EKS-POA-00379
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00379
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11364.63.7E-109635891257
StatusUnreviewed
Ensembl ProteinENSPPYP00000019077
UniProt AccessionH2PKF0;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000017034ENSPPYP00000019077ENSPPYT00000019828
OrganismPongo abelii
Functional Description
Protein Length1327
Protein Sequence
(FASTA)
PIPPPGSFWN VESAAAPGIG CPAATSASSA TRGRGSSVGG GSRRTTVAYV INEASQGQLV 60
VAESEALQSL REACETVGAT LETHFGKLDF GETTVLDRFY NADIAVVEMS DAFRQPSLFY 120
HLGVRESFSM ANNIILYCDT NSDSLQSLKE IICQKNTMCT GNYTFVPYMI TPHNKVYCCD 180
SSFMKGLTEL MQPNFELLLG PICLPLVDRF IQLLKVAQAS SSQYFRESIL NDIRKARNLY 240
TGKELAAELA RIRQRVDNIE VLTADIVINL LLSYRDIQDY DSIVKLVETL EKLPTFDLAS 300
HHHVKFHYAF ALNRRNLPGD RAKALDIMIP MVQSEGQVAS DMYCLVGRIY KDMFLDSNFT 360
DTESRDHGAS WFKKAFESEP TLQSGINYAV LLLAAGHQFE SSFELRKVGV KLSSLLGKKG 420
NLEKLQSYWE VGFFLGASVL ANDHMRVIQA SEKLFKLKTP AWYLKSIVET ILIYKHFVKL 480
TTEQPVAKQE LVDFWMDFLV EATKTDVTVV RFPVLILEPT KIYQPSYLSI NNEVEEKTIS 540
IWHVLPDDKK GIHEWNFSAS SVRGVSISKF EERCCFLYVL HNSDDFQIYF CTELHCKKFF 600
EMVNTITEEK GRSTEEGDCE SDSLEYDYEY DENGDRVVLG KGTYGIVYAG RDLSNQVRIA 660
IKEIPERDSR YSQPLHEEIA LHKHLKHKNI VQYLGSFSEN GFIKIFMEQV PGGSLSALLR 720
SKWGPLKDNE QTIGFYTKQI LEGLKYLHDN QIVHRDIKGD NVLINTYSGV LKISDFGTSK 780
RLAGINPCTE TFTGTLQYMA PEIIDKGPRG YGKAADIWSL GCTIIEMATG KPPFYELGEP 840
QAAMFKVGMF KVHPEIPESM SAEAKAFILK CFEPDPDKRA CANDLLVDEF LKVSSKKKKT 900
QPKLSALSAG SNEYLRSISL PVPVLVEDAS SSSEYGSVSP DTELKVDPFS FKTRAKSCGE 960
RDVKGIRTLF LGIPDENFED HSAPPSPEEK DSGFFMLRKD SERRATLHRI LTEDQDKIVR 1020
NLMESLAQGA EEPKLKWEHI TTLIASLREF VRSTDRKIIA TTLSKLKLEL DFDSHGISQV 1080
QVVLFGFQDA VNKVLRNHNI KPHWMFALDS IIRKAVQTAI TILVPELRPH FSLASESDTA 1140
DQEDLDVEDD HEEQPSNQTV RRPQAVIEDA VATSGVSTLS STVSHDSQSA HRSLNVQLGR 1200
MKIETNRLLE ELVRKEKELQ ALLHRAIEEK DQEIKHLKLK SQPIEIPELP VFHLNSSGTN 1260
TEGSELTDWL RVNGADEDTI SRFLAEDYTL LDVLYYVTRD DLKCLRLRGG MLCTLWKAII 1320
DFRNKQT 1327
Nucleotide Sequence
(FASTA)
CCAATTCCGC CGCCGGGCAG CTTCTGGAAC GTGGAGAGCG CCGCTGCCCC TGGCATCGGT 60
TGTCCGGCGG CCACCTCCGC GAGCAGTGCC ACCCGAGGCC GGGGCAGCTC TGTTGGCGGG 120
GGCAGCCGAC GGACCACGGT GGCATATGTG ATCAACGAAG CGAGCCAGGG GCAACTGGTG 180
GTGGCCGAGA GCGAGGCCCT GCAGAGCTTG CGGGAGGCGT GCGAGACAGT GGGCGCCACC 240
CTGGAAACCC ATTTTGGGAA ACTCGACTTT GGAGAAACCA CCGTACTGGA CCGCTTTTAC 300
AATGCAGATA TTGCGGTGGT GGAGATGAGC GATGCCTTCC GGCAGCCGTC CTTGTTTTAC 360
CACCTTGGGG TGAGAGAAAG TTTCAGCATG GCCAACAACA TCATCCTCTA CTGTGATACT 420
AACTCGGACT CTCTGCAGTC ACTGAAGGAA ATCATTTGCC AGAAGAATAC TATGTGCACT 480
GGGAACTACA CCTTTGTTCC TTACATGATA ACTCCACATA ACAAAGTCTA CTGCTGTGAC 540
AGCAGCTTCA TGAAGGGGTT GACAGAGCTC ATGCAACCAA ACTTCGAGCT GCTTCTTGGA 600
