EKS-POA-00381

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00381

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	348.9	2.3E-104	1252	1510	259

Status

Unreviewed

Ensembl Protein

ENSPPYP00000019213

UniProt Accession

H2PKT5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000017155	ENSPPYP00000019213	ENSPPYT00000019969

Organism

Pongo abelii

Functional Description

Protein Length

1517

Protein Sequence
(FASTA)

MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPPEPE TESEPECCLA ARQEGTLGDS 60

ACKSPESDPE DFSDETNTEN LYGTSPPSTP RQMKRMSTKH QRNNVGRPAS RSNLKEKMNA 120

PNQPPHKDTG KTVENVEEYS YKQEKKIRAA LRTTERDHKK NVQCSFMLDS VGGSLPKKSI 180

PDVDLNKPYL SLGCSDFFLY TARQAIPDII NEILTFKVDY GSFAFVRDGA GFNGTSVEGQ 240

CKATPGTKFV GYSTHHEHLQ RQRVSFEQVK RIMELLEYIE ALYPSLQALQ KDYEKYAAKD 300

FQDRVQALCL WLNITKDLNQ KLRIMGTVLG IKNLSDIGWP VFEIPSPRPS KGNEPEYEGD 360

DTEGELKELE SSTDESEEEQ ISDPRVPEIR QPIDNSFDIQ SQDCISKKLE RLESEDDSIG 420

WGAPDWSTEA GFSRHCLTSI YRPFVDKALK QMGLRKLILR LHKLMDGSLQ RARVALVKND 480

RPVEFSEFPD PMWGSDYVQL SRSPPSSEQK HSAVSWEELK AMDLPSFEPA FLVLCRVLLN 540

VIHECLKLRL EQRPAGEPSL LSIKQLVREC KEVLKGGLLM KQYYQFMLQE VLEDLEKPDC 600

NIDAFEEDLH KMLMVYFDYM RSWIQMLQQL PQASHSLKNL LEEEWNFTKE ITHYIRGGEA 660

QAGKLFCDIA GMLLKSTGSF LEFGLQESCA EFWTSADDSS ASDEIRRSVI EISRALKELF 720

HEARERASKA LGFAKMLRKD LEIAAEFRLS APVRDLLDVL KSKQYVKVQI PGLENLQVFV 780

PDTLAEEKSI ILQLLNAAAG KDCSKDSDDV LIDAYLLLTK HGDRARDSED SWGTWEAQPV 840

KVVPQVETVD TLRSMQVDNL LLVVMQSAHL TIQRKAFQQS IEGLMTLCQE QTSSQPVIAK 900

ALQQLKNDAL ELCNRISNAI DRVDHMFTSE FDAEVDESES VTLQQYYREA MIQGYNFGFE 960

YHKEVVRLMS GEFRQKIGDK YISFARKWMN YVLTKCESGR GTRPRWATQG FDFLQAIEPA 1020

FISALPEDDF LSLQALMNEC IGHVIGKPHS PVTGLYLAIH RNSPRPMKVP RCHSDPPNPH 1080

LIIPTPEGFS TRSVPSDPRS HGSPAAAAVA ARRPSPSGGD TVLPKSISSA HDTRGSSVPE 1140

NDRLASIAAE LQFRSLSRHS SPTEERDEPA YPRGDSSGST RRSWELRTLI SQSKDSASKL 1200

GPIEAIQKSV RLFEEKRYRE MRRKNIIGQV CDTPKSYDNV MHVGLRKVTF KWQRGNKIGE 1260

GQYGKVYTCI SVDTGELMAM KEIRFQPNDH KTIKETADEL KIFEGIKHPN LVRYFGVELH 1320

REEMYIFMEY CDEGTLEEVS RLGLQEHVIR LYSKQITIAI NVLHEHGIVH RDIKGANIFL 1380

TSSGLIKLGD FGCSVKLKNN AQTMPGEVNS TLGTAAYMAP EVITRAKGEG HGRAADIWSL 1440

GCVVIEMVTG KRPWHEYEHN FQIMYKVGMG HKPPIPERLS PEGKDFLSHC LESDPKMRWT 1500

ASQLLDHSFV KVCTDEE 1517

Nucleotide Sequence
(FASTA)

