EKS-POA-00289
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00289
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR498.24.8E-150712969258
StatusUnreviewed
Ensembl ProteinENSPPYP00000019671
UniProt AccessionH2PM35;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR
Gene Synonyms/Alias EGFR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000017549ENSPPYP00000019671ENSPPYT00000020445
OrganismPongo abelii
Functional Description
Protein Length1210
Protein Sequence
(FASTA)
MRSSRTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 60
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA 120
VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF 180
QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC 240
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360
NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF 420
ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL 480
FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN 540
ILEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM 600
GENNTLVWKY ADAGHVCHLC HPNCTYGCAG PGLEGCAVNG PKIPSIATGM VGALLLLLVV 660
ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS 720
GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 780
CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA 840
RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY 900
GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 960
FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ 1020
QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED 1080
SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN 1140
TVQPSCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV 1200
TPQSSEFIGA 1210
Nucleotide Sequence
(FASTA)
ATGCGATCCT CCCGGACGGC CGGGGCAGCG CTCCTGGCGC TGCTAGCTGC GCTCTGCCCG 60
GCGAGTCGGG CTCTGGAGGA AAAGAAAGTT TGCCAAGGCA CGAGTAACAA GCTCACGCAG 120
TTGGGCACTT TTGAAGATCA TTTTCTCAGC CTCCAGAGGA TGTTCAATAA CTGTGAGGTG 180
GTCCTTGGGA ATCTGGAAAT TACCTATGTA CAGAGGAATT ATGATCTTTC CTTCTTAAAG 240
ACCATCCAGG AGGTGGCTGG TTATGTCCTC ATCGCCCTCA ACACAGTGGA GCGGATTCCT 300
TTGGAAAACC TGCAGATCAT CAGAGGAAAT ATGTACTATG AAAATTCCTA TGCCTTAGCA 360
GTCTTATCTA ACTATGATGC AAATAAAACC GGACTAAAGG AGCTGCCCAT GAGAAATTTA 420
CAGGAAATCC TGCATGGCGC CGTGCGGTTC AGCAACAACC CTGCCCTGTG CAACGTGGAG 480
AGCATCCAGT GGCGGGACAT AGTCAGCAGC GACTTTCTCA GCAACATGTC GATGGACTTC 540
CAGAACCACC TGGGCAGCTG CCAAAAGTGT GATCCAAGCT GTCCCAATGG GAGCTGCTGG 600
GGTGCAGGAG AGGAGAACTG CCAGAAACTG ACCAAAATCA TCTGTGCCCA GCAGTGCTCT 660
GGGCGCTGCC GCGGCAAATC CCCCAGTGAC TGCTGCCACA ACCAGTGTGC CGCTGGCTGC 720
ACGGGCCCCC GGGAGAGCGA CTGCCTGGTC TGCCGCAAAT TCCGAGACGA AGCCACGTGC 780
AAGGACACCT GCCCCCCACT CATGCTCTAC AACCCCACCA CATACCAGAT GGATGTGAAC 840
CCCGAGGGCA AATACAGCTT TGGTGCCACC TGCGTGAAGA AGTGTCCCCG TAATTATGTG 900
GTGACAGATC ACGGCTCGTG CGTCCGAGCC TGTGGGGCCG ACAGCTATGA GATGGAGGAA 960
GACGGCGTCC GCAAGTGTAA GAAGTGCGAA GGGCCTTGCC GCAAAGTGTG TAACGGAATA 1020
GGTATTGGTG AATTTAAAGA CACACTCTCC ATAAATGCTA CGAATATTAA ACACTTCAAA 1080
