EKS-POA-00361
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00361
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src423.62.5E-127241490250
StatusUnreviewed
Ensembl ProteinENSPPYP00000020565
UniProt AccessionH2PPJ4;
Protein Name
Protein Synonyms/Alias
Gene NameBLK
Gene Synonyms/Alias BLK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000018352ENSPPYP00000020565ENSPPYT00000021392
OrganismPongo abelii
Functional Description
Protein Length505
Protein Sequence
(FASTA)
MGLVSSKKPD KEKPIKEKDK GRWSPLKVSA QDKEPPPLPP LVVFNHLTPP PPDEHLDEDE 60
HLVVALYDYA AMNDRDLQML KGEKLQVLKG TGDWWLAKSL VTGREGYVPS NFVARVESLE 120
VERWFFRSLG RKEAERQLLA PINKAGSFLI RESETSKGAF SLSVKDVTTQ GELIKHYKIR 180
SLDGGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VSPAPQNPWA QDEWEIPRQS 240
LRLVRKLGSG QFGEVWMGYY KNNMKVAVKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 300
AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD 360
LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 420
FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER 480
PTFEFLQSVL EDFYTATERQ YELQP 505
Nucleotide Sequence
(FASTA)
ATGGGGCTGG TGAGCAGCAA AAAGCCGGAC AAGGAAAAGC CGATCAAGGA GAAGGACAAG 60
GGCCGATGGA GCCCCCTGAA GGTCAGCGCC CAAGACAAGG AGCCCCCGCC ACTGCCACCC 120
CTGGTTGTCT TCAACCACCT TACTCCTCCA CCGCCCGATG AACACCTGGA TGAAGACGAG 180
CATCTCGTGG TGGCTCTGTA TGACTACGCC GCTATGAATG ATCGGGACCT GCAGATGCTG 240
AAGGGGGAGA AGCTACAGGT CCTGAAGGGA ACTGGAGACT GGTGGCTGGC CAAGTCACTC 300
GTCACGGGAA GAGAAGGCTA TGTGCCCAGC AACTTTGTGG CCCGAGTGGA AAGCCTGGAA 360
GTGGAAAGGT GGTTCTTTAG ATCACTGGGC CGGAAGGAGG CCGAGAGGCA GCTTCTTGCT 420
CCAATCAACA AGGCCGGCTC CTTTCTTATC AGAGAGAGTG AAACCAGCAA AGGTGCCTTC 480
TCCCTGTCTG TGAAGGATGT CACCACCCAG GGGGAGCTGA TCAAGCACTA TAAGATCCGC 540
TCCCTGGATG GAGGGGGCTA CTACATCTCC CCCCGGATCA CCTTCCCCTC GCTCCAGGCC 600
CTGGTGCAGC ACTATTCTAA GAAGGGGGAT GGTCTGTGCC AGAGGCTGAC CCTACCCTGT 660
GTAAGCCCGG CCCCGCAGAA CCCCTGGGCC CAGGATGAAT GGGAGATCCC CCGGCAGTCT 720
CTCAGGCTGG TCAGGAAACT CGGGTCTGGA CAATTCGGCG AAGTCTGGAT GGGTTACTAC 780
AAAAACAACA TGAAGGTGGC CGTTAAGACG CTGAAGGAGG GAACCATGTC TCCGGAAGCC 840
TTCCTGGGCG AGGCCAACGT GATGAAAGCT CTGCAGCACG AGCGGCTGGT CCGACTCTAC 900
GCCGTGGTCA CCAAGGAGCC CATCTACATT GTCACCGAGT ACATGGCCAG AGGATGCCTG 960
CTGGATTTCC TGAAGACGGA TGAAGGGAGC AGATTGTCAC TCCCAAGGCT GATTGACATG 1020
TCGGCGCAGA TTGCTGAAGG GATGGCATAC ATTGAGCGCA TGAATTCCAT CCACCGTGAC 1080
CTGCGGGCGG CCAACATCCT GGTGTCTGAG GCCTTGTGCT GCAAAATTGC TGATTTTGGC 1140
TTAGCTCGAA TCATCGACAG TGAATACACG GCCCAAGAGG GGGCCAAGTT CCCCATCAAG 1200
TGGACAGCCC CGGAAGCCAT CCACTTCGGG GTCTTCACCA TCAAAGCAGA CGTGTGGTCG 1260
TTTGGCGTCC TCCTGATGGA AGTTGTCACT TATGGGCGGG TGCCATACCC AGGGATGAGC 1320
AACCCCGAGG TCATCCGCAA CCTGGAGCGC GGCTACCGCA TGCCGCGCCC CGACACATGC 1380
CCGCCGGAGC TGTACCGCGG CGTCATCGCC GAGTGCTGGC GCAGCCGGCC CGAGGAGCGG 1440
CCCACCTTCG AGTTCCTGCA GTCGGTGCTG GAGGACTTCT ACACGGCCAC CGAGCGGCAG 1500
TACGAGCTGC AGCCCTAG 1518
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+lv+klG+GqfGevw+g++k+++kvavktlkegt+speafl ea+++k l+he+lv+ly
Q: 241   LRLVRKLGSGQFGEVWMGYYKNNMKVAVKTLKEGTMSPEAFLGEANVMKALQHERLVRLY  300
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyivte+ma+G+lldflk++eg++l+lp+l+d++aq+aeGmay+e++n ihr
Q: 301   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHR  359
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+e l++k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv
Q: 360   DLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  418
         **************************.899******************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239
         WsfG+ll+e+vt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe
Q: 419   WSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRgVIAECWRSRPE  478
         ************************************************9***********
S: 240   erPtfetlqevl  251
         erPtfe+lq+vl
Q: 479   ERPTFEFLQSVL  490
         ********9986
Domain Sequence
(FASTA)
LRLVRKLGSG QFGEVWMGYY KNNMKVAVKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 60
AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD 120
LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180
FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER 240
PTFEFLQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00345
EKS-ANC-00360
EKS-BOT-00372
EKS-CAJ-00377
EKS-CAF-00372
EKS-CAP-00405
EKS-DAR-00751
EKS-EQC-00363
EKS-FEC-00359
EKS-GAG-00314
EKS-GOG-00363
EKS-HOS-00379
EKS-ICT-00353
EKS-LAC-00386
EKS-LOA-00381
EKS-MAM-00373
EKS-MEG-00304
EKS-MOD-00360
EKS-MUM-00404
EKS-MUP-00366
EKS-NOL-00339
EKS-ORN-00479
EKS-ORC-00351
EKS-OTG-00375
EKS-PAT-00352
EKS-PES-00329
EKS-PTV-00095
EKS-RAN-00386
EKS-SAH-00342
EKS-SUS-00325
EKS-TAG-00443
EKS-TAR-00476
EKS-TUT-00099
EKS-XIM-00469
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0032024; P:positive regulation of insulin secretion
KEGG
pon:100442545;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013