ATGAGAGAAG CCGCTGCCGC GCTGGTCCCT CCTCCCGCCT TTGCCGTCAC GCCTGCCGCC 60

GCCATGGAGG AGCCGCCGCC ACCGCCGCCG CCGCCACCAC CGCCGCCGCC GGAACCCGAG 120

ACCGAGTCAG AACCCGAGTG CTGCTTGGCG GCGAGGCAAG AGGGCACATT GGGAGATTCA 180

GCTTGCAAGA GTCCTGAATC TGATCCAGAA GACTTCTCCG ATGAAACAAA TACAGAGAAT 240

CTTTATGGTA CCTCTCCCCC CAGCACACCT CGACAGATGA AACGCATGTC AACCAAACAC 300

CAGAGGAATA ATGTGGGGAG GCCAGCCAGT CGGTCTAATT TGAAAGAAAA AATGAATGCA 360

CCAAATCAGC CTCCACATAA AGACACTGGA AAAACAGTGG AGAATGTGGA AGAATACAGC 420

TATAAGCAGG AGAAAAAGAT CCGAGCAGCT CTTAGAACAA CAGAGCGTGA TCATAAAAAA 480

AATGTACAGT GCTCATTCAT GTTAGACTCA GTGGGTGGAT CTTTGCCAAA AAAATCAATT 540

CCAGATGTGG ATCTCAATAA GCCTTACCTC AGCCTTGGCT GTAGCGACTT CTTTTTATAT 600

ACAGCCCGTC AAGCCATCCC AGATATTATT AATGAAATCC TTACTTTCAA AGTCGACTAT 660

GGGAGCTTCG CCTTTGTTAG AGATGGAGCT GGTTTTAATG GTACTTCAGT AGAAGGGCAG 720

TGCAAAGCCA CTCCTGGAAC AAAGTTTGTA GGTTACTCAA CGCATCACGA GCATCTCCAA 780

CGCCAGAGGG TCTCATTTGA GCAGGTAAAA CGGATAATGG AGCTGCTAGA GTACATAGAA 840

GCACTTTATC CATCATTGCA GGCTCTTCAG AAGGACTATG AAAAATATGC TGCAAAAGAC 900

TTCCAGGACA GGGTGCAGGC ACTCTGTTTG TGGTTAAACA TCACAAAAGA CTTAAATCAG 960

AAATTAAGGA TTATGGGCAC TGTTTTGGGC ATCAAGAATT TATCAGACAT TGGCTGGCCA 1020

GTGTTTGAAA TCCCTTCCCC TCGACCATCC AAAGGTAATG AGCCGGAGTA TGAGGGTGAC 1080

GACACAGAAG GAGAATTAAA GGAGTTGGAA AGTAGTACGG ATGAGAGTGA AGAAGAACAA 1140

ATCTCTGATC CTAGGGTACC GGAAATCAGA CAGCCCATAG ATAACAGCTT CGACATCCAG 1200

TCGCAGGACT GCATATCCAA GAAGCTTGAG AGGCTCGAAT CTGAGGATGA TTCTATTGGC 1260

TGGGGAGCAC CAGACTGGAG CACAGAAGCA GGCTTTAGCA GACATTGTCT GACTTCTATT 1320

TATAGACCAT TTGTAGACAA AGCACTGAAG CAGATGGGGT TAAGAAAGTT AATTTTAAGA 1380

CTTCACAAGC TAATGGATGG TTCCTTGCAA AGGGCACGTG TAGCATTGGT AAAGAACGAT 1440

CGTCCAGTGG AGTTTTCTGA ATTTCCAGAT CCCATGTGGG GTTCAGATTA TGTGCAGCTG 1500

TCAAGGTCAC CGCCTTCATC TGAGCAGAAA CACAGTGCTG TGTCGTGGGA GGAGCTGAAG 1560

GCCATGGATT TACCTTCATT CGAACCTGCC TTCCTGGTTC TCTGCCGAGT CCTTCTGAAT 1620

GTCATACATG AGTGTCTGAA GTTAAGATTG GAGCAGAGAC CTGCTGGAGA ACCATCTCTC 1680

TTGAGTATTA AGCAGCTGGT GAGAGAGTGT AAGGAGGTGC TGAAGGGCGG CCTGCTGATG 1740

AAGCAGTACT ACCAGTTCAT GCTGCAGGAG GTTCTGGAGG ACTTGGAGAA GCCCGACTGC 1800

