EKS-POA-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	481.8	5.1E-145	1097	1357	261

Status

Reviewed

Ensembl Protein

ENSPPYP00000020106

UniProt Accession

Q2IBD8;

Protein Name

Hepatocyte growth factor receptor

Protein Synonyms/Alias

HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met;

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000017932	ENSPPYP00000020106	ENSPPYT00000020898

Organism

Pongo abelii

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).

Protein Length

1409

Protein Sequence
(FASTA)

MKSKSKSLAE CLAQDKPLIM KAPAVLAPGI LVLLFTLVQR SNGECKEALA KSEMNVNMKY 60

QLPNFTAETL IQNVILHEHH IFLGATNYIY VLNEEDLQKV AEYKTGPVLE HPDCFPCQDC 120

SSKANLSGGV WKDNINMALV VDTYYDDQLI SCGSVNRGTC QRHVFPHNHT ADIQSEVHCI 180

FSPQIEEPSQ CPDCVVSALG AKVLSSVKDR FINFFVGNTI NSSYFPDHPL HSISVRRLKE 240

TKDGFMFLTD QSYIDVLPEF RDSYPIKYVH AFESNNFIYF LTVQRETLDA QTFHTRIIRF 300

CSINSGLHSY MEMPLECILT EKRKKRSTKK EVFNILQAAY VSKPGAQLAR QIGASLNDDI 360

LFGVFAQSKP DSAEPMDRSA MCAFPIKYVN DFFNKIVNKN NVRCLQHFYG PNHEHCFNRT 420

LLRNSSGCEA RRDEYRTEFT TALQRVDLFM GQFSEVLLTS ISTFIKGDLT IANLGTSEGR 480

FMQVVVSRSG PSTPHVNFLL DSHPVSPEVI VEHPLNQNGY TLVVTGKKIT KIPLNGLGCR 540

HFQSCSQCLS APPFVQCGWC HDKCVRSEEC SSGTWTQQIC LPAIYKVFPS SAPLEGGTRL 600

TICGWDFGFR RNNKFDLKKT RVLLGNESCT LTLSESTMNI LKCTVGPAMN KHFNMSIIIS 660

NGHGTTQYST FSYVDPVITG ISPKYGPMAG GTLLTLTGNY LNSGNSRHIS IGGKTCTLKS 720

VSNSILECYT PAQTISTEFA VKLKIDLANR ETSIFSYRED PIVYEIHPTK SFISGGSTIT 780

GVGKNLNSVS VPRMVINVHE AGRNFTVACQ HRSNSEIICC TTPSLQQLNL QLPLKTKAFF 840

MLDGILSKYF DLIYVHNPVF KPFEKPVMIS MGNENVLEIK GNDIDPEAVK GEVLKVGNKS 900

CENIHLHSEA VLCTVPNDLL KLNSELNIEW KQAISSTVLG KVIVQPDQNF TGLIAGVVSI 960

SIALLLLLGF FLWLKKRKQI KDLGSELVRY DARVHTPHLD RLVSARSVSP TTEMVSNESV 1020

DYRATFPEDQ FPNSSQNGSC RQVQYPLTDM SPILTSGDSD ISSPLLQNTV HIDLSALNPE 1080

LVQAVQHVVI GPSSLIVHFN EVIGRGHFGC VYHGTLLDND GKKIHCAVKS LNRITDIGEV 1140

SQFLTEGIIM KDFSHPNVLS LLGICLRSEG SPLVVLPYMK HGDLRNFIRN ETHNPTVKDL 1200

IGFGLQVAKG MKYLASKKFV HRDLAARNCM LDEKFTVKVA DFGLARDMYD KEYYSVHNKT 1260

GAKLPVKWMA LESLQTQKFT TKSDVWSFGV LLWELMTRGA PPYPDVNTFD ITVYLLQGRR 1320

LLQPEYCPDP LYEVMLKCWH PKAEMRPSFS ELVSRISAIF STFIGEHYVH VNATYVNVKC 1380

VAPYPSLLSS EDNADDEVDT RPASFWETS 1409

Nucleotide Sequence
(FASTA)

