EKS-POA-00088

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00088

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	430.1	6.3E-129	3563	3912	350

Status

Unreviewed

Ensembl Protein

ENSPPYP00000020829

UniProt Accession

H2PQ95;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKDC

Gene Synonyms/Alias

PRKDC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000018573	ENSPPYP00000020829	ENSPPYT00000021662

Organism

Pongo abelii

Functional Description

Protein Length

3972

Protein Sequence
(FASTA)

MAGSGAGVRC SLLRLQETLS AADRCGAALA GHQLIRGLGQ ECVLSSSSAV LALQTSLVFS 60

RDFGLLVFVR KSLNSIEFRE CREEILKFLC IFLEKMGQKI APYSVEIKNT CTSVYTKDRA 120

AKCKIPALDL LIKLLQTFRS SRLMDEFKIG ELFSKFYGEL ALKKKIPDTV LEKVYELLGL 180

LGEVHPSEMI NNAENLFRAF LGELKTQMTS AVREPKLPVL AGCLKGLSSL LCNFTKSMEE 240

DPQTSREIFN FVLKAIRPQI DLKRYAVPSA GLRLFALHAS QFSTCLLDNY VSLFEVLLKW 300

CAHTNVELKK AALSALESFL KQVSNMVAKN AEMHKNKLQY FMEQFYGIIR NVDSNNKELS 360

IAIRGYGLFA GPCKVINAKD VDFMYVELIQ RCKQMFLTQT DTGDDRVYQM PSFLQSVASV 420

LLYLDTVPEV YTPHQGLIRI CSKPVVLPKG PESESEDHRA SGEVRTGKWK VPTYKDYVDL 480

FRHLLSSDQM MDSILADEAF FSVNSSSESL NHLLYDEFVK SVLKIVEKLD LTLETQTVGE 540

QENGDEAPGV WMIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKQAE FFEPWVYSFS 600

