CTGGTCATCA CGGAGTACTG TTGCTATGGC GACCTGCTCA ACTTTCTGCG AAGGAAGGCT 1800
GAGGCCATGC TGGGACCCAG CCTGAGCCCC GGCCAGGACC CCAAGGGAGG CGTCGACTAT 1860
AAGAACATCC ACCTCGAGAA GAAATATGTC CACAGGGACA GTGGCTTCTC CAGCCAGGGT 1920
GTGGACACCT ATGTGGAGAT GAGGCCTGTC TCCACTTCTT CAAATGACTC CTTCTCTGAG 1980
CAAGACCTGG ACAAGGAGGA TGGACGGCCC CTGGAGCTCT GGGACCTGCT TCACTTCTCC 2040
AGCCAAGTAG CCCAGGGCAT GGCCTTCCTC GCTTCTAAGA ATTGCATCCA CCGGGATGTG 2100
GCAGCACGTA ACGTGCTGTT GACCAATGGT CATGTGGCCA AGATTGGGGA CTTCGGGCTG 2160
GCTAGGGACA TCATGAATGA CTCCAACTAC ATCGTCAAGG GCAATGCCCG CCTGCCTGTG 2220
AAGTGGATGG CCCCAGAGAG CATCTTTGAC TGTATCTACA CGGTTCAGAG CGACGTCTGG 2280
TCCTATGGCA TCCTCCTCTG GGAGATCTTC TCGCTTGGGC TGAATCCCTA CCCTGGCATC 2340
CTGGTGAACA GCAAGTTCTA TAAACTGGTG AAGGATGGAT ACCAAATGGC CCAGCCTGCA 2400
TTTGCCCCAA AGAATATATA CAGCATCATG CAGGCCTGCT GGGCCTTGGA GCCCACCCAC 2460
AGACCCACCT TCCAGCAGAT CTGCTCCTTC CTTCAGGAGC AGGCCCAAGA GGACAGGAGA 2520
CAGCAGGACT ATACCAATCT GCCGAGCAGC AGCAGAAGCG GTGGCAGCGG CAGCGGCAGC 2580
GGCAGCGGCA GCAGCAGTGA ACTGGAGGAG GAGAGCGCTA GTGAGCACCT GACCTGCTGC 2640
GAGCAAGGGG ATATCGCCCA GCCCTTGCTG CAGCCCAACA ACTATCAGTT CTGCTGA 2697
Domain Profile
S: 37    lkstarssekealmselkilshlGehenivnllGactkgGpiyviteyccyGdllnylrr  96
          k+ta+++ekealmselki+shlG+henivnllGact+gGp++viteyccyGdlln+lrr
Q: 539   YKQTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRR  598
         599*********************************************************
S: 97    kresflkkslekkkekeeeldskal.ladkslrsksslssesseeyvdlkkdvsdvsssk  155
         k+e++l  sl+  ++++  +d+k++ l++k+++++s +ss++ ++yv++++    vs+s+
Q: 599   KAEAMLGPSLSPGQDPKGGVDYKNIhLEKKYVHRDSGFSSQGVDTYVEMRP----VSTSS  654
         *************************999***********************....99999
S: 156   adklasekkksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaa  215
         +d++++++            l++ed ++lel+dll+fs+qva+Gm+flasknc+hrd+aa
Q: 655   NDSFSEQD------------LDKEDGRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAA  702
         99999988............88999***********************************
S: 216   rnvllteGkvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsy  275
         rnvllt+G+v+ki+dfGlardim+dsny+vkGnarlpvkwmapesifd++ytv+sdvwsy
Q: 703   RNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCIYTVQSDVWSY  762
         ************************************************************
S: 276   GillweifslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrp  335
         GillweifslG +pypg+lv+skfykl+k+Gy+maqpa+a+++iy+imq+cw+ ep++rp
Q: 763   GILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRP  822
         ************************************************************
S: 336   sfkqlvell  344
         +f+q++++l
Q: 823   TFQQICSFL  831
         ******986
Domain Sequence
(FASTA)
YKQTAHADEK EALMSELKIM SHLGQHENIV NLLGACTHGG PVLVITEYCC YGDLLNFLRR 60
KAEAMLGPSL SPGQDPKGGV DYKNIHLEKK YVHRDSGFSS QGVDTYVEMR PVSTSSNDSF 120
SEQDLDKEDG RPLELWDLLH FSSQVAQGMA FLASKNCIHR DVAARNVLLT NGHVAKIGDF 180
GLARDIMNDS NYIVKGNARL PVKWMAPESI FDCIYTVQSD VWSYGILLWE IFSLGLNPYP 240
GILVNSKFYK LVKDGYQMAQ PAFAPKNIYS IMQACWALEP THRPTFQQIC SFL 293
KeywordComplete proteome; Disulfide bond; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00376
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-EQC-00397
EKS-FEC-00389
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LOA-00414
EKS-MAM-00404
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-OTG-00407
EKS-PAT-00383
EKS-PTV-00115
EKS-RAN-00419
EKS-SUS-00355
EKS-TUT-00118
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0030316; P:osteoclast differentiation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013