EKS-POA-00009
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00009
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph435.06.9E-131542796255
StatusUnreviewed
Ensembl ProteinENSPPYP00000020327
UniProt AccessionH2PNW1;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA1
Gene Synonyms/Alias EPHA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000018119ENSPPYP00000020327ENSPPYT00000021124
OrganismPongo abelii
Functional Description
Protein Length893
Protein Sequence
(FASTA)
MERRWPLGLG LVLLLCAPLP PGARAKEVTL MDTSKAQGEL GWLLDPPKDG GIQLRRPLFQ 60
KVTTVAADQS FTIRDLASGS MKLNVERCSL GRLTRRGLYL AFHNPGACVA LVSVRVFYQR 120
CPETLNGLAQ FPDTLPGPAG LVEVAGTCLP HARASPRPSG APRMHCSPDG EWLVPVGRCH 180
CEPGYEEGGS GEGCVACPSG SYRMDMDTPH CLTCPQHSTA ESEGATICTC ESGHYRAPGE 240
GPQVACTGPP SAPRNLSFSA SGTQLSLHWE PPADTGGRQD VRYSVRCSQC QGTAQDGGPC 300
QPCGVGVHFL PGAQGLTTPA VHVNGLEPYA NYTFNVEAQN GVSGLGSSGH ASTSVSISMG 360
HAESLSGLSL RLVKKEPRQL ELTWAGSRPR SPGANLSYEL HVLNQDEERY QMVLEPRVLL 420
TELQPDTTYI VRVRMLTPLG PGPFSPDHEF RTSPPVSRGL TGGEIVAVIF GLLLGAALLL 480
GILVFRSRRT QRQRQQRQCD HTTDVDREDK LWLKPYVDLQ AYEDPAQGAL DFTQELDPAW 540
LMVDTVIGEG EFGEVYRGTL RLPSQDCTTV AIKTLKDTSP GGQWWNFLRE ATIMGQFSHP 600
HILHLEGVVT KRKPIMIITE FMENGALDAF LREREDQLVP GQLVAMLQGI ASGMNYLSNH 660
NYVHRDLAAR NILVNQNLCC KVSDFGLTRL LDDFDGTYET QGGKIPIRWT APEAIAHRIF 720
TTASDVWSFG IVMWEVLSFG DKPYGEMSNQ EVMKSIEDGY RLPPPVDCPA PLYELMKNCW 780
AYDRARRPHF QKLQAHLEQL LANPHSLRTI ANFDPRVTLR LPSLSGSDGI PYRSVSEWLE 840
SIRMKRYILH FHSAGLDTME CVLELTAEDL TQMGITLPGH QKRILCSIQG FKD 893
Nucleotide Sequence
(FASTA)
ATGGAGCGGC GCTGGCCCCT GGGGCTAGGG CTGGTGCTGC TGCTCTGCGC CCCGCTGCCC 60
CCGGGGGCGC GCGCCAAGGA AGTTACTCTG ATGGACACAA GCAAGGCACA GGGAGAGCTG 120
GGCTGGCTGC TGGATCCCCC AAAAGATGGG GGCATTCAGC TCCGACGGCC CTTGTTCCAG 180
AAGGTAACCA CGGTGGCTGC AGACCAGAGC TTCACCATTC GAGACCTCGC ATCTGGCTCC 240
ATGAAGCTGA ATGTGGAGCG CTGCTCTCTG GGCCGCCTGA CCCGCCGTGG CCTCTACCTC 300
GCTTTCCACA ACCCGGGTGC CTGTGTGGCC CTGGTGTCTG TCCGGGTCTT CTACCAGCGC 360
TGTCCTGAGA CCCTGAATGG CTTGGCCCAA TTCCCAGACA CTCTGCCTGG CCCCGCTGGG 420
TTGGTGGAAG TGGCAGGGAC CTGCTTGCCC CACGCGCGGG CCAGCCCCAG GCCCTCAGGT 480
GCACCCCGCA TGCACTGCAG CCCTGATGGC GAGTGGCTGG TGCCTGTAGG ACGGTGCCAC 540
TGTGAGCCTG GCTATGAGGA AGGTGGCAGT GGCGAGGGAT GTGTTGCCTG CCCTAGCGGC 600
TCCTACCGGA TGGACATGGA CACACCCCAT TGTCTCACGT GCCCCCAGCA CAGCACTGCT 660