CCCATCTGCT TACCTCTTGT GGATCGTTTT ATTCAACTTT TGAAGGTGGC ACAAGCAAGT 660
TCTAGCCAGT ATTTCCGGGA ATCTATACTC AATGACATCA GGAAAGCTCG TAATTTATAC 720
ACTGGTAAAG AATTGGCAGC TGAGTTGGCA AGAATTCGGC AGCGAGTAGA TAATATCGAA 780
GTCTTGACAG CAGATATTGT CATAAATCTG TTACTTTCCT ACAGAGATAT CCAGGACTAT 840
GATTCTATTG TGAAGCTGGT AGAGACTTTA GAAAAACTGC CAACCTTTGA TTTGGCCTCC 900
CATCACCATG TGAAGTTTCA TTATGCATTT GCACTGAATA GGAGAAATCT CCCTGGAGAC 960
AGAGCAAAAG CTCTTGATAT TATGATTCCC ATGGTGCAAA GTGAAGGACA GGTTGCTTCA 1020
GATATGTATT GCCTAGTTGG TCGAATCTAC AAAGATATGT TTTTGGACTC TAATTTCACG 1080
GACACTGAAA GCAGAGACCA TGGAGCTTCT TGGTTCAAAA AGGCATTTGA ATCTGAGCCA 1140
ACACTACAGT CAGGAATTAA TTATGCGGTC CTCCTCCTGG CAGCTGGGCA CCAGTTTGAA 1200
TCTTCCTTTG AGCTCCGGAA AGTTGGGGTG AAGCTAAGTA GTCTTCTTGG TAAAAAGGGA 1260
AACTTGGAAA AACTCCAGAG CTACTGGGAA GTTGGATTTT TTCTGGGGGC CAGCGTCCTA 1320
GCCAATGACC ACATGAGAGT CATTCAAGCA TCTGAAAAGC TTTTTAAACT GAAGACACCA 1380
GCATGGTACC TCAAGTCTAT TGTAGAGACA ATTTTGATAT ATAAACATTT TGTGAAACTG 1440
ACCACAGAAC AGCCTGTGGC CAAGCAAGAA CTTGTGGACT TTTGGATGGA TTTCCTGGTC 1500
GAGGCCACAA AGACAGATGT TACTGTGGTT AGGTTTCCAG TATTAATATT AGAACCAACC 1560
AAAATCTATC AACCTTCTTA TTTGTCTATC AACAATGAAG TTGAGGAAAA GACAATCTCT 1620
ATTTGGCACG TGCTTCCTGA TGACAAGAAA GGTATACATG AGTGGAATTT TAGTGCCTCT 1680
TCTGTCAGGG GAGTGAGTAT TTCCAAATTT GAAGAAAGAT GCTGCTTTCT TTATGTGCTC 1740
CACAATTCTG ATGATTTCCA AATCTATTTC TGTACAGAAC TTCATTGTAA AAAGTTTTTT 1800
GAGATGGTGA ACACCATTAC CGAAGAGAAG GGGAGAAGCA CAGAGGAAGG AGACTGTGAA 1860
AGTGACTCGC TGGAGTATGA CTATGAATAT GATGAAAATG GTGACAGAGT CGTTTTAGGA 1920
AAAGGCACTT ACGGGATAGT CTACGCAGGT CGGGACTTGA GCAATCAAGT CAGAATTGCT 1980
ATTAAGGAAA TCCCAGAGAG AGACAGCAGA TACTCTCAGC CCCTGCATGA AGAAATAGCA 2040
TTGCATAAAC ACCTGAAGCA CAAAAATATT GTCCAGTATC TGGGCTCTTT CAGTGAGAAT 2100
GGTTTCATTA AAATCTTCAT GGAGCAGGTC CCTGGAGGAA GTCTTTCTGC TCTCCTTCGT 2160
TCCAAATGGG GTCCATTAAA AGACAATGAG CAAACAATTG GCTTTTATAC AAAGCAAATA 2220
CTGGAAGGAT TAAAATATCT CCATGACAAT CAGATAGTTC ACCGAGACAT AAAGGGTGAC 2280
AATGTGTTGA TTAATACCTA CAGTGGTGTT CTCAAGATCT CTGACTTCGG GACGTCAAAG 2340
AGGCTTGCTG GCATAAACCC CTGTACTGAA ACTTTTACTG GTACCCTCCA GTATATGGCA 2400
CCAGAAATAA TAGATAAAGG ACCAAGAGGC TACGGAAAAG CAGCGGACAT CTGGTCTCTG 2460
GGCTGTACAA TCATTGAAAT GGCCACAGGA AAACCCCCAT TTTATGAACT GGGAGAACCA 2520
CAAGCAGCTA TGTTCAAGGT GGGAATGTTT AAAGTTCACC CTGAGATCCC AGAGTCCATG 2580
TCTGCAGAAG CCAAGGCATT CATACTGAAA TGTTTTGAAC CAGATCCTGA CAAGAGAGCC 2640
TGTGCTAACG ACTTGCTTGT TGATGAGTTT TTAAAAGTTT CAAGCAAAAA GAAAAAGACA 2700
CAACCTAAAC TTTCAGCTCT TTCAGCTGGA TCAAATGAAT ATCTCAGGAG TATATCCTTG 2760
CCGGTACCTG TGCTGGTGGA GGACGCCAGC AGCAGCAGTG AGTACGGCTC TGTTTCACCT 2820
GACACGGAGT TGAAAGTGGA CCCCTTCTCT TTCAAAACAA GAGCCAAGTC CTGCGGAGAA 2880
AGAGACGTCA AGGGAATTCG GACACTCTTT TTGGGCATTC CAGATGAGAA TTTTGAAGAT 2940