ATGAAGAGTA AATCCAAGAG TTTAGCAGAA TGCCTCGCAC AGGATAAACC TCTCATAATG 60

AAGGCCCCCG CTGTGCTTGC ACCTGGCATC CTCGTGCTCC TGTTTACCTT GGTGCAGAGG 120

AGCAATGGGG AGTGTAAAGA GGCACTAGCA AAGTCCGAGA TGAATGTGAA TATGAAGTAT 180

CAGCTTCCCA ACTTCACCGC GGAAACACTC ATCCAGAATG TCATTCTACA TGAGCATCAC 240

ATTTTCCTTG GTGCCACTAA CTACATTTAT GTTTTAAATG AGGAAGACCT TCAGAAGGTT 300

GCTGAGTACA AGACCGGGCC TGTGTTGGAA CACCCAGATT GTTTCCCATG TCAGGACTGC 360

AGCAGCAAAG CCAATTTATC AGGAGGCGTT TGGAAAGATA ACATCAACAT GGCTCTAGTT 420

GTCGACACCT ACTATGATGA TCAACTCATT AGCTGTGGCA GCGTCAACAG AGGGACCTGC 480

CAGCGACATG TCTTTCCCCA CAATCATACT GCTGACATAC AGTCGGAGGT TCACTGCATA 540

TTCTCCCCAC AGATAGAAGA GCCCAGCCAG TGTCCTGACT GTGTGGTGAG CGCCCTGGGA 600

GCCAAAGTCC TTTCATCTGT AAAGGACCGG TTCATCAACT TCTTTGTAGG TAATACCATA 660

AATTCTTCTT ATTTCCCAGA TCATCCATTG CATTCAATAT CAGTGAGAAG GCTAAAGGAA 720

ACGAAAGATG GTTTTATGTT TTTGACGGAC CAGTCCTACA TTGATGTTTT ACCTGAGTTC 780

AGAGATTCTT ACCCCATTAA GTATGTCCAT GCCTTTGAAA GCAACAATTT TATTTACTTC 840

TTGACGGTCC AAAGGGAAAC TCTAGATGCT CAGACTTTTC ACACAAGAAT AATCAGGTTC 900

TGTTCCATAA ACTCTGGATT GCATTCCTAC ATGGAAATGC CTCTGGAGTG TATTCTTACA 960

GAAAAGAGAA AAAAGAGATC CACAAAGAAG GAAGTGTTTA ATATCCTTCA GGCTGCGTAT 1020

GTCAGCAAGC CTGGGGCCCA ACTTGCTAGA CAAATAGGAG CCAGCCTGAA TGATGACATT 1080

CTCTTTGGGG TGTTCGCACA AAGCAAGCCA GATTCTGCCG AACCAATGGA TCGATCTGCC 1140

ATGTGTGCAT TCCCTATCAA ATATGTCAAC GACTTCTTCA ACAAGATCGT CAACAAAAAC 1200

AATGTGAGAT GTCTCCAGCA TTTTTACGGA CCCAATCATG AGCACTGTTT TAATAGGACA 1260

CTTCTGAGAA ATTCATCAGG CTGTGAAGCG CGCCGTGATG AATATCGAAC AGAGTTTACC 1320

ACAGCTTTGC AGCGCGTTGA CTTATTCATG GGTCAATTCA GCGAAGTCCT CTTAACATCT 1380

ATATCCACCT TCATTAAAGG AGACCTCACC ATAGCTAATC TTGGGACATC AGAGGGTCGC 1440

TTCATGCAGG TTGTGGTTTC TCGATCAGGA CCATCAACCC CTCATGTGAA TTTTCTCCTG 1500

GACTCCCATC CGGTGTCTCC AGAAGTGATT GTGGAGCATC CATTAAACCA GAATGGCTAC 1560

ACACTGGTTG TCACTGGGAA GAAGATCACG AAGATCCCAT TGAATGGCTT GGGCTGCAGA 1620

CATTTCCAGT CCTGCAGTCA GTGCCTCTCT GCCCCACCCT TTGTTCAGTG TGGCTGGTGC 1680

CATGACAAAT GTGTGCGATC GGAGGAATGC TCGAGCGGGA CATGGACTCA ACAGATCTGT 1740

CTGCCTGCAA TCTACAAGGT TTTCCCAAGT AGTGCACCCC TTGAAGGAGG GACAAGGCTG 1800

ACCATATGTG GCTGGGACTT TGGATTTCGG AGGAATAATA AATTTGATTT AAAGAAAACT 1860

AGAGTTCTCC TTGGAAATGA GAGCTGCACC TTGACTTTAA GTGAGAGCAC GATGAATATA 1920

TTGAAATGCA CAGTTGGTCC TGCCATGAAT AAGCATTTCA ATATGTCCAT AATTATTTCA 1980

AATGGCCACG GGACAACACA ATACAGTACA TTCTCCTATG TGGATCCTGT AATAACAGGT 2040

ATTTCGCCGA AATATGGTCC TATGGCTGGT GGCACTTTAC TTACTTTAAC TGGAAATTAC 2100

CTAAACAGTG GGAATTCCAG ACACATTTCA ATTGGTGGAA AAACATGTAC TTTAAAAAGT 2160

GTGTCAAACA GTATTCTTGA ATGTTATACC CCAGCCCAAA CCATTTCAAC TGAGTTTGCT 2220

GTTAAATTGA AAATTGACTT AGCCAACCGA GAGACAAGCA TCTTCAGTTA CCGGGAAGAT 2280

CCCATTGTCT ACGAAATTCA TCCAACCAAA TCTTTTATTA GTGGTGGGAG CACAATAACA 2340

GGTGTTGGGA AAAACCTGAA TTCAGTTAGT GTCCCGAGGA TGGTCATAAA TGTGCATGAA 2400

GCAGGAAGGA ACTTTACTGT GGCATGTCAA CATCGCTCTA ATTCAGAGAT AATCTGCTGT 2460

ACCACTCCTT CCCTGCAACA GCTGAATCTG CAACTCCCCC TGAAAACCAA AGCCTTTTTC 2520

ATGTTAGATG GGATCCTTTC CAAATACTTT GATCTCATTT ATGTACATAA TCCTGTGTTT 2580

AAGCCTTTTG AAAAGCCAGT GATGATCTCA ATGGGCAATG AAAATGTACT GGAAATTAAG 2640