GAGTCTGAGG GGGCCACCAT CTGTACCTGT GAGAGCGGCC ATTACAGAGC TCCCGGGGAG 720
GGCCCCCAGG TGGCATGCAC AGGTCCCCCC TCGGCCCCCC GAAACCTGAG CTTCTCTGCC 780
TCAGGGACTC AGCTCTCCCT GCATTGGGAA CCCCCAGCAG ATACGGGGGG ACGCCAGGAT 840
GTCAGATACA GTGTGAGGTG TTCCCAGTGT CAGGGCACAG CACAGGACGG GGGGCCCTGC 900
CAGCCCTGTG GGGTGGGCGT GCACTTCTTG CCGGGGGCCC AGGGGCTCAC CACACCTGCA 960
GTGCACGTCA ATGGCCTTGA ACCTTACGCC AACTACACCT TTAACGTGGA AGCCCAAAAT 1020
GGAGTGTCAG GGCTGGGCAG CTCTGGCCAT GCCAGCACCT CGGTCAGCAT CAGCATGGGG 1080
CATGCAGAGT CACTGTCAGG CCTGTCTCTG AGACTGGTGA AGAAAGAACC GAGGCAACTA 1140
GAGCTGACCT GGGCGGGGTC CCGGCCCCGA AGCCCTGGGG CGAACCTGAG CTATGAGCTG 1200
CATGTGCTGA ACCAGGATGA AGAACGGTAC CAGATGGTTC TAGAACCCAG GGTCTTGCTG 1260
ACAGAGCTGC AGCCTGACAC CACATACATC GTTAGAGTCC GAATGCTGAC CCCACTGGGT 1320
CCTGGCCCTT TCTCCCCTGA TCATGAGTTT CGGACCAGCC CACCAGTGTC CAGGGGCCTG 1380
ACTGGAGGAG AGATTGTGGC CGTCATCTTT GGGCTGCTGC TTGGTGCAGC CTTGCTGCTT 1440
GGGATTCTCG TTTTCCGGTC CAGGAGAACC CAGCGGCAGA GGCAGCAGAG GCAGTGTGAC 1500
CACACCACCG ATGTGGATCG GGAGGACAAG CTGTGGCTGA AGCCCTATGT GGACCTCCAG 1560
GCATACGAGG ACCCTGCACA GGGAGCCTTG GACTTTACCC AGGAGCTCGA TCCAGCGTGG 1620
CTGATGGTGG ACACTGTCAT AGGAGAAGGA GAGTTTGGGG AAGTGTATCG AGGGACCCTG 1680
AGGCTCCCCA GCCAGGACTG CACGACTGTG GCCATTAAGA CCTTAAAAGA CACATCCCCA 1740
GGTGGCCAGT GGTGGAACTT CCTTCGAGAG GCAACTATCA TGGGCCAGTT TAGCCACCCG 1800
CATATTCTGC ATCTGGAAGG CGTTGTCACA AAGCGAAAGC CGATCATGAT CATCACTGAA 1860
TTTATGGAGA ATGGAGCCCT GGATGCCTTC CTGAGGGAGC GGGAGGACCA GCTGGTCCCT 1920
GGGCAGTTAG TGGCCATGCT GCAGGGCATA GCATCTGGCA TGAACTACCT CAGTAATCAC 1980
AATTATGTCC ACCGGGACCT GGCTGCCAGA AACATCTTGG TGAATCAAAA CCTGTGCTGC 2040
AAGGTGTCTG ACTTTGGCCT GACTCGCCTC CTGGATGACT TTGATGGCAC ATACGAAACC 2100
CAGGGAGGAA AGATCCCTAT CCGTTGGACA GCCCCTGAAG CCATTGCCCA TCGGATCTTC 2160
ACCACGGCCA GTGATGTGTG GAGCTTTGGG ATTGTGATGT GGGAGGTGCT GAGCTTTGGC 2220
GACAAGCCTT ATGGGGAGAT GAGCAATCAG GAGGTTATGA AGAGCATTGA GGATGGGTAC 2280
CGGTTGCCCC CTCCTGTGGA CTGCCCTGCC CCTCTGTATG AGCTCATGAA GAACTGCTGG 2340
GCATATGACC GTGCCCGCCG GCCACACTTC CAGAAGCTTC AGGCACATCT GGAGCAACTG 2400
CTTGCCAACC CCCACTCCCT GCGGACCATT GCCAACTTTG ACCCCAGGGT GACTCTCCGC 2460
CTGCCCAGCC TGAGCGGCTC AGATGGGATC CCGTATCGAA GCGTCTCTGA GTGGCTGGAG 2520
TCCATACGCA TGAAACGCTA CATCCTGCAC TTCCACTCGG CTGGGCTGGA CACCATGGAG 2580
