EKS-POA-00355

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00355

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	450.0	2.1E-135	271	520	250

Status

Unreviewed

Ensembl Protein

ENSPPYP00000018952

UniProt Accession

H2PK28;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN

Gene Synonyms/Alias

FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000016930	ENSPPYP00000018952	ENSPPYT00000019701

Organism

Pongo abelii

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60

LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120

EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180

TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 240

RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 300

LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR 360

ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 420

TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEHVE 480

RGYRMPCPHD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL 537

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAACAAAAC TGACGGAGGA GAGGGACGGC 60

AGCCTGAACC AGAGCTCCGG GTACCGCTAT GGCACAGACC CCACCCCTCA GCACTACCCC 120

AGCTTCGGCG TGACCTCCAT CCCCAACTAC AACAACTTCC ACGCAGCCGG GGGCCAAGGA 180

CTCACCGTCT TTGGAGGTGT GAACTCTTCG TCTCATACGG GGACCTTGCG TACGAGAGGA 240

GGAACAGGAG TGACACTCTT TGTGGCCCTT TATGACTATG AAGCACGGAC AGAAGATGAC 300

CTGAGTTTTC ACAAAGGAGA AAAATTTCAA ATATTGAACA GCTCGGAAGG AGATTGGTGG 360

GAAGCCCGCT CCTTGACAAC TGGAGAGACA GGTTACATTC CCAGCAATTA TGTGGCTCCG 420

GTTGACTCTA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TTGGCCGAAA AGATGCTGAG 480

CGACAGCTAT TGTCCTTTGG AAACCCAAGA GGTACCTTTC TTATCCGTGA GAGTGAAACC 540

ACCAAAGGTG CCTATTCACT TTCCATCCGT GATTGGGATG ATATGAAAGG AGACCATGTC 600

AAACATTATA AAATTCGCAA ACTTGACAAT GGTGGATACT ACATTACCAC CCGGGCCCAG 660

TTTGAAACAC TTCAGCAGCT TGTACAACAT TACTCAGAGA GAGCTGCAGG TCTCTGCTGC 720

CGCCTAGTAG TTCCCTGTCA CAAAGGGATG CCAAGGCTTA CCGATCTGTC TGTCAAAACC 780

AAAGATGTCT GGGAAATCCC TCGAGAATCC CTGCAGTTGA TCAAGAGACT GGGAAATGGG 840

CAGTTTGGGG AAGTATGGAT GGGTACCTGG AATGGAAACA CAAAAGTAGC CATAAAGACT 900

CTTAAACCAG GCACAATGTC CCCCGAATCA TTCCTTGAGG AAGCGCAGAT CATGAAGAAG 960

CTGAAGCACG ACAAGCTGGT CCAGCTCTAC GCAGTGGTGT CTGAGGAGCC CATCTACATC 1020

GTCACCGAGT ATATGAACAA AGGAAGTTTA CTGGATTTCT TAAAAGATGG AGAAGGAAGA 1080

GCTCTGAAAT TACCAAATCT TGTGGACATG GCAGCACAGG TGGCTGCAGG AATGGCTTAC 1140

ATCGAGCGCA TGAATTATAT CCATAGAGAT CTGCGATCAG CAAACATTCT AGTGGGGAAT 1200

GGACTCATAT GCAAGATTGC TGACTTTGGA TTGGCCCGAT TGATCGAAGA CAATGAGTAC 1260

ACAGCAAGAC AAGGTGCAAA GTTCCCCATC AAGTGGACGG CCCCCGAGGC AGCCCTGTAC 1320

GGGAGGTTCA CAATCAAGTC TGACGTGTGG TCTTTTGGAA TCTTACTCAC AGAGCTGGTC 1380

ACCAAAGGAA GAGTGCCATA CCCAGGCATG AACAACCGGG AGGTGCTGGA GCACGTGGAG 1440

CGAGGCTACA GGATGCCCTG CCCGCACGAC TGCCCCATCT CTCTGCATGA GCTCATGATC 1500

CACTGCTGGA AAAAGGACCC TGAAGAACGC CCCACTTTTG AGTACTTGCA GAGCTTCCTG 1560

GAAGACTACT TTACCGCGAC AGAGCCCCAG TACCAACCTG GTGAAAACCT GTAA 1614

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+ly

Q: 271   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY  330

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 331   AVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  389

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 390   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  449

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm+n+evle+vergyr+p+p++cp +l+el+++cwkkdpee

Q: 450   WSFGILLTELVTKGRVPYPGMNNREVLEHVERGYRMPCPHDCPISLHELMIHCWKKDPEE  509

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 510   RPTFEYLQSFL  520

         ********986

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY 60

AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD 120

LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM NNREVLEHVE RGYRMPCPHD CPISLHELMI HCWKKDPEER 240

PTFEYLQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005768	; C:endosome
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0050798	; P:activated T cell proliferation
GO:0048813	; P:dendrite morphogenesis
GO:0050966	; P:detection of mechanical stimulus involved in sensory perception of pain
GO:0030900	; P:forebrain development
GO:0010629	; P:negative regulation of gene expression
GO:0042177	; P:negative regulation of protein catabolic process
GO:0001764	; P:neuron migration
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0008360	; P:regulation of cell shape
GO:0045471	; P:response to ethanol
GO:0050852	; P:T cell receptor signaling pathway

KEGG

pon:100439712

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013