EKS-POA-00145
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00145
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR511.93.3E-154427701275
StatusUnreviewed
Ensembl ProteinENSPPYP00000017999
UniProt AccessionH2PHH5;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000016083ENSPPYP00000017999ENSPPYT00000018718
OrganismPongo abelii
Functional Description
Protein Length760
Protein Sequence
(FASTA)
MWLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA 60
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLSEDAGRYL CLARGSMIVL QNLTLIIDDS 120
LTSSNDDKDP KSHMDSSNRH IYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPMP 180
TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD 240
VLERSPHRPI LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPGTGRIPHL 360
TCGSLSPAGR TKSPTLQFSL ESGSSGKSSS SLVPGVRLSS SGPALLAGLV SLDLPLDPLW 420
EFPRDRLVLG KPLGEGCFGQ VVRAEAFGMD PARPDQASTV AVKMLKDNAS DKDLADLVSE 480
MEVMKLIGRH KNIINLLGVC TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS 540
EGPLSFPVLV SCAYQVARGM QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI 600
DYYKKTSNGR LPVKWMAPEA LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS 660
LLREGHRMDR PPHCPYLYGM RECWHAAPSQ RPTFKQLVEA LDKVLLAVSE EYLDLRLTFG 720
PYSPSGGDAS STCSSSDSVF SHDPLPLGSS SFPFGSGVQT 760
Nucleotide Sequence
(FASTA)
ATGTGGCTGC TGCTGGCCCT GTTGGGGGTC CTGCTGAGTG TGCCTGGGCC TCCAGTCTTG 60
TCCCTGGAGG CCTCTGAGGA AGTGGAGCTG GAGCCCTGCC TGGCTCCCAG CCTGGAGCAG 120
CAAGAGCAGG AGCTGACAGT AGCCCTTGGG CAGCCTGTGC GGCTGTGCTG TGGGCGGGCT 180
GAGCGTGGTG GCCACTGGTA CAAGGAGGGC AGTCGCCTGG CACCTGCCGG CCGTGTACGG 240
GGCTGGAGGG GCCGCCTAGA GATTGCCAGC TTCCTATCTG AGGATGCTGG CCGCTACCTC 300
TGCCTGGCAC GAGGCTCCAT GATCGTCCTG CAGAATCTCA CCTTGATTAT AGATGACTCC 360
TTGACCTCCA GCAACGATGA TAAGGACCCC AAGTCCCATA TGGACTCCTC GAATAGGCAC 420
ATTTACCCCC AGCAAGCACC TTACTGGACA CACCCCCAGC GCATGGAGAA GAAACTGCAT 480
GCAGTACCTG CGGGGAACAC CGTCAAGTTC CGCTGTCCAG CTGCAGGCAA CCCCATGCCC 540
ACCATCCGCT GGCTTAAGGA TGGACAGGCC TTTCATGGGG AGAACCGCAT TGGAGGCATT 600
CGGCTGCGCC ATCAGCACTG GAGTCTCGTG ATGGAGAGCG TGGTGCCCTC GGACCGCGGC 660
ACGTACACCT GCCTGGTAGA GAATGCTGTG GGCAGCATCC GCTATAACTA CCTGCTAGAT 720
GTGCTGGAGC GGTCCCCGCA CCGGCCCATC CTGCAGGCCG GGCTCCCGGC CAACACCACA 780
GCCGTGGTGG GCAGCGACGT GGAGCTGCTG TGTAAGGTGT ACAGCGATGC CCAGCCCCAC 840
ATCCAGTGGC TGAAGCACAT CGTCATCAAC GGCAGCAGCT TCGGAGCCGA CGGTTTCCCC 900
TATGTGCAAG TCCTAAAGAC TGCAGACATC AATAGCTCAG AGGTGGAGGT CCTGTACCTG 960
CGGAACGTGT CAGCCGAGGA TGCAGGCGAG TACACCTGCC TCGCAGGCAA TTCCATCGGC 1020
CTCTCCTACC AGTCTGCCTG GCTCACGGTG CTGCCAGGTA CTGGGCGCAT CCCCCACCTC 1080
ACATGCGGCA GCCTGAGTCC AGCAGGCAGA ACCAAGTCTC CCACTTTGCA GTTCTCCCTG 1140
GAGTCAGGCT CTTCCGGCAA GTCAAGCTCA TCCCTAGTAC CAGGCGTGCG TCTCTCCTCC 1200
