EKS-POA-00158
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00158
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb493.11.7E-148491748258
StatusUnreviewed
Ensembl ProteinENSPPYP00000019227
UniProt AccessionH2PKU9;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000017167ENSPPYP00000019227ENSPPYT00000019984
OrganismPongo abelii
Functional Description
Protein Length809
Protein Sequence
(FASTA)
MSRRGRRRRE RLRPRPRWPA RPALCFRSPR PTPRAHGRRA GLPGHACPPA DLSPAPWDAG 60
DARPPALRLL RAGRGAMDLS MKKFAVRRFF SVYLRRKSRS KSSSLSRLEE EGVVKEIDIS 120
HHVKEGFEKA DPSQFELLKV LGQGSYGKVF LVRKVKGSDA GQLYAMKVLK KATLKVRDRV 180
RSKMERDILA EVNHPFIVKL HYAFQTEGKL YLILDFLRGG DLFTRLSKEV MFTEEDVKFY 240
LAELALALDH LHSLGIIYRD LKPENILLDE EGHIKITDFG LSKEAIDHDK RAYSFCGTIE 300
YMAPEVVNRR GHTQSADWWS FGVLMFEMLT GSLPFQGKDR KETMALILKA KLGMPQFLSG 360
EAQSLLRALF KRNPCNRLGA GIDGVEEIKR HPFFVTIDWN TLYRKEIKPP FKPAVGRPED 420
TFHFDPEFTA RTPTDSPGVP PSANAHHLFR GFSFVASSLI QEPSQQDLHK VPVHPIVQQL 480
HGNNIHFTDG YEIKEDIGVG SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG 540
QHPNIITLKD VYDDGKFVYL VMELMRGGEL LDRILRQRYF SEREASDVLC TITKTMDYLH 600
SQGVVHRDLK PSNILYRDES GSPESIRVCD FGFAKQLRAG NGLLMTPCYT ANFVAPEVLK 660
RQGYDAACDI WSLGILLYTM LAGFTPFANG PDDTPEEILV RIGSGKYALS GGNWDSISDA 720
AKDVVSKMLH VDPHQRLTAM QVLKHPWVVN REYLSPNQLS RQDVHLVKGA MAATYFALNR 780
TPQAPRLEPV LSSNLAQRRG MKRLTSTRL 809
Nucleotide Sequence
(FASTA)
ATGAGCAGGC GGGGACGGAG GCGGAGGGAG CGCCTAAGGC CTCGGCCGCG GTGGCCGGCG 60
CGGCCTGCCC TTTGTTTCCG CAGCCCGCGC CCCACGCCCC GCGCCCATGG CCGCCGTGCC 120
GGGCTCCCTG GCCACGCGTG CCCGCCCGCG GACCTGAGCC CCGCGCCCTG GGATGCCGGG 180
GATGCGCGTC CCCCGGCCCT GCGGCTGCTC CGGGCTGGGC GCGGGGCGAT GGACCTGAGC 240
ATGAAGAAGT TCGCCGTGCG CAGGTTCTTC TCCGTGTACC TGCGCAGGAA GTCGCGCTCC 300
AAGAGCTCCA GCCTGAGCCG GCTCGAGGAA GAAGGCGTCG TGAAGGAGAT AGACATCAGC 360
CATCACGTGA AGGAGGGCTT TGAGAAGGCA GACCCTTCCC AGTTTGAGCT GCTGAAGGTT 420
TTAGGACAAG GATCCTATGG AAAGGTGTTC CTGGTGAGGA AGGTGAAGGG GTCCGACGCT 480
GGGCAGCTCT ATGCCATGAA GGTCCTTAAG AAAGCCACCC TAAAAGTTCG GGACCGCGTG 540
AGATCGAAGA TGGAGAGAGA CATCTTGGCA GAAGTGAATC ACCCCTTCAT TGTGAAGCTT 600
CATTATGCCT TTCAGACAGA AGGAAAGCTC TACCTGATCC TGGACTTCCT GCGGGGAGGG 660
GACCTCTTCA CCCGGCTCTC CAAAGAGGTC ATGTTCACCG AGGAGGATGT CAAGTTCTAC 720
CTGGCTGAGC TGGCCTTGGC TTTAGATCAT CTCCACAGCC TGGGGATCAT CTACAGAGAT 780
CTGAAGCCCG AGAACATCCT CCTGGATGAA GAGGGACATA TTAAGATCAC AGATTTCGGC 840
CTGAGTAAGG AGGCCATTGA CCACGACAAG AGAGCGTACT CCTTCTGCGG GACGATCGAG 900
TACATGGCGC CCGAGGTGGT GAACCGGCGA GGACACACGC AGAGTGCCGA CTGGTGGTCC 960
TTCGGCGTGC TCATGTTCGA GATGCTCACG GGGTCCCTGC CGTTCCAGGG GAAGGACAGG 1020
AAGGAGACCA TGGCTCTCAT CCTCAAAGCC AAGCTGGGGA TGCCGCAGTT CCTCAGTGGG 1080
GAGGCACAGA GTTTGCTGCG AGCTCTCTTC AAACGGAACC CTTGCAACCG GCTGGGTGCT 1140
GGCATTGACG GAGTGGAGGA AATTAAGCGC CATCCCTTCT TTGTGACCAT AGACTGGAAC 1200
ACGCTGTACC GGAAGGAGAT CAAGCCACCG TTCAAACCAG CAGTGGGCAG GCCTGAGGAC 1260
ACCTTCCACT TTGACCCCGA GTTCACAGCA CGGACGCCCA CAGACTCTCC TGGCGTCCCC 1320
CCGAGTGCAA ATGCTCATCA CCTGTTTAGA GGATTCAGCT TTGTGGCCTC AAGCCTGATC 1380
