EKS-POA-00448

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00448

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	449.5	4.7E-135	24	308	285

Status

Unreviewed

Ensembl Protein

ENSPPYP00000018500

UniProt Accession

H2PIU7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK14

Gene Synonyms/Alias

MAPK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000016539	ENSPPYP00000018500	ENSPPYT00000019237

Organism

Pongo abelii

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ 60

SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFS DVYLVTHLMG ADLNNIVKCQ 120

KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 180

GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG 240

TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 300

QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES 360

Nucleotide Sequence
(FASTA)

ATGTCTCAGG AGAGGCCCAC GTTCTACCGG CAGGAGCTGA ACAAGACAAT CTGGGAGGTG 60

CCCGAGCGTT ACCAGAACCT GTCTCCAGTG GGCTCCGGCG CCTATGGCTC TGTGTGTGCT 120

GCTTTTGACA CAAAAACGGG GTTACGTGTG GCAGTGAAGA AGCTCTCCAG ACCATTTCAG 180

TCCATCATTC ATGCCAAAAG AACCTACAGA GAACTGCGGT TACTTAAACA TATGAAACAT 240

GAAAATGTGA TTGGTCTGTT GGATGTTTTT ACACCTGCAA GGTCTCTGGA GGAATTCAGT 300

GATGTGTATT TGGTGACCCA TCTCATGGGG GCAGATCTGA ACAACATTGT GAAATGTCAG 360

AAGCTCACAG ATGACCATGT TCAGTTCCTT ATCTACCAAA TTCTCCGAGG TCTAAAGTAT 420

ATACATTCAG CTGACATAAT TCACAGGGAC CTAAAACCTA GTAATCTAGC TGTGAATGAA 480

GACTGTGAGC TGAAGATTCT GGATTTTGGA CTGGCTCGGC ACACAGATGA TGAAATGACA 540

GGCTACGTGG CCACTAGGTG GTACAGGGCT CCTGAGATCA TGCTGAACTG GATGCATTAC 600

AACCAGACAG TTGATATTTG GTCAGTGGGA TGCATAATGG CCGAGCTGTT GACTGGAAGA 660

ACATTGTTTC CTGGTACAGA CCATATTGAT CAGTTGAAGC TCATTTTAAG ACTCGTTGGA 720

ACCCCAGGGG CTGAGCTTTT GAAGAAAATC TCCTCAGAGT CTGCAAGAAA CTATATTCAG 780

TCTTTGACTC AGATGCCGAA GATGAACTTT GCGAATGTAT TTATTGGTGC CAATCCCCTG 840

GCTGTCGACT TGCTGGAGAA GATGCTTGTA TTGGACTCAG ATAAGAGAAT TACGGCGGCC 900

CAAGCCCTTG CACATGCCTA CTTTGCTCAG TACCACGATC CTGATGATGA ACCAGTGGCC 960

GATCCTTATG ATCAGTCCTT TGAAAGCAGG GACCTCCTTA TAGATGAGTG GAAAAGCCTG 1020

ACCTATGATG AAGTCATCAG CTTTGTGCCA CCACCCCTTG ACCAAGAAGA GATGGAGTCC 1080

TGA 1083

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+p+g+Gayg v++a+d++t+ rva+kklsrpfq+ ++akrt+REl+llk++kheN+

Q: 24    YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV  83

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp+++lee++dvYlvt+lm++dL++++k qkl+d+h+++l+yqilrglky+Hs

Q: 84    IGLLDVFTPARSLEEFSDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS  143

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsNl+vnedcelkildFGlar++d+e    +t+yvatrwYraPei+l++++

Q: 144   ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMH  199

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI+aElltg++lfpg+d+idql++il+++gtp +e lkki+se+arnyi

Q: 200   YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI  259

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +sl++++k++f+++f  a++ a+dLlek+Lvld+dkRi++++aL+h Y+

Q: 260   QSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF  308

         ***********************************************96

Domain Sequence
(FASTA)

YQNLSPVGSG AYGSVCAAFD TKTGLRVAVK KLSRPFQSII HAKRTYRELR LLKHMKHENV 60

IGLLDVFTPA RSLEEFSDVY LVTHLMGADL NNIVKCQKLT DDHVQFLIYQ ILRGLKYIHS 120

ADIIHRDLKP SNLAVNEDCE LKILDFGLAR HTDDEMTGYV ATRWYRAPEI MLNWMHYNQT 180

VDIWSVGCIM AELLTGRTLF PGTDHIDQLK LILRLVGTPG AELLKKISSE SARNYIQSLT 240

QMPKMNFANV FIGANPLAVD LLEKMLVLDS DKRITAAQAL AHAYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0000922	; C:spindle pole
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0001525	; P:angiogenesis
GO:0000902	; P:cell morphogenesis
GO:0071363	; P:cellular response to growth factor stimulus
GO:0071479	; P:cellular response to ionizing radiation
GO:0002062	; P:chondrocyte differentiation
GO:0000077	; P:DNA damage checkpoint
GO:0019395	; P:fatty acid oxidation
GO:0006006	; P:glucose metabolic process
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0030316	; P:osteoclast differentiation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032495	; P:response to muramyl dipeptide
GO:0042770	; P:signal transduction in response to DNA damage
GO:0007519	; P:skeletal muscle tissue development
GO:0090400	; P:stress-induced premature senescence
GO:0051146	; P:striated muscle cell differentiation
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

pon:100449269

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013