YELILQSTRL PLISGFYKLL SITVRNAKKI KYFEGVSPKS LKHSPEDPEK YSCFALFVKF 660

GKEVAVKMKQ YKDELLASCL TFLLSLPHNI IERDVRAYVP ALQMAFKLGL SYTPLAEVGL 720

NALEEWSIYI DRHVMQPYYK DILPCLDGYL KTSALSDETK NNWEVSALSR AAQKGFNKVV 780

LKHLKKTKNL SSNEAISLEE IRIRVVQMLG SLGGQINKNL LTVTSSDEMM KSYVAWDREK 840

RLSFAVPFRE MKPVIFLDVF LPRVTELALT ASDRQTKVAA CELLHSIVMF MLGKATQMPE 900

GGQGAPPMYQ LYKRTFPVLL RLACDVDQVT RQLYEPLVMQ LIHWFTNNKK FESQDTVALL 960

EAILDGIVDP VDSTLRDFCG RCIREFLKWS IKQITPQQQE KSPVNTKSLF KRLYSLALHP 1020

NAFKRLGASL AFNNIYREFR EEESLVEQFV FEALVIYMES LALAHADEKS LGTIQQCCDA 1080

IDHLCRIIEK KHVSLNKAKK RRLPRGFPPS ASLCLLDLVK WLLAHCGRPQ TECRHKSIEL 1140

FYKFVPLLPG NRSPNLWLKD VLKEEGVSFL INTFEGGSCG QSSGILAQPT LLHRGPFSLQ 1200

ATLCWLDLLL AALECYNTFI GERTVGALQV LGTEAQSSLL KAVAFFLESI AMHDIIAAEK 1260

CFGTGAAGNR PSPQEGERYN YSKCTVVVRI MEFTTTLLNT SPEGWKLLKK DLCNTHLMRV 1320

LVQTLCEPAS VGFNIGDVQV MAHLPDVCVN LMKALKMSPY KDILETHLRE KITAQSIEEL 1380

CAVNLYGPDA QVDRSRLAAV VSACKQLHRA GLLHSILPSQ STDLHHSIGT ELLSLVYKGI 1440

APGDERQCLP SLDLSCKQLA SGLLELAFAF GGLVSAVLNG MLDQSFRERA SQKHQGLKLA 1500

TTILQHWKKC DSWWAKDSPL ETKMAVLALL AKILQGQAVT LLPFFTSLTG GSLEELRRVL 1560

EQLIVAHFPM QSREFPPGTP RFNNYVDCMK KFLDALELSQ SPMLLELMTE VLCREQQHVM 1620

EELFQSSFKR IARRGSCVTQ VGLLESVYEM FRKDDPRLSF TRQSFVDRSL LTLLWHCSLD 1680

ALREFFSTIV VDAIDVLKSR FTKLNESTFD TQITKKMGYY KILDVMYSRL PKDDVHAKES 1740

KINQVFHGSC ITEGNELTKT LIRLCYDAFT ENMAGENQLL ERRRLYHCAA YNCAISVICC 1800

VFNELKFYQG FLFSEKPEKN LLIFENLIDL KRRYNFPVEV EVPMERKKKY IEIRKEAREA 1860

ANGDSDGPSY MSSLSYLADS TLSEEMSQFD FSTGVQSYSY SSQDPRPATG RFRRREQRDP 1920

AVHDDVLELE MDELNRHECM APLTALVKHM HRSLGPPQEE DSVPRDLPPW MKFLHGKLGN 1980

PIVPLNIRLF LAKLVINTEE VFRPYAKHWL SPLLQLAASE NNGGEGIHYM VVEIVATILS 2040

WTGLATPTGV PKDEVLANRL LNFLMKHVFH PKRAVFRHNL EIIKTVVECW KDCLSIPYRL 2100

IFEKFSGKDP NSKDNSVGIQ LLGIVMANDL PPYDPQCGIQ SSEYFQALVN NMSFVRYKEV 2160

YAAAAEVLGL ILRYVMERKN ILEESLCELV AKQLKQHQNT MEDKFIVCLN KVTKSFPPLA 2220

DRFMNAVFFL LPKFHGVLKT LCLEVVLCRV EGMTELYFQL KSKDFVQVMR HRDDERQKVC 2280

LDIIYKMMPK LKPVELRELL NPVVEFASHP STTCREQMYN ILMWIHDNYR DPESETDNDS 2340

QEIFKLAKDV LIQGLIDENP GLQLIIRNFW SHETRLPSNT LDRLLALNSL YSPKIEVHFL 2400

SLATNFLLEM TSMSPDYPNP MFEHPLSECE FQEYTIDSDW RFRSTVLTPM FVETQASQGT 2460

LQTRTQEGSL SARWPMAGQI RATQQQHDFT LTQTADGRSS FDWLTGSSTD PLVDHTSPSS 2520

DSLLFAHKRS ERLQRAPLKS VGPDFGKKRL GLPGDEVDNK AKGVAGRTDL LRLRRRFMRD 2580

QEKLSLMYAR KGVAEQKREK EIKSELKMKQ DAQVVLYRSY RHGDLPDIQI KHSSLITPLQ 2640

AVAQRDPIIA KQLFSSLFSG ILKEMDKFKT LSEKNNITQK LLQDFNRFLN TTFSFFPPFV 2700

SCIQDISCQH AALLSLDPAA SAGCLASLQQ PVGIRLLEEA LLRLLPAELP AKRVRGKARL 2760

PPDVLRWVEL AKLYRSIGEY DVLRGIFTSE IGTKQITQSA LLAEARSDYS EAAKQYDEAL 2820

NKQDWVDGEP TEAEKDFWEL ASLDCYNHLA EWKSLEYCST ASVDSENPPD LNKIWSEPFY 2880

QETYLPYMIR SKLKLLLQGE ADQSLLTFID KAMHGELQKA ILELHYSQEL SLLYLLQDDV 2940

DRAKYYIQNG IQSFMQNYSS IDVLLHQSRL TKLQSVQALT EIQEFIGFIS KQGNLSSQVP 3000

LKRLLNTWTN RYPDAKMDPM NIWDDIITNR CFFLSKIEEK LTPLPEDNSM NVDQDGDSSD 3060

RMEVQEQEED ISSLIRSCKF SMKMMMIDSA RKQNNFSLAM KLLKELHKES KTRDDWLVSW 3120

VQSYCRLSHC RSRSQGCSEQ VLTVLKTVSL LDENNVSSYL SKNILAFRDQ NILLGTTYRI 3180

IANALSIEPA CLAEIEEDKA RRILELSGSS SEDSEKVIAG LYQRAFQHLS EAVQAAEEEA 3240

QPPSWSCGPA AGVIDAYMTL ADFCDQQLRK EEENASVIDS AELQAYPALV VEKMLKALKL 3300

NSNEARLKFP RLLQIIERYP EETLSLMTKE ISSIPCWQFI GWISHMVALL DKDQAVAVQH 3360

SVEEITDNYP QAIVYPFIIS SESYSFKDTS TGHKNKEFVA RIKSKLDQGG VIQDFINALD 3420

QLSNPELLFK DWSNDVRAEL AKTPVNKKNI EKMYERMYAA LGDPKAPGLG AFRRKFIQTF 3480

GKEFDKHFGK GGSKLLRMKL SDFNDITNML LLKMNKDSKP PGNLKECSPW MSDFKVEFLR 3540

NELEIPGQYD GRGKPLPEYH VRIAGFDERV TVMASMRRPK RIIIRGHDER EHPFLVKGGE 3600

DLRQDQRVEQ LFQVMNGILA QDSACSQRAL QLRTYSVVPM TSRLGLIEWL ENTVTLKDLL 3660

LNTMSQEEKA AYLSDPKAPP CEYKDWLTKM SGKHDVGAYM LMYKGANRTE TVTSFRKRES 3720

KVPADLLKRA FVRMSTSPEA FLALRSHFAS SHALICISHW ILGIGDRHLN NFMVAMETGS 3780

MIGIDFGHAF GSATQFLPVP ELMPFRLTRQ FINLMLPMKE TGLMYSVMVH ALRAFRSDPG 3840

LLTNTMDVFV KEPSFDWKNF EQKMLKKGGS WIQEINVAEK NWYPRQKICY AKRKLAGANP 3900

AVITCDELLL GHEKAPAFRD YVAVARGSKD HNIRAREPEG GLSEETQVKC LMDQATDPNI 3960

LGRTWEGWEP WM 3972

Nucleotide Sequence
(FASTA)