AACATTGACG CTTTTGAAGA GGATCTGCAT AAAATGCTTA TGGTGTATTT TGATTACATG 1860

AGAAGCTGGA TCCAAATGCT ACAGCAATTA CCTCAAGCAT CGCATAGTTT AAAAAATCTG 1920

TTAGAAGAAG AATGGAATTT CACCAAAGAA ATAACTCATT ACATACGGGG AGGAGAAGCA 1980

CAGGCCGGGA AGCTTTTCTG TGACATTGCA GGAATGCTGC TGAAATCTAC AGGAAGTTTT 2040

TTAGAATTTG GCTTACAGGA GAGCTGTGCT GAATTTTGGA CTAGTGCGGA TGACAGCAGT 2100

GCTTCCGACG AAATCAGGAG GTCTGTTATA GAGATCAGCC GAGCCCTGAA GGAGCTCTTC 2160

CATGAAGCCA GAGAAAGGGC TTCCAAAGCA CTTGGATTTG CTAAAATGTT GAGAAAGGAC 2220

CTGGAAATAG CAGCAGAATT CAGGCTTTCA GCCCCAGTTA GAGACCTCCT GGATGTTCTG 2280

AAATCAAAAC AGTATGTCAA GGTACAAATT CCTGGGTTAG AAAACTTGCA AGTGTTTGTT 2340

CCAGACACTC TTGCTGAGGA GAAGAGTATT ATTTTGCAGT TACTCAATGC AGCTGCAGGA 2400

AAGGACTGTT CAAAAGATTC AGATGACGTG CTCATCGATG CCTATCTGCT TCTGACCAAG 2460

CACGGTGATC GAGCCCGTGA TTCAGAGGAC AGCTGGGGCA CCTGGGAGGC ACAGCCTGTC 2520

AAAGTCGTGC CTCAGGTGGA GACTGTTGAC ACCCTGAGAA GCATGCAGGT GGATAATCTT 2580

TTACTAGTTG TCATGCAGTC TGCCCATCTC ACAATTCAGA GAAAAGCTTT CCAGCAGTCC 2640

ATTGAGGGAC TTATGACTCT GTGCCAGGAG CAGACATCCA GTCAGCCGGT CATCGCCAAA 2700

GCTTTGCAGC AGCTGAAGAA TGATGCATTG GAGCTATGCA ACAGAATAAG CAATGCCATT 2760

GACCGCGTGG ACCACATGTT CACATCAGAA TTTGATGCTG AGGTTGATGA ATCTGAATCT 2820

GTTACCTTGC AACAGTACTA CCGAGAAGCA ATGATTCAAG GGTACAATTT TGGATTTGAG 2880

TATCATAAAG AAGTTGTTCG TTTGATGTCT GGGGAGTTTA GACAGAAGAT AGGAGACAAA 2940

TATATAAGCT TTGCTCGGAA GTGGATGAAT TATGTCCTGA CTAAATGTGA GAGTGGTAGA 3000

GGTACAAGAC CCAGGTGGGC GACTCAAGGA TTTGATTTTC TACAAGCAAT TGAACCTGCC 3060

TTTATTTCAG CTTTACCAGA AGATGACTTC TTGAGTTTAC AAGCCTTGAT GAATGAATGC 3120

ATTGGCCATG TCATAGGAAA ACCACACAGT CCTGTTACAG GTTTGTACCT TGCCATTCAT 3180

CGGAACAGCC CCCGTCCTAT GAAGGTACCT CGATGCCATA GTGACCCTCC TAACCCACAC 3240

CTCATTATCC CCACTCCAGA GGGATTCAGC ACTCGGAGCG TGCCTTCCGA CCCGCGGAGC 3300

CATGGCAGCC CTGCTGCTGC TGCTGTTGCT GCCCGTCGGC CCAGCCCCTC TGGTGGCGAC 3360

ACTGTGCTGC CCAAATCCAT CAGCAGTGCC CATGATACCA GGGGTTCCAG CGTCCCTGAA 3420

AATGATCGGT TGGCTTCCAT AGCTGCTGAA TTGCAGTTTA GGTCCCTGAG TCGTCACTCA 3480

AGCCCCACGG AGGAGCGAGA CGAACCAGCA TATCCAAGAG GAGATTCAAG TGGGTCCACA 3540