CACAGTGCTC CTCCTTCCCC CGAAGAAAAA GATTCTGGAT TCTTCATGCT GAGGAAGGAC 3000
AGTGAGAGGC GAGCTACCCT TCACAGGATC CTGACGGAAG ACCAAGACAA AATTGTGAGA 3060
AACCTAATGG AATCTTTAGC TCAGGGGGCT GAAGAACCGA AACTAAAATG GGAACACATC 3120
ACAACCCTCA TTGCAAGCCT CAGAGAATTT GTGAGATCCA CTGACCGAAA AATCATAGCC 3180
ACCACACTGT CAAAGCTGAA ACTGGAGCTG GACTTCGACA GCCACGGCAT TAGCCAAGTC 3240
CAGGTGGTAC TCTTTGGTTT TCAAGATGCT GTCAATAAAG TTCTTCGGAA TCATAACATC 3300
AAGCCACACT GGATGTTTGC CTTAGACAGT ATCATCCGGA AGGCAGTACA GACAGCCATT 3360
ACTATCCTGG TTCCAGAACT AAGGCCACAT TTCAGCCTTG CATCTGAGAG TGATACTGCT 3420
GATCAAGAAG ACTTGGATGT AGAAGATGAC CATGAGGAAC AGCCTTCAAA TCAAACTGTC 3480
CGAAGACCTC AGGCTGTCAT TGAAGATGCC GTGGCTACCT CAGGCGTGAG CACGCTCAGT 3540
TCTACTGTGT CTCATGATTC CCAGAGTGCT CACCGGTCAC TGAATGTACA GCTTGGAAGG 3600
ATGAAAATAG AAACCAATAG ATTACTGGAA GAATTGGTTC GGAAAGAGAA AGAGTTACAA 3660
GCACTCCTTC ATCGAGCTAT TGAAGAAAAA GACCAAGAAA TTAAACACCT GAAGCTTAAG 3720
TCCCAACCCA TAGAAATTCC TGAATTGCCT GTATTTCACC TAAATTCTTC TGGCACAAAT 3780
ACTGAAGGTT CTGAACTTAC CGACTGGCTG AGAGTGAATG GAGCTGATGA AGACACTATA 3840
AGCCGGTTTT TGGCTGAAGA TTATACACTA TTGGATGTTC TCTACTATGT TACACGTGAT 3900
GACTTAAAAT GCTTGAGACT AAGGGGAGGG ATGCTGTGCA CACTGTGGAA GGCTATCATT 3960
GACTTTCGAA ACAAACAGAC T 3981
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 635   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  689
         5789**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 690   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  749
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k
Q: 750   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  806
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+
Q: 807   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  866
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         f+ kc+e dp+kr++a++LL +efl
Q: 867   FILKCFEPDPDKRACANDLLVDEFL  891
         **********************996
Domain Sequence
(FASTA)
DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180
ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240
DPDKRACAND LLVDEFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00361
EKS-ANC-00378
EKS-BOT-00387
EKS-CAE-00316
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-DRM-00182
EKS-EQC-00380
EKS-FEC-00376
EKS-GAG-00327
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-ICT-00372
EKS-LAC-00401
EKS-LOA-00395
EKS-MAM-00386
EKS-MEG-00320
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-NOL-00355
EKS-ORN-00500
EKS-ORA-00336
EKS-ORC-00364
EKS-ORL-00460
EKS-OTG-00390
EKS-PES-00346
EKS-RAN-00402
EKS-SAH-00359
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-XET-00502
EKS-XIM-00493
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013