EKS-POA-00263
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00263
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK406.67.9E-122199484286
StatusUnreviewed
Ensembl ProteinENSPPYP00000020253
UniProt AccessionH2PNN9;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK2
Gene Synonyms/Alias HIPK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000018051ENSPPYP00000020253ENSPPYT00000021049
OrganismPongo abelii
Functional Description
Protein Length1136
Protein Sequence
(FASTA)
LRPVYESMAS HVQVFSPHTL QSSAFCSVKK LKIEPSSNWD MTGYGSHSKV YSQSKNIPPS 60
QPATTTVSTS LPVPNPSLPY EQTIIFPGST GHIVVTSASS TSVTGQVLGG PHNLMRRSTV 120
SLLDTYQKCG LKRKSEEIEN TSSVQIIEEH PPMIQNNASG ATVATATTST ATSKNSGSNS 180
EGDYQLVQHE VLCSMTNTYE VLEFLGRGTF GQVVKCWKRG TNEIVAIKIL KNHPSYARQG 240
QIEVSILARL STESADDYNF VRAYECFQHK NHTCLVFEML EQNLYDFLKQ NKFSPLPLKY 300
IRPVLQQVAT ALMKLKSLGL IHADLKPENI MLVDPSRQPY RVKVIDFGSA SHVSKAVCST 360
YLQSRYYRAP EIILGLPFCE AIDMWSLGCV IAELFLGWPL YPGASEYDQI RYISQTQGLP 420
AEYLLSAGTK TTRFFNRDTD SPYPLWRLKT PDDHEAETGI KSKEARKYIF NCLDDMAQVK 480
SCFQNMEICK RRVNMYDTVN QSKTPFITHV APSTSTNLTM TFNNQLTTVH NQAPSSTSAT 540
ISLANPEVSI LNYPSTLYQP SAASMAAVAQ RSMPLQTGTA QICARPDPFQ QALIVCPPGF 600
QGLQASPSKH AGYSVRMENA VPIVTQAPGA QPLQIQPGLL AQQAWPSGTQ QILLPPAWQQ 660
LTGVATHTSV QHATVIPETM AGTQQLADWR NTHAHGSHYN PIMQQPALLT GHVTLPAAQP 720
LNVGVAHVMR QQPTSTTSSR KSKQHQSSVR NVSTCEVSSS QAISSPQRSK RVKENTPPRC 780
AMVHSSPACS TSVTCGWGDV ASSTTRERQR QTIVIPDTPS PTVSVITISS DTDEEEEQKH 840
APTSTVSKQR KNVISCVTVH DSPYSDSSSN TSPYSVQQRA GHNNANAFDA KGSLENHCTG 900
NPRTIIVPPL KTQASEVLVE CDSLVPVNTS HHSSSYKSKS SSNVTSTSGH SSGSSSGAIT 960
YRQQRPGPHF QQQQPLNLSQ AQQHITADRT GSHRRQQAYI TPTMGQAPYS FPHNSPSHGA 1020
VHPHLAAAAA AAHLPTQPHL YTYTAPAALG STGTVAHLVA SQGSARHTVQ HTAYPASIVH 1080
QVPVSMGPRV LPSPTIHPSQ YPAQFAHQTY ISASPASTVY TGYPLSPAKV NQYPYI 1136
Nucleotide Sequence
(FASTA)
CTTCGGCCTG TTTATGAGAG TATGGCCTCA CATGTGCAAG TTTTCTCCCC TCACACCCTT 60
CAATCAAGTG CCTTCTGTAG CGTGAAGAAA CTGAAAATAG AGCCGAGTTC CAACTGGGAC 120
ATGACTGGGT ACGGCTCCCA CAGCAAAGTG TATAGCCAGA GCAAGAACAT CCCCCCGTCA 180
CAGCCAGCCA CCACAACCGT CAGCACCTCC TTGCCGGTCC CAAACCCGAG CCTACCTTAC 240
GAGCAGACCA TCATCTTCCC AGGAAGCACC GGGCACATCG TGGTCACCTC AGCAAGCAGC 300
ACTTCTGTCA CCGGGCAGGT CCTCGGCGGA CCACACAACC TAATGCGTCG AAGCACTGTG 360
AGCCTCCTTG ATACCTACCA AAAATGTGGA CTCAAGCGTA AGAGCGAGGA GATCGAGAAC 420
ACAAGCAGCG TGCAGATCAT CGAGGAGCAT CCACCCATGA TTCAGAATAA TGCAAGCGGG 480
GCCACTGTCG CCACTGCCAC CACGTCGACT GCCACCTCCA AAAACAGCGG CTCCAACAGC 540
GAGGGTGACT ATCAGCTGGT GCAGCATGAG GTGCTGTGCT CCATGACCAA CACCTACGAG 600
GTCTTAGAGT TCTTGGGCCG AGGGACGTTT GGGCAAGTGG TCAAGTGCTG GAAACGGGGC 660
ACCAATGAGA TTGTAGCCAT CAAGATCCTG AAGAACCACC CGTCCTATGC CCGACAAGGT 720
CAGATTGAAG TGAGCATCCT GGCCCGGTTG AGCACGGAGA GTGCCGATGA CTATAACTTC 780
GTACGGGCCT ACGAATGCTT CCAGCACAAG AACCACACGT GCTTAGTCTT CGAGATGTTG 840
GAGCAGAACC TCTATGACTT TCTGAAGCAA AACAAGTTTA GCCCCTTGCC CCTCAAATAC 900
ATTCGCCCAG TTCTCCAGCA GGTAGCCACA GCCCTGATGA AACTCAAAAG CCTAGGTCTT 960
ATCCATGCTG ACCTCAAACC AGAAAACATC ATGCTGGTGG ATCCATCTAG ACAACCATAC 1020
