EKS-POA-00144

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00144

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	554.9	2.6E-167	478	754	277

Status

Unreviewed

Ensembl Protein

ENSPPYP00000020767

UniProt Accession

H2PQ36;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000018526	ENSPPYP00000020767	ENSPPYT00000021600

Organism

Pongo abelii

Functional Description

Protein Length

822

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD 60

VQSINWLRDG VQLAESNRTR ITGEEVEVQD SMPADSGLYA CVTSSPSGSD TTYFSVNVSD 120

ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS 180

SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN 240

HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI 300

GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE 360

ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS 420

IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL 480

GKPLGEGCFG QVVLAEAVGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK 540

HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL 600

VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG 660

RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD 720

KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF 780

PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR 822

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCACC 60

GCTAGGCCAT CCCCAACCTT GCCTGAACAA GCCCAGCCCT GGGGAGCCCC TGTGGAAGTG 120

GAGTCCTTCC TGGTCCACCC CGGTGACCTG CTGCAGCTTC GCTGTCGGCT GCGGGACGAT 180

GTGCAGAGCA TCAACTGGCT GCGGGACGGG GTGCAGCTGG CGGAAAGCAA CCGCACCCGC 240

ATCACAGGGG AGGAGGTGGA GGTGCAGGAC TCCATGCCCG CAGACTCCGG CCTCTATGCT 300

TGCGTAACCA GCAGCCCCTC GGGCAGTGAC ACCACCTACT TCTCCGTCAA TGTTTCAGAT 360

GCTCTCCCCT CCTCGGAGGA TGATGATGAT GATGATGACT CCTCTTCAGA GGAGAAAGAA 420

ACAGATAACA CCAAACCAAA CCGTATGCCC GTAGCTCCAT ATTGGACATC CCCAGAAAAA 480

ATGGAAAAGA AATTGCATGC AGTGCCGGCT GCCAAGACAG TGAAGTTCAA ATGCCCTTCC 540

AGTGGGACCC CAAACCCCAC ACTGCGCTGG TTGAAAAATG GCAAAGAATT CAAACCTGAC 600

CACAGAATTG GAGGCTACAA GGTCCGTTAT GCTACCTGGA GCATCATAAT GGACTCCGTG 660

GTGCCCTCTG ACAAGGGCAA CTACACCTGC ATTGTGGAGA ATGAGTACGG CAGCATCAAC 720

CACACGTACC AGCTGGATGT CGTGGAGCGG TCCCCTCACC GGCCCATCCT GCAAGCAGGG 780

TTGCCCGCCA ACAAGACAGT GGCCCTGGGT AGCAACGTGG AGTTCATGTG TAAGGTGTAC 840

AGTGATCCGC AGCCGCACAT CCAGTGGCTA AAGCACATCG AGGTGAACGG GAGCAAGATT 900

GGTCCAGACA ACCTGCCTTA TGTCCAGATC TTGAAGACTG CTGGAGTTAA TACCACCGAC 960

AAAGAGATGG AGGTGCTTCA CTTAAGAAAT GTCTCCTTTG AGGACGCAGG GGAGTATACG 1020

TGCTTGGCGG GTAACTCTAT CGGACTCTCC CATCACTCTG CATGGTTGAC CGTTCTGGAA 1080

GCCCTGGAAG AGAGGCCGGC AGTGATGACC TCGCCCCTGT ACCTGGAGAT CATCATCTAT 1140

TGCACAGGGG CCTTCCTCAT CTCCTGCATG GTGGGGTCGG TCATCGTCTA CAAGATGAAG 1200

AGTGGTACCA AGAAGAGCGA CTTCCACAGC CAGATGGCTG TGCACAAGCT GGCCAAGAGC 1260

ATCCCTCTGC GCAGACAGGT AACAGTGTCT GCTGACTCCA GTGCATCCAT GAACTCTGGA 1320

GTTCTTCTGG TTCGGCCGTC ACGGCTCTCC TCCAGTGGGA CTCCCATGCT AGCAGGGGTC 1380

TCTGAGTATG AGCTTCCCGA AGACCCTCGC TGGGAGCTGC CTCGGGACAG ACTGGTCTTA 1440

GGCAAACCCC TGGGAGAGGG CTGCTTTGGG CAGGTGGTGT TGGCAGAGGC TGTCGGGCTG 1500

GACAAGGACA AACCCAACCG TGTGACCAAA GTGGCTGTGA AGATGTTGAA GTCGGACGCA 1560

ACAGAGAAAG ACTTGTCAGA CCTGATCTCA GAAATGGAGA TGATGAAGAT GATCGGGAAG 1620

CATAAGAATA TCATCAACCT GCTGGGGGCC TGCACGCAGG ACGGTCCCTT GTATGTCATC 1680

GTGGAGTATG CCTCCAAGGG CAACCTGCGG GAGTACCTGC AGGCCCGGAG GCCCCCAGGG 1740

CTGGAATACT GCTACAACCC CAGCCACAAC CCAGAGGAGC AGCTCTCCTC CAAGGACCTG 1800

GTGTCCTGCG CCTACCAGGT GGCCCGAGGC ATGGAGTATC TGGCCTCCAA GAAGTGCATA 1860

CACCGAGACC TGGCGGCCAG GAATGTCCTG GTGACAGAGG ACAATGTGAT GAAGATAGCA 1920

GACTTTGGCC TCGCACGGGA CATTCACCAC ATCGACTACT ATAAAAAGAC AACCAACGGC 1980

CGACTGCCTG TGAAGTGGAT GGCGCCCGAG GCATTATTTG ACCGGATCTA CACCCACCAG 2040

AGTGATGTGT GGTCTTTTGG GGTGCTCCTG TGGGAGATCT TCACTCTGGG TGGCTCCCCG 2100

TACCCCGGTG TGCCTGTGGA GGAGCTTTTC AAGCTGCTGA AGGAGGGTCA CCGCATGGAC 2160

AAGCCCAGTA ACTGCACCAA CGAGCTGTAC ATGATGATGC GGGACTGCTG GCATGCAGTG 2220

CCCTCACAGA GACCCACCTT CAAGCAGCTG GTGGAAGACC TGGACCGCAT CGTGGCCTTG 2280

ACCTCCAACC AGGAGTACCT GGACCTGTCC ATGCCCCTGG ACCAGTACTC CCCCAGCTTT 2340

CCCGACACCC GGAGCTCTAC GTGCTCCTCA GGGGAGGATT CCGTCTTCTC TCATGAGCCG 2400

CTGCCCGAGG AGCCCTGCCT GCCCCGACAC CCAGCCCAGC TTGCCAATGG CGGACTCAAA 2460

CGCCGCTGA 2469

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aea+gldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 478   LVLGKPLGEGCFGQVVLAEAVGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  537

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 538   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  597

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 598   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  657

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 658   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  717

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 718   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  754

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA VGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0002062	; P:chondrocyte differentiation
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0007605	; P:sensory perception of sound
GO:0001657	; P:ureteric bud development
GO:0021847	; P:ventricular zone neuroblast division

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013