TGTGTGCTGG AGCTGACCGC TGAGGACCTG ACGCAGATGG GAATCACACT GCCCGGGCAC 2640
CAGAAGCGCA TTCTTTGCAG TATTCAGGGA TTCAAGGACT GA 2682
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
         ++++viG+GefGev++G+l+lp++  ++vaiktlk++s   q+++fl+ea+i+Gqf+hp+
Q: 542   MVDTVIGEGEFGEVYRGTLRLPSQDCTTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPH  601
         6899******************999999********************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         i++leGvvtk+kp+mi+te+mengald+flr++++q++  qlv+ml+Giasgm+yls+++
Q: 602   ILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHN  661
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilvn+nl+ckvsdfGl+r l dd + +y+t+ggkipirwtapeaia+r f
Q: 662   YVHRDLAARNILVNQNLCCKVSDFGLTRLL-DDFDGTYETQGGKIPIRWTAPEAIAHRIF  720
         ****************************98.7889*************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         t+asdvws+Giv+wevls+G++py +msnq+v+k+ie+gyrlppp+dcpa ly+lm++cw
Q: 721   TTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCW  780
         ************************************************************
S: 242   qkdraerpkfeqivsi  257
           dra+rp+f++++++
Q: 781   AYDRARRPHFQKLQAH  796
         ************9986
Domain Sequence
(FASTA)
MVDTVIGEGE FGEVYRGTLR LPSQDCTTVA IKTLKDTSPG GQWWNFLREA TIMGQFSHPH 60
ILHLEGVVTK RKPIMIITEF MENGALDAFL REREDQLVPG QLVAMLQGIA SGMNYLSNHN 120
YVHRDLAARN ILVNQNLCCK VSDFGLTRLL DDFDGTYETQ GGKIPIRWTA PEAIAHRIFT 180
TASDVWSFGI VMWEVLSFGD KPYGEMSNQE VMKSIEDGYR LPPPVDCPAP LYELMKNCWA 240
YDRARRPHFQ KLQAH 255
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00011
EKS-ANC-00010
EKS-BOT-00011
EKS-CAJ-00011
EKS-CAF-00012
EKS-CAP-00009
EKS-EQC-00012
EKS-FEC-00009
EKS-GAG-00011
EKS-GOG-00012
EKS-HOS-00012
EKS-ICT-00011
EKS-LOA-00012
EKS-MAM-00010
EKS-MEG-00010
EKS-MOD-00011
EKS-MUM-00012
EKS-MUP-00012
EKS-MYL-00013
EKS-NOL-00011
EKS-OCP-00003
EKS-ORC-00011
EKS-OTG-00012
EKS-PAT-00010
EKS-PES-00009
EKS-RAN-00011
EKS-SAH-00009
EKS-SUS-00009
EKS-TAG-00011
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0032862; P:activation of Rho GTPase activity
GO:0030336; P:negative regulation of cell migration
GO:0006469; P:negative regulation of protein kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0051496; P:positive regulation of stress fiber assembly
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013