CAGGAGCCCT CACAGCAAGA TCTGCACAAA GTCCCAGTTC ACCCAATCGT GCAGCAGTTA 1440
CACGGGAACA ACATCCACTT CACCGATGGC TACGAGATCA AGGAGGACAT CGGGGTGGGC 1500
TCCTACTCAG TGTGCAAGCG ATGTGTGCAT AAAGCCACGG ACACCGAGTA TGCCGTGAAG 1560
ATCATCGATA AGAGCAAGAG AGACCCCTCG GAAGAGATTG AGATCCTCCT GCGGTACGGC 1620
CAGCACCCGA ACATCATCAC CCTCAAGGAT GTCTATGACG ATGGCAAGTT TGTGTACCTG 1680
GTAATGGAGC TGATGCGCGG TGGGGAGCTC CTGGACCGCA TCCTCCGGCA GAGATACTTC 1740
TCGGAGCGCG AGGCCAGTGA CGTCCTGTGC ACCATCACCA AGACCATGGA CTACCTCCAT 1800
TCCCAGGGGG TTGTTCATCG AGACCTGAAG CCGAGTAACA TCCTGTACAG GGATGAGTCG 1860
GGGAGCCCAG AATCCATCCG AGTCTGCGAC TTCGGCTTTG CCAAGCAGCT GCGCGCGGGG 1920
AACGGGCTGC TCATGACGCC CTGCTACACA GCCAATTTCG TGGCCCCGGA GGTCCTGAAG 1980
CGTCAAGGCT ATGATGCGGC GTGTGACATC TGGAGTTTGG GAATCCTGTT GTACACCATG 2040
CTGGCAGGAT TTACCCCTTT TGCAAATGGG CCAGACGATA CCCCTGAGGA GATTTTGGTG 2100
CGGATCGGCA GTGGGAAGTA TGCCCTTTCT GGGGGAAACT GGGACTCGAT ATCTGACGCA 2160
GCCAAAGACG TCGTGTCCAA GATGCTCCAC GTGGACCCTC ATCAGCGCCT GACGGCGATG 2220
CAAGTGCTCA AACACCCGTG GGTGGTCAAC AGAGAGTACC TGTCCCCAAA CCAGCTCAGC 2280
CGACAGGACG TGCACCTGGT GAAGGGCGCG ATGGCCGCCA CCTACTTTGC TCTAAACAGA 2340
ACACCTCAGG CCCCGCGGCT GGAGCCCGTG CTGTCGTCCA ACCTGGCTCA GCGCAGAGGC 2400
ATGAAGAGAC TCACGTCCAC GCGGTTGTAG 2430
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat++e+avkiidkskrd+seeieillry+qhpni+tlkd
Q: 491   YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  550
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelldri+++++fsereas++l+t++k+++ylh+qGvvhrdlk
Q: 551   VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK  610
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+++esi+++dfGfak++ra ngll+tpcyt+nfvapevlkrqGyd+acd+
Q: 611   PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI  670
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaG++pfangp+dt+eeil++i++Gk++lsG++wds+s++akd+vsk+l+
Q: 671   WSLGILLYTMLAGFTPFANGPDDTPEEILVRIGSGKYALSGGNWDSISDAAKDVVSKMLH  730
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl+++q+lkh+w+
Q: 731   VDPHQRLTAMQVLKHPWV  748
         *****************7
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKFVYL VMELMRGGEL LDRILRQRYF SEREASDVLC TITKTMDYLH SQGVVHRDLK 120
PSNILYRDES GSPESIRVCD FGFAKQLRAG NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGILLYTM LAGFTPFANG PDDTPEEILV RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240
VDPHQRLTAM QVLKHPWV 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GAG-00139
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-OTG-00167
EKS-PES-00142
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-XET-00150
EKS-XIM-00198
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0002035; P:brain renin-angiotensin system
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0060047; P:heart contraction
GO:0007507; P:heart development
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0001556; P:oocyte maturation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
pon:100450481;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013