AGAGTCAAGG TCATCGACTT TGGTTCAGCC AGCCACGTGT CCAAGGCTGT GTGCTCCACC 1080
TACTTGCAGT CCAGATATTA CAGGGCCCCT GAGATCATCC TTGGTTTACC ATTTTGTGAG 1140
GCAATTGACA TGTGGTCCCT GGGCTGTGTT ATTGCAGAAT TGTTCCTGGG TTGGCCGTTA 1200
TATCCAGGAG CTTCAGAGTA TGATCAGATT CGGTATATTT CACAAACACA GGGTTTGCCT 1260
GCTGAATATT TATTAAGCGC AGGGACAAAG ACAACTAGGT TTTTCAACCG TGACACGGAC 1320
TCACCATATC CTTTGTGGAG ACTGAAGACA CCAGATGACC ATGAAGCAGA GACAGGGATT 1380
AAGTCAAAAG AAGCAAGAAA GTACATTTTC AACTGTTTAG ATGATATGGC CCAGGTCAAA 1440
TCATGTTTCC AGAACATGGA GATCTGCAAG CGTCGGGTGA ATATGTATGA CACGGTGAAC 1500
CAGAGCAAAA CCCCTTTCAT CACGCACGTG GCCCCCAGCA CGTCCACCAA CCTGACCATG 1560
ACCTTTAACA ACCAGCTGAC CACTGTCCAC AACCAGGCTC CCTCCTCTAC CAGTGCCACT 1620
ATTTCCTTAG CCAATCCCGA AGTCTCCATA CTAAACTACC CATCTACACT CTACCAGCCC 1680
TCAGCGGCAT CCATGGCTGC AGTGGCCCAG CGGAGCATGC CCCTGCAGAC AGGAACAGCC 1740
CAGATTTGTG CCCGGCCTGA CCCATTCCAG CAAGCTCTCA TCGTGTGTCC CCCCGGCTTC 1800
CAAGGCTTGC AGGCCTCTCC CTCTAAGCAC GCTGGCTACT CGGTGCGAAT GGAAAATGCG 1860
GTTCCCATCG TCACTCAAGC CCCAGGAGCT CAGCCTCTTC AGATCCAACC AGGTCTGCTT 1920
GCCCAGCAGG CATGGCCAAG TGGGACCCAG CAGATCCTGC TTCCCCCAGC GTGGCAGCAG 1980
CTGACTGGAG TGGCCACCCA CACATCAGTG CAGCACGCCA CTGTGATTCC TGAGACCATG 2040
GCAGGCACCC AGCAGCTGGC GGACTGGAGG AACACGCATG CTCATGGAAG CCATTACAAT 2100
CCCATCATGC AGCAGCCTGC GCTATTGACC GGTCATGTGA CCCTTCCAGC AGCCCAGCCC 2160
TTAAATGTGG GTGTGGCCCA CGTGATGCGG CAGCAGCCAA CCAGCACCAC CTCCTCCCGG 2220
AAGAGTAAGC AGCACCAGTC ATCTGTGAGA AATGTCTCCA CCTGTGAGGT GTCCTCCTCT 2280
CAGGCCATCA GCTCCCCACA GCGATCCAAG CGTGTCAAGG AGAACACACC TCCCCGCTGT 2340
GCCATGGTGC ACAGTAGCCC GGCCTGCAGC ACCTCGGTCA CCTGTGGGTG GGGCGACGTG 2400
GCCTCCAGCA CTACCCGGGA GCGGCAGCGG CAGACAATTG TCATTCCCGA CACTCCCAGC 2460
CCCACGGTCA GCGTCATCAC CATCAGCAGT GACACGGACG AGGAGGAGGA ACAGAAACAT 2520
GCCCCCACCA GCACTGTCTC CAAGCAAAGA AAAAACGTCA TCAGCTGTGT CACAGTCCAC 2580
GACTCCCCCT ACTCTGACTC CTCCAGCAAC ACCAGCCCCT ACTCCGTGCA GCAGCGTGCC 2640
GGGCACAACA ATGCCAACGC CTTTGACGCC AAGGGGAGCC TGGAGAATCA CTGCACGGGG 2700
AACCCCCGAA CCATCATCGT GCCACCCCTG AAAACCCAGG CCAGCGAAGT ATTGGTGGAG 2760
TGTGATAGCC TGGTGCCAGT CAACACCAGT CACCACTCGT CCTCCTACAA GTCCAAGTCC 2820
TCCAGCAACG TGACCTCCAC CAGCGGTCAC TCTTCAGGGA GCTCATCTGG AGCCATCACC 2880
TACCGGCAGC AGCGGCCGGG CCCCCACTTC CAGCAGCAGC AGCCACTCAA TCTCAGCCAG 2940
GCTCAGCAGC ACATCACCGC GGACCGCACT GGGAGCCACC GAAGGCAGCA GGCCTACATC 3000
ACTCCCACCA TGGGCCAGGC TCCGTACTCC TTCCCGCACA ACAGCCCCAG CCACGGCGCT 3060
GTGCACCCCC ATCTGGCTGC AGCCGCCGCC GCTGCCCACC TCCCCACCCA GCCCCACCTC 3120
TACACCTACA CCGCGCCTGC GGCCCTGGGC TCCACCGGCA CCGTGGCCCA CCTGGTGGCC 3180
TCGCAAGGCT CGGCGCGCCA CACCGTGCAG CACACTGCCT ACCCAGCCAG CATCGTCCAC 3240
CAGGTCCCCG TGAGCATGGG CCCCCGGGTC CTGCCCTCGC CCACCATCCA CCCGAGTCAG 3300
TATCCAGCCC AATTTGCCCA CCAGACCTAC ATCAGCGCCT CGCCAGCCTC CACCGTCTAC 3360
ACTGGATACC CACTGAGCCC CGCCAAGGTC AACCAGTACC CTTACATATA A 3411
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 199   YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ESADD  257