ATGGCGGGCT CCGGAGCCGG TGTGCGTTGC TCCCTGCTGC GGCTGCAGGA GACCTTGTCC 60

GCCGCGGACC GCTGCGGTGC TGCCCTGGCC GGTCATCAAC TGATCCGCGG CCTGGGGCAG 120

GAATGCGTCC TGAGCAGCAG CTCCGCGGTG CTGGCATTAC AGACATCTTT AGTTTTTTCC 180

AGAGATTTTG GTTTGCTTGT ATTTGTCCGG AAGTCACTCA ACAGTATTGA ATTTCGTGAA 240

TGTAGAGAAG AAATCCTAAA GTTTTTATGT ATTTTCTTAG AAAAAATGGG CCAGAAGATC 300

GCGCCTTACT CTGTTGAAAT TAAGAATACT TGTACCAGTG TTTATACAAA AGATAGAGCT 360

GCTAAATGTA AAATTCCAGC CCTGGACCTT CTTATTAAGT TACTTCAGAC TTTTAGAAGT 420

TCTAGACTCA TGGATGAATT TAAAATTGGA GAATTATTTA GTAAATTCTA TGGAGAACTT 480

GCATTGAAAA AAAAAATACC AGATACAGTT TTAGAAAAAG TATATGAGCT CCTAGGATTA 540

TTGGGTGAAG TTCATCCTAG TGAGATGATA AATAATGCAG AAAACCTGTT CCGCGCTTTT 600

CTGGGTGAAC TTAAGACCCA GATGACATCA GCAGTAAGAG AGCCCAAACT ACCTGTTCTG 660

GCAGGATGTC TGAAGGGGTT GTCCTCACTT CTGTGCAACT TCACTAAGTC CATGGAAGAA 720

GATCCCCAGA CTTCAAGGGA GATTTTTAAT TTTGTACTAA AGGCAATTCG TCCTCAGATT 780

GATCTGAAGA GATATGCTGT GCCCTCAGCT GGCTTGCGCC TATTTGCCCT GCATGCATCT 840

CAGTTTAGCA CCTGCCTTCT GGACAACTAC GTGTCTCTAT TTGAAGTCTT GCTAAAGTGG 900

TGTGCCCACA CAAATGTAGA ATTGAAAAAA GCTGCACTTT CAGCCCTGGA ATCCTTTCTG 960

AAACAGGTTT CTAATATGGT GGCGAAAAAT GCAGAAATGC ATAAAAATAA ACTGCAGTAC 1020

TTTATGGAGC AGTTTTATGG AATCATCAGA AATGTGGATT CGAACAACAA GGAGTTATCT 1080

ATTGCTATCC GTGGATATGG ACTTTTTGCA GGACCCTGCA AGGTTATAAA CGCAAAAGAT 1140

GTTGACTTCA TGTACGTTGA GCTCATTCAG CGCTGCAAGC AGATGTTCCT CACCCAGACA 1200

GACACTGGTG ACGACCGTGT TTATCAGATG CCAAGCTTCC TCCAGTCTGT TGCAAGCGTC 1260

TTGCTGTACC TTGACACAGT TCCTGAGGTG TATACTCCAC ATCAGGGTTT AATCAGAATA 1320

TGTTCTAAAC CAGTGGTCCT TCCAAAGGGC CCTGAGTCTG AATCTGAAGA CCACCGTGCT 1380

TCAGGGGAAG TCAGAACTGG CAAATGGAAG GTGCCAACAT ACAAAGACTA CGTGGATCTC 1440

TTCAGACATC TCCTGAGCTC TGACCAGATG ATGGATTCTA TTTTAGCGGA TGAAGCATTT 1500

TTCTCTGTGA ATTCCTCCAG TGAAAGTCTG AATCATTTAC TTTATGATGA ATTTGTAAAA 1560

TCCGTTTTGA AGATTGTTGA GAAATTGGAT CTTACACTAG AAACACAGAC TGTTGGGGAA 1620

CAAGAGAACG GAGATGAGGC GCCTGGTGTT TGGATGATCC CGACTTCAGA TCCAGCGGCT 1680

AACTTGCATC CGGCTAAACC TAAAGATTTT TCGGCTTTCA TTAACCTGGT GGAATTTTGC 1740

AGAGAGATTC TCCCTGAGAA ACAAGCAGAA TTTTTTGAAC CATGGGTGTA CTCATTTTCA 1800

TATGAATTAA TTTTGCAATC TACAAGGTTG CCCCTCATCA GTGGTTTCTA CAAATTGCTT 1860

TCTATTACAG TAAGAAATGC CAAGAAAATA AAATATTTCG AGGGAGTTAG TCCAAAGAGT 1920

CTGAAACACT CTCCTGAAGA CCCAGAAAAG TATTCTTGCT TTGCTTTATT TGTGAAATTT 1980

GGCAAAGAGG TGGCAGTTAA AATGAAGCAG TACAAAGATG AACTTTTGGC CTCTTGTTTG 2040

ACCTTTCTTC TGTCCTTGCC ACACAACATC ATTGAACGCG ATGTTAGAGC CTACGTTCCT 2100

GCGCTGCAGA TGGCTTTCAA ACTGGGCCTG AGCTATACTC CCTTGGCAGA AGTAGGCCTG 2160

AATGCTCTAG AAGAATGGTC AATTTATATT GACAGACATG TAATGCAGCC TTATTACAAA 2220

GACATTCTCC CCTGCCTGGA TGGATACCTG AAGACTTCAG CCTTGTCAGA TGAGACCAAG 2280

AATAACTGGG AAGTGTCAGC TCTTTCTCGT GCTGCCCAGA AAGGATTTAA TAAAGTGGTG 2340

TTAAAGCACC TGAAGAAGAC AAAGAACCTT TCATCAAATG AAGCAATATC CTTAGAAGAA 2400

ATAAGAATTA GAGTAGTACA AATGCTTGGA TCTCTAGGAG GACAAATAAA CAAAAATCTT 2460

