EKS-POA-00362

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00362

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	420.9	1.6E-126	234	487	254

Status

Unreviewed

Ensembl Protein

ENSPPYP00000018967

UniProt Accession

H2PK43;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000016942	ENSPPYP00000018967	ENSPPYT00000019716

Organism

Pongo abelii

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MSNICQRLWE YLEPYLPCLS TEADKSTVIE NPGARCSPQS QRHGHYFVAL FDYQARTAED 60

LSFRAGDKLQ VLDTLHEGWW FARHLEKRRD GSSQQLQGYI PSNYVAEDRS LQAEPWFFGA 120

IGRSDAEKQL LYSENKTGAF LIRESESQKG EFSLSVLDGG VVKHYRIKRL DEGGFFLTRR 180

RTFSTLNEFV SHYTKTSDGL CVKLGKPCLK IQVPAPFDLS YKTVDQWEID RNSIQLLKRL 240

GAGQFGEVWE GLWNNTTPVA VKTLKPGSMD PNDFLREAQI MKNLRHPRLI QLYAVCTLED 300

PIYIITELMR HGSLQEYLQN DAGSKIHLTQ QVDMAAQVAS GMAYLESRNY IHRDLAARNV 360

LVGEHNIYKV ADFGLARVFK VDNEDIYESK HEIKLPVKWT APEAIRSNKF SIKSDVWSFG 420

ILLYEIITYG KMPYSGMTGA QVIQMLVQNY RLPQPSNCPQ QFYNIMLECW NAEPKERPTF 480

ETLHWKFEDY FETDSSYSDA NNCIR 505

Nucleotide Sequence
(FASTA)

ATGAGCAACA TCTGTCAGAG GCTCTGGGAG TACCTGGAAC CCTATCTCCC CTGTTTGTCC 60

ACGGAGGCAG ACAAGTCAAC TGTGATTGAA AATCCAGGGG CCCGTTGCTC TCCCCAGTCA 120

CAGAGGCATG GCCACTACTT TGTGGCTTTG TTTGATTACC AGGCTCGGAC TGCTGAGGAC 180

TTGAGCTTCC GGGCAGGTGA CAAACTTCAA GTTCTGGACA CTTTGCATGA GGGCTGGTGG 240

TTTGCCAGAC ACTTGGAGAA AAGACGAGAT GGCTCTAGTC AGCAACTACA AGGCTATATT 300

CCTTCTAACT ACGTGGCTGA GGACAGGAGC CTACAGGCAG AGCCGTGGTT CTTTGGAGCA 360

ATCGGAAGAT CAGATGCAGA GAAACAACTA TTATATTCAG AAAACAAGAC GGGTGCCTTT 420

CTAATCAGAG AAAGTGAAAG CCAAAAAGGA GAATTCTCTC TTTCAGTTTT AGATGGAGGA 480

GTTGTAAAAC ACTACAGAAT TAAAAGACTG GATGAAGGGG GCTTTTTTCT CACCCGGAGA 540

AGAACCTTTT CAACACTGAA CGAATTTGTG AGCCACTACA CCAAGACAAG TGACGGCCTG 600

TGTGTCAAGC TGGGGAAACC ATGCTTAAAG ATCCAGGTCC CAGCTCCATT TGATTTGTCA 660

TATAAAACCG TGGACCAATG GGAGATAGAC CGCAACTCCA TACAGCTTCT GAAGCGATTG 720

GGAGCTGGTC AGTTTGGCGA AGTATGGGAA GGGCTGTGGA ACAATACCAC TCCAGTAGCA 780

GTGAAAACAT TAAAACCAGG TTCAATGGAT CCAAATGACT TCCTGAGGGA GGCACAGATA 840

ATGAAGAACC TAAGACATCC AAGGCTTATC CAGCTTTATG CTGTTTGCAC TTTAGAAGAT 900

CCAATTTATA TTATTACAGA GTTGATGAGA CATGGAAGTC TGCAAGAATA TCTCCAAAAT 960

GACGCTGGAT CAAAAATCCA TCTGACTCAA CAGGTAGACA TGGCGGCACA GGTTGCCTCT 1020

GGAATGGCCT ATCTGGAGTC TCGGAACTAC ATTCACAGAG ATCTGGCTGC CAGAAATGTC 1080

CTTGTTGGTG AACATAATAT CTACAAAGTA GCAGATTTTG GACTTGCCAG AGTTTTTAAG 1140

GTAGATAATG AAGACATCTA TGAATCTAAA CACGAAATAA AGCTGCCGGT GAAGTGGACT 1200

GCGCCCGAAG CCATTCGTAG TAATAAATTC AGCATTAAGT CCGATGTGTG GTCATTTGGA 1260

ATCCTTCTTT ATGAAATCAT TACTTATGGC AAAATGCCTT ACAGTGGTAT GACAGGTGCC 1320

CAGGTAATCC AGATGTTGGT TCAAAACTAT AGACTTCCGC AACCATCCAA CTGTCCACAG 1380

CAATTTTACA ACATCATGTT GGAGTGCTGG AATGCAGAGC CTAAGGAACG ACCTACATTT 1440

GAGACACTGC ATTGGAAATT TGAAGACTAT TTTGAAACAG ACTCTTCATA TTCAGATGCA 1500

AATAACTGCA TAAGATGA 1518

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh++l++ly

Q: 234   IQLLKRLGAGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPRLIQLY  293

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g+k++l+++vd+aaqva+Gmayle++n+ihr

Q: 294   AVCTLEDPIYIITELMRHGSLQEYLQNDAGSKIHLTQQVDMAAQVASGMAYLESRNYIHR  353

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+ +kf+ik

Q: 354   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRSNKFSIK  413

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p++cp+++y+++lecw+++

Q: 414   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLVQNYRLPQPSNCPQQFYNIMLECWNAE  473

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfetl++++

Q: 474   PKERPTFETLHWKF  487

         **********9975

Domain Sequence
(FASTA)

IQLLKRLGAG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKN LRHPRLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG SKIHLTQQVD MAAQVASGMA YLESRNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRSNKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLVQNYRLP QPSNCPQQFY NIMLECWNAE 240

PKERPTFETL HWKF 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

pon:100448548

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013