AGAAGAAGTT GGGAACTTCG GACACTAATC AGCCAGAGTA AAGATAGTGC TTCTAAACTA 3600

GGACCCATAG AAGCTATCCA GAAGTCAGTC CGATTGTTTG AAGAAAAGAG GTACCGAGAA 3660

ATGAGGAGAA AGAATATCAT TGGTCAAGTT TGTGATACGC CTAAGTCGTA TGATAATGTT 3720

ATGCATGTTG GCTTGAGGAA GGTGACCTTC AAGTGGCAAA GAGGAAACAA AATTGGAGAA 3780

GGCCAGTATG GGAAGGTGTA CACCTGCATC AGCGTCGACA CCGGGGAGCT GATGGCCATG 3840

AAGGAGATTC GATTTCAACC TAATGACCAT AAGACTATCA AGGAAACTGC AGATGAATTG 3900

AAGATATTCG AAGGCATCAA ACACCCCAAT CTGGTTCGGT ATTTTGGTGT GGAGCTCCAT 3960

AGAGAAGAAA TGTACATCTT CATGGAGTAC TGCGATGAGG GGACTTTAGA AGAGGTGTCA 4020

AGGCTGGGAC TTCAGGAACA TGTGATTAGG CTGTATTCAA AGCAGATCAC CATTGCAATC 4080

AATGTCCTCC ATGAGCATGG CATAGTCCAC CGTGACATTA AAGGTGCCAA TATCTTCCTT 4140

ACCTCATCTG GATTAATCAA ACTGGGAGAT TTTGGATGTT CAGTAAAGCT CAAAAACAAT 4200

GCCCAGACCA TGCCTGGTGA AGTGAACAGC ACCCTGGGGA CTGCAGCATA CATGGCACCT 4260

GAAGTCATCA CTCGTGCCAA AGGAGAGGGC CATGGGCGTG CGGCCGACAT CTGGAGTCTG 4320

GGGTGTGTTG TCATAGAGAT GGTCACTGGC AAGAGGCCTT GGCATGAGTA CGAGCACAAC 4380

TTTCAAATTA TGTATAAAGT GGGGATGGGA CATAAGCCAC CAATCCCTGA AAGATTAAGC 4440

CCTGAAGGAA AGGACTTCCT TTCTCACTGC CTTGAGAGTG ACCCAAAGAT GAGATGGACC 4500

GCCAGCCAGC TCCTCGACCA TTCGTTTGTC AAGGTTTGCA CAGATGAAGA ATGA 4554

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1252  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1308

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1309  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEH  1366

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1367  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1426

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls+egkd

Q: 1427  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKD  1485

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle+dpk r++a++LL+h+f+

Q: 1486  FLSHCLESDPKMRWTASQLLDHSFV  1510

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITIAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERLSP EGKDFLSHCL 240

ESDPKMRWTA SQLLDHSFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0019100	; P:male germ-line sex determination
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013