EKS-POA-00408

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00408

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	431.9	8.1E-130	63	321	259

Status

Unreviewed

Ensembl Protein

ENSPPYP00000019735

UniProt Accession

H2PM99;

Protein Name

Protein Synonyms/Alias

Gene Name

STK17A

Gene Synonyms/Alias

STK17A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000017607	ENSPPYP00000019735	ENSPPYT00000020512

Organism

Pongo abelii

Functional Description

Protein Length

414

Protein Sequence
(FASTA)

MIPLEKPGSG GSSPGATSGP GRAGRGLSGP CRPPPPPQAR GLLTEIRAAV RTEPFQDGYS 60

LCPGRELGRG KFAVVRKCIK KDSGKEFAAK FMRKRRKGQD CRMEIIHEIA VLELAQDNPW 120

VINLHEVYET ASEMILVLEY AAGGEIFDQC VADREEAFKE KDVQRLMRQI LEGVHFLHTR 180

DVVHLDLKPQ NILLTSESPL GDIKIVDFGL SRILKNSEEL REIMGTPEYV APEILSYDPI 240

SMATDMWSIG VLTYVMLTGI SPFLGNDKQE TFLNISQMNL SYSEEEFDVL SESAIDFIRT 300

LLVKKPEDRA TAEECLKHPW LTQSSIQEPS FRMEKALEEA NALQEGHSVP EINSDTDKSE 360

TEESIVTEEL IVVTSYTLGQ CRQSEKEKME QKAISKRFKF EEPLLQEIPG EFIY 414

Nucleotide Sequence
(FASTA)

ATGATCCCTT TGGAGAAGCC GGGCAGCGGC GGCTCCTCCC CAGGCGCCAC CTCAGGCCCT 60

GGCCGGGCCG GCAGGGGTCT GAGCGGGCCG TGCCGGCCGC CGCCGCCGCC CCAGGCCCGC 120

GGGCTGCTGA CAGAGATCCG CGCAGCGGTG CGCACCGAGC CCTTCCAGGA CGGCTACAGC 180

CTGTGCCCGG GCCGGGAGCT GGGCAGGGGG AAATTTGCAG TGGTGAGAAA ATGTATAAAG 240

AAAGATTCTG GGAAAGAATT TGCTGCAAAG TTCATGAGAA AAAGAAGAAA AGGCCAAGAT 300

TGTCGGATGG AAATAATTCA TGAGATTGCT GTACTTGAAC TAGCACAGGA CAATCCTTGG 360

GTCATTAATT TACATGAAGT TTATGAGACT GCCTCAGAAA TGATCTTAGT TCTGGAATAT 420

GCTGCTGGGG GTGAAATCTT TGACCAGTGT GTTGCAGACA GAGAAGAAGC CTTTAAAGAA 480

AAAGATGTTC AAAGACTTAT GCGACAGATT TTAGAAGGTG TTCACTTTTT ACACACTCGT 540

GATGTAGTTC ATCTTGATTT GAAGCCTCAG AATATTCTGT TGACAAGCGA ATCTCCATTG 600

GGTGACATTA AGATTGTTGA TTTTGGCCTT TCAAGAATAT TGAAGAACAG TGAAGAGCTC 660

CGAGAAATTA TGGGTACCCC TGAATATGTG GCTCCTGAAA TTCTTAGTTA TGATCCTATA 720

AGCATGGCAA CAGATATGTG GAGCATTGGA GTGTTAACAT ATGTCATGCT TACAGGAATA 780

TCACCTTTCT TAGGCAATGA TAAACAAGAA ACATTCTTAA ACATCTCACA GATGAATTTA 840

AGTTATTCTG AGGAAGAATT TGATGTTTTG TCTGAGTCGG CTATTGATTT TATCAGGACA 900

CTTTTAGTTA AGAAACCTGA AGATCGAGCC ACTGCTGAAG AATGTCTAAA ACACCCCTGG 960

TTGACACAGA GCAGTATTCA AGAGCCTTCT TTCAGGATGG AAAAGGCACT AGAAGAAGCA 1020

AATGCCCTCC AAGAAGGTCA TTCTGTGCCT GAAATTAATT CAGATACCGA CAAATCAGAA 1080

ACCGAGGAAT CCATTGTAAC CGAAGAGTTA ATTGTAGTTA CTTCATATAC TCTAGGACAA 1140

TGCAGACAGT CTGAAAAAGA GAAAATGGAG CAAAAGGCCA TTTCCAAACG ATTTAAATTT 1200

GAGGAACCTT TGCTACAAGA AATTCCAGGA GAATTTATCT ACTGA 1245

Domain Profile

S: 3     tgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirse  62

          g+elg+Gkfavvrkc++k++Gke+aakf++krr    +++++r+ei +e+avl++++++

Q: 63    PGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRR----KGQDCRMEIIHEIAVLELAQDN  118

         689*******************************....**********************

S: 63    pnvinlhevyenksdvililelvaGGelfd..llaekeslseeeatellkqilegvkylh  120

         p+vinlhevye++s++il+le++aGGe+fd  +++++e+++e+++++l++qilegv++lh

Q: 119   PWVINLHEVYETASEMILVLEYAAGGEIFDqcVADREEAFKEKDVQRLMRQILEGVHFLH  178

         ******************************988999************************

S: 121   skkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivny  180

         ++++vhldlkP+nill++++ p gdik++dfGlsr +++++el+ei+GtPe+vaPei++y

Q: 179   TRDVVHLDLKPQNILLTSES-PLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSY  237

         ********************.***************************************

S: 181   eplsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdf  240

         +p+s++tdmwsiGv+ty++l+g+sPflG++kqet+lnis++nl++see f+ +se+a+df

Q: 238   DPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAIDF  297

         ************************************************************

S: 241   irrllvkdpekrltieeclehswl  264

         ir+llvk+pe+r+t+eecl+h+wl

Q: 298   IRTLLVKKPEDRATAEECLKHPWL  321

         ***********************7

Domain Sequence
(FASTA)

PGRELGRGKF AVVRKCIKKD SGKEFAAKFM RKRRKGQDCR MEIIHEIAVL ELAQDNPWVI 60

NLHEVYETAS EMILVLEYAA GGEIFDQCVA DREEAFKEKD VQRLMRQILE GVHFLHTRDV 120

VHLDLKPQNI LLTSESPLGD IKIVDFGLSR ILKNSEELRE IMGTPEYVAP EILSYDPISM 180

ATDMWSIGVL TYVMLTGISP FLGNDKQETF LNISQMNLSY SEEEFDVLSE SAIDFIRTLL 240

VKKPEDRATA EECLKHPWL 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade
GO:2000377	; P:regulation of reactive oxygen species metabolic process

KEGG

pon:100436018

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013