CTGACAGTCA CGTCCTCAGA TGAGATGATG AAGAGCTATG TGGCCTGGGA CAGAGAGAAG 2520

CGACTGAGCT TTGCAGTGCC CTTTAGAGAG ATGAAACCTG TCATTTTCCT GGACGTGTTC 2580

CTGCCTCGAG TCACAGAATT AGCGCTCACA GCCAGTGACA GACAAACTAA AGTTGCAGCC 2640

TGTGAACTTT TACATAGCAT TGTTATGTTT ATGTTGGGCA AAGCCACGCA GATGCCAGAA 2700

GGGGGACAGG GAGCCCCACC CATGTACCAG CTCTATAAGC GGACATTTCC TGTGCTGCTT 2760

CGACTTGCGT GTGATGTTGA TCAGGTGACA AGGCAACTGT ATGAGCCACT AGTTATGCAG 2820

CTGATTCACT GGTTCACTAA CAATAAGAAA TTTGAAAGTC AGGATACTGT CGCCTTACTA 2880

GAAGCTATAT TGGATGGAAT TGTGGACCCT GTTGACAGTA CTTTAAGAGA TTTTTGTGGT 2940

CGGTGTATTC GAGAATTCCT TAAATGGTCC ATTAAGCAAA TAACACCACA GCAGCAGGAG 3000

AAGAGTCCAG TAAACACCAA ATCGCTTTTC AAGCGACTTT ACAGCCTCGC GCTTCACCCC 3060

AATGCTTTCA AGAGGCTGGG AGCATCACTT GCCTTTAATA ATATCTACAG GGAATTCAGG 3120

GAAGAAGAGT CTTTGGTGGA ACAGTTTGTG TTTGAAGCCT TGGTGATATA CATGGAGAGT 3180

CTGGCCTTAG CACATGCAGA TGAGAAGTCC TTAGGTACAA TTCAACAGTG TTGTGATGCC 3240

ATTGATCACC TATGCCGCAT CATTGAAAAG AAGCATGTTT CTTTAAATAA AGCAAAGAAA 3300

CGACGTTTGC CGCGAGGATT TCCACCTTCC GCATCATTGT GTTTATTGGA TCTGGTCAAG 3360

TGGCTTTTAG CTCATTGTGG GAGGCCCCAG ACAGAATGTC GACACAAATC CATTGAACTC 3420

TTTTATAAAT TCGTTCCTTT ATTGCCAGGC AACAGATCCC CTAATTTGTG GCTGAAAGAT 3480

GTTCTCAAGG AAGAAGGTGT CTCTTTTCTC ATCAACACTT TTGAGGGGGG CAGCTGTGGC 3540

CAGTCCTCGG GCATCCTGGC CCAGCCCACC CTCTTGCACC GGGGGCCATT CAGCCTGCAG 3600

GCCACGCTAT GCTGGCTGGA CCTGCTCCTG GCTGCGCTGG AGTGCTACAA CACGTTCATC 3660

GGCGAGAGAA CTGTGGGAGC GCTCCAGGTC CTAGGTACTG AAGCCCAGTC TTCACTTTTG 3720

AAAGCAGTGG CTTTCTTTTT AGAAAGCATT GCCATGCATG ACATTATAGC AGCAGAAAAG 3780

TGCTTTGGCA CTGGGGCAGC AGGTAACAGA CCAAGCCCAC AAGAGGGAGA AAGATACAAC 3840

TACAGCAAAT GCACCGTTGT GGTCCGGATT ATGGAGTTTA CCACGACTCT GCTGAACACC 3900

TCCCCAGAAG GATGGAAGCT CCTGAAGAAG GACTTGTGTA ATACACACCT GATGAGAGTC 3960

CTGGTGCAGA CGCTGTGTGA GCCCGCGAGC GTAGGTTTCA ACATCGGAGA CGTCCAGGTT 4020

ATGGCTCATC TTCCTGATGT TTGTGTGAAC CTGATGAAAG CTCTTAAGAT GTCCCCATAC 4080

AAAGATATCC TGGAGACCCA TCTGAGAGAG AAAATAACAG CACAGAGCAT TGAGGAGCTT 4140

TGTGCTGTCA ACTTGTATGG CCCTGACGCG CAAGTGGACA GGAGCAGGCT GGCTGCTGTT 4200

GTGTCTGCCT GTAAACAGCT TCACAGAGCT GGGCTTCTGC ATAGTATATT ACCATCTCAG 4260

TCCACAGATC TGCATCATTC TATTGGCACA GAACTTCTTT CCCTGGTTTA TAAAGGCATT 4320

GCCCCTGGAG ATGAGAGACA GTGTCTGCCT TCTCTAGACC TCAGTTGTAA GCAGCTGGCC 4380

AGCGGACTTC TGGAGTTAGC CTTTGCTTTT GGAGGACTGG TGAGTGCCGT TTTGAATGGC 4440

ATGTTAGACC AGAGCTTCAG GGAGCGAGCA AGCCAGAAAC ACCAAGGACT AAAACTTGCA 4500

ACTACAATTC TGCAACACTG GAAGAAGTGT GATTCATGGT GGGCCAAAGA TTCCCCTCTG 4560

GAAACTAAAA TGGCAGTGCT GGCCTTACTG GCAAAAATTT TACAGGGCCA AGCTGTCACT 4620

CTTCTTCCAT TCTTCACCAG CCTCACTGGA GGCAGTCTGG AGGAACTTAG ACGTGTTCTG 4680

GAGCAGCTCA TTGTTGCTCA CTTTCCCATG CAGTCCAGGG AATTTCCCCC AGGAACTCCG 4740

CGGTTCAATA ATTATGTGGA CTGCATGAAA AAGTTTTTAG ATGCATTGGA ATTATCTCAG 4800

AGCCCTATGT TGTTGGAATT GATGACAGAA GTTCTTTGTC GGGAACAGCA GCATGTCATG 4860

GAAGAATTAT TTCAATCCAG TTTTAAGAGG ATTGCCAGAA GGGGTTCATG TGTCACACAA 4920