AACTGCACCT CCATCAGTGG CGATCTCCAC ATCCTGCCGG TGGCATTTAG GGGTGACTCC 1140
TTCACACACA CTCCACCTCT GGATCCACAG GAACTGGATA TTCTGAAAAC CGTAAAGGAA 1200
ATCACAGGGT TTTTGCTGAT TCAGGCTTGG CCTGAAAACA GGACGGACCT CCATGCTTTT 1260
GAGAACCTAG AAATCATACG CGGCAGGACC AAGCAACATG GGCAGTTTTC TCTTGCAGTC 1320
GTCAGCCTGA ACATAACATC CTTGGGATTA CGCTCCCTCA AGGAGATAAG CGATGGAGAT 1380
GTGATAATTT CAGGAAACAA AAATTTGTGC TATGCAAATA CAATAAACTG GAAAAAACTG 1440
TTTGGGACCT CCGGTCAGAA AACCAAAATT ATAAGCAACA GAGGTGAAAA CAGCTGCAAG 1500
GCCACAGGCC AGGTCTGCCA TGCCTTGTGC TCCCCCGAGG GCTGCTGGGG CCCGGAGCCC 1560
AGGGACTGCG TCTCCTGCCG GAATGTCAGC CGAGGCAGAG AATGCGTGGA CAAGTGCAAC 1620
ATTCTGGAGG GCGAGCCAAG GGAGTTTGTG GAGAACTCTG AGTGCATACA GTGCCACCCA 1680
GAATGCCTGC CCCAGGCCAT GAACATCACC TGCACGGGAC GGGGACCAGA CAACTGTATC 1740
CAGTGTGCCC ACTACATTGA CGGCCCCCAC TGCGTCAAGA CCTGCCCGGC AGGAGTCATG 1800
GGAGAAAACA ACACCCTGGT CTGGAAGTAC GCAGACGCCG GCCACGTGTG CCACCTGTGC 1860
CATCCAAACT GCACCTACGG ATGCGCTGGG CCAGGTCTTG AAGGCTGTGC AGTGAATGGG 1920
CCTAAGATCC CGTCCATCGC CACTGGGATG GTGGGGGCCC TCCTTCTGCT GCTGGTGGTG 1980
GCCCTGGGGA TCGGCCTCTT CATGCGAAGG CGCCACATCG TTCGGAAGCG CACGCTGCGG 2040
AGGCTGCTGC AGGAGAGGGA GCTTGTGGAG CCTCTTACAC CCAGTGGAGA AGCTCCCAAC 2100
CAAGCTCTCT TGAGGATCTT GAAGGAAACT GAATTCAAAA AGATCAAAGT GCTGGGCTCC 2160
GGCGCGTTCG GCACTGTGTA TAAGGGACTC TGGATCCCAG AAGGTGAGAA AGTTAAAATT 2220
CCCGTCGCTA TCAAGGAATT AAGAGAAGCA ACATCTCCGA AAGCCAACAA GGAAATCCTC 2280
GATGAAGCCT ACGTGATGGC CAGCGTGGAC AACCCCCACG TGTGCCGCCT GCTGGGCATC 2340
TGCCTCACCT CCACCGTGCA GCTCATCACG CAGCTCATGC CCTTCGGCTG CCTCCTGGAC 2400
TATGTCCGGG AACACAAAGA CAATATTGGC TCCCAGTACC TGCTCAATTG GTGTGTGCAG 2460
ATCGCAAAGG GTATGAACTA CTTGGAGGAC CGTCGCTTGG TGCACCGTGA CCTGGCAGCC 2520
AGGAACGTAC TGGTGAAAAC GCCGCAGCAT GTCAAGATCA CAGATTTTGG GCTGGCCAAA 2580
TTGCTGGGTG CAGAAGAGAA AGAATACCAT GCAGAAGGAG GCAAAGTGCC TATCAAGTGG 2640
ATGGCATTGG AATCAATTTT ACACAGAATT TATACCCACC AGAGTGATGT CTGGAGCTAT 2700
GGGGTGACCG TTTGGGAGTT GATGACCTTT GGATCCAAGC CATATGACGG AATCCCTGCC 2760
AGCGAGATCT CCTCCATCCT GGAGAAAGGA GAACGCCTCC CCCAGCCACC CATATGTACC 2820
ATCGATGTCT ACATGATCAT GGTCAAGTGC TGGATGATAG ACGCAGATAG TCGCCCAAAG 2880
TTCCGTGAGT TGATCATCGA ATTCTCCAAA ATGGCCCGAG ACCCCCAGCG CTACCTTGTC 2940
ATTCAGGGGG ATGAAAGAAT GCATTTGCCA AGCCCTACAG ACTCCAACTT CTATCGTGCC 3000
CTGATGGATG AAGAAGACAT GGACGACGTG GTGGATGCCG ACGAGTACCT CATCCCACAG 3060
CAGGGCTTCT TCAGCAGCCC CTCCACGTCA CGGACTCCCC TCCTGAGCTC TCTGAGTGCA 3120
ACCAGCAATA ATTCCACTGT GGCTTGCATT GATAGAAATG GGCTGCAAAG CTGTCCCATC 3180
AAGGAAGACA GCTTCTTGCA GCGATACAGC TCAGACCCCA CAGGCGCCTT GACTGAGGAC 3240
AGCATAGACG ACACCTTCCT CCCAGTGCCT GAATACATAA ACCAGTCCGT TCCCAAAAGG 3300
CCCGCTGGCT CTGTGCAGAA TCCTGTCTAT CACAATCAGC CTCTGAACCC CGCGCCCAGC 3360
AGAGACCCAC ACTACCAGGA CCCCCACAGC ACTGCAGTGG GCAACCCCGA GTATCTCAAC 3420
ACTGTCCAGC CCAGCTGTGT CAACAGCACA TTCGACAGCC CTGCCCACTG GGCCCAGAAA 3480
GGCAGCCACC AAATTAGCCT GGACAACCCT GACTACCAGC AGGACTTCTT TCCCAAGGAA 3540
GCCAAGCCAA ATGGCATCTT TAAGGGCTCC ACAGCTGAAA ATGCAGAATA CCTAAGGGTC 3600