AGCGGCCCCG CCTTGCTCGC CGGCCTCGTG AGTCTAGATC TACCTCTCGA CCCACTATGG 1260
GAGTTCCCCC GGGACAGGCT GGTGCTTGGA AAGCCCCTGG GCGAGGGCTG CTTTGGCCAG 1320
GTAGTACGTG CAGAGGCCTT TGGCATGGAC CCTGCCCGGC CTGACCAAGC CAGCACTGTG 1380
GCCGTCAAGA TGCTCAAAGA CAACGCCTCC GACAAGGACC TGGCCGACCT GGTCTCGGAG 1440
ATGGAGGTGA TGAAGCTGAT TGGCCGACAC AAGAACATCA TCAACCTGCT GGGTGTCTGC 1500
ACCCAGGAAG GGCCCCTGTA TGTGATCGTG GAGTGCGCCG CCAAGGGAAA CCTGCGGGAG 1560
TTCCTGCGGG CCCGGCGCCC CCCAGGCCCC GACCTCAGCC CTGACGGTCC TCGGAGCAGT 1620
GAGGGGCCGC TCTCCTTCCC AGTCCTGGTC TCCTGCGCCT ACCAGGTGGC CCGAGGCATG 1680
CAGTATCTGG AGTCCCGGAA GTGTATCCAC CGGGACCTGG CTGCCCGCAA TGTGCTGGTG 1740
ACCGAGGACA ATGTGATGAA GATTGCTGAC TTTGGGCTGG CCCGCGGCGT CCACCACATT 1800
GACTACTATA AGAAAACCAG CAATGGCCGC CTGCCTGTCA AGTGGATGGC GCCCGAGGCC 1860
TTGTTTGACC GGGTGTACAC ACACCAGAGT GACGTGTGGT CTTTTGGGAT CCTACTGTGG 1920
GAGATCTTCA CCCTCGGGGG CTCCCCGTAT CCTGGCATCC CGGTGGAGGA GCTGTTCTCG 1980
CTGCTGCGGG AGGGACATCG GATGGACCGA CCCCCACACT GCCCCTATCT GTACGGGATG 2040
CGTGAGTGCT GGCACGCGGC ACCCTCCCAG AGGCCTACCT TCAAGCAACT GGTGGAGGCG 2100
CTGGACAAGG TCCTGCTGGC CGTCTCTGAG GAGTACCTCG ACCTCCGCCT GACCTTCGGA 2160
CCCTATTCCC CCTCTGGTGG GGACGCCAGC AGCACCTGCT CCTCCAGCGA TTCTGTCTTC 2220
AGCCACGACC CCCTGCCACT GGGATCCAGC TCCTTCCCCT TCGGGTCTGG GGTGCAGACA 2280
TGA 2283
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl
Q: 427   LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  486
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++
Q: 487   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF  546
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt
Q: 547   PVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT  606
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh
Q: 607   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  666
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p +c+  ly  mrecwha++s+rptfkqlve+l
Q: 667   RMDRPPHCPY-LYG-MRECWHAAPSQRPTFKQLVEAL  701
         ********96.776.8******************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVRAEA FGMDPARPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60
IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PRSSEGPLSF 120
PVLVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG VHHIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPPHCPY LYGMRECWHA APSQRPTFKQ LVEAL 275
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Callithrix jacchus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Taeniopygia guttata"; ?>
EKS-ANC-00141
EKS-CAJ-00153
EKS-GOG-00149
EKS-HOS-00153
EKS-MAM-00146
EKS-OTG-00155
EKS-PAT-00140
EKS-TAG-00178
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0061144; P:alveolar secondary septum development
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013