GTAGGCCTTC TGGAAAGTGT GTATGAAATG TTCAGGAAGG ATGACCCCCG CCTAAGTTTC 4980

ACACGCCAAT CCTTTGTGGA CCGCTCCCTC CTCACTCTGC TGTGGCACTG TAGCCTGGAT 5040

GCTTTGAGAG AATTCTTCAG CACAATTGTG GTGGATGCCA TTGATGTGTT GAAGTCCAGG 5100

TTTACAAAGC TAAATGAATC TACCTTTGAT ACTCAAATCA CCAAGAAGAT GGGCTACTAT 5160

AAGATTCTAG ATGTGATGTA TTCTCGTCTT CCCAAAGATG ATGTTCACGC TAAGGAATCA 5220

AAAATTAATC AAGTTTTCCA TGGCTCGTGT ATTACAGAAG GAAATGAACT TACAAAGACA 5280

TTGATTAGAT TGTGCTACGA TGCATTTACA GAGAACATGG CAGGAGAGAA TCAGCTGCTG 5340

GAGAGGAGAA GACTTTACCA TTGTGCAGCA TACAACTGTG CCATATCTGT CATCTGCTGT 5400

GTCTTCAATG AGTTAAAATT TTACCAAGGT TTTCTGTTTA GTGAAAAACC AGAAAAGAAC 5460

TTGCTTATTT TTGAAAATCT GATCGACCTG AAGCGCCGCT ATAATTTTCC TGTAGAAGTT 5520

GAGGTTCCTA TGGAAAGAAA GAAAAAGTAC ATTGAAATTA GGAAAGAAGC CAGAGAAGCA 5580

GCAAATGGGG ATTCAGATGG TCCTTCCTAT ATGTCTTCCC TGTCATATTT GGCAGACAGT 5640

ACCCTGAGTG AGGAAATGAG TCAATTTGAT TTCTCAACCG GAGTTCAGAG CTATTCATAC 5700

AGCTCCCAAG ACCCTAGACC TGCCACTGGT CGTTTTCGGA GACGGGAGCA GCGGGACCCC 5760

GCGGTGCATG ATGATGTGCT AGAGCTGGAG ATGGACGAGC TCAATCGGCA TGAATGCATG 5820

GCGCCCCTGA CGGCCCTGGT GAAGCACATG CACAGAAGCC TGGGCCCGCC TCAAGAAGAG 5880

GATTCAGTGC CAAGAGATCT TCCTCCCTGG ATGAAATTCC TCCATGGCAA ACTGGGAAAT 5940

CCAATAGTAC CATTAAATAT CCGTCTCTTC TTAGCCAAGC TTGTTATTAA TACAGAAGAG 6000

GTCTTTCGCC CTTACGCAAA GCACTGGCTT AGCCCCTTGC TGCAGCTGGC TGCTTCTGAA 6060

AACAATGGAG GAGAAGGAAT TCACTACATG GTGGTTGAGA TAGTGGCCAC TATTCTTTCA 6120

TGGACAGGCT TGGCCACTCC AACAGGGGTC CCTAAAGATG AAGTGTTAGC AAATCGATTG 6180

CTTAATTTCC TAATGAAACA TGTCTTTCAT CCAAAAAGAG CTGTGTTTAG ACACAACCTT 6240

GAAATTATAA AGACTGTTGT CGAGTGCTGG AAGGACTGTT TATCCATCCC TTATAGGTTA 6300

ATATTTGAAA AGTTTTCCGG TAAAGATCCT AATTCTAAAG ACAACTCAGT AGGGATTCAA 6360

TTGCTAGGCA TCGTGATGGC CAATGACCTG CCTCCCTATG ACCCACAGTG TGGCATCCAG 6420

AGTAGCGAAT ACTTCCAGGC TTTGGTGAAT AATATGTCCT TTGTAAGATA TAAAGAAGTG 6480

TATGCCGCTG CAGCAGAAGT TCTAGGACTT ATACTTCGAT ATGTTATGGA GAGAAAAAAT 6540

ATACTGGAGG AGTCTCTGTG TGAACTGGTT GCGAAACAAT TGAAGCAACA TCAGAATACT 6600

ATGGAGGACA AGTTTATTGT GTGCTTGAAC AAAGTGACCA AGAGCTTCCC TCCTCTTGCA 6660

GACAGGTTCA TGAATGCTGT GTTCTTTCTG CTGCCAAAAT TTCATGGAGT GTTGAAAACA 6720

CTCTGTCTGG AGGTGGTACT TTGTCGTGTG GAGGGAATGA CAGAGCTGTA CTTCCAGTTA 6780

AAGAGCAAGG ACTTCGTTCA AGTCATGAGA CATAGAGATG ATGAAAGACA AAAAGTATGT 6840

TTGGACATAA TTTATAAGAT GATGCCAAAG TTAAAACCAG TAGAACTCCG AGAACTTCTG 6900

AACCCCGTTG TGGAATTCGC TTCCCATCCT TCTACAACAT GTAGGGAACA AATGTATAAT 6960

ATTCTCATGT GGATTCATGA TAATTACAGA GATCCAGAAA GTGAGACAGA TAATGACTCC 7020

CAGGAAATAT TTAAGTTGGC AAAAGATGTG CTGATTCAAG GATTGATTGA CGAGAACCCT 7080

GGACTTCAAT TAATTATTCG AAATTTCTGG AGCCATGAAA CTAGGTTACC TTCAAATACC 7140

TTGGACCGGT TGCTGGCACT AAATTCCTTA TATTCTCCTA AGATAGAAGT GCACTTTTTA 7200

AGTTTAGCAA CAAATTTTCT GCTTGAAATG ACCAGCATGA GCCCAGATTA TCCAAATCCC 7260

ATGTTCGAGC ATCCTCTGTC AGAATGCGAA TTTCAGGAAT ATACCATTGA TTCCGATTGG 7320

CGTTTCCGAA GTACTGTTCT CACTCCGATG TTTGTGGAGA CCCAGGCCTC CCAGGGCACT 7380

CTCCAGACCC GTACCCAGGA AGGGTCCCTC TCAGCTCGCT GGCCAATGGC AGGGCAGATA 7440

AGGGCCACCC AGCAACAGCA TGACTTCACA CTGACACAGA CTGCAGATGG AAGAAGCTCA 7500

TTTGATTGGC TGACCGGGAG CAGCACTGAC CCGCTGGTCG ACCACACCAG TCCCTCATCT 7560

GACTCCTTGC TGTTTGCCCA CAAGAGAAGT GAAAGGTTAC AGAGAGCACC CTTGAAGTCA 7620

GTGGGGCCTG ATTTTGGGAA AAAAAGGCTG GGCCTTCCAG GGGACGAGGT GGATAACAAA 7680

GCGAAAGGTG TGGCCGGCCG GACGGACCTA CTGCGACTGC GCAGACGGTT TATGAGGGAC 7740

CAGGAGAAGC TCAGTTTGAT GTATGCCAGA AAAGGCGTTG CTGAGCAAAA ACGAGAGAAG 7800

GAAATCAAGA GTGAGTTAAA AATGAAGCAG GATGCCCAGG TCGTTCTGTA CAGAAGCTAC 7860

CGGCACGGAG ACCTTCCTGA CATTCAGATC AAGCACAGCA GCCTCATCAC CCCGTTACAG 7920

GCCGTGGCCC AGAGAGACCC AATAATTGCA AAACAGCTCT TTAGCAGCTT GTTTTCTGGA 7980

ATTTTGAAAG AGATGGATAA ATTTAAGACA CTGTCTGAAA AAAACAACAT CACTCAAAAG 8040

TTGCTCCAAG ACTTCAATCG TTTTCTTAAT ACCACCTTCT CTTTCTTTCC ACCTTTTGTC 8100

TCTTGTATTC AGGACATCAG CTGTCAGCAC GCAGCCCTGC TGAGCCTCGA CCCAGCGGCT 8160

AGCGCTGGTT GCCTGGCCAG TCTACAGCAG CCCGTGGGCA TCCGCCTGCT AGAGGAGGCT 8220

CTGCTCCGCC TGCTGCCTGC AGAGCTGCCT GCCAAGCGAG TCCGCGGGAA GGCCCGCCTC 8280

CCTCCTGATG TCCTCAGATG GGTGGAGCTT GCTAAGCTTT ATAGATCAAT TGGAGAATAC 8340

GACGTCCTCC GTGGGATTTT TACCAGTGAG ATAGGAACAA AGCAAATCAC TCAGAGTGCA 8400

TTATTAGCAG AAGCCAGAAG TGATTATTCT GAAGCTGCTA AGCAGTATGA TGAGGCTCTC 8460

AATAAACAAG ACTGGGTAGA TGGTGAGCCC ACAGAAGCCG AGAAGGATTT TTGGGAACTT 8520

GCATCCCTTG ACTGTTACAA CCACCTTGCT GAGTGGAAAT CACTTGAATA CTGTTCTACA 8580

GCCAGTGTAG ACAGTGAGAA CCCCCCAGAC CTAAATAAAA TCTGGAGTGA ACCATTTTAT 8640

CAGGAGACAT ATCTACCTTA CATGATCCGC AGCAAGCTGA AGCTGCTGCT CCAGGGAGAG 8700

GCTGACCAGT CCCTGCTGAC ATTTATTGAC AAAGCTATGC ACGGGGAGCT CCAGAAGGCG 8760

ATTCTAGAGC TTCATTACAG TCAAGAGCTG AGTCTGCTTT ACCTCCTGCA AGATGATGTT 8820

GACAGAGCCA AATATTACAT TCAAAATGGC ATTCAGAGTT TTATGCAGAA TTATTCTAGT 8880

ATTGATGTCC TCTTACACCA AAGTAGACTC ACCAAATTGC AGTCTGTACA GGCTTTAACA 8940

GAAATTCAGG AGTTCATCGG CTTTATAAGC AAACAAGGCA ATTTATCATC TCAAGTTCCC 9000

CTTAAGAGAC TTCTGAACAC CTGGACAAAC AGATATCCAG ATGCTAAAAT GGACCCAATG 9060

AACATCTGGG ATGACATCAT CACAAATCGA TGTTTCTTTC TCAGCAAAAT AGAGGAGAAG 9120

CTTACCCCTC TTCCAGAAGA TAATAGTATG AATGTGGATC AAGATGGAGA CTCCAGTGAC 9180

AGGATGGAAG TGCAAGAGCA GGAAGAAGAT ATCAGCTCCC TGATCAGGAG TTGCAAGTTT 9240

TCCATGAAAA TGATGATGAT AGACAGTGCC CGGAAGCAGA ACAATTTCTC ACTTGCCATG 9300

AAACTACTGA AGGAGCTGCA TAAAGAGTCA AAAACCAGAG ACGATTGGCT GGTGAGCTGG 9360

GTGCAGAGCT ACTGCCGCCT GAGCCACTGC CGGAGCCGGT CCCAGGGCTG CTCTGAGCAG 9420

GTGCTCACTG TGCTGAAAAC AGTCTCTTTG TTGGATGAGA ACAACGTGTC AAGCTACTTA 9480

AGCAAAAATA TTCTGGCTTT CCGTGACCAG AACATTCTCT TGGGTACAAC TTACAGGATC 9540

ATAGCGAATG CTCTCAGCAT TGAGCCAGCC TGTCTTGCTG AAATCGAGGA GGACAAGGCT 9600

AGAAGAATCT TAGAGCTTTC TGGATCCAGT TCAGAGGATT CAGAGAAGGT GATCGCGGGT 9660

CTGTACCAGA GAGCATTCCA GCACCTCTCT GAGGCTGTGC AGGCGGCTGA GGAGGAAGCC 9720

CAGCCTCCCT CCTGGAGCTG TGGGCCTGCA GCTGGGGTGA TTGATGCTTA CATGACGCTG 9780

GCAGATTTCT GTGACCAACA GCTGCGCAAG GAGGAAGAGA ATGCATCAGT TATTGATTCT 9840

GCAGAACTGC AGGCATATCC AGCACTTGTG GTGGAGAAAA TGTTGAAAGC TTTAAAATTA 9900

AATTCCAATG AAGCCAGATT GAAGTTTCCT AGATTACTTC AGATTATAGA ACGGTATCCA 9960

GAGGAGACTT TGAGCCTCAT GACAAAAGAG ATCTCTTCCA TTCCCTGCTG GCAGTTCATT 10020

GGCTGGATCA GCCACATGGT GGCTTTACTG GACAAAGACC AAGCCGTTGC TGTTCAGCAC 10080

TCTGTGGAAG AAATCACTGA TAACTACCCG CAGGCTATTG TTTATCCCTT CATCATAAGC 10140

AGCGAAAGCT ATTCCTTCAA GGATACTTCT ACTGGTCATA AGAATAAGGA GTTTGTGGCA 10200

AGGATTAAAA GTAAGTTGGA TCAAGGAGGA GTGATTCAAG ATTTTATTAA TGCCTTAGAT 10260

CAGCTCTCTA ATCCTGAACT GCTCTTTAAG GATTGGAGCA ATGATGTAAG AGCTGAACTA 10320

GCAAAAACCC CTGTAAATAA AAAAAACATT GAAAAAATGT ATGAAAGAAT GTATGCAGCC 10380

TTGGGTGACC CAAAGGCTCC AGGCCTGGGG GCCTTTAGAA GGAAGTTTAT TCAGACTTTT 10440

GGAAAAGAAT TTGATAAACA TTTTGGGAAA GGAGGTTCTA AGCTACTGAG AATGAAGCTC 10500

AGTGACTTCA ACGACATTAC CAACATGCTA CTTTTAAAAA TGAACAAAGA CTCAAAGCCC 10560

CCTGGGAATC TGAAAGAATG TTCGCCCTGG ATGAGCGACT TCAAAGTGGA GTTCCTGAGA 10620

AATGAGCTGG AGATTCCTGG TCAGTATGAC GGTAGGGGAA AGCCATTGCC AGAGTACCAC 10680

GTGCGAATCG CCGGGTTTGA TGAGCGGGTG ACAGTCATGG CGTCTATGCG AAGGCCCAAG 10740

CGCATCATCA TCCGTGGCCA CGACGAGAGG GAACACCCTT TCCTGGTGAA GGGTGGTGAG 10800

GACCTGCGGC AGGACCAGCG CGTAGAGCAG CTCTTCCAGG TCATGAATGG GATCCTGGCC 10860

CAAGACTCCG CCTGCAGCCA GAGGGCCCTG CAGCTGAGGA CCTATAGCGT GGTGCCCATG 10920

ACCTCCAGGT TAGGATTAAT TGAGTGGCTT GAAAATACTG TTACCTTGAA GGACCTTCTT 10980

TTGAACACCA TGTCCCAAGA GGAGAAGGCG GCTTACCTGA GTGATCCCAA GGCACCGCCA 11040

TGTGAATATA AAGATTGGCT GACAAAAATG TCAGGAAAAC ATGATGTCGG AGCTTACATG 11100

CTAATGTATA AGGGCGCTAA TCGTACCGAA ACAGTCACGT CTTTTAGAAA ACGAGAAAGT 11160

AAAGTGCCTG CTGATCTCTT AAAGCGGGCC TTCGTGAGGA TGAGTACAAG CCCTGAGGCT 11220

TTCCTGGCGC TCCGCTCCCA CTTCGCCAGC TCTCACGCTC TGATATGCAT CAGCCACTGG 11280

ATCCTCGGGA TTGGAGACAG ACATCTGAAC AACTTTATGG TGGCCATGGA GACCGGCAGC 11340

ATGATCGGGA TCGACTTTGG GCATGCGTTT GGATCCGCTA CACAGTTTCT GCCAGTCCCT 11400

GAGTTGATGC CTTTTCGGCT AACTCGCCAG TTTATCAATC TGATGTTACC AATGAAAGAA 11460

ACGGGCCTTA TGTACAGCGT CATGGTACAC GCGCTCCGGG CCTTCCGCTC AGACCCTGGC 11520

CTGCTCACCA ACACCATGGA TGTGTTTGTC AAGGAGCCCT CCTTTGATTG GAAAAATTTT 11580

GAACAGAAAA TGCTGAAAAA AGGAGGGTCA TGGATTCAAG AAATAAATGT TGCTGAAAAA 11640

AATTGGTACC CCCGACAGAA AATATGTTAT GCTAAGAGAA AGTTAGCAGG TGCCAATCCA 11700

GCAGTCATTA CTTGTGATGA GCTACTCCTG GGTCATGAGA AGGCTCCTGC CTTCAGAGAC 11760

TATGTGGCTG TTGCACGAGG AAGCAAAGAT CACAACATTC GTGCCCGAGA ACCAGAGGGT 11820

GGGCTTTCAG AAGAGACTCA AGTGAAGTGC TTGATGGACC AGGCGACAGA CCCCAACATC 11880

CTTGGCAGAA CCTGGGAAGG ATGGGAGCCC TGGATGTGA 11919

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         iagfderv+++as ++pk++++rG+d++e+p+Lvkg eDlrqd+rv+qlf+++N +La+d

Q: 3563  IAGFDERVTVMASMRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQD  3622

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkkl..vekkavlldqpi..syr  116

         +++s+r+L++rty+Vvp+++r+gliew+entv+Lk+ll ++  +e+ka++l++p+  +++

Q: 3623  SACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTmsQEEKAAYLSDPKapPCE  3682

         ***************************************998999*********999***

S: 117   ykdlstvqarkpklkhlkls.........levfkevlenlvpkdllkklllekfpspeew  167

         ykd+ t+++ k+++ +++l+         +++f++++++ vp+dllk++++++++spe++

Q: 3683  YKDWLTKMSGKHDVGAYMLMykganrtetVTSFRKRESK-VPADLLKRAFVRMSTSPEAF  3741

         ***************************************.********************

S: 168   felrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpe  227

         ++lr+++++s+A+i+++++iLg+gdrhl+n+++++etg ++ idfg+af++a+++l+vpe

Q: 3742  LALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGSMIGIDFGHAFGSATQFLPVPE  3801

         ************************************************************

S: 228   kvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk..  285

          +PFRLTr+++n++ +++++G++++ ++++lr++r+++  l+++++vf+++p++dwk+

Q: 3802  LMPFRLTRQFINLMLPMKETGLMYSVMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNfe  3861

         ************************************************************

S: 286   ....kkktsketeeelaekakaealkikkllskvekaenavatrdllllee  332

             kk++s+++e+++aek++++++ki+++++k+++a++av+t+d+lll++

Q: 3862  qkmlKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGH  3912

         **9999****************************************99987

Domain Sequence
(FASTA)

IAGFDERVTV MASMRRPKRI IIRGHDEREH PFLVKGGEDL RQDQRVEQLF QVMNGILAQD 60

SACSQRALQL RTYSVVPMTS RLGLIEWLEN TVTLKDLLLN TMSQEEKAAY LSDPKAPPCE 120

YKDWLTKMSG KHDVGAYMLM YKGANRTETV TSFRKRESKV PADLLKRAFV RMSTSPEAFL 180

ALRSHFASSH ALICISHWIL GIGDRHLNNF MVAMETGSMI GIDFGHAFGS ATQFLPVPEL 240

MPFRLTRQFI NLMLPMKETG LMYSVMVHAL RAFRSDPGLL TNTMDVFVKE PSFDWKNFEQ 300

KMLKKGGSWI QEINVAEKNW YPRQKICYAK RKLAGANPAV ITCDELLLGH 350

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005958	; C:DNA-dependent protein kinase-DNA ligase 4 complex
GO:0005667	; C:transcription factor complex
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0006915	; P:apoptotic process
GO:0002326	; P:B cell lineage commitment
GO:0007420	; P:brain development
GO:0032869	; P:cellular response to insulin stimulus
GO:0006303	; P:double-strand break repair via nonhomologous end joining
GO:0035234	; P:germ cell programmed cell death
GO:0007507	; P:heart development
GO:0033152	; P:immunoglobulin V(D)J recombination
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0002328	; P:pro-B cell differentiation
GO:0031648	; P:protein destabilization
GO:0010332	; P:response to gamma radiation
GO:0001756	; P:somitogenesis
GO:0033077	; P:T cell differentiation in thymus
GO:0002360	; P:T cell lineage commitment
GO:0033153	; P:T cell receptor V(D)J recombination
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR012582	; NUC194.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF08163	; NUC194; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013