GGAAATGATA TTGACCCTGA AGCAGTTAAA GGTGAAGTGT TAAAAGTTGG AAATAAGAGC 2700

TGTGAGAATA TACACTTACA TTCTGAAGCC GTTTTATGCA CGGTCCCCAA TGACCTGCTG 2760

AAATTGAACA GCGAGCTAAA TATAGAGTGG AAGCAAGCAA TTTCTTCAAC CGTCCTTGGA 2820

AAAGTAATAG TTCAACCAGA TCAGAATTTC ACAGGATTGA TTGCTGGTGT TGTCTCAATA 2880

TCAATAGCAC TGTTATTACT ACTTGGGTTT TTCCTGTGGC TGAAAAAGAG AAAGCAAATT 2940

AAAGATCTGG GCAGTGAATT AGTTCGCTAT GATGCAAGAG TACACACTCC TCATTTGGAT 3000

AGGCTTGTAA GTGCCCGAAG TGTAAGCCCA ACTACAGAAA TGGTTTCAAA TGAATCTGTA 3060

GACTACCGAG CTACTTTTCC AGAAGATCAG TTTCCTAATT CATCTCAGAA CGGTTCATGC 3120

CGACAAGTGC AGTATCCTCT GACAGACATG TCCCCCATCC TAACTAGTGG GGACTCTGAT 3180

ATATCCAGTC CATTACTGCA AAATACTGTC CACATTGACC TCAGTGCCCT AAATCCAGAG 3240

CTGGTCCAGG CAGTGCAACA TGTAGTGATT GGGCCCAGTA GCCTGATTGT GCATTTCAAT 3300

GAAGTCATAG GAAGAGGGCA TTTTGGTTGT GTATATCATG GGACTTTGTT GGACAATGAT 3360

GGCAAGAAAA TTCACTGTGC TGTGAAATCC TTGAATAGAA TCACTGACAT AGGAGAAGTT 3420

TCCCAATTTC TGACCGAGGG AATCATCATG AAAGATTTTA GTCATCCCAA TGTCCTCTCG 3480

CTCCTGGGAA TCTGCCTGCG AAGTGAAGGG TCTCCACTGG TGGTCCTACC ATACATGAAA 3540

CATGGAGATC TTCGAAATTT CATTCGAAAT GAGACTCATA ATCCAACTGT AAAAGATCTT 3600

ATTGGCTTTG GTCTTCAAGT AGCCAAAGGC ATGAAATATC TTGCAAGCAA AAAGTTTGTC 3660

CACAGAGACT TGGCTGCAAG AAACTGTATG CTGGATGAAA AATTCACAGT CAAGGTTGCT 3720

GATTTTGGTC TTGCCAGAGA CATGTATGAT AAAGAATACT ATAGTGTACA CAACAAAACA 3780

GGTGCAAAGC TGCCAGTGAA GTGGATGGCT TTGGAAAGTC TGCAAACTCA AAAGTTTACC 3840

ACCAAGTCAG ATGTGTGGTC CTTTGGCGTG CTCCTCTGGG AGCTGATGAC AAGAGGAGCC 3900

CCACCTTATC CTGACGTGAA CACCTTTGAT ATAACTGTTT ACTTGTTGCA AGGGAGAAGG 3960

CTCCTACAAC CCGAATACTG CCCAGACCCC TTATATGAAG TAATGCTAAA ATGCTGGCAC 4020

CCTAAAGCCG AAATGCGCCC ATCCTTTTCT GAACTGGTGT CCCGGATATC AGCGATCTTC 4080

TCTACTTTCA TTGGGGAGCA CTATGTCCAT GTGAACGCTA CTTATGTGAA CGTAAAATGT 4140

GTCGCTCCAT ATCCTTCTCT GTTGTCATCA GAAGATAACG CTGATGATGA GGTGGACACA 4200

CGACCAGCCT CCTTCTGGGA GACATCATAG 4230

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 1097  VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1156

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1157  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1216

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1217  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1276

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 1277  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1335

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k+++rp+fs+lvs+is

Q: 1336  LKCWHPKAEMRPSFSELVSRIS  1357

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDNDGKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKAEMR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0030534	; P:adult behavior
GO:0007420	; P:brain development
GO:0048754	; P:branching morphogenesis of a tube
GO:0042593	; P:glucose homeostasis
GO:0001889	; P:liver development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0014902	; P:myotube differentiation
GO:0001890	; P:placenta development
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

pon:100137030

;

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013