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr++e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 258   YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS  317
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv+++r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 318   LGLIHADLKPENIMLVDPSRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  377
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 378   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  437
         **********************************************************88
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkapls  273
          t++ +p ++lkt          ks++++k+++n+ ++++++k+  +
Q: 438   dTDSPYPLWRLKTPddheaetgiKSKEARKYIFNCLDDMAQVKSCFQ  484
         878899999999999************************99876544
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTESADDY 60
NFVRAYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPVLQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPSRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240
TDSPYPLWRL KTPDDHEAET GIKSKEARKY IFNCLDDMAQ VKSCFQ 286
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>
EKS-AIM-00249
EKS-ANC-00256
EKS-BOT-00267
EKS-CAJ-00273
EKS-CAF-00274
EKS-CAP-00302
EKS-DAR-00602
EKS-EQC-00259
EKS-FEC-00253
EKS-GAG-00224
EKS-GAA-00331
EKS-GOG-00267
EKS-HOS-00273
EKS-ICT-00252
EKS-LAC-00284
EKS-MAM-00269
EKS-MEG-00212
EKS-MOD-00264
EKS-MUM-00298
EKS-MUP-00264
EKS-MYL-00269
EKS-NOL-00252
EKS-ORN-00344
EKS-ORC-00252
EKS-OTG-00273
EKS-PAT-00252
EKS-PES-00237
EKS-RAN-00282
EKS-SAH-00251
EKS-SUS-00240
EKS-TAG-00282
EKS-TAR-00340
EKS-TEN-00334
EKS-TUT-00032
Gene Ontology
GO:0005813; C:centrosome
GO:0031965; C:nuclear membrane
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0001105; F:RNA polymerase II transcription coactivator activity
GO:0003714; F:transcription corepressor activity
GO:0046790; F:virion binding
GO:0007628; P:adult walking behavior
GO:0009952; P:anterior/posterior pattern specification
GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0048596; P:embryonic camera-type eye morphogenesis
GO:0060059; P:embryonic retina morphogenesis in camera-type eye
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072; P:iris morphogenesis
GO:0060235; P:lens induction in camera-type eye
GO:0030514; P:negative regulation of BMP signaling pathway
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0030182; P:neuron differentiation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0008284; P:positive regulation of cell proliferation
GO:0043388; P:positive regulation of DNA binding
GO:0046330; P:positive regulation of JNK cascade
GO:0032092; P:positive regulation of protein binding
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0010842; P:retina layer formation
GO:0060395; P:SMAD protein signal transduction
GO:0007224; P:smoothened signaling pathway
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0050882; P:voluntary musculoskeletal movement
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013