ACGCCACAAA GCAGTGAATT TATTGGAGCA TGA 3633
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+
Q: 712   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  771
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++
Q: 772   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR  831
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y
Q: 832   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  891
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw
Q: 892   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW  951
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkf+el+ efs
Q: 952   MIDADSRPKFRELIIEFS  969
         ****************96
Domain Sequence
(FASTA)
FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60
PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VREHKDNIGS QYLLNWCVQI AKGMNYLEDR 120
RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180
THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPICTI DVYMIMVKCW 240
MIDADSRPKF RELIIEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00290
EKS-BOT-00297
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-CII-00175
EKS-CIS-00072
EKS-DAR-00646
EKS-EQC-00289
EKS-FEC-00283
EKS-GAG-00251
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LAC-00310
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-MYL-00300
EKS-NOL-00274
EKS-ORN-00386
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00359
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-RAN-00314
EKS-SAH-00279
EKS-SUS-00262
EKS-TAG-00314
EKS-TAR-00390
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0030139; C:endocytic vesicle
GO:0005768; C:endosome
GO:0016021; C:integral to membrane
GO:0045121; C:membrane raft
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005006; F:epidermal growth factor-activated receptor activity
GO:0030235; F:nitric-oxide synthase regulator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0000902; P:cell morphogenesis
GO:0008283; P:cell proliferation
GO:0016337; P:cell-cell adhesion
GO:0021795; P:cerebral cortex cell migration
GO:0048546; P:digestive tract morphogenesis
GO:0001892; P:embryonic placenta development
GO:0001942; P:hair follicle development
GO:0060571; P:morphogenesis of an epithelial fold
GO:0043066; P:negative regulation of apoptotic process
GO:0042177; P:negative regulation of protein catabolic process
GO:0035413; P:positive regulation of catenin import into nucleus
GO:0030335; P:positive regulation of cell migration
GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0045739; P:positive regulation of DNA repair
GO:0045740; P:positive regulation of DNA replication
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0046777; P:protein autophosphorylation
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0070141; P:response to UV-A
GO:0007435; P:salivary gland morphogenesis
GO:0023014; P:signal transduction by phosphorylation
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013