EKS-POA-00358
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00358
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src442.44.5E-133247497251
StatusUnreviewed
Ensembl ProteinENSPPYP00000020857
UniProt AccessionH2PQC0;
Protein Name
Protein Synonyms/Alias
Gene NameLYN
Gene Synonyms/Alias LYN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000018598ENSPPYP00000020857ENSPPYT00000021690
OrganismPongo abelii
Functional Description
Protein Length512
Protein Sequence
(FASTA)
MGCIKSKGKD SLNDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD 60
PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK 120
LNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI 180
KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW 240
EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300
KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 360
KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 420
TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW 480
KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP 512
Nucleotide Sequence
(FASTA)
ATGGGATGTA TAAAATCAAA AGGGAAAGAC AGCTTGAATG ACGATGGAGT AGATTTGAAG 60
ACTCAACCAG TACGTAATAC TGAAAGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120
CAGCAAAGGC CAGTTCCAGA ATCTCAGCTT TTACCTGGAC AGAGGTTTCA AACTAAAGAT 180
CCAGAAGAAC AAGGAGACAT TGTGGTAGCC TTGTACCCCT ATGATGGCAT CCACCCGGAC 240
GACTTGTCTT TCAAGAAAGG AGAGAAGATG AAAGTCCTGG AGGAGCATGG AGAATGGTGG 300
AAAGCAAAGT CCCTTTTAAC AAAAAAAGAA GGCTTCATCC CCAGCAACTA TGTGGCCAAA 360
CTCAACACCT TAGAAACAGA AGAGTGGTTT TTCAAGGATA TAACCAGGAA GGACGCAGAA 420
AGGCAGCTTT TGGCACCAGG GAATAGCGCT GGAGCTTTCC TTATTAGAGA AAGTGAAACA 480
TTAAAAGGAA GCTTCTCTCT ATCTGTCAGA GACTTTGACC CTGTGCATGG TGATGTTATT 540
AAGCACTACA AAATTAGAAG TCTGGATAAT GGGGGCTATT ACATCTCTCC ACGAATCACT 600
TTTCCCTGTA TCAGCGACAT GATTAAACAT TACCAAAAGC AGGCAGATGG CTTGTGCAGA 660
AGATTGGAGA AGGCTTGTAT TAGTCCCAAG CCACAGAAGC CATGGGATAA AGATGCCTGG 720
GAGATCCCCC GGGAGTCCAT CAAGTTGGTG AAAAGGCTCG GCGCTGGGCA GTTTGGGGAA 780
GTCTGGATGG GTTACTATAA CAACAGTACC AAGGTGGCTG TGAAAACCCT GAAGCCAGGC 840
ACTATGTCTG TGCAAGCCTT CCTGGAAGAA GCCAACCTCA TGAAGACCCT GCAGCACGAC 900
AAGCTTGTGA GGCTCTACGC TGTGGTCACC AGGGAGGAGC CCATTTACAT CATCACCGAG 960
TACATGGCCA AGGGTAGTTT GCTGGATTTC CTGAAGAGTG ATGAAGGTGG CAAAGTGCTG 1020
CTTCCAAAGC TCATTGACTT TTCTGCTCAG ATTGCAGAGG GAATGGCATA CATCGAGCGG 1080
AAGAACTACA TTCACCGGGA CCTGCGAGCA GCTAATGTCC TGGTCTCCGA GTCACTCATG 1140
TGCAAAATTG CAGATTTTGG CCTTGCTAGA GTAATTGAAG ATAATGAGTA CACAGCAAGG 1200
GAAGGTGCTA AGTTCCCTAT TAAGTGGACA GCTCCAGAAG CAATCAACTT TGGATGTTTC 1260
ACTATTAAGT CTGATGTGTG GTCCTTTGGA ATCCTCCTAT ATGAAATCGT CACCTATGGG 1320
AAAATTCCCT ACCCAGGGAG AACTAATGCC GACGTGATGA CTGCCCTGTC CCAGGGATAC 1380
AGGATGCCCC GTGTGGAGAA CTGCCCAGAT GAGCTCTATG ACATTATGAA AATGTGCTGG 1440
AAAGAAAAGG CAGAAGAGAG ACCAACATTT GATTACTTAC AGAGCGTCCT GGATGATTTC 1500
TACACAGCCA CGGAAGGGCA GTACCAGCAG CAGCCTTAG 1539
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         +klvk+lG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly
Q: 247   IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr
Q: 307   AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  366
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 367   DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr e+cp+ely+++++cwk+++ee
Q: 427   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE  486
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++lq+vl
Q: 487   RPTFDYLQSVL  497
         ********986
Domain Sequence
(FASTA)
IKLVKRLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60
AVVTREEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120
DLRAANVLVS ESLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180
WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRVE NCPDELYDIM KMCWKEKAEE 240
RPTFDYLQSV L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00342
EKS-ANC-00358
EKS-BOT-00368
EKS-CAJ-00372
EKS-CAF-00369
EKS-CAP-00401
EKS-DAR-00748
EKS-EQC-00359
EKS-FEC-00356
EKS-GAM-00222
EKS-GAG-00312
EKS-GAA-00452
EKS-GOG-00359
EKS-HOS-00374
EKS-ICT-00348
EKS-LAC-00384
EKS-LOA-00377
EKS-MAM-00368
EKS-MEG-00306
EKS-MOD-00359
EKS-MUM-00400
EKS-MUP-00362
EKS-MYL-00366
EKS-NOL-00336
EKS-OCP-00073
EKS-ORN-00477
EKS-ORA-00322
EKS-ORC-00346
EKS-ORL-00439
EKS-OTG-00372
EKS-PAT-00348
EKS-PES-00327
EKS-PEM-00193
EKS-PTV-00094
EKS-RAN-00382
EKS-SAH-00338
EKS-SUS-00327
EKS-TAG-00441
EKS-TAR-00474
EKS-TAS-00040
EKS-TEN-00466
EKS-XET-00488
EKS-XIM-00465
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001782; P:B cell homeostasis
GO:0050853; P:B cell receptor signaling pathway
GO:0071300; P:cellular response to retinoic acid
GO:0097028; P:dendritic cell differentiation
GO:0030218; P:erythrocyte differentiation
GO:0002774; P:Fc receptor mediated inhibitory signaling pathway
GO:0002431; P:Fc receptor mediated stimulatory signaling pathway
GO:0035556; P:intracellular signal transduction
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0030889; P:negative regulation of B cell proliferation
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade
GO:0043407; P:negative regulation of MAP kinase activity
GO:0070667; P:negative regulation of mast cell proliferation
GO:0002762; P:negative regulation of myeloid leukocyte differentiation
GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175; P:neuron projection development
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0002576; P:platelet degranulation
GO:0030335; P:positive regulation of cell migration
GO:2000670; P:positive regulation of dendritic cell apoptotic process
GO:0070668; P:positive regulation of mast cell proliferation
GO:0010976; P:positive regulation of neuron projection development
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002902; P:regulation of B cell apoptotic process
GO:0050855; P:regulation of B cell receptor signaling pathway
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0050707; P:regulation of cytokine secretion
GO:0045646; P:regulation of erythrocyte differentiation
GO:0050727; P:regulation of inflammatory response
GO:0043304; P:regulation of mast cell degranulation
GO:0090025; P:regulation of monocyte chemotaxis
GO:0090330; P:regulation of platelet aggregation
GO:0006974; P:response to DNA damage stimulus
GO:0009725; P:response to hormone stimulus
GO:0002513; P:tolerance induction to self antigen
